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Protein

Transcription factor SOX-18

Gene

Sox18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the consensus sequence 5'-AACAAAG-3' and is able to trans-activate transcription via this site.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi79 – 14769HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. protein heterodimerization activity Source: MGI
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
  5. sequence-specific DNA binding Source: MGI
  6. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: MGI
  7. sequence-specific DNA binding transcription factor activity Source: MGI
  8. transcription regulatory region DNA binding Source: MGI

GO - Biological processi

  1. angiogenesis Source: MGI
  2. blood vessel development Source: MGI
  3. blood vessel endothelial cell migration Source: Ensembl
  4. cell maturation Source: MGI
  5. embryonic heart tube development Source: MGI
  6. endocardial cell differentiation Source: MGI
  7. endocardium formation Source: MGI
  8. establishment of endothelial barrier Source: MGI
  9. hair cycle process Source: MGI
  10. hair follicle development Source: MGI
  11. heart development Source: MGI
  12. in utero embryonic development Source: MGI
  13. lymphangiogenesis Source: MGI
  14. lymphatic endothelial cell differentiation Source: MGI
  15. lymph vessel development Source: MGI
  16. mRNA transcription from RNA polymerase II promoter Source: MGI
  17. negative regulation of transcription, DNA-templated Source: MGI
  18. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  19. positive regulation of transcription, DNA-templated Source: UniProtKB
  20. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  21. regulation of stem cell proliferation Source: MGI
  22. regulation of transcription, DNA-templated Source: MGI
  23. stem cell fate specification Source: MGI
  24. vasculature development Source: MGI
  25. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-18
Gene namesi
Name:Sox18
Synonyms:Sox-18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:103559. Sox18.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromatin Source: MGI
  2. nuclear transcription factor complex Source: MGI
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Transcription factor SOX-18PRO_0000048768Add
BLAST

Proteomic databases

PRIDEiP43680.

PTM databases

PhosphoSiteiP43680.

Expressioni

Tissue specificityi

Expressed only in lung, heart and skeletal muscles.

Gene expression databases

BgeeiP43680.
CleanExiMM_SOX18.
GenevestigatoriP43680.

Interactioni

Protein-protein interaction databases

BioGridi203404. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP43680.
SMRiP43680. Positions 78-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini256 – 376121Sox C-terminalPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation
Contains 1 Sox C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG252325.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiP43680.
KOiK09270.
OMAiYLNCSRT.
OrthoDBiEOG7R8329.
PhylomeDBiP43680.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43680-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRSPPGYGA QDDPPSRRDC AWAPGIGAAA EARGLPVTNV SPTSPASPSS
60 70 80 90 100
LPRSPPRSPE SGRYGFGRGE RQTADELRIR RPMNAFMVWA KDERKRLAQQ
110 120 130 140 150
NPDLHNAVLS KMLGKAWKEL NTAEKRPFVE EAERLRVQHL RDHPNYKYRP
160 170 180 190 200
RRKKQARKVR RLEPGLLLPG LVQPSAPPEA FAAASGSARS FRELPTLGAE
210 220 230 240 250
FDGLGLPTPE RSPLDGLEPG EASFFPPPLA PEDCALRAFR APYAPELARD
260 270 280 290 300
PSFCYGAPLA EALRTAPPAA PLAGLYYGTL GTPGPFPNPL SPPPESPSLE
310 320 330 340 350
GTEQLEPTAD LWADVDLTEF DQYLNCSRTR PDATTLPYHV ALAKLGPRAM
360 370
SCPEESSLIS ALSDASSAVY YSACISG
Length:377
Mass (Da):40,898
Last modified:October 10, 2002 - v3
Checksum:i29F4C9B9D50F94D0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti156 – 1561A → E in AAB18615. (PubMed:7665083)Curated
Sequence conflicti260 – 2601A → G in AAB18615. (PubMed:7665083)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35032 mRNA. Translation: AAB18615.1.
AF288518 Genomic DNA. Translation: AAG48578.1.
BC006612 mRNA. Translation: AAH06612.1.
L29086 mRNA. Translation: AAA56844.1.
CCDSiCCDS17218.1.
RefSeqiNP_033262.2. NM_009236.2.
UniGeneiMm.264904.

Genome annotation databases

EnsembliENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470.
GeneIDi20672.
KEGGimmu:20672.
UCSCiuc008ona.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L35032 mRNA. Translation: AAB18615.1.
AF288518 Genomic DNA. Translation: AAG48578.1.
BC006612 mRNA. Translation: AAH06612.1.
L29086 mRNA. Translation: AAA56844.1.
CCDSiCCDS17218.1.
RefSeqiNP_033262.2. NM_009236.2.
UniGeneiMm.264904.

3D structure databases

ProteinModelPortaliP43680.
SMRiP43680. Positions 78-181.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203404. 1 interaction.

PTM databases

PhosphoSiteiP43680.

Proteomic databases

PRIDEiP43680.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054491; ENSMUSP00000062759; ENSMUSG00000046470.
GeneIDi20672.
KEGGimmu:20672.
UCSCiuc008ona.1. mouse.

Organism-specific databases

CTDi54345.
MGIiMGI:103559. Sox18.

Phylogenomic databases

eggNOGiNOG252325.
GeneTreeiENSGT00760000118988.
HOGENOMiHOG000069999.
HOVERGENiHBG000517.
InParanoidiP43680.
KOiK09270.
OMAiYLNCSRT.
OrthoDBiEOG7R8329.
PhylomeDBiP43680.

Miscellaneous databases

NextBioi299155.
PROiP43680.
SOURCEiSearch...

Gene expression databases

BgeeiP43680.
CleanExiMM_SOX18.
GenevestigatoriP43680.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
IPR021934. Sox_C_TAD.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF12067. Sox_C_TAD. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
PS51516. SOX_C. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and expression of Sox-18 encoding a new HMG-box transcription factor."
    Dunn T.L., Mynett-Johnson L., Wright E.M., Hosking B.M., Koopman P.A., Muscat G.E.O.
    Gene 161:223-225(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Heart muscle.
  2. Dunn T.L.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Layfield R., Mynett-Johnson L., Yarwood P.J., Muscat G.E.O., Koopman P.A., Hume D.A.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 83-142.
    Strain: BALB/c.
    Tissue: Heart muscle.
  6. "Trans-activation and DNA-binding properties of the transcription factor, Sox-18."
    Hosking B.M., Muscat G.E.O., Koopman P.A., Dowhan D.H., Dunn T.L.
    Nucleic Acids Res. 23:2626-2628(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiSOX18_MOUSE
AccessioniPrimary (citable) accession number: P43680
Secondary accession number(s): Q9EQ73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 10, 2002
Last modified: February 4, 2015
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.