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P43726

- PGK_HAEIN

UniProt

P43726 - PGK_HAEIN

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361SubstrateBy similarity
    Binding sitei112 – 1121SubstrateBy similarity
    Binding sitei145 – 1451SubstrateBy similarity
    Binding sitei196 – 1961ATPBy similarity
    Binding sitei313 – 3131ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi339 – 3424ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:pgk
    Ordered Locus Names:HI_0525
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 386385Phosphoglycerate kinasePRO_0000145948Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi71421.HI0525.

    Structurei

    3D structure databases

    ProteinModelPortaliP43726.
    SMRiP43726. Positions 2-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 233Substrate bindingBy similarity
    Regioni59 – 624Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.
    PhylomeDBiP43726.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43726-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVIKMTDLD LAGKRVFIRA DLNVPVKDGK VTSDARIRAT IPTLKLALEK    50
    GAKVMVTSHL GRPTEGEFKP EDSLQPVVDY LKNAGFNVRL EQDYLNGVDV 100
    KDGEIVVLEN VRVNKGEKKN DPELGKKYAA LCDVFVMDAF GTAHRAQAST 150
    YGVAEFAPIA CAGPLLAAEL DALGKALKEP ARPMVAIVGG SKVSTKLEVL 200
    NSLSKIADQI IVGGGIANTF IAAAGHNVGK SLYEADLIPV AKELAANTDI 250
    PVPVDVRVGL EFSETAAATE KVVNEVKDDE SIFDIGDKSA EQLAEIIKNA 300
    KTVLWNGPVG VFEFPHFRKG TEIISHAIAN SDAFSIAGGG DTLAAIDLFG 350
    IADKISYIST GGGAFLEFVE GKVLPAVEIL EKRAKN 386
    Length:386
    Mass (Da):40,983
    Last modified:January 23, 2007 - v2
    Checksum:i9029D21368DEB66D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22183.1.
    PIRiD64074.
    RefSeqiNP_438683.1. NC_000907.1.
    WP_005694128.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC22183; AAC22183; HI_0525.
    GeneIDi949587.
    KEGGihin:HI0525.
    PATRICi20189603. VBIHaeInf48452_0544.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC22183.1 .
    PIRi D64074.
    RefSeqi NP_438683.1. NC_000907.1.
    WP_005694128.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43726.
    SMRi P43726. Positions 2-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0525.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC22183 ; AAC22183 ; HI_0525 .
    GeneIDi 949587.
    KEGGi hin:HI0525.
    PATRICi 20189603. VBIHaeInf48452_0544.

    Phylogenomic databases

    eggNOGi COG0126.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.
    PhylomeDBi P43726.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
    2. "Two-dimensional map of the proteome of Haemophilus influenzae."
      Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
      Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-6.
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiPGK_HAEIN
    AccessioniPrimary (citable) accession number: P43726
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3