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P43710 (FABB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1

EC=2.3.1.41
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name=KAS I
Gene names
Name:fabB
Ordered Locus Names:HI_1533
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.

Catalytic activity

Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
   Biological processFatty acid biosynthesis
Fatty acid metabolism
Lipid biosynthesis
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfatty acid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function3-oxoacyl-[acyl-carrier-protein] synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4064063-oxoacyl-[acyl-carrier-protein] synthase 1
PRO_0000180313

Sites

Active site1621 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43710 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A17B8673156FDDAF

FASTA40642,649
        10         20         30         40         50         60 
MRRTVITGFG IISSIGNNKE EVLASLKAGK SGIEVVPEFV EMNMRSHVAG TIKLNPSEHI 

        70         80         90        100        110        120 
DRKVFRFMGD AAAYAYLSMR EAIEDAGLTE DQVSNDRTGL VIGAGTGSAH NQLVACDAVR 

       130        140        150        160        170        180 
GPRGVKAIGP YAVTKTMASS VSACLATPYK IRGVNYSMSS ACATSAHCIG HAVELIQLGK 

       190        200        210        220        230        240 
QDVVFAGGAE ELSWECATEF DAMGAVSTKY NETPEKASRA YDANRDGFVI AGGGAVVVVE 

       250        260        270        280        290        300 
ELEHALARGA KIYAEIVGYG ATSDGYDMVA PSGEGAERCM KQAMATVDTP IDYINVHGTS 

       310        320        330        340        350        360 
TPVGDVKELG AIKNVFGDKI PAISSTKSMT GHSLGAAGAH EAIYTLLMLD NDFIAPSINI 

       370        380        390        400 
ETLDEAAEGC NIVTETKENA GLQTVMSNSF GFGGTNATLI FKRYNG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23183.1.
PIRA64128.
RefSeqNP_439682.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43710.
SMRP43710. Positions 1-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1533.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23183; AAC23183; HI_1533.
GeneID950395.
KEGGhin:HI1533.
PATRIC20191791. VBIHaeInf48452_1604.

Phylogenomic databases

eggNOGCOG0304.
KOK00647.
OMAHYPTRIA.
OrthoDBEOG6DG2SR.
PhylomeDBP43710.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. SSF53901. 2 hits.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABB_HAEIN
AccessionPrimary (citable) accession number: P43710
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names