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P43680

- SOX18_MOUSE

UniProt

P43680 - SOX18_MOUSE

Protein

Transcription factor SOX-18

Gene

Sox18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 3 (10 Oct 2002)
      Previous versions | rss
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    Functioni

    Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi79 – 14769HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. protein binding Source: UniProtKB
    3. protein heterodimerization activity Source: MGI
    4. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
    5. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
    6. sequence-specific DNA binding Source: MGI
    7. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
    8. sequence-specific DNA binding transcription factor activity Source: MGI
    9. transcription regulatory region DNA binding Source: MGI

    GO - Biological processi

    1. angiogenesis Source: MGI
    2. blood vessel development Source: MGI
    3. blood vessel endothelial cell migration Source: Ensembl
    4. cell maturation Source: MGI
    5. embryonic heart tube development Source: MGI
    6. endocardial cell differentiation Source: MGI
    7. endocardium formation Source: MGI
    8. establishment of endothelial barrier Source: Ensembl
    9. hair follicle development Source: MGI
    10. heart development Source: MGI
    11. in utero embryonic development Source: MGI
    12. lymphangiogenesis Source: MGI
    13. lymphatic endothelial cell differentiation Source: MGI
    14. lymph vessel development Source: MGI
    15. mRNA transcription from RNA polymerase II promoter Source: Ensembl
    16. negative regulation of transcription, DNA-templated Source: MGI
    17. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    18. positive regulation of transcription, DNA-templated Source: UniProtKB
    19. regulation of stem cell proliferation Source: MGI
    20. regulation of transcription, DNA-templated Source: MGI
    21. stem cell fate specification Source: MGI
    22. vasculature development Source: MGI
    23. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription factor SOX-18
    Gene namesi
    Name:Sox18
    Synonyms:Sox-18
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:103559. Sox18.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromatin Source: Ensembl
    2. nuclear transcription factor complex Source: MGI
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Transcription factor SOX-18PRO_0000048768Add
    BLAST

    Proteomic databases

    PRIDEiP43680.

    PTM databases

    PhosphoSiteiP43680.

    Expressioni

    Tissue specificityi

    Expressed only in lung, heart and skeletal muscles.

    Gene expression databases

    BgeeiP43680.
    CleanExiMM_SOX18.
    GenevestigatoriP43680.

    Structurei

    3D structure databases

    ProteinModelPortaliP43680.
    SMRiP43680. Positions 78-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini256 – 376121Sox C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 Sox C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252325.
    GeneTreeiENSGT00750000117281.
    HOGENOMiHOG000069999.
    HOVERGENiHBG000517.
    InParanoidiP43680.
    KOiK09270.
    OMAiYLNCSRT.
    OrthoDBiEOG7R8329.
    PhylomeDBiP43680.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    IPR021934. Sox_C_TAD.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF12067. Sox_C_TAD. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    PS51516. SOX_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43680-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS    50
    LPRSPPRSPE SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ 100
    NPDLHNAVLS KMLGKAWKEL NTAEKRPFVE EAERLRVQHL RDHPNYKYRP 150
    RRKKQARKVR RLEPGLLLPG LVQPSAPPEA FAAASGSARS FRELPTLGAE 200
    FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR APYAPELARD 250
    PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE 300
    GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM 350
    SCPEESSLIS ALSDASSAVY YSACISG 377
    Length:377
    Mass (Da):40,898
    Last modified:October 10, 2002 - v3
    Checksum:i29F4C9B9D50F94D0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti156 – 1561A → E in AAB18615. (PubMed:7665083)Curated
    Sequence conflicti260 – 2601A → G in AAB18615. (PubMed:7665083)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35032 mRNA. Translation: AAB18615.1.
    AF288518 Genomic DNA. Translation: AAG48578.1.
    BC006612 mRNA. Translation: AAH06612.1.
    L29086 mRNA. Translation: AAA56844.1.
    CCDSiCCDS17218.1.
    RefSeqiNP_033262.2. NM_009236.2.
    UniGeneiMm.264904.

    Genome annotation databases

    EnsembliENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470.
    GeneIDi20672.
    KEGGimmu:20672.
    UCSCiuc008ona.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35032 mRNA. Translation: AAB18615.1 .
    AF288518 Genomic DNA. Translation: AAG48578.1 .
    BC006612 mRNA. Translation: AAH06612.1 .
    L29086 mRNA. Translation: AAA56844.1 .
    CCDSi CCDS17218.1.
    RefSeqi NP_033262.2. NM_009236.2.
    UniGenei Mm.264904.

    3D structure databases

    ProteinModelPortali P43680.
    SMRi P43680. Positions 78-181.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P43680.

    Proteomic databases

    PRIDEi P43680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054491 ; ENSMUSP00000062759 ; ENSMUSG00000046470 .
    GeneIDi 20672.
    KEGGi mmu:20672.
    UCSCi uc008ona.1. mouse.

    Organism-specific databases

    CTDi 54345.
    MGIi MGI:103559. Sox18.

    Phylogenomic databases

    eggNOGi NOG252325.
    GeneTreei ENSGT00750000117281.
    HOGENOMi HOG000069999.
    HOVERGENi HBG000517.
    InParanoidi P43680.
    KOi K09270.
    OMAi YLNCSRT.
    OrthoDBi EOG7R8329.
    PhylomeDBi P43680.

    Miscellaneous databases

    NextBioi 299155.
    PROi P43680.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43680.
    CleanExi MM_SOX18.
    Genevestigatori P43680.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    IPR021934. Sox_C_TAD.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF12067. Sox_C_TAD. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    PS51516. SOX_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and expression of Sox-18 encoding a new HMG-box transcription factor."
      Dunn T.L., Mynett-Johnson L., Wright E.M., Hosking B.M., Koopman P.A., Muscat G.E.O.
      Gene 161:223-225(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Heart muscle.
    2. Dunn T.L.
      Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Layfield R., Mynett-Johnson L., Yarwood P.J., Muscat G.E.O., Koopman P.A., Hume D.A.
      Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 83-142.
      Strain: BALB/c.
      Tissue: Heart muscle.
    6. "Trans-activation and DNA-binding properties of the transcription factor, Sox-18."
      Hosking B.M., Muscat G.E.O., Koopman P.A., Dowhan D.H., Dunn T.L.
      Nucleic Acids Res. 23:2626-2628(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.

    Entry informationi

    Entry nameiSOX18_MOUSE
    AccessioniPrimary (citable) accession number: P43680
    Secondary accession number(s): Q9EQ73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 10, 2002
    Last modified: October 1, 2014
    This is version 122 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3