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P43699

- NKX21_HUMAN

UniProt

P43699 - NKX21_HUMAN

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Protein
Homeobox protein Nkx-2.1
Gene
NKX2-1, NKX2A, TITF1, TTF1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi161 – 22060Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  3. core promoter binding Source: UniProtKB
  4. enzyme binding Source: UniProt
  5. protein binding Source: UniProtKB
  6. sequence-specific DNA binding Source: Ensembl
  7. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  8. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. Clara cell differentiation Source: Ensembl
  2. Leydig cell differentiation Source: Ensembl
  3. Type II pneumocyte differentiation Source: Ensembl
  4. anatomical structure formation involved in morphogenesis Source: Ensembl
  5. axon guidance Source: Ensembl
  6. brain development Source: UniProtKB
  7. cerebral cortex GABAergic interneuron differentiation Source: Ensembl
  8. cerebral cortex cell migration Source: Ensembl
  9. developmental induction Source: Ensembl
  10. endoderm development Source: Ensembl
  11. epithelial tube branching involved in lung morphogenesis Source: UniProtKB
  12. forebrain development Source: UniProtKB
  13. forebrain dorsal/ventral pattern formation Source: Ensembl
  14. forebrain neuron fate commitment Source: Ensembl
  15. globus pallidus development Source: UniProtKB
  16. hippocampus development Source: Ensembl
  17. locomotory behavior Source: Ensembl
  18. lung development Source: UniProtKB
  19. lung saccule development Source: Ensembl
  20. menarche Source: Ensembl
  21. negative regulation of cell migration Source: UniProtKB
  22. negative regulation of epithelial to mesenchymal transition Source: UniProtKB
  23. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  24. negative regulation of transcription, DNA-templated Source: UniProtKB
  25. negative regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
  26. neuron migration Source: Ensembl
  27. oligodendrocyte differentiation Source: Ensembl
  28. phospholipid metabolic process Source: Ensembl
  29. pituitary gland development Source: Ensembl
  30. positive regulation of circadian rhythm Source: UniProtKB
  31. positive regulation of gene expression Source: UniProtKB
  32. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  33. positive regulation of transcription, DNA-templated Source: UniProtKB
  34. response to hormone Source: UniProtKB
  35. thyroid gland development Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Nkx-2.1
Alternative name(s):
Homeobox protein NK-2 homolog A
Thyroid nuclear factor 1
Thyroid transcription factor 1
Short name:
TTF-1
Thyroid-specific enhancer-binding protein
Short name:
T/EBP
Gene namesi
Name:NKX2-1
Synonyms:NKX2A, TITF1, TTF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:11825. NKX2-1.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Chorea, hereditary benign (BHC) [MIM:118700]: A rare autosomal dominant movement disorder, defined by early onset in childhood, a stable or non-progressive course of chorea, and no mental deterioration. Chorea is characterized by involuntary, forcible, rapid, jerky movements that may be subtle or become confluent, markedly altering normal patterns of movement.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081W → L in BHC. 1 Publication
Corresponds to variant rs28936672 [ dbSNP | Ensembl ].
VAR_015188
Natural varianti213 – 2131R → S in BHC. 1 Publication
Corresponds to variant rs28936671 [ dbSNP | Ensembl ].
VAR_015189
Choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD) [MIM:610978]: This syndrome include neurological, thyroid, and respiratory problems.
Note: The disease is caused by mutations affecting the gene represented in this entry.4 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti205 – 2051V → F in CHNRD. 1 Publication
VAR_034906

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi118700. phenotype.
610978. phenotype.
Orphaneti95713. Athyreosis.
1429. Benign familial chorea.
209905. Brain-lung-thyroid syndrome.
146. Papillary or follicular thyroid carcinoma.
95720. Thyroid hypoplasia.
PharmGKBiPA36531.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Homeobox protein Nkx-2.1
PRO_0000049343Add
BLAST

Post-translational modificationi

Phosphorylated on serine residues by STK3/MST2 By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43699.
PaxDbiP43699.
PRIDEiP43699.

PTM databases

PhosphoSiteiP43699.

Expressioni

Tissue specificityi

Thyroid and lung.

Gene expression databases

ArrayExpressiP43699.
BgeeiP43699.
CleanExiHS_NKX2-1.
HS_TTF1.
GenevestigatoriP43699.

Organism-specific databases

HPAiCAB000078.

Interactioni

Subunit structurei

Interacts with WWTR1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCDC59Q9P0314EBI-1391923,EBI-1047110
NCK1P163332EBI-1391923,EBI-389883

Protein-protein interaction databases

BioGridi112936. 11 interactions.
IntActiP43699. 8 interactions.
MINTiMINT-192847.
STRINGi9606.ENSP00000346879.

