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Protein

Transcription factor GATA-6

Gene

GATA6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 205GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri235 – 259GATA-type 2PROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:GATA6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834271 – 387Transcription factor GATA-6Add BLAST387

Proteomic databases

PaxDbiP43693

Expressioni

Tissue specificityi

More abundant in stomach, and in small intestine. Lower levels in lung, liver, ovary and heart.

Gene expression databases

BgeeiENSGALG00000014976

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024112

Structurei

3D structure databases

ProteinModelPortaliP43693
SMRiP43693
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi240 – 244Poly-Thr5

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri181 – 205GATA-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri235 – 259GATA-type 2PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1601 Eukaryota
COG5641 LUCA
HOGENOMiHOG000047700
HOVERGENiHBG051703
InParanoidiP43693
KOiK17897
OrthoDBiEOG091G0AUR
PhylomeDBiP43693

Family and domain databases

Gene3Di3.30.50.102 hits
InterProiView protein in InterPro
IPR008013 GATA_N
IPR016375 TF_GATA_4/5/6
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00320 GATA, 2 hits
PF05349 GATA-N, 1 hit
PIRSFiPIRSF003028 TF_GATA_4/5/6, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 2 hits
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 2 hits
PS50114 GATA_ZN_FINGER_2, 2 hits

Sequencei

Sequence statusi: Complete.

P43693-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ
60 70 80 90 100
GGGAAQPGHA PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA
110 120 130 140 150
SREQYGGGLA AREQYGALPR PLNGSYPAPY ASYVGPQLGP AWPAAPFENS
160 170 180 190 200
VLHCLQGRAA PIPVRAPSAE LLEDLSESRE CVNCGSIQTP LWRRDGTGNY
210 220 230 240 250
LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT TTTTLWRRNA
260 270 280 290 300
EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST
310 320 330 340 350
TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS
360 370 380
NLKYSGQDGL YTGVSLTSTA EVTASVRQDH WCALALA
Length:387
Mass (Da):40,249
Last modified:November 1, 1995 - v1
Checksum:i6EEF457BB34DB2C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11889 mRNA Translation: AAA57505.1
PIRiI50703
RefSeqiNP_990751.1, NM_205420.1
UniGeneiGga.2061

Genome annotation databases

GeneIDi396390
KEGGigga:396390

Similar proteinsi

Entry informationi

Entry nameiGATA6_CHICK
AccessioniPrimary (citable) accession number: P43693
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome