ID   GATA6_CHICK             Reviewed;         387 AA.
AC   P43693;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 138.
DE   RecName: Full=Transcription factor GATA-6;
DE   AltName: Full=GATA-binding factor 6;
GN   Name=GATA6;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=White leghorn;
RX   PubMed=8083222; DOI=10.1016/s0021-9258(17)31636-8;
RA   Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E.,
RA   Evans T.;
RT   "GATA-4/5/6, a subfamily of three transcription factors transcribed in
RT   developing heart and gut.";
RL   J. Biol. Chem. 269:23177-23184(1994).
CC   -!- FUNCTION: Transcriptional activator. {ECO:0000250|UniProtKB:Q92908}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: More abundant in stomach, and in small intestine.
CC       Lower levels in lung, liver, ovary and heart.
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DR   EMBL; U11889; AAA57505.1; -; mRNA.
DR   PIR; I50703; I50703.
DR   RefSeq; NP_990751.1; NM_205420.1.
DR   AlphaFoldDB; P43693; -.
DR   SMR; P43693; -.
DR   STRING; 9031.ENSGALP00000030913; -.
DR   PaxDb; 9031-ENSGALP00000030913; -.
DR   GeneID; 396390; -.
DR   KEGG; gga:396390; -.
DR   CTD; 2627; -.
DR   VEuPathDB; HostDB:geneid_396390; -.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_027524_0_1_1; -.
DR   InParanoid; P43693; -.
DR   PhylomeDB; P43693; -.
DR   Reactome; R-GGA-5683826; Surfactant metabolism.
DR   Reactome; R-GGA-983231; Factors involved in megakaryocyte development and platelet production.
DR   PRO; PR:P43693; -.
DR   Proteomes; UP000000539; Chromosome 2.
DR   Bgee; ENSGALG00000014976; Expressed in liver and 10 other cell types or tissues.
DR   ExpressionAtlas; P43693; baseline and differential.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR   InterPro; IPR008013; GATA_N.
DR   InterPro; IPR016375; TF_GATA_4/5/6.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR   PANTHER; PTHR10071:SF23; TRANSCRIPTION FACTOR GATA-6; 1.
DR   Pfam; PF00320; GATA; 2.
DR   Pfam; PF05349; GATA-N; 1.
DR   PIRSF; PIRSF003028; TF_GATA_4/5/6; 1.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..387
FT                   /note="Transcription factor GATA-6"
FT                   /id="PRO_0000083427"
FT   ZN_FING         181..205
FT                   /note="GATA-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   ZN_FING         235..259
FT                   /note="GATA-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT   REGION          54..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          276..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   387 AA;  40249 MW;  6EEF457BB34DB2C0 CRC64;
     MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ GGGAAQPGHA
     PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA SREQYGGGLA AREQYGALPR
     PLNGSYPAPY ASYVGPQLGP AWPAAPFENS VLHCLQGRAA PIPVRAPSAE LLEDLSESRE
     CVNCGSIQTP LWRRDGTGNY LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT
     TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST
     TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS NLKYSGQDGL
     YTGVSLTSTA EVTASVRQDH WCALALA
//