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Protein

Oxytetracycline polyketide synthase acyl carrier protein

Gene
N/A
Organism
Streptomyces rimosus
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Acyl carrier protein.

Pathwayi: oxytetracycline biosynthesis

This protein is involved in the pathway oxytetracycline biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway oxytetracycline biosynthesis and in Antibiotic biosynthesis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00926.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxytetracycline polyketide synthase acyl carrier protein
Short name:
ACP
OrganismiStreptomyces rimosus
Taxonomic identifieri1927 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9595Oxytetracycline polyketide synthase acyl carrier proteinPRO_0000180253Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei41 – 411O-(pantetheine 4'-phosphoryl)serineCurated

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of the apo-ACP-like protein.Curated

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Structurei

Secondary structure

1
95
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1712Combined sources
Beta strandi30 – 323Combined sources
Helixi34 – 374Combined sources
Helixi42 – 5413Combined sources
Helixi63 – 664Combined sources
Helixi70 – 8314Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NQ4NMR-A1-95[»]
ProteinModelPortaliP43677.
SMRiP43677. Positions 14-95.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43677.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLLTLSDLL TLLRECAGEE ESIDLGGDVE DVAFDALGYD SLALLNTVGR
60 70 80 90
IERDYGVQLG DDAVEKATTP RALIEMTNAS LTGASPSAGG AARDK
Length:95
Mass (Da):9,916
Last modified:November 1, 1995 - v1
Checksum:iD0C92084807BB244
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25538 Genomic DNA. Translation: CAA80986.1.
U01666 Genomic DNA. Translation: AAA03334.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z25538 Genomic DNA. Translation: CAA80986.1.
U01666 Genomic DNA. Translation: AAA03334.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NQ4NMR-A1-95[»]
ProteinModelPortaliP43677.
SMRiP43677. Positions 14-95.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00926.

Miscellaneous databases

EvolutionaryTraceiP43677.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
InterProiIPR009081. PP-bd_ACP.
IPR006162. Ppantetheine_attach_site.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequences of the oxytetracycline polyketide synthase-encoding otc genes from Streptomyces rimosus."
    Kim E.S., Bibb M.J., Butler M.J., Hopwood D.A., Sherman D.H.
    Gene 141:141-142(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The acyl-carrier protein for biosynthesis of oxytetracycline from Streptomyces rimosus: overexpression in Escherichia coli, purification and characterization of the apoprotein."
    Linton K.J., Hunter I.S.
    Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 15883.

Entry informationi

Entry nameiACPX_STRRM
AccessioniPrimary (citable) accession number: P43677
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.