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P43694 (GATA4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor GATA-4
Alternative name(s):
GATA-binding factor 4
Gene names
Name:GATA4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. Ref.5 Ref.6

Subunit structure

Interacts with ZNF260 By similarity. Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts with NFATC4 and LMCD1 By similarity. Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1 and ZFPM2. Ref.5 Ref.6

Subcellular location

Nucleus Ref.6.

Post-translational modification

Methylation at Lys-300 attenuates transcriptional activity By similarity.

Involvement in disease

Atrial septal defect 2 (ASD2) [MIM:607941]: A congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria. Patients show other heart abnormalities including ventricular and atrioventricular septal defects, pulmonary valve thickening or insufficiency of the cardiac valves. The disease is not associated with defects in the cardiac conduction system or non-cardiac abnormalities.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8 Ref.9 Ref.10 Ref.11 Ref.13 Ref.15

Ventricular septal defect 1 (VSD1) [MIM:614429]: A common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.10 Ref.12 Ref.14 Ref.16 Ref.17

Tetralogy of Fallot (TOF) [MIM:187500]: A congenital heart anomaly which consists of pulmonary stenosis, ventricular septal defect, dextroposition of the aorta (aorta is on the right side instead of the left) and hypertrophy of the right ventricle. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing cyanosis.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.14

Atrioventricular septal defect 4 (AVSD4) [MIM:614430]: A congenital heart malformation characterized by a common atrioventricular junction coexisting with deficient atrioventricular septation. The complete form involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum; the valve itself is also shared. A less severe form, known as ostium primum atrial septal defect, is characterized by separate atrioventricular valvar orifices despite a common junction.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.11

Testicular anomalies with or without congenital heart disease (TACHD) [MIM:615542]: A 46,XY disorder of sex development with variable clinical presentation and defects in testicular differentiation and function. Clinical features include ambiguous genitalia, fused labioscrotal folds, hypospadias, microphallus, and bilateral inguinal hernia containing gonads.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.6

Sequence similarities

Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DiseaseAtrial septal defect
Cardiomyopathy
Disease mutation
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   PTMMethylation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processBMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

SMAD protein signal transduction

Inferred from electronic annotation. Source: Ensembl

Sertoli cell differentiation

Inferred from electronic annotation. Source: Ensembl

atrial septum morphogenesis

Inferred from mutant phenotype Ref.8. Source: BHF-UCL

atrial septum primum morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

atrial septum secundum morphogenesis

Inferred from mutant phenotype Ref.15. Source: BHF-UCL

atrioventricular valve morphogenesis

Inferred from electronic annotation. Source: Ensembl

blood coagulation

Traceable author statement. Source: Reactome

canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

cardiac muscle hypertrophy in response to stress

Inferred from electronic annotation. Source: Ensembl

cardiac right ventricle morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

cardiac ventricle morphogenesis

Traceable author statement Ref.15. Source: BHF-UCL

cell growth involved in cardiac muscle cell development

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Inferred from sequence or structural similarity. Source: BHF-UCL

cellular response to follicle-stimulating hormone stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to glucose stimulus

Inferred from electronic annotation. Source: Ensembl

embryonic digestive tract morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic foregut morphogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic heart tube anterior/posterior pattern specification

Inferred from sequence or structural similarity. Source: BHF-UCL

endocardial cushion development

Inferred from mutant phenotype PubMed 21330551. Source: BHF-UCL

endoderm development

Traceable author statement Ref.15. Source: BHF-UCL

endoderm formation

Inferred from electronic annotation. Source: Ensembl

epithelial cell fate commitment

Inferred from electronic annotation. Source: Ensembl

gastrulation with mouth forming second

Inferred from electronic annotation. Source: Ensembl

heart looping

Inferred from sequence or structural similarity. Source: BHF-UCL

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

intestinal epithelial cell differentiation

Inferred from direct assay PubMed 9566909. Source: MGI

lung lobe formation

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from expression pattern. Source: UniProtKB

negative regulation of autophagy

Inferred from electronic annotation. Source: Ensembl

positive regulation of BMP signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardioblast differentiation

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 21330551. Source: BHF-UCL

positive regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation vascular endothelial growth factor production

