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Protein

Developmentally-regulated GTP-binding protein 1

Gene

drg1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Critical regulator of cell growth under specific conditions. Implicated in differentiation and cell cycle arrest (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 788GTPPROSITE-ProRule annotation
Nucleotide bindingi117 – 1215GTPPROSITE-ProRule annotation
Nucleotide bindingi248 – 2514GTPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Developmentally-regulated GTP-binding protein 1
Short name:
DRG-1
Short name:
xDRG
Gene namesi
Name:drg1
Synonyms:drg
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-980759. drg1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367Developmentally-regulated GTP-binding protein 1PRO_0000205426Add
BLAST

Proteomic databases

PRIDEiP43690.

Expressioni

Tissue specificityi

Expressed in many adult amd embryonic tissues. In adults, highest levels in ovaries and testes, followed by skeletal muscle, stomach, brain, kidney and liver. Weak expression in heart and brain.1 Publication

Developmental stagei

At stage 22, expressed in blood islands, somites, eyes, trunk neural crest, mandibular crest segment, hyoid crest segment and branchial crest segment. At stage 32, expressed in otic vesicle, pronephros, forebraiin, midbrain, hindbrain, branchial arch, eyes, lens, spinal cord and notochord.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi100578. 1 interaction.
IntActiP43690. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP43690.
SMRiP43690. Positions 288-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini65 – 290226OBG-type GPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.PROSITE-ProRule annotation
Contains 1 OBG-type G (guanine nucleotide-binding) domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG000948.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGTLARIAE IEAEMARTQK NKATAYHLGL LKARLAKLRR ELITPKGGGG
60 70 80 90 100
GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT
110 120 130 140 150
TVPGVVRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD
160 170 180 190 200
VLKPLGHKKI IENELEGFGI RLNKQPPNIG FKKKDKGGIN LTATCAQSEL
210 220 230 240 250
DNDTVKSILA EYKIHNADIT LRSDATADDL IDVVEGNRVY IPCIYVLNKI
260 270 280 290 300
DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLQ LVRIYTKPKG
310 320 330 340 350
QLPDYTSPVV LPCSHTAAED FCTKIHKNLI KEFKYALVWG SSVKHNPQKV
360
GKDHVLEDED VIQIVKK
Length:367
Mass (Da):40,415
Last modified:November 1, 1995 - v1
Checksum:i27189D72BA3A2386
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13865 mRNA. Translation: BAA02978.1.
PIRiI51426.
RefSeqiNP_001084013.1. NM_001090544.1.
UniGeneiXl.92.

Genome annotation databases

GeneIDi399253.
KEGGixla:399253.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13865 mRNA. Translation: BAA02978.1.
PIRiI51426.
RefSeqiNP_001084013.1. NM_001090544.1.
UniGeneiXl.92.

3D structure databases

ProteinModelPortaliP43690.
SMRiP43690. Positions 288-367.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi100578. 1 interaction.
IntActiP43690. 1 interaction.

Proteomic databases

PRIDEiP43690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399253.
KEGGixla:399253.

Organism-specific databases

CTDi4733.
XenbaseiXB-GENE-980759. drg1.

Phylogenomic databases

HOVERGENiHBG000948.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR012675. Beta-grasp_dom.
IPR031167. G_OBG.
IPR031662. GTP-binding_2.
IPR006074. GTP1-OBG_CS.
IPR006073. GTP_binding_domain.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR004095. TGS.
IPR012676. TGS-like.
[Graphical view]
PfamiPF01926. MMR_HSR1. 1 hit.
PF16897. MMR_HSR1_Xtn. 1 hit.
PF02824. TGS. 1 hit.
[Graphical view]
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF81271. SSF81271. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51710. G_OBG. 1 hit.
PS00905. GTP1_OBG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of GTP-binding protein gene drg during Xenopus laevis development."
    Kumar S., Iwao M., Yamagishi T., Noda M., Asashima M.
    Int. J. Dev. Biol. 37:539-546(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "Identification of DRG family regulatory proteins (DFRPs): specific regulation of DRG1 and DRG2."
    Ishikawa K., Azuma S., Ikawa S., Semba K., Inoue J.
    Genes Cells 10:139-150(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiDRG1_XENLA
AccessioniPrimary (citable) accession number: P43690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.