Reviewed, UniProtKB/Swiss-Prot P43712 (FABD_HAEIN)

Names and origin

Protein names

Recommended name:
    Malonyl CoA-acyl carrier protein transacylase
      Short name=MCT
    EC=2.3.1.39

Gene names

Name:	fabD
Ordered Locus Names:	HI0156

Organism

Haemophilus influenzae [Complete proteome] [HAMAP]

Taxonomic identifier

727 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Sequence similarities	Belongs to the fabD family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	[acyl-carrier-protein] S-malonyltransferase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Malonyl CoA-acyl carrier protein transacylase		PRO_0000194216
Sites
	Active site	93	1	By similarity
	Active site	202	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43712-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 6261622B834AE878	FASTA	312	33,425
	10 20 30 40 50 60 MKKFAMVFPG QGSQTVGMLA DLATEYPIVI ETFKQASDAL GYDLWYLVQQ GPAEELNKTW 70 80 90 100 110 120 QTQPALLAAS VAIYRVWKEK FPQLKPEVMA GHSLGEYSAL VCAGVLDFQD AIKLVELRGK 130 140 150 160 170 180 LMQQAVPEGT GAMYAIIGLD NEAIINACKQ AEEGEVVSAV NFNSPGQVVI AGAKAAVERA 190 200 210 220 230 240 AALCKEAGAK RALPLAVSVP SHCALMKPAA EQLAVTLENI QINTPTISVL NNVDVKAETE 250 260 270 280 290 300 GTEIRTALVR QLYSPVRWTE TVEKMAQDGV LVLAEVGPGK VLNGLTKRIV GDLQAISVND 310 VASFNAVEEF LV

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L42023 Genomic DNA. Translation: AAC21825.1.
PIR	E64051.
RefSeq	NP_438326.1.
3D structure databases
HSSP	HSSP built from PDB template 1MLA based on UniProtKB P25715.
SMR	P43712. Positions 3-306.
ModBase	Search...
Genome annotation databases
GeneID	951062.
GenomeReviews	Gene locus HI0156 in contig L42023_GR.
KEGG	hin:HI0156.
NMPDR	fig|71421.1.peg.147.
TIGR	HI0156.
Phylogenomic databases
HOGENOM	P43712.
OMA	CEIAKAK.
Enzyme and pathway databases
BioCyc	HINF71421:HI_0156-MON.
BRENDA	2.3.1.39. 109.
Family and domain databases
InterPro	IPR001227. Ac_transferase_reg. IPR014043. Acyl_transferase. IPR004410. FabD. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00128. fabD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FABD_HAEIN

Accession

Primary (citable) accession number: P43712

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)