Structurei

3D structure databases

ProteinModelPortaliP43699.
SMRiP43699. Positions 161-227.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi234 – 24310Poly-Gly
Compositional biasi246 – 2538Poly-Gln
Compositional biasi294 – 30310Poly-Ala

Sequence similaritiesi

Belongs to the NK-2 homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG328614.
HOGENOMiHOG000231923.
HOVERGENiHBG006689.
InParanoidiP43699.
KOiK09342.
OMAiKSMAPLQ.
OrthoDBiEOG769ZK0.
PhylomeDBiP43699.
TreeFamiTF351204.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43699-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSMSPKHTTP FSVSDILSPL EESYKKVGME GGGLGAPLAA YRQGQAAPPT    50
AAMQQHAVGH HGAVTAAYHM TAAGVPQLSH SAVGGYCNGN LGNMSELPPY 100
QDTMRNSASG PGWYGANPDP RFPAISRFMG PASGMNMSGM GGLGSLGDVS 150
KNMAPLPSAP RRKRRVLFSQ AQVYELERRF KQQKYLSAPE REHLASMIHL 200
TPTQVKIWFQ NHRYKMKRQA KDKAAQQQLQ QDSGGGGGGG GTGCPQQQQA 250
QQQSPRRVAV PVLVKDGKPC QAGAPAPGAA SLQGHAQQQA QHQAQAAQAA 300
AAAISVGSGG AGLGAHPGHQ PGSAGQSPDL AHHAASPAAL QGQVSSLSHL 350
NSSGSDYGTM SCSTLLYGRT W 371
Length:371
Mass (Da):38,596
Last modified:November 1, 1995 - v1
Checksum:i5F1E3B40A1BBD862
GO
Isoform 3 (identifier: P43699-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MWSGGSGKARGWEAAAGGRSSPGRLSRRRIM

Show »
Length:401
Mass (Da):41,737
Checksum:i40324D55128D4394
GO

Sequence cautioni

The sequence AAH06221.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA23527.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti205 – 2051V → F in CHNRD. 1 Publication
VAR_034906
Natural varianti208 – 2081W → L in BHC. 1 Publication
Corresponds to variant rs28936672 [ dbSNP | Ensembl ].
VAR_015188
Natural varianti213 – 2131R → S in BHC. 1 Publication
Corresponds to variant rs28936671 [ dbSNP | Ensembl ].
VAR_015189

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MWSGGSGKARGWEAAAGGRS SPGRLSRRRIM in isoform 3.
VSP_037890

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 491P → H in BAA23527. 1 Publication
Sequence conflicti49 – 491P → H in BAA23529. 1 Publication
Sequence conflicti61 – 611H → P in BAA23527. 1 Publication
Sequence conflicti61 – 611H → P in BAA23529. 1 Publication
Sequence conflicti158 – 1581S → T in BAA23527. 1 Publication
Sequence conflicti158 – 1581S → T in BAA23529. 1 Publication
Sequence conflicti161 – 1611R → G in BAA23527. 1 Publication
Sequence conflicti161 – 1611R → G in BAA23529. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19756 mRNA. Translation: AAA86099.1.
X82850 mRNA. Translation: CAA58053.1.
U19816 Genomic DNA. Translation: AAC50125.1.
U33749 mRNA. Translation: AAB52381.1.
U43203 mRNA. Translation: AAA89066.1.
D50739 Genomic DNA. Translation: BAA23527.1. Sequence problems.
D50740 mRNA. Translation: BAA23529.1.
BT009773 mRNA. Translation: AAP88775.1.
AL132857 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65858.1.
CH471078 Genomic DNA. Translation: EAW65856.1.
CH471078 Genomic DNA. Translation: EAW65859.1.
BC006221 mRNA. Translation: AAH06221.2. Different initiation.
CCDSiCCDS41945.1. [P43699-3]
CCDS9659.1. [P43699-1]
PIRiG02321.
RefSeqiNP_001073136.1. NM_001079668.2. [P43699-3]
NP_003308.1. NM_003317.3. [P43699-1]
UniGeneiHs.94367.

Genome annotation databases

EnsembliENST00000354822; ENSP00000346879; ENSG00000136352. [P43699-3]
ENST00000498187; ENSP00000429607; ENSG00000136352. [P43699-1]
ENST00000518149; ENSP00000428341; ENSG00000136352. [P43699-1]
ENST00000522719; ENSP00000429519; ENSG00000136352. [P43699-1]
GeneIDi7080.
KEGGihsa:7080.
UCSCiuc001wtt.3. human. [P43699-1]
uc001wtu.3. human. [P43699-3]

Polymorphism databases

DMDMi1174819.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19756 mRNA. Translation: AAA86099.1 .
X82850 mRNA. Translation: CAA58053.1 .
U19816 Genomic DNA. Translation: AAC50125.1 .
U33749 mRNA. Translation: AAB52381.1 .
U43203 mRNA. Translation: AAA89066.1 .
D50739 Genomic DNA. Translation: BAA23527.1 . Sequence problems.
D50740 mRNA. Translation: BAA23529.1 .
BT009773 mRNA. Translation: AAP88775.1 .
AL132857 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW65858.1 .
CH471078 Genomic DNA. Translation: EAW65856.1 .
CH471078 Genomic DNA. Translation: EAW65859.1 .
BC006221 mRNA. Translation: AAH06221.2 . Different initiation.
CCDSi CCDS41945.1. [P43699-3 ]
CCDS9659.1. [P43699-1 ]
PIRi G02321.
RefSeqi NP_001073136.1. NM_001079668.2. [P43699-3 ]
NP_003308.1. NM_003317.3. [P43699-1 ]
UniGenei Hs.94367.

