Reviewed, UniProtKB/Swiss-Prot P43672 (UUP_ECOLI)

Names and origin

Protein names

Recommended name:
    ABC transporter ATP-binding protein uup

Gene names

Name:	uup
Synonyms:	ycbH, ycbI
Ordered Locus Names:	b0949, JW0932

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities	Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. Contains 2 ABC transporter domains.
Sequence caution	The sequence X81561 differs from that shown. Reason: Frameshift at positions 407, 437, 541 and 617.

Ontologies

Keywords
Biological process	Transport
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
lysS	P0A8N3	1	EBI-559429,EBI-552719

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	ABC transporter ATP-binding protein uup		PRO_0000093029
Regions
	Domain	1 – 253	253	ABC transporter 1
	Domain	320 – 546	227	ABC transporter 2
	Nucleotide binding	36 – 43	8	ATP 1 Potential
	Nucleotide binding	352 – 359	8	ATP 2 Potential
	Compositional bias	547 – 552	6	Poly-Ala

Sequences

	Sequence		Length	Mass (Da)
	P43672-1 [UniParc]. Last modified November 1, 1997. Version 2. Checksum: B1EAC2086BE193D2	FASTA	635	72,067
	10 20 30 40 50 60 MSLISMHGAW LSFSDAPLLD NAELHIEDNE RVCLVGRNGA GKSTLMKILN REQGLDDGRI 70 80 90 100 110 120 IYEQDLIVAR LQQDPPRNVE GSVYDFVAEG IEEQAEYLKR YHDISRLVMN DPSEKNLNEL 130 140 150 160 170 180 AKVQEQLDHH NLWQLENRIN EVLAQLGLDP NVALSSLSGG WLRKAALGRA LVSNPRVLLL 190 200 210 220 230 240 DEPTNHLDIE TIDWLEGFLK TFNGTIIFIS HDRSFIRNMA TRIVDLDRGK LVTYPGNYDQ 250 260 270 280 290 300 YLLEKEEALR VEELQNAEFD RKLAQEEVWI RQGIKARRTR NEGRVRALKA MRRERGERRE 310 320 330 340 350 360 VMGTAKMQVE EASRSGKIVF EMEDVCYQVN GKQLVKDFSA QVLRGDKIAL IGPNGCGKTT 370 380 390 400 410 420 LLKLMLGQLQ ADSGRIHVGT KLEVAYFDQH RAELDPDKTV MDNLAEGKQE VMVNGKPRHV 430 440 450 460 470 480 LGYLQDFLFH PKRAMTPVRA LSGGERNRLL LARLFLKPSN LLILDEPTND LDVETLELLE 490 500 510 520 530 540 ELIDSYQGTV LLVSHDRQFV DNTVTECWIF EGGGKIGRYV GGYHDARGQQ EQYVALKQPA 550 560 570 580 590 600 VKKTEEAAAA KAETVKRSSS KLSYKLQREL EQLPQLLEDL EAKLEALQTQ VADASFFSQP 610 620 630 HEQTQKVLAD MAAAEQELEQ AFERWEYLEA LKNGG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T. DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli." Reddy M., Gowrishankar J. J. Bacteriol. 179:2892-2899(1997) [PubMed: 9139905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-614. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Isolation of a novel paraquat-inducible (pqi) gene regulated by the soxRS locus in Escherichia coli." Koh Y.-S., Roe J.-H. J. Bacteriol. 177:2673-2678(1995) [PubMed: 7751275] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 395-635. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	Rudd K.E. Unpublished observations (JUL-1995) Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U00096 Genomic DNA. Translation: AAC74035.1. AP009048 Genomic DNA. Translation: BAA35707.1. Y09439 Genomic DNA. Translation: CAA70589.1. X81561 Genomic DNA. No translation available.
PIR	D64835.
RefSeq	AP_001579.1. NP_415469.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:11099N.
IntAct	P43672. 13 interactions.
STRING	P43672.
Genome annotation databases
GeneID	945566.
GenomeReviews	Gene locus JW0932 in contig AP009048_GR. Gene locus b0949 in contig U00096_GR.
KEGG	ecj:JW0932. eco:b0949.
Organism-specific databases
EchoBASE	EB2933.
EcoGene	EG13134. uup.
CMR	Search...
Phylogenomic databases
HOGENOM	P43672.
OMA	AMPELME
Enzyme and pathway databases
BioCyc	EcoCyc:UUP-MON. ECOL168927:B0949-MON.
Gene expression databases
Genevestigator	P43672.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UUP_ECOLI

Accession

Primary (citable) accession number: P43672
Secondary accession number(s): O05662, P43673, P75865

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	November 24, 2009
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)