Inferred from sequence or structural similarity. Source: BHF-UCL

regulation of cardiac muscle cell contraction

Inferred from electronic annotation. Source: Ensembl

regulation of transcription, DNA-templated

Inferred from sequence or structural similarity. Source: BHF-UCL

response to drug

Inferred from mutant phenotype PubMed 20585342. Source: BHF-UCL

response to estrogen

Inferred from electronic annotation. Source: Ensembl

response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

seminiferous tubule development

Inferred from electronic annotation. Source: Ensembl

signal transduction involved in regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity Ref.8. Source: BHF-UCL

ventricular cardiac muscle tissue development

Inferred from electronic annotation. Source: Ensembl

ventricular septum development

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentnucleoplasm

Traceable author statement. Source: Reactome

nucleus

Non-traceable author statement. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from sequence or structural similarity. Source: BHF-UCL

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II regulatory region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II transcription factor binding transcription factor activity

Inferred from direct assay PubMed 21330551. Source: BHF-UCL

activating transcription factor binding

Inferred from sequence or structural similarity. Source: BHF-UCL

chromatin binding

Inferred from electronic annotation. Source: Ensembl

co-SMAD binding

Inferred from physical interaction PubMed 21330551. Source: BHF-UCL

enhancer sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from sequence or structural similarity. Source: BHF-UCL

transcription factor binding

Inferred from physical interaction PubMed 9858576. Source: BHF-UCL

transcription regulatory region DNA binding

Inferred from direct assay. Source: MGI

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

KLF13Q9Y2Y93EBI-7049352,EBI-1255893

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 442442Transcription factor GATA-4
PRO_0000083413

Regions

Zinc finger217 – 24125GATA-type 1
Zinc finger271 – 29525GATA-type 2
Compositional bias118 – 1269Poly-Ala
Compositional bias174 – 1818Poly-Ala
Compositional bias276 – 2805Poly-Thr

Amino acid modifications

Modified residue3001N6-methyllysine; by EZH2 By similarity

Natural variations

Natural variant61A → V in VSD1. Ref.12
Corresponds to variant rs199922907 [ dbSNP | Ensembl ].
VAR_067605
Natural variant431R → W in VSD1; significantly reduced activation of the NPPA promoter with the mutant protein compared to wild-type. Ref.17
VAR_067606
Natural variant461Missing in VSD1. Ref.12
VAR_067607
Natural variant521S → F in ASD2. Ref.9
VAR_038195
Natural variant931G → A in ASD2; uncertain pathological significance. Ref.10
VAR_067608
Natural variant1181A → AA in TOF. Ref.12
VAR_067609
Natural variant1631P → S in AVSD4; also in a patient with VSD1 and a patient with TOF. Ref.11 Ref.12 Ref.14
VAR_067610
Natural variant2211G → R in TACHD; impairs the ability to bind and transactivate the promoter of AMH gene. Abolishes interaction with ZFPM2. Ref.6
VAR_070670
Natural variant2801T → M in ASD2. Ref.13
VAR_067611
Natural variant2961G → C in ASD2. Ref.11
VAR_067612
Natural variant2961G → R in VSD1. Ref.16
VAR_067613
Natural variant2961G → S in ASD2. Ref.8 Ref.9
VAR_016204
Natural variant3101M → V in ASD2. Ref.15
VAR_067614
Natural variant3161Q → E in ASD2. Ref.10
VAR_067615
Natural variant3461A → V in AVSD4. Ref.11
Corresponds to variant rs115372595 [ dbSNP | Ensembl ].
VAR_067616
Natural variant3591E → K in VSD1. Ref.12
VAR_067617
Natural variant3771S → G.
Corresponds to variant rs3729856 [ dbSNP | Ensembl ].
VAR_038196
Natural variant4031L → M in ASD2. Ref.11
VAR_067618
Natural variant4071P → Q in VSD1 and TOF. Ref.12 Ref.14
Corresponds to variant rs115099192 [ dbSNP | Ensembl ].
VAR_067619
Natural variant4111A → V in VSD1; uncertain pathological significance. Ref.10
Corresponds to variant rs55633527 [ dbSNP | Ensembl ].
VAR_067620
Natural variant4251D → N in ASD2; also found in a patient with TOF. Ref.10
VAR_067621
Natural variant4291S → T in VSD1. Ref.12
VAR_067622
Natural variant4421A → V in VSD1. Ref.12
VAR_067623

Experimental info

Sequence conflict191E → Q in AAA58496. Ref.1
Sequence conflict251A → P in AAA58496. Ref.1
Sequence conflict391V → L in AAA58496. Ref.1
Sequence conflict661A → P in AAA58496. Ref.1
Sequence conflict711S → P in AAA58496. Ref.1
Sequence conflict951D → T in AAA58496. Ref.1
Sequence conflict2801T → A in AAW51922. Ref.2

Secondary structure

........ 442
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43694 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 141B8CD841E12C7B

