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P43680 (SOX18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription factor SOX-18
Gene names
Name:Sox18
Synonyms:Sox-18
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.

Subcellular location

Nucleus.

Tissue specificity

Expressed only in lung, heart and skeletal muscles.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Contains 1 Sox C-terminal domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
   Molecular functionActivator
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from genetic interaction PubMed 16895970. Source: MGI

blood vessel development

Inferred from mutant phenotype PubMed 10742113PubMed 19429912. Source: MGI

blood vessel endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

cell maturation

Inferred from direct assay PubMed 20228271. Source: MGI

embryonic heart tube development

Inferred from genetic interaction PubMed 17610846. Source: MGI

endocardial cell differentiation

Inferred from genetic interaction PubMed 17610846. Source: MGI

endocardium formation

Inferred from genetic interaction PubMed 17610846. Source: MGI

establishment of endothelial barrier

Inferred from electronic annotation. Source: Ensembl

hair follicle development

Inferred from mutant phenotype PubMed 10742113PubMed 11094083. Source: MGI

heart development

Inferred from mutant phenotype PubMed 10742113. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 10742113PubMed 18931657PubMed 19429912. Source: MGI

lymph vessel development

Inferred from mutant phenotype PubMed 19515696PubMed 291594. Source: MGI

lymphangiogenesis

Inferred from mutant phenotype PubMed 18931657. Source: MGI

lymphatic endothelial cell differentiation

Inferred from mutant phenotype PubMed 18931657. Source: MGI

mRNA transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 18931657. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 11554755. Source: UniProtKB

regulation of stem cell proliferation

Inferred from direct assay PubMed 20228271. Source: MGI

regulation of transcription, DNA-templated

Inferred from direct assay PubMed 12446692. Source: MGI

stem cell fate specification

Inferred from direct assay PubMed 20228271. Source: MGI

vasculature development

Inferred from mutant phenotype PubMed 19429912. Source: MGI

vasculogenesis

Inferred from genetic interaction PubMed 16895968. Source: MGI

   Cellular_componentnuclear chromatin

Inferred from electronic annotation. Source: Ensembl

nuclear transcription factor complex

Inferred from direct assay PubMed 22344693. Source: MGI

nucleus

Inferred from direct assay PubMed 11554755. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from direct assay PubMed 12446692. Source: MGI

RNA polymerase II core promoter proximal region sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Inferred from electronic annotation. Source: Ensembl

protein heterodimerization activity

Inferred from direct assay PubMed 22344693. Source: MGI

sequence-specific DNA binding

Inferred from direct assay Ref.6. Source: MGI

sequence-specific DNA binding RNA polymerase II transcription factor activity

Inferred from direct assay PubMed 22344693. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 10742113PubMed 12446692PubMed 14634005Ref.6. Source: MGI

transcription regulatory region DNA binding

Inferred from direct assay PubMed 14634005PubMed 18931657. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 377377Transcription factor SOX-18
PRO_0000048768

Regions

Domain256 – 376121Sox C-terminal
DNA binding79 – 14769HMG box

Experimental info

Sequence conflict1561A → E in AAB18615. Ref.1
Sequence conflict2601A → G in AAB18615. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P43680 [UniParc].

Last modified October 10, 2002. Version 3.
Checksum: 29F4C9B9D50F94D0

FASTA37740,898
        10         20         30         40         50         60 
MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS LPRSPPRSPE 

        70         80         90        100        110        120 
SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ NPDLHNAVLS KMLGKAWKEL 

       130        140        150        160        170        180 
NTAEKRPFVE EAERLRVQHL RDHPNYKYRP RRKKQARKVR RLEPGLLLPG LVQPSAPPEA 

       190        200        210        220        230        240 
FAAASGSARS FRELPTLGAE FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR 

       250        260        270        280        290        300 
APYAPELARD PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE 

       310        320        330        340        350        360 
GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM SCPEESSLIS 

       370 
ALSDASSAVY YSACISG 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and expression of Sox-18 encoding a new HMG-box transcription factor."
Dunn T.L., Mynett-Johnson L., Wright E.M., Hosking B.M., Koopman P.A., Muscat G.E.O.
Gene 161:223-225(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Heart muscle.
[2]Dunn T.L.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Structure, mapping, and expression of human SOX18."
Pennisi D.J., James K.M., Hosking B.M., Muscat G.E., Koopman P.
Mamm. Genome 11:1147-1149(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Layfield R., Mynett-Johnson L., Yarwood P.J., Muscat G.E.O., Koopman P.A., Hume D.A.
Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 83-142.
Strain: BALB/c.
Tissue: Heart muscle.
[6]"Trans-activation and DNA-binding properties of the transcription factor, Sox-18."
Hosking B.M., Muscat G.E.O., Koopman P.A., Dowhan D.H., Dunn T.L.
Nucleic Acids Res. 23:2626-2628(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L35032 mRNA. Translation: AAB18615.1.
AF288518 Genomic DNA. Translation: AAG48578.1.
BC006612 mRNA. Translation: AAH06612.1.
L29086 mRNA. Translation: AAA56844.1.
RefSeqNP_033262.2. NM_009236.2.
UniGeneMm.264904.

3D structure databases

ProteinModelPortalP43680.
SMRP43680. Positions 78-181.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP43680.

Proteomic databases

PRIDEP43680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470.
GeneID20672.
KEGGmmu:20672.
UCSCuc008ona.1. mouse.

Organism-specific databases

CTD54345.
MGIMGI:103559. Sox18.

Phylogenomic databases

eggNOGNOG252325.
GeneTreeENSGT00750000117281.
HOGENOMHOG000069999.
HOVERGENHBG000517.
InParanoidP43680.
KOK09270.
OMAYLNCSRT.
OrthoDBEOG7R8329.
PhylomeDBP43680.

Gene expression databases

BgeeP43680.
CleanExMM_SOX18.
GenevestigatorP43680.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. SSF47095. 1 hit.
PROSITEPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio299155.
PROP43680.
SOURCESearch...

Entry information

Entry nameSOX18_MOUSE
AccessionPrimary (citable) accession number: P43680
Secondary accession number(s): Q9EQ73
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2002
Last modified: April 16, 2014
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot