Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43693 (GATA6_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene names
Name:GATA6
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length387 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus.

Tissue specificity

More abundant in stomach, and in small intestine. Lower levels in lung, liver, ovary and heart.

Sequence similarities

Contains 2 GATA-type zinc fingers.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processClara cell differentiation

Inferred from electronic annotation. Source: Ensembl

Type II pneumocyte differentiation

Inferred from electronic annotation. Source: Ensembl

cardiac muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

cardiac muscle hypertrophy in response to stress

Inferred from electronic annotation. Source: Ensembl

cardiac vascular smooth muscle cell differentiation

Inferred from electronic annotation. Source: Ensembl

cellular response to BMP stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to gonadotropin stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to hypoxia

Inferred from electronic annotation. Source: Ensembl

endodermal cell fate determination

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

intestinal epithelial cell differentiation

Inferred from electronic annotation. Source: Ensembl

liver development

Inferred from electronic annotation. Source: Ensembl

lung saccule development

Inferred from electronic annotation. Source: Ensembl

male gonad development

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta1 production

Inferred from electronic annotation. Source: Ensembl

negative regulation of transforming growth factor beta2 production

Inferred from electronic annotation. Source: Ensembl

organ formation

Inferred from electronic annotation. Source: Ensembl

outflow tract septum morphogenesis

Inferred from electronic annotation. Source: Ensembl

pancreatic A cell differentiation

Inferred from electronic annotation. Source: Ensembl

phospholipid metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardiac muscle cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cardioblast differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell cycle arrest

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estrogen

Inferred from electronic annotation. Source: Ensembl

tube morphogenesis

Inferred from electronic annotation. Source: Ensembl

type B pancreatic cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

transcription factor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

chromatin binding

Inferred from electronic annotation. Source: Ensembl

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 387387Transcription factor GATA-6
PRO_0000083427

Regions

Zinc finger181 – 20525GATA-type 1
Zinc finger235 – 25925GATA-type 2
Compositional bias240 – 2445Poly-Thr

Sequences

Sequence LengthMass (Da)Tools
P43693 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 6EEF457BB34DB2C0

FASTA38740,249
        10         20         30         40         50         60 
MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ GGGAAQPGHA 

        70         80         90        100        110        120 
PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA SREQYGGGLA AREQYGALPR 

       130        140        150        160        170        180 
PLNGSYPAPY ASYVGPQLGP AWPAAPFENS VLHCLQGRAA PIPVRAPSAE LLEDLSESRE 

       190        200        210        220        230        240 
CVNCGSIQTP LWRRDGTGNY LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT 

       250        260        270        280        290        300 
TTTTLWRRNA EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST 

       310        320        330        340        350        360 
TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS NLKYSGQDGL 

       370        380 
YTGVSLTSTA EVTASVRQDH WCALALA 

« Hide

References

[1]"GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: White leghorn.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U11889 mRNA. Translation: AAA57505.1.
PIRI50703.
RefSeqNP_990751.1. NM_205420.1.
UniGeneGga.2061.

3D structure databases

ProteinModelPortalP43693.
SMRP43693. Positions 176-220, 229-284.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000024112.

Proteomic databases

PaxDbP43693.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID396390.
KEGGgga:396390.

Organism-specific databases

CTD2627.

Phylogenomic databases

eggNOGCOG5641.
HOGENOMHOG000047700.
HOVERGENHBG051703.
InParanoidP43693.
KOK17897.
PhylomeDBP43693.

Family and domain databases

Gene3D3.30.50.10. 2 hits.
InterProIPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSPR00619. GATAZNFINGER.
SMARTSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816432.
PROP43693.

Entry information

Entry nameGATA6_CHICK
AccessionPrimary (citable) accession number: P43693
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families