FASTA44244,565
        10         20         30         40         50         60 
MYQSLAMAAN HGPPPGAYEA GGPGAFMHGA GAASSPVYVP TPRVPSSVLG LSYLQGGGAG 

        70         80         90        100        110        120 
SASGGASGGS SGGAASGAGP GTQQGSPGWS QAGADGAAYT PPPVSPRFSF PGTTGSLAAA 

       130        140        150        160        170        180 
AAAAAAREAA AYSSGGGAAG AGLAGREQYG RAGFAGSYSS PYPAYMADVG ASWAAAAAAS 

       190        200        210        220        230        240 
AGPFDSPVLH SLPGRANPAA RHPNLDMFDD FSEGRECVNC GAMSTPLWRR DGTGHYLCNA 

       250        260        270        280        290        300 
CGLYHKMNGI NRPLIKPQRR LSASRRVGLS CANCQTTTTT LWRRNAEGEP VCNACGLYMK 

       310        320        330        340        350        360 
LHGVPRPLAM RKEGIQTRKR KPKNLNKSKT PAAPSGSESL PPASGASSNS SNATTSSSEE 

       370        380        390        400        410        420 
MRPIKTEPGL SSHYGHSSSV SQTFSVSAMS GHGPSIHPVL SALKLSPQGY ASPVSQSPQT 

       430        440 
SSKQDSWNSL VLADSHGDII TA 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a GATA motif in the cardiac alpha-myosin heavy-chain-encoding gene and isolation of a human GATA-4 cDNA."
Huang W.Y., Cukerman E., Liew C.C.
Gene 155:219-223(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart.
[2]Palaszewski I., Dame C.
Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart and Lung.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Cyclin-dependent kinase-9 is a component of the p300/GATA4 complex required for phenylephrine-induced hypertrophy in cardiomyocytes."
Sunagawa Y., Morimoto T., Takaya T., Kaichi S., Wada H., Kawamura T., Fujita M., Shimatsu A., Kita T., Hasegawa K.
J. Biol. Chem. 285:9556-9568(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CARDIAC HYPERTROPHY, IDENTIFICATION IN COMPLEX WITH CCNT1; EP300 AND GATA4.
[6]"Loss-of-function mutation in GATA4 causes anomalies of human testicular development."
Lourenco D., Brauner R., Rybczynska M., Nihoul-Fekete C., McElreavey K., Bashamboo A.
Proc. Natl. Acad. Sci. U.S.A. 108:1597-1602(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DNA-BINDING, INTERACTION WITH NR5A1 AND ZFPM2, VARIANT TACHD ARG-221, CHARACTERIZATION OF VARIANT TACHD ARG-221.
[7]"Solution NMR structure of a transcription factor gata-4 from Homo sapiens, Northeast structural genomics consortium (NESG) target HR4783B."
Northeast structural genomics consortium (NESG)
Submitted (JUL-2013) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 262-321.
[8]"GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5."
Garg V., Kathiriya I.S., Barnes R., Schluterman M.K., King I.N., Butler C.A., Rothrock C.R., Eapen R.S., Hirayama-Yamada K., Joo K., Matsuoka R., Cohen J.C., Srivastava D.
Nature 424:443-447(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASD2 SER-296.
[9]"Phenotypes with GATA4 or NKX2.5 mutations in familial atrial septal defect."
Hirayama-Yamada K., Kamisago M., Akimoto K., Aotsuka H., Nakamura Y., Tomita H., Furutani M., Imamura S., Takao A., Nakazawa M., Matsuoka R.
Am. J. Med. Genet. A 135:47-52(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASD2 PHE-52 AND SER-296.
[10]"GATA4 sequence variants in patients with congenital heart disease."
Tomita-Mitchell A., Maslen C.L., Morris C.D., Garg V., Goldmuntz E.
J. Med. Genet. 44:779-783(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASD2 ALA-93; GLU-316 AND ASN-425, VARIANT VSD1 VAL-411.
[11]"Spectrum of heart disease associated with murine and human GATA4 mutation."
Rajagopal S.K., Ma Q., Obler D., Shen J., Manichaikul A., Tomita-Mitchell A., Boardman K., Briggs C., Garg V., Srivastava D., Goldmuntz E., Broman K.W., Benson D.W., Smoot L.B., Pu W.T.
J. Mol. Cell. Cardiol. 43:677-685(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ASD2 CYS-296 AND MET-403, VARIANTS AVSD4 SER-163 AND VAL-346.
[12]"GATA4 mutations in 486 Chinese patients with congenital heart disease."
Zhang W., Li X., Shen A., Jiao W., Guan X., Li Z.
Eur. J. Med. Genet. 51:527-535(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS VSD1 VAL-6; SER-46 DEL; SER-163; LYS-359; THR-429 AND VAL-442, VARIANTS TOF ALA-118 INS AND GLN-407.
[13]"A novel mutation of GATA4 in a familial atrial septal defect."
Chen Y., Mao J., Sun Y., Zhang Q., Cheng H.B., Yan W.H., Choy K.W., Li H.
Clin. Chim. Acta 411:1741-1745(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASD2 MET-280.
[14]"Mutations of the GATA4 and NKX2.5 genes in Chinese pediatric patients with non-familial congenital heart disease."
Peng T., Wang L., Zhou S.F., Li X.
Genetica 138:1231-1240(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VSD1 GLN-407, VARIANT TOF SER-163.
[15]"A novel mutation in GATA4 gene associated with dominant inherited familial atrial septal defect."
Chen Y., Han Z.Q., Yan W.D., Tang C.Z., Xie J.Y., Chen H., Hu D.Y.
J. Thorac. Cardiovasc. Surg. 140:684-687(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASD2 VAL-310.
[16]"A novel GATA4 mutation responsible for congenital ventricular septal defects."
Wang J., Fang M., Liu X.Y., Xin Y.F., Liu Z.M., Chen X.Z., Wang X.Z., Fang W.Y., Liu X., Yang Y.Q.
Int. J. Mol. Med. 28:557-564(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VSD1 ARG-296.
[17]"A novel GATA4 loss-of-function mutation associated with congenital ventricular septal defect."
Yang Y.Q., Li L., Wang J., Liu X.Y., Chen X.Z., Zhang W., Wang X.Z., Jiang J.Q., Liu X., Fang W.Y.
Pediatr. Cardiol. 33:539-546(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT VSD1 TRP-43, CHARACTERIZATION OF VARIANT VSD1 TRP-43.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L34357 mRNA. Translation: AAA58496.1.
AY740706 mRNA. Translation: AAW51922.1.
BC101580 mRNA. Translation: AAI01581.1.
BC105108 mRNA. Translation: AAI05109.1.
BC143434 mRNA. Translation: AAI43435.1.
RefSeqNP_002043.2. NM_002052.3.
UniGeneHs.243987.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2M9WNMR-A262-321[»]
ProteinModelPortalP43694.
SMRP43694. Positions 213-321.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108896. 23 interactions.
IntActP43694. 1 interaction.
MINTMINT-3379484.
STRING9606.ENSP00000334458.

