P43710 (FABB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 1
EC=2.3.1.41

Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase I
Beta-ketoacyl-ACP synthase I
Short name=KAS I

Gene names

Name:	fabB
Ordered Locus Names:	HI_1533

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Taxonomic identifier

71421 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids By similarity.
Catalytic activity	Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].
Pathway	Lipid metabolism; fatty acid biosynthesis.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-oxoacyl-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	3-oxoacyl-[acyl-carrier-protein] synthase 1		PRO_0000180313
Sites
	Active site	162	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43710 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: A17B8673156FDDAF	FASTA	406	42,649
	10 20 30 40 50 60 MRRTVITGFG IISSIGNNKE EVLASLKAGK SGIEVVPEFV EMNMRSHVAG TIKLNPSEHI 70 80 90 100 110 120 DRKVFRFMGD AAAYAYLSMR EAIEDAGLTE DQVSNDRTGL VIGAGTGSAH NQLVACDAVR 130 140 150 160 170 180 GPRGVKAIGP YAVTKTMASS VSACLATPYK IRGVNYSMSS ACATSAHCIG HAVELIQLGK 190 200 210 220 230 240 QDVVFAGGAE ELSWECATEF DAMGAVSTKY NETPEKASRA YDANRDGFVI AGGGAVVVVE 250 260 270 280 290 300 ELEHALARGA KIYAEIVGYG ATSDGYDMVA PSGEGAERCM KQAMATVDTP IDYINVHGTS 310 320 330 340 350 360 TPVGDVKELG AIKNVFGDKI PAISSTKSMT GHSLGAAGAH EAIYTLLMLD NDFIAPSINI 370 380 390 400 ETLDEAAEGC NIVTETKENA GLQTVMSNSF GFGGTNATLI FKRYNG

References

[1]

"Whole-genome random sequencing and assembly of Haemophilus influenzae Rd." Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F., Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M., McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D., Scott J.D., Shirley R., Liu L.-I. , Glodek A., Kelley J.M., Weidman J.F., Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R., Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D., Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A., Small K.V., Fraser C.M., Smith H.O., Venter J.C. Science 269:496-512(1995) [PubMed: 7542800] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L42023 Genomic DNA. Translation: AAC23183.1.
PIR	A64128.
RefSeq	NP_439682.1. NC_000907.1.
3D structure databases
ProteinModelPortal	P43710.
SMR	P43710. Positions 1-403.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	950395.
GenomeReviews	Gene locus HI_1533 in contig L42023_GR.
KEGG	hin:HI1533.
NMPDR	fig|71421.1.peg.1460.
PATRIC	20191791. VBIHaeInf48452_1604.
TIGR	HI_1533.
Phylogenomic databases
HOGENOM	HBG757733.
OMA	MQMALAD.
ProtClustDB	PRK07967.
Enzyme and pathway databases
BioCyc	HINF71421:HI_1533-MONOMER.
Family and domain databases
InterPro	IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KO	K00647.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 2 hits.
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FABB_HAEIN

Accession

Primary (citable) accession number: P43710

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program