Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43713 (FABG_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:HI_0155
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2422423-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054673

Regions

Nucleotide binding10 – 134NADP By similarity
Nucleotide binding57 – 582NADP By similarity
Nucleotide binding149 – 1535NADP By similarity

Sites

Active site1491Proton acceptor By similarity
Binding site351NADP By similarity
Binding site841NADP; via carbonyl oxygen By similarity
Binding site1361Substrate By similarity
Binding site1821NADP; via amide nitrogen and carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P43713 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B3DE2E2C020D2F71

FASTA24225,507
        10         20         30         40         50         60 
MQGKIALVTG STRGIGRAIA EELSSKGAFV IGTATSEKGA EAISAYLGDK GKGLVLNVTD 

        70         80         90        100        110        120 
KESIETLLEQ IKNDFGDIDI LVNNAGITRD NLLMRMKDEE WFDIMQTNLT SVYHLSKAML 

       130        140        150        160        170        180 
RSMMKKRFGR IINIGSVVGS TGNPGQTNYC AAKAGVVGFS KSLAKEVAAR GITVNVVAPG 

       190        200        210        220        230        240 
FIATDMTEVL TDEQKAGILS NVPAGRLGEA KDIAKAVAFL ASDDAGYITG TTLHVNGGLY 


LS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC21824.1.
PIRD64051.
RefSeqNP_438325.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43713.
SMRP43713. Positions 2-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI0155.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC21824; AAC21824; HI_0155.
GeneID951066.
KEGGhin:HI0155.
PATRIC20188805. VBIHaeInf48452_0159.

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMADEFGAID.
OrthoDBEOG6N3CR8.
PhylomeDBP43713.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_HAEIN
AccessionPrimary (citable) accession number: P43713
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names