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Protein

Transcription factor GATA-6

Gene

GATA6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri181 – 20525GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25925GATA-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: Ensembl
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. cardiac muscle cell differentiation Source: Ensembl
  2. cardiac muscle hypertrophy in response to stress Source: Ensembl
  3. cardiac vascular smooth muscle cell differentiation Source: Ensembl
  4. cellular response to BMP stimulus Source: Ensembl
  5. cellular response to gonadotropin stimulus Source: Ensembl
  6. cellular response to hypoxia Source: Ensembl
  7. Clara cell differentiation Source: Ensembl
  8. endodermal cell fate determination Source: Ensembl
  9. intestinal epithelial cell differentiation Source: Ensembl
  10. liver development Source: Ensembl
  11. lung saccule development Source: Ensembl
  12. male gonad development Source: Ensembl
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  15. negative regulation of transforming growth factor beta1 production Source: Ensembl
  16. negative regulation of transforming growth factor beta2 production Source: Ensembl
  17. organ formation Source: Ensembl
  18. outflow tract septum morphogenesis Source: Ensembl
  19. pancreatic A cell differentiation Source: Ensembl
  20. phospholipid metabolic process Source: Ensembl
  21. positive regulation of angiogenesis Source: Ensembl
  22. positive regulation of cardiac muscle cell proliferation Source: Ensembl
  23. positive regulation of cardioblast differentiation Source: Ensembl
  24. positive regulation of cell cycle arrest Source: Ensembl
  25. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  26. response to drug Source: Ensembl
  27. response to estrogen Source: Ensembl
  28. type B pancreatic cell differentiation Source: Ensembl
  29. Type II pneumocyte differentiation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_197541. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor GATA-6
Alternative name(s):
GATA-binding factor 6
Gene namesi
Name:GATA6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 387387Transcription factor GATA-6PRO_0000083427Add
BLAST

Proteomic databases

PaxDbiP43693.

Expressioni

Tissue specificityi

More abundant in stomach, and in small intestine. Lower levels in lung, liver, ovary and heart.

Gene expression databases

ExpressionAtlasiP43693. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024112.

Structurei

3D structure databases

ProteinModelPortaliP43693.
SMRiP43693. Positions 176-220, 229-284.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi240 – 2445Poly-Thr

Sequence similaritiesi

Contains 2 GATA-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri181 – 20525GATA-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri235 – 25925GATA-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP43693.
KOiK17897.
PhylomeDBiP43693.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43693-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYQTLAISAS QGPAPYDGSP GGFMHSAPSS PVYVPTTRVG SVLPTLPYLQ
60 70 80 90 100
GGGAAQPGHA PAGHVWSQPA AESPSYGAAG GAHPSGRFPY SASPPVANGA
110 120 130 140 150
SREQYGGGLA AREQYGALPR PLNGSYPAPY ASYVGPQLGP AWPAAPFENS
160 170 180 190 200
VLHCLQGRAA PIPVRAPSAE LLEDLSESRE CVNCGSIQTP LWRRDGTGNY
210 220 230 240 250
LCNACGLYTK MNGLSRPLIK PQKRVPSSRR LGLSCANCHT TTTTLWRRNA
260 270 280 290 300
EGEPVCNACG LYMKLHGVPR PLAMKKEGIQ TRKRKPKNIN KSKACSGNST
310 320 330 340 350
TAVPMTPTST SSTNSDDCSK NASPSTQPAA SGASSSVMSG PGESTSPESS
360 370 380
NLKYSGQDGL YTGVSLTSTA EVTASVRQDH WCALALA
Length:387
Mass (Da):40,249
Last modified:November 1, 1995 - v1
Checksum:i6EEF457BB34DB2C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11889 mRNA. Translation: AAA57505.1.
PIRiI50703.
RefSeqiNP_990751.1. NM_205420.1.
UniGeneiGga.2061.

Genome annotation databases

GeneIDi396390.
KEGGigga:396390.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11889 mRNA. Translation: AAA57505.1.
PIRiI50703.
RefSeqiNP_990751.1. NM_205420.1.
UniGeneiGga.2061.

3D structure databases

ProteinModelPortaliP43693.
SMRiP43693. Positions 176-220, 229-284.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000024112.

Proteomic databases

PaxDbiP43693.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396390.
KEGGigga:396390.

Organism-specific databases

CTDi2627.

Phylogenomic databases

eggNOGiCOG5641.
HOGENOMiHOG000047700.
HOVERGENiHBG051703.
InParanoidiP43693.
KOiK17897.
PhylomeDBiP43693.

Enzyme and pathway databases

ReactomeiREACT_197541. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi20816432.
PROiP43693.

Gene expression databases

ExpressionAtlasiP43693. baseline.

Family and domain databases

Gene3Di3.30.50.10. 2 hits.
InterProiIPR008013. GATA_N.
IPR016375. TF_GATA_4/5/6.
IPR028437. TF_GATA_6.
IPR000679. Znf_GATA.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PANTHERiPTHR10071:SF23. PTHR10071:SF23. 1 hit.
PfamiPF00320. GATA. 2 hits.
PF05349. GATA-N. 1 hit.
[Graphical view]
PIRSFiPIRSF003028. TF_GATA_4/5/6. 1 hit.
PRINTSiPR00619. GATAZNFINGER.
SMARTiSM00401. ZnF_GATA. 2 hits.
[Graphical view]
PROSITEiPS00344. GATA_ZN_FINGER_1. 2 hits.
PS50114. GATA_ZN_FINGER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "GATA-4/5/6, a subfamily of three transcription factors transcribed in developing heart and gut."
    Laverriere A.C., Macneill C., Mueller C., Poelmann R.E., Burch J.B.E., Evans T.
    J. Biol. Chem. 269:23177-23184(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: White leghorn.

Entry informationi

Entry nameiGATA6_CHICK
AccessioniPrimary (citable) accession number: P43693
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 4, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.