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Protein

Probable bacterial non-heme ferritin

Gene

ftnA

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Iron-storage protein.By similarity

Catalytic activityi

4 Fe2+ + O2 + 6 H2O = 4 (FeO(OH)) + 8 H+.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 1PROSITE-ProRule annotation
Metal bindingi50 – 501Iron 2PROSITE-ProRule annotation
Metal bindingi53 – 531Iron 1PROSITE-ProRule annotation
Metal bindingi94 – 941Iron 2PROSITE-ProRule annotation
Metal bindingi127 – 1271Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable bacterial non-heme ferritin (EC:1.16.3.2)
Gene namesi
Name:ftnA
Synonyms:rsgA-A
Ordered Locus Names:HI_1384
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Probable bacterial non-heme ferritinPRO_0000201093Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms.By similarity

Protein-protein interaction databases

STRINGi71421.HI1384.

Structurei

3D structure databases

ProteinModelPortaliP43707.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43707-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNQIIINKL NDQINLEFYS SNVYLQMSAW CSKHGYEGAA TFLLRHADEE
60 70 80 90 100
LEHMQKLFNY VSETSGMPIL GKIDAPKHDY SSLREVFEIT LEHEKLVTSK
110 120 130 140 150
INELVEVTFE SKDYSTFNFL QWYVAEQHEE EKLFSGIIDR FNLVGEDGKG
160
LFFIDRELAT LE
Length:162
Mass (Da):18,896
Last modified:June 1, 2001 - v2
Checksum:iCDF256FA7F02799A
GO

Sequence cautioni

The sequence AAC23031.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23031.1. Different initiation.
PIRiA64121.
RefSeqiNP_439536.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23031; AAC23031; HI_1384.
GeneIDi950297.
KEGGihin:HI1384.
PATRICi20191459. VBIHaeInf48452_1440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42023 Genomic DNA. Translation: AAC23031.1. Different initiation.
PIRiA64121.
RefSeqiNP_439536.1. NC_000907.1.

3D structure databases

ProteinModelPortaliP43707.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi71421.HI1384.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC23031; AAC23031; HI_1384.
GeneIDi950297.
KEGGihin:HI1384.
PATRICi20191459. VBIHaeInf48452_1440.

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Two-dimensional map of the proteome of Haemophilus influenzae."
    Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
    Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFTN1_HAEIN
AccessioniPrimary (citable) accession number: P43707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: January 7, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.