3D structure databases

ProteinModelPortali P43699.
SMRi P43699. Positions 161-227.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112936. 11 interactions.
IntActi P43699. 8 interactions.
MINTi MINT-192847.
STRINGi 9606.ENSP00000346879.

PTM databases

PhosphoSitei P43699.

Polymorphism databases

DMDMi 1174819.

Proteomic databases

MaxQBi P43699.
PaxDbi P43699.
PRIDEi P43699.

Protocols and materials databases

DNASUi 7080.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354822 ; ENSP00000346879 ; ENSG00000136352 . [P43699-3 ]
ENST00000498187 ; ENSP00000429607 ; ENSG00000136352 . [P43699-1 ]
ENST00000518149 ; ENSP00000428341 ; ENSG00000136352 . [P43699-1 ]
ENST00000522719 ; ENSP00000429519 ; ENSG00000136352 . [P43699-1 ]
GeneIDi 7080.
KEGGi hsa:7080.
UCSCi uc001wtt.3. human. [P43699-1 ]
uc001wtu.3. human. [P43699-3 ]

Organism-specific databases

CTDi 7080.
GeneCardsi GC14M036985.
HGNCi HGNC:11825. NKX2-1.
HPAi CAB000078.
MIMi 118700. phenotype.
600635. gene.
610978. phenotype.
neXtProti NX_P43699.
Orphaneti 95713. Athyreosis.
1429. Benign familial chorea.
209905. Brain-lung-thyroid syndrome.
146. Papillary or follicular thyroid carcinoma.
95720. Thyroid hypoplasia.
PharmGKBi PA36531.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG328614.
HOGENOMi HOG000231923.
HOVERGENi HBG006689.
InParanoidi P43699.
KOi K09342.
OMAi KSMAPLQ.
OrthoDBi EOG769ZK0.
PhylomeDBi P43699.
TreeFami TF351204.

Miscellaneous databases

GeneWikii NK2_homeobox_1.
GenomeRNAii 7080.
NextBioi 27693.
PROi P43699.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43699.
Bgeei P43699.
CleanExi HS_NKX2-1.
HS_TTF1.
Genevestigatori P43699.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The complete nucleotide sequence of the mouse thyroid-specific enhancer-binding protein (T/EBP) gene: extensive identity of the deduced amino acid sequence with the human protein."
    Oguchi H., Pan Y.-T., Kimura S.
    Biochim. Biophys. Acta 1261:304-306(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lung.
  2. "Cloning and sequence analysis of human thyroid transcription factor 1."
    Saiardi A., Tassi V., de Filippis V., Civitareale D.
    Biochim. Biophys. Acta 1261:307-310(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  3. "Gene structure and expression of human thyroid transcription factor-1 in respiratory epithelial cells."
    Ikeda K., Clark J.C., Shaw-White J.R., Stahlman M.T., Boutell C.J., Whitsett J.A.
    J. Biol. Chem. 270:8108-8114(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3).
    Tissue: Lung.
  5. "Cloning of the human TTF-1 gene."
    Endo T., Ohno M., Nakazato M.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1).
    Tissue: Thyroid.
  6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  7. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Lung.
  10. "TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation."
    Di Palma T., D'Andrea B., Liguori G.L., Liguoro A., de Cristofaro T., Del Prete D., Pappalardo A., Mascia A., Zannini M.
    Exp. Cell Res. 315:162-175(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH WWTR1.
  11. Cited for: VARIANTS BHC LEU-208 AND SER-213.
  12. "Partial deficiency of thyroid transcription factor 1 produces predominantly neurological defects in humans and mice."
    Pohlenz J., Dumitrescu A., Zundel D., Martine U., Schoenberger W., Koo E., Weiss R.E., Cohen R.N., Kimura S., Refetoff S.
    J. Clin. Invest. 109:469-473(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CHNRD.
  13. Cited for: VARIANT CHNRD PHE-205.
  14. "Autosomal dominant transmission of congenital hypothyroidism, neonatal respiratory distress, and ataxia caused by a mutation of NKX2-1."
    Doyle D.A., Gonzalez I., Thomas B., Scavina M.
    J. Pediatr. 145:190-193(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CHNRD.
  15. "A novel TITF-1 mutation causes benign hereditary chorea with response to levodopa."
    Asmus F., Horber V., Pohlenz J., Schwabe D., Zimprich A., Munz M., Schoening M., Gasser T.
    Neurology 64:1952-1954(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN CHNRD AND IN BHC.

Entry informationi

Entry nameiNKX21_HUMAN
AccessioniPrimary (citable) accession number: P43699
Secondary accession number(s): D3DSA3
, O14954, O14955, Q7KZF6, Q9BRJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi