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P43672 (UUP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter ATP-binding protein uup
Gene names
Name:uup
Synonyms:ycbH, ycbI
Ordered Locus Names:b0949, JW0932
OrganismEscherichia coli (strain K12)
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length635 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.

Contains 2 ABC transporter domains.

Sequence caution

The sequence X81561 differs from that shown. Reason: Frameshift at positions 407, 437, 541 and 617.

Ontologies

Keywords
   Biological processTransport
   DomainRepeat
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtransport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from direct assay. Source: EcoCyc

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from direct assay. Source: EcoCyc

DNA binding

Inferred from direct assay. Source: EcoCyc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 635635ABC transporter ATP-binding protein uup
PRO_0000093029

Regions

Domain1 – 253253ABC transporter 1
Domain320 – 546227ABC transporter 2
Nucleotide binding36 – 438ATP 1 Potential
Nