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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 1

Gene

fabB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids (By similarity).By similarity

Catalytic activityi

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciHINF71421:G1GJ1-1555-MONOMER
UniPathwayiUPA00094

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1 (EC:2.3.1.41)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name:
KAS I
Gene namesi
Name:fabB
Ordered Locus Names:HI_1533
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
Proteomesi
  • UP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001803131 – 4063-oxoacyl-[acyl-carrier-protein] synthase 1Add BLAST406

Proteomic databases

PRIDEiP43710

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi71421.HI1533

Structurei

3D structure databases

ProteinModelPortaliP43710
SMRiP43710
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiENOG4105C0Q Bacteria
COG0304 LUCA
KOiK00647
OMAiYAYLSMQ
PhylomeDBiP43710

Family and domain databases

Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
SMARTiView protein in SMART
SM00825 PKS_KS, 1 hit
SUPFAMiSSF53901 SSF53901, 2 hits
PROSITEiView protein in PROSITE
PS00606 B_KETOACYL_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

P43710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRTVITGFG IISSIGNNKE EVLASLKAGK SGIEVVPEFV EMNMRSHVAG
60 70 80 90 100
TIKLNPSEHI DRKVFRFMGD AAAYAYLSMR EAIEDAGLTE DQVSNDRTGL
110 120 130 140 150
VIGAGTGSAH NQLVACDAVR GPRGVKAIGP YAVTKTMASS VSACLATPYK
160 170 180 190 200
IRGVNYSMSS ACATSAHCIG HAVELIQLGK QDVVFAGGAE ELSWECATEF
210 220 230 240 250
DAMGAVSTKY NETPEKASRA YDANRDGFVI AGGGAVVVVE ELEHALARGA
260 270 280 290 300
KIYAEIVGYG ATSDGYDMVA PSGEGAERCM KQAMATVDTP IDYINVHGTS
310 320 330 340 350
TPVGDVKELG AIKNVFGDKI PAISSTKSMT GHSLGAAGAH EAIYTLLMLD
360 370 380 390 400
NDFIAPSINI ETLDEAAEGC NIVTETKENA GLQTVMSNSF GFGGTNATLI

FKRYNG
Length:406
Mass (Da):42,649
Last modified:November 1, 1995 - v1
Checksum:iA17B8673156FDDAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA Translation: AAC23183.1
PIRiA64128
RefSeqiNP_439682.1, NC_000907.1
WP_005693560.1, NC_000907.1

Genome annotation databases

EnsemblBacteriaiAAC23183; AAC23183; HI_1533
GeneIDi950395
KEGGihin:HI1533
PATRICifig|71421.8.peg.1604

Similar proteinsi

Entry informationi

Entry nameiFABB_HAEIN
AccessioniPrimary (citable) accession number: P43710
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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