Chemistry

ChEMBLCHEMBL1687679.

PTM databases

PhosphoSiteP43694.

Polymorphism databases

DMDM215274105.

Proteomic databases

PaxDbP43694.
PRIDEP43694.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335135; ENSP00000334458; ENSG00000136574.
GeneID2626.
KEGGhsa:2626.
UCSCuc003wub.1. human.

Organism-specific databases

CTD2626.
GeneCardsGC08P011599.
HGNCHGNC:4173. GATA4.
HPACAB013125.
MIM187500. phenotype.
600576. gene.
607941. phenotype.
614429. phenotype.
614430. phenotype.
615542. phenotype.
neXtProtNX_P43694.
Orphanet251510. 46,XY partial gonadal dysgenesis.
251071. 8p23.1 microdeletion syndrome.
99103. Atrial septal defect, ostium secundum type.
1329. Complete atrioventricular canal.
334. Familial atrial fibrillation.
1330. Partial atrioventricular canal.
3303. Tetralogy of Fallot.
1480. Ventricular septal defect.
PharmGKBPA28587.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5641.
HOVERGENHBG051703.
InParanoidP43694.
KOK09183.
PhylomeDBP43694.
TreeFamTF315391.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.
SignaLinkP43694.

Gene expression databases

ArrayExpressP43694.
BgeeP43694.
CleanExHS_GATA4.
GenevestigatorP43694.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR008013. GATA_N.
IPR028436. TF_GATA_4.
IPR016375. TF_GATA_4/5/6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERPTHR10071:SF25. PTHR10071:SF25. 1 hit.
PfamPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGATA4.
GenomeRNAi2626.
NextBio10345.
PROP43694.
SOURCESearch...

Entry information

Entry nameGATA4_HUMAN
AccessionPrimary (citable) accession number: P43694
Secondary accession number(s): B7ZKX0, Q3MJ45, Q5IFM8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 25, 2008
Last modified: April 16, 2014
This is version 139 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM