P43680 (SOX18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Transcription factor SOX-18

Gene names

Name:	Sox18
Synonyms:	Sox-18

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.
Subcellular location	Nucleus.
Tissue specificity	Expressed only in lung, heart and skeletal muscles.
Sequence similarities	Contains 1 HMG box DNA-binding domain. Contains 1 Sox C-terminal domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from genetic interaction PubMed 16895970. Source: MGI blood vessel endothelial cell migration Inferred from electronic annotation. Source: Compara cell maturation Inferred from direct assay PubMed 20228271. Source: MGI embryonic heart tube development Inferred from genetic interaction PubMed 17610846. Source: MGI endocardial cell differentiation Inferred from genetic interaction PubMed 17610846. Source: MGI endocardium formation Inferred from genetic interaction PubMed 17610846. Source: MGI establishment of endothelial barrier Inferred from electronic annotation. Source: Compara hair follicle development Inferred from mutant phenotype PubMed 10742113PubMed 11094083. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 10742113PubMed 18931657PubMed 19429912. Source: MGI lymphangiogenesis Inferred from mutant phenotype PubMed 18931657. Source: MGI lymphatic endothelial cell differentiation Inferred from mutant phenotype PubMed 18931657. Source: MGI negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 18931657. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara positive regulation of transcription, DNA-dependent Inferred from direct assay PubMed 11554755. Source: UniProtKB regulation of stem cell proliferation Inferred from direct assay PubMed 20228271. Source: MGI stem cell fate specification Inferred from direct assay PubMed 20228271. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW vasculogenesis Inferred from genetic interaction PubMed 16895968. Source: MGI
Cellular_component	nucleus Inferred from direct assay PubMed 11554755. Source: UniProtKB
Molecular_function	sequence-specific DNA binding Inferred from direct assay Ref.6. Source: MGI sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 10742113PubMed 12446692PubMed 14634005Ref.6. Source: MGI transcription regulatory region DNA binding Inferred from direct assay PubMed 14634005PubMed 18931657. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Transcription factor SOX-18		PRO_0000048768
Regions
	Domain	256 – 376	121	Sox C-terminal
	DNA binding	79 – 147	69	HMG box
Experimental info
	Sequence conflict	156	1	A → E in AAB18615. Ref.1
	Sequence conflict	260	1	A → G in AAB18615. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P43680 [UniParc]. Last modified October 10, 2002. Version 3. Checksum: 29F4C9B9D50F94D0	FASTA	377	40,898
	10 20 30 40 50 60 MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS LPRSPPRSPE 70 80 90 100 110 120 SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ NPDLHNAVLS KMLGKAWKEL 130 140 150 160 170 180 NTAEKRPFVE EAERLRVQHL RDHPNYKYRP RRKKQARKVR RLEPGLLLPG LVQPSAPPEA 190 200 210 220 230 240 FAAASGSARS FRELPTLGAE FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR 250 260 270 280 290 300 APYAPELARD PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE 310 320 330 340 350 360 GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM SCPEESSLIS 370 ALSDASSAVY YSACISG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and expression of Sox-18 encoding a new HMG-box transcription factor." Dunn T.L., Mynett-Johnson L., Wright E.M., Hosking B.M., Koopman P.A., Muscat G.E.O. Gene 161:223-225(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Heart muscle.
[2]	Dunn T.L. Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Structure, mapping, and expression of human SOX18." Pennisi D.J., James K.M., Hosking B.M., Muscat G.E., Koopman P. Mamm. Genome 11:1147-1149(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Layfield R., Mynett-Johnson L., Yarwood P.J., Muscat G.E.O., Koopman P.A., Hume D.A. Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE OF 83-142. Strain: BALB/c. Tissue: Heart muscle.
[6]	"Trans-activation and DNA-binding properties of the transcription factor, Sox-18." Hosking B.M., Muscat G.E.O., Koopman P.A., Dowhan D.H., Dunn T.L. Nucleic Acids Res. 23:2626-2628(1995) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35032 mRNA. Translation: AAB18615.1. AF288518 Genomic DNA. Translation: AAG48578.1. BC006612 mRNA. Translation: AAH06612.1. L29086 mRNA. Translation: AAA56844.1.
IPI	IPI00377924.
RefSeq	NP_033262.2. NM_009236.2.
UniGene	Mm.264904.
3D structure databases
ProteinModelPortal	P43680.
SMR	P43680. Positions 78-181.
ModBase	Search...
PTM databases
PhosphoSite	P43680.
Proteomic databases
PRIDE	P43680.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470.
GeneID	20672.
KEGG	mmu:20672.
UCSC	uc008ona.1. mouse.
Organism-specific databases
CTD	54345.
MGI	MGI:103559. Sox18.
Phylogenomic databases
eggNOG	NOG252325.
GeneTree	ENSGT00670000097649.
HOGENOM	HOG000069999.
HOVERGEN	HBG000517.
InParanoid	P43680.
KO	K09270.
OMA	YLNCSRT.
OrthoDB	EOG4KSPKP.
Gene expression databases
ArrayExpress	P43680.
Bgee	P43680.
CleanEx	MM_SOX18.
Genevestigator	P43680.
GermOnline	ENSMUSG00000046470. Mus musculus.
Family and domain databases
Gene3D	1.10.30.10. 1 hit.
InterPro	IPR009071. HMG_box_dom. IPR021934. Sox_C_TAD. [Graphical view]
Pfam	PF00505. HMG_box. 1 hit. PF12067. Sox_C_TAD. 1 hit. [Graphical view]
SMART	SM00398. HMG. 1 hit. [Graphical view]
SUPFAM	SSF47095. HMG-box. 1 hit.
PROSITE	PS50118. HMG_BOX_2. 1 hit. PS51516. SOX_C. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	299155.
SOURCE	Search...

Entry information

Entry name

SOX18_MOUSE

Accession

Primary (citable) accession number: P43680
Secondary accession number(s): Q9EQ73

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 10, 2002
Last modified:	May 29, 2013
This is version 110 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program