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P43700 (GYRA_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA gyrase subunit A
EC=5.99.1.3
Gene names
Name:gyrA
Ordered Locus Names:HI_1264
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Haemophilus

Protein attributes

Sequence length880 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings. HAMAP MF_01897

Catalytic activity

ATP-dependent breakage, passage and rejoining of double-stranded DNA. HAMAP MF_01897

Subunit structure

Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer.

Subcellular location

Cytoplasm Potential HAMAP MF_01897.

Sequence similarities

Belongs to the topoisomerase GyrA/ParC subunit family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 880880DNA gyrase subunit A HAMAP MF_01897
PRO_0000145235

Sites

Active site1231O-(5'-phospho-DNA)-tyrosine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
P43700 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0B2E9DD34155A322

FASTA88097,818
        10         20         30         40         50         60 
MTDSIQSSIT PVNIEEELKS SYLDYAMSVI VGRALPDVRD GLKPVHRRVL FSMDREGNTA 

        70         80         90        100        110        120 
NKKYVKSARV VGDVIGKYHP HGDSAVYDTI VRMAQPFSLR YMLVDGQGNF GSIDGDAPAA 

       130        140        150        160        170        180 
MRYTEVRMQK ITQALLTDLD KETVNFSPNY DGELMIPDVL PTRIPALLAN GSSGIAVGMA 

       190        200        210        220        230        240 
TNIPPHNLNE VLNGCLAYID KNEITIDELM QHIPGPDFPT AALINGRKGI EEAYRTGRGK 

       250        260        270        280        290        300 
VYVRARATVE TNEKGREQII VSELPYQVNK AKLVEKIAEL IREKKIEGIS NITDLSNKEG 

       310        320        330        340        350        360 
IRIEIDIKRD AVGEVVLNHL YSLTQMQVTF GINMVALDHG QPRLFNLKEI IEAFVLHRRE 

       370        380        390        400        410        420 
VVTRRSIFEL RKARERTHIL EGLAVARSNI DEMIAIIRNS KNREEAATSI SSRSWTLHSD 

       430        440        450        460        470        480 
IINLLDASAR PDELEENLGI QGEQYYLSPA QVNAILELRL HRLTGIAFEE VIKEYEELLV 

       490        500        510        520        530        540 
KIADLLHILS SAERLMEVIR EELEEVKAQF GDDRLTEITA ASGDIDLEDL IAQEDVVVTL 

       550        560        570        580        590        600 
SHEGYVKYQP LTDYEAQRRG GKGKSATKMK EEDFIEKLLV ANTHDTILCF SSRGRLYWLK 

       610        620        630        640        650        660 
VYQLPQASRG ARGRPIVNIL PLQENERITA ILPVSAYEED KFVVMATAGG IVKKIALTEF 

       670        680        690        700        710        720 
SRPRSNGIIA LNLRDEDELI GVDITDGSNE IMLFSSQGRV VRFAENAVRA MGRLATGVRG 

       730        740        750        760        770        780 
IKLALTNDIS DDESAVEIED ISDDNAEASL DLNIDKVVSL VVPKGEGAIL TATQNGYGKR 

       790        800        810        820        830        840 
TQLSEYPTKS RNTKGVISIK VSERNGKVVA ATQVEETDQI MLITDAGTLV RTRVSEVSIV 

       850        860        870        880 
GRNTQGVRLI RTADDEHVVS LERVCDADED DSLEESSSEE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L42023 Genomic DNA. Translation: AAC22917.1.
PIRE64113.
RefSeqNP_439419.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43700.
SMRP43700. Positions 31-519, 533-866.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID950199.
GenomeReviewsGene locus HI_1264 in contig L42023_GR.
KEGGhin:HI1264.
NMPDRfig|71421.1.peg.1209.
PATRIC20191209. VBIHaeInf48452_1316.
TIGRHI_1264.

Phylogenomic databases

HOGENOMHBG635183.
OMATGRGRIY.
PhylomeDBP43700.
ProtClustDBPRK05560.

Enzyme and pathway databases

BioCycHINF71421:HI_1264-MONOMER.

Family and domain databases

HAMAPMF_01897. GyrA.
[Tree]
InterProIPR005743. GyrA.
IPR006691. GyrA/parC_pinwhl.
IPR002205. Topo_IIA_A/C.
IPR013758. Topo_IIA_A/C_ab.
IPR013757. Topo_IIA_A_a.
IPR013760. Topo_IIA_cen.
[Graphical view]
Gene3DG3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit.
G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KOK02469.
PfamPF03989. DNA_gyraseA_C. 6 hits.
PF00521. DNA_topoisoIV. 1 hit.
[Graphical view]
SMARTSM00434. TOP4c. 1 hit.
[Graphical view]
SUPFAMSSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMsTIGR01063. GyrA. 1 hit.
ProtoNetSearch...

Other

DrugBankDB00537. Ciprofloxacin.
DB00467. Enoxacin.
DB01044. Gatifloxacin.
DB01155. Gemifloxacin.
DB00365. Grepafloxacin.
DB01137. Levofloxacin.
DB00978. Lomefloxacin.
DB00218. Moxifloxacin.
DB01059. Norfloxacin.
DB01165. Ofloxacin.
DB00487. Pefloxacin.
DB01208. Sparfloxacin.
DB01405. Temafloxacin.
DB00685. Trovafloxacin.

Entry information

Entry nameGYRA_HAEIN
AccessionPrimary (citable) accession number: P43700
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents