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P43707

- FTN1_HAEIN

UniProt

P43707 - FTN1_HAEIN

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Protein

Probable ferritin-1

Gene
ftnA, rsgA-A, HI_1384
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-storage protein By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi17 – 171Iron 1 By similarity
Metal bindingi50 – 501Iron 1 By similarity
Metal bindingi50 – 501Iron 2 By similarity
Metal bindingi53 – 531Iron 1 By similarity
Metal bindingi94 – 941Iron 2 By similarity
Metal bindingi127 – 1271Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ferritin-1 (EC:1.16.3.1)
Gene namesi
Name:ftnA
Synonyms:rsgA-A
Ordered Locus Names:HI_1384
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 162162Probable ferritin-1PRO_0000201093Add
BLAST

Interactioni

Subunit structurei

Homooligomer of 24 subunits that assemble into a spherical protein shell (12 +/- 1 nM diameter) that can sequester at least 2000 iron atoms By similarity.

Protein-protein interaction databases

STRINGi71421.HI1384.

Structurei

3D structure databases

ProteinModelPortaliP43707.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 145145Ferritin-like diironAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1528.
KOiK02217.
OMAiCEDKGFE.
OrthoDBiEOG6G4W12.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43707-1 [UniParc]FASTAAdd to Basket

« Hide

MLNQIIINKL NDQINLEFYS SNVYLQMSAW CSKHGYEGAA TFLLRHADEE    50
LEHMQKLFNY VSETSGMPIL GKIDAPKHDY SSLREVFEIT LEHEKLVTSK 100
INELVEVTFE SKDYSTFNFL QWYVAEQHEE EKLFSGIIDR FNLVGEDGKG 150
LFFIDRELAT LE 162
Length:162
Mass (Da):18,896
Last modified:June 1, 2001 - v2
Checksum:iCDF256FA7F02799A
GO

Sequence cautioni

The sequence AAC23031.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23031.1. Different initiation.
PIRiA64121.
RefSeqiNP_439536.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23031; AAC23031; HI_1384.
GeneIDi950297.
KEGGihin:HI1384.
PATRICi20191459. VBIHaeInf48452_1440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23031.1 . Different initiation.
PIRi A64121.
RefSeqi NP_439536.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43707.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1384.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23031 ; AAC23031 ; HI_1384 .
GeneIDi 950297.
KEGGi hin:HI1384.
PATRICi 20191459. VBIHaeInf48452_1440.

Phylogenomic databases

eggNOGi COG1528.
KOi K02217.
OMAi CEDKGFE.
OrthoDBi EOG6G4W12.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Two-dimensional map of the proteome of Haemophilus influenzae."
    Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C., Fountoulakis M.
    Electrophoresis 21:411-429(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-10.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiFTN1_HAEIN
AccessioniPrimary (citable) accession number: P43707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi