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Protein

Uncharacterized metalloprotease YcaL

Gene

ycaL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi134Zinc; catalyticSequence analysis1
Active sitei135Sequence analysis1
Metal bindingi138Zinc; catalyticSequence analysis1
Metal bindingi193Zinc; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6470-MONOMER

Protein family/group databases

MEROPSiM48.A03

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized metalloprotease YcaL (EC:3.4.24.-)
Gene namesi
Name:ycaL
Ordered Locus Names:b0909, JW0892
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13133 ycaL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001389371 – 254Uncharacterized metalloprotease YcaLAdd BLAST254

Proteomic databases

PaxDbiP43674
PRIDEiP43674

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
hybGP0AAM72EBI-9128400,EBI-562426

Protein-protein interaction databases

BioGridi4260012, 9 interactors
DIPiDIP-11467N
IntActiP43674, 2 interactors
STRINGi316385.ECDH10B_0979

Structurei

3D structure databases

ProteinModelPortaliP43674
SMRiP43674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.Curated

Phylogenomic databases

eggNOGiENOG4108K0D Bacteria
COG0501 LUCA
HOGENOMiHOG000264551
InParanoidiP43674
KOiK07387
OMAiDQSCAEM
PhylomeDBiP43674

Family and domain databases

InterProiView protein in InterPro
IPR001915 Peptidase_M48
PfamiView protein in Pfam
PF01435 Peptidase_M48, 1 hit

Sequencei

Sequence statusi: Complete.

P43674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTKLLLAI ATSAALLTGC QNTHGIDTNM AISSGLNAYK AATLSDADAK
60 70 80 90 100
AIANQGCAEM DSGNQVASKS SKYGKRLAKI AKALGNNING TPVNYKVYMT
110 120 130 140 150
SDVNAWAMAN GCVRVYSGLM DMMNDNEIEG VLGHELGHVA LGHSLAEMKA
160 170 180 190 200
SYAIVAARDA ISATSGVASQ LSRSQLGDIA EGAINAKYSR DKESEADDFS
210 220 230 240 250
FDLLKKRGIS TQGLVGSFET LASLDGGRTQ SMFDSHPPST ERAQHIRDRI

ASGK
Length:254
Mass (Da):26,740
Last modified:July 15, 1998 - v3
Checksum:i4DDF70D17E9D93A0
GO

Sequence cautioni

The sequence AAA81515 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241 – 254ERAQH…IASGK → DVRNTSVIVSPLVSKSLSSL RWSSASPL in CAA58106 (PubMed:7836281).CuratedAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC73995.2
AP009048 Genomic DNA Translation: BAA35644.1
U31523 Genomic DNA Translation: AAA81515.1 Different initiation.
X82933 Genomic DNA Translation: CAA58106.1
PIRiD64830
RefSeqiNP_415429.2, NC_000913.3
WP_001350496.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC73995; AAC73995; b0909
BAA35644; BAA35644; BAA35644
GeneIDi945534
KEGGiecj:JW0892
eco:b0909
PATRICifig|1411691.4.peg.1367

Similar proteinsi

Entry informationi

Entry nameiYCAL_ECOLI
AccessioniPrimary (citable) accession number: P43674
Secondary accession number(s): P75840
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: March 28, 2018
This is version 116 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health