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P43693

- GATA6_CHICK

UniProt

P43693 - GATA6_CHICK

Protein

Transcription factor GATA-6

Gene

GATA6

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri181 – 20525GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25925GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: Ensembl
    2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
    3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: Ensembl
    2. cardiac muscle hypertrophy in response to stress Source: Ensembl
    3. cardiac vascular smooth muscle cell differentiation Source: Ensembl
    4. cellular response to BMP stimulus Source: Ensembl
    5. cellular response to gonadotropin stimulus Source: Ensembl
    6. cellular response to hypoxia Source: Ensembl
    7. Clara cell differentiation Source: Ensembl
    8. endodermal cell fate determination Source: Ensembl
    9. intestinal epithelial cell differentiation Source: Ensembl
    10. in utero embryonic development Source: Ensembl
    11. liver development Source: Ensembl
    12. lung saccule development Source: Ensembl
    13. male gonad development Source: Ensembl
    14. negative regulation of apoptotic process Source: Ensembl
    15. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    16. negative regulation of transforming growth factor beta1 production Source: Ensembl
    17. negative regulation of transforming growth factor beta2 production Source: Ensembl
    18. organ formation Source: Ensembl
    19. outflow tract septum morphogenesis Source: Ensembl
    20. pancreatic A cell differentiation Source: Ensembl
    21. phospholipid metabolic process Source: Ensembl
    22. positive regulation of angiogenesis Source: Ensembl
    23. positive regulation of cardiac muscle cell proliferation Source: Ensembl
    24. positive regulation of cardioblast differentiation Source: Ensembl
    25. positive regulation of cell cycle arrest Source: Ensembl
    26. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    27. response to drug Source: Ensembl
    28. response to estrogen Source: Ensembl
    29. tube morphogenesis Source: Ensembl
    30. type B pancreatic cell differentiation Source: Ensembl
    31. Type II pneumocyte differentiation Source: Ensembl

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_197541. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor GATA-6
    Alternative name(s):
    GATA-binding factor 6
    Gene namesi
    Name:GATA6
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 387387Transcription factor GATA-6PRO_0000083427Add
    BLAST

    Proteomic databases

    PaxDbiP43693.

    Expressioni

    Tissue specificityi

    More abundant in stomach, and in small intestine. Lower levels in lung, liver, ovary and heart.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000024112.

    Structurei

    3D structure databases

    ProteinModelPortaliP43693.
    SMRiP43693. Positions 176-220, 229-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi240 – 2445Poly-Thr

    Sequence similaritiesi

    Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri181 – 20525GATA-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri235 – 25925GATA-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5641.
    HOGENOMiHOG000047700.
    HOVERGENiHBG051703.
    InParanoidiP43693.
    KOiK17897.
    PhylomeDBiP43693.

    Family and domain databases

    Gene3Di3.30.50.10. 2 hits.
    InterProiIPR008013. GATA_N.
    IPR016375. TF_GATA_4/5/6.
    IPR028437. TF_GATA_6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
    PfamiPF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSiPR00619. GATAZNFINGER.
    SMARTiSM00401. ZnF_GATA. 2 hits.
    [Graphical view]
    PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43693-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ    50
    GGGAAQPGHA PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA 100
    SREQYGGGLA AREQYGALPR PLNGSYPAPY ASYVGPQLGP AWPAAPFENS 150
    VLHCLQGRAA PIPVRAPSAE LLEDLSESRE CVNCGSIQTP LWRRDGTGNY 200
    LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT TTTTLWRRNA 250
    EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST 300
    TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS 350
    NLKYSGQDGL YTGVSLTSTA EVTASVRQDH WCALALA 387
    Length:387
    Mass (Da):40,249
    Last modified:November 1, 1995 - v1
    Checksum:i6EEF457BB34DB2C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11889 mRNA. Translation: AAA57505.1.
    PIRiI50703.
    RefSeqiNP_990751.1. NM_205420.1.
    UniGeneiGga.2061.

    Genome annotation databases

    GeneIDi396390.
    KEGGigga:396390.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11889 mRNA. Translation: AAA57505.1 .
    PIRi I50703.
    RefSeqi NP_990751.1. NM_205420.1.
    UniGenei Gga.2061.

    3D structure databases

    ProteinModelPortali P43693.
    SMRi P43693. Positions 176-220, 229-284.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000024112.

    Proteomic databases

    PaxDbi P43693.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396390.
    KEGGi gga:396390.

    Organism-specific databases

    CTDi 2627.

    Phylogenomic databases

    eggNOGi COG5641.
    HOGENOMi HOG000047700.
    HOVERGENi HBG051703.
    InParanoidi P43693.
    KOi K17897.
    PhylomeDBi P43693.

    Enzyme and pathway databases

    Reactomei REACT_197541. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 20816432.
    PROi P43693.

    Family and domain databases

    Gene3Di 3.30.50.10. 2 hits.
    InterProi IPR008013. GATA_N.
    IPR016375. TF_GATA_4/5/6.
    IPR028437. TF_GATA_6.
    IPR000679. Znf_GATA.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    PANTHERi PTHR10071:SF23. PTHR10071:SF23. 1 hit.
    Pfami PF00320. GATA. 2 hits.
    PF05349. GATA-N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003028. TF_GATA_4/5/6. 1 hit.
    PRINTSi PR00619. GATAZNFINGER.
    SMARTi SM00401. ZnF_GATA. 2 hits.
    [Graphical view ]
    PROSITEi PS00344. GATA_ZN_FINGER_1. 2 hits.
    PS50114. GATA_ZN_FINGER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
      Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
      J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: White leghorn.

    Entry informationi

    Entry nameiGATA6_CHICK
    AccessioniPrimary (citable) accession number: P43693
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3