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P43712

- FABD_HAEIN

UniProt

P43712 - FABD_HAEIN

Protein

Malonyl CoA-acyl carrier protein transacylase

Gene

fabD

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Malonyl-CoA + an [acyl-carrier-protein] = CoA + a malonyl-[acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei93 – 931By similarity
    Active sitei202 – 2021By similarity

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-malonyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malonyl CoA-acyl carrier protein transacylase (EC:2.3.1.39)
    Short name:
    MCT
    Gene namesi
    Name:fabD
    Ordered Locus Names:HI_0156
    OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
    Taxonomic identifieri71421 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
    ProteomesiUP000000579: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Malonyl CoA-acyl carrier protein transacylasePRO_0000194216Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi71421.HI0156.

    Structurei

    3D structure databases

    ProteinModelPortaliP43712.
    SMRiP43712. Positions 3-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FabD family.Curated

    Phylogenomic databases

    eggNOGiCOG0331.
    KOiK00645.
    OMAiIWRVWQE.
    OrthoDBiEOG6W19KW.
    PhylomeDBiP43712.

    Family and domain databases

    Gene3Di3.40.366.10. 2 hits.
    InterProiIPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000446. Mct. 1 hit.
    SUPFAMiSSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsiTIGR00128. fabD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P43712-1 [UniParc]FASTAAdd to Basket

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    MKKFAMVFPG QGSQTVGMLA DLATEYPIVI ETFKQASDAL GYDLWYLVQQ    50
    GPAEELNKTW QTQPALLAAS VAIYRVWKEK FPQLKPEVMA GHSLGEYSAL 100
    VCAGVLDFQD AIKLVELRGK LMQQAVPEGT GAMYAIIGLD NEAIINACKQ 150
    AEEGEVVSAV NFNSPGQVVI AGAKAAVERA AALCKEAGAK RALPLAVSVP 200
    SHCALMKPAA EQLAVTLENI QINTPTISVL NNVDVKAETE GTEIRTALVR 250
    QLYSPVRWTE TVEKMAQDGV LVLAEVGPGK VLNGLTKRIV GDLQAISVND 300
    VASFNAVEEF LV 312
    Length:312
    Mass (Da):33,425
    Last modified:November 1, 1995 - v1
    Checksum:i6261622B834AE878
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21825.1.
    PIRiE64051.
    RefSeqiNP_438326.1. NC_000907.1.

    Genome annotation databases

    EnsemblBacteriaiAAC21825; AAC21825; HI_0156.
    GeneIDi951062.
    KEGGihin:HI0156.
    PATRICi20188807. VBIHaeInf48452_0160.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L42023 Genomic DNA. Translation: AAC21825.1 .
    PIRi E64051.
    RefSeqi NP_438326.1. NC_000907.1.

    3D structure databases

    ProteinModelPortali P43712.
    SMRi P43712. Positions 3-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 71421.HI0156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAC21825 ; AAC21825 ; HI_0156 .
    GeneIDi 951062.
    KEGGi hin:HI0156.
    PATRICi 20188807. VBIHaeInf48452_0160.

    Phylogenomic databases

    eggNOGi COG0331.
    KOi K00645.
    OMAi IWRVWQE.
    OrthoDBi EOG6W19KW.
    PhylomeDBi P43712.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .

    Family and domain databases

    Gene3Di 3.40.366.10. 2 hits.
    InterProi IPR001227. Ac_transferase_dom.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR024925. Malonyl_CoA-ACP_transAc.
    IPR004410. Malonyl_CoA-ACP_transAc_FabD.
    IPR016036. Malonyl_transacylase_ACP-bd.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000446. Mct. 1 hit.
    SUPFAMi SSF52151. SSF52151. 2 hits.
    SSF55048. SSF55048. 1 hit.
    TIGRFAMsi TIGR00128. fabD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

    Entry informationi

    Entry nameiFABD_HAEIN
    AccessioniPrimary (citable) accession number: P43712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Haemophilus influenzae
      Haemophilus influenzae (strain Rd): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3