P43678 (KAS1_STRRM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Oxytetracycline polyketide putative beta-ketoacyl synthase 1
Organism	Streptomyces rimosus
Taxonomic identifier	1927 [NCBI]
Taxonomic lineage	Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Pathway	Antibiotic biosynthesis; oxytetracycline biosynthesis.
Sequence similarities	Belongs to the beta-ketoacyl-ACP synthases family.

Ontologies

Keywords
Biological process	Antibiotic biosynthesis
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	antibiotic biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 425	425	Oxytetracycline polyketide putative beta-ketoacyl synthase 1		PRO_0000180339
Sites
	Active site	173	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43678 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: B350D6D589887438	FASTA	425	45,005
	10 20 30 40 50 60 MSKIHDARRV VITGIGVVAP GDVGTKPFWE MLTAGRTATR PISSFDASPF RSQVAAECDF 70 80 90 100 110 120 DPAAEGLSQR QVRAWDRTMQ FAYVAAREAL ADSGVTGEAD PLRTGVMAGT ACGMTMSLDR 130 140 150 160 170 180 EYAVVSDEGR LWQVDDAHGV PYLYDYFVPS SMAAEIAWLA EAEGPAGVVS AGCTSGIDVL 190 200 210 220 230 240 THAADLVRDG AAEVMVAGAS DAAISPITVA CFDAIKATTP RNDEPETASR PFDRTRNGFV 250 260 270 280 290 300 LGEGAAFFVL EEYAHARRRG ARAYAEIAGY AGRCNAYSMT GLRSDGRELA EAVSRALDIA 310 320 330 340 350 360 RVDPSEVDYV NAHGSATKQN DLHETAAFKR SLGPHAYSVP ISSIKSMIGH SLGAICALEV 370 380 390 400 410 420 AASALRIEHG VIPPTANLRE PDPDCDLDYV PLVAREAEVS TVVSVASGFG GFQSAIVLTE PGRQR

References

[1]	"Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus." Kim E.S., Bibb M.J., Butler M.J., Hopwood D.A., Sherman D.H. Gene 141:141-142(1994) [PubMed: 8163168] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z25538 Genomic DNA. Translation: CAA80985.1.
3D structure databases
ProteinModelPortal	P43678.
SMR	P43678. Positions 8-420.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000794. Beta-ketoacyl_synthase. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. [Graphical view]
SUPFAM	SSF53901. Thiolase-like. 2 hits.
PROSITE	PS00606. B_KETOACYL_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KAS1_STRRM

Accession

Primary (citable) accession number: P43678

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	October 19, 2011
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program