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Protein

Uncharacterized metalloprotease YcaL

Gene

ycaL

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi134 – 1341Zinc; catalyticSequence analysis
Active sitei135 – 1351Sequence analysis
Metal bindingi138 – 1381Zinc; catalyticSequence analysis
Metal bindingi193 – 1931Zinc; catalyticBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciEcoCyc:G6470-MONOMER.
ECOL316407:JW0892-MONOMER.

Protein family/group databases

MEROPSiM48.A03.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized metalloprotease YcaL (EC:3.4.24.-)
Gene namesi
Name:ycaL
Ordered Locus Names:b0909, JW0892
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13133. ycaL.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Uncharacterized metalloprotease YcaLPRO_0000138937Add
BLAST

Proteomic databases

PaxDbiP43674.

Interactioni

Protein-protein interaction databases

BioGridi4260012. 9 interactions.
DIPiDIP-11467N.
IntActiP43674. 2 interactions.
STRINGi511145.b0909.

Structurei

3D structure databases

ProteinModelPortaliP43674.
SMRiP43674. Positions 44-251.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M48B family.Curated

Phylogenomic databases

eggNOGiENOG4108K0D. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000264551.
InParanoidiP43674.
KOiK07387.
OMAiGHDSATM.
OrthoDBiEOG67430H.
PhylomeDBiP43674.

Family and domain databases

InterProiIPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43674-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNTKLLLAI ATSAALLTGC QNTHGIDTNM AISSGLNAYK AATLSDADAK
60 70 80 90 100
AIANQGCAEM DSGNQVASKS SKYGKRLAKI AKALGNNING TPVNYKVYMT
110 120 130 140 150
SDVNAWAMAN GCVRVYSGLM DMMNDNEIEG VLGHELGHVA LGHSLAEMKA
160 170 180 190 200
SYAIVAARDA ISATSGVASQ LSRSQLGDIA EGAINAKYSR DKESEADDFS
210 220 230 240 250
FDLLKKRGIS TQGLVGSFET LASLDGGRTQ SMFDSHPPST ERAQHIRDRI

ASGK
Length:254
Mass (Da):26,740
Last modified:July 15, 1998 - v3
Checksum:i4DDF70D17E9D93A0
GO

Sequence cautioni

The sequence AAA81515.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti241 – 25414ERAQH…IASGK → DVRNTSVIVSPLVSKSLSSL RWSSASPL in CAA58106 (PubMed:7836281).CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73995.2.
AP009048 Genomic DNA. Translation: BAA35644.1.
U31523 Genomic DNA. Translation: AAA81515.1. Different initiation.
X82933 Genomic DNA. Translation: CAA58106.1.
PIRiD64830.
RefSeqiNP_415429.2. NC_000913.3.
WP_001350496.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC73995; AAC73995; b0909.
BAA35644; BAA35644; BAA35644.
GeneIDi945534.
KEGGiecj:JW0892.
eco:b0909.
PATRICi32117031. VBIEscCol129921_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC73995.2.
AP009048 Genomic DNA. Translation: BAA35644.1.
U31523 Genomic DNA. Translation: AAA81515.1. Different initiation.
X82933 Genomic DNA. Translation: CAA58106.1.
PIRiD64830.
RefSeqiNP_415429.2. NC_000913.3.
WP_001350496.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP43674.
SMRiP43674. Positions 44-251.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260012. 9 interactions.
DIPiDIP-11467N.
IntActiP43674. 2 interactions.
STRINGi511145.b0909.

Protein family/group databases

MEROPSiM48.A03.

Proteomic databases

PaxDbiP43674.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC73995; AAC73995; b0909.
BAA35644; BAA35644; BAA35644.
GeneIDi945534.
KEGGiecj:JW0892.
eco:b0909.
PATRICi32117031. VBIEscCol129921_0940.

Organism-specific databases

EchoBASEiEB2932.
EcoGeneiEG13133. ycaL.

Phylogenomic databases

eggNOGiENOG4108K0D. Bacteria.
COG0501. LUCA.
HOGENOMiHOG000264551.
InParanoidiP43674.
KOiK07387.
OMAiGHDSATM.
OrthoDBiEOG67430H.
PhylomeDBiP43674.

Enzyme and pathway databases

BioCyciEcoCyc:G6470-MONOMER.
ECOL316407:JW0892-MONOMER.

Miscellaneous databases

PROiP43674.

Family and domain databases

InterProiIPR001915. Peptidase_M48.
[Graphical view]
PfamiPF01435. Peptidase_M48. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-183.
    Strain: K12 / MG1655 / ATCC 47076.
  5. "The cmk gene encoding cytidine monophosphate kinase is located in the rpsA operon and is required for normal replication rate in Escherichia coli."
    Fricke J., Neuhard J., Kelln R.A., Pedersen S.
    J. Bacteriol. 177:517-523(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-254.
    Strain: K12.

Entry informationi

Entry nameiYCAL_ECOLI
AccessioniPrimary (citable) accession number: P43674
Secondary accession number(s): P75840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 15, 1998
Last modified: January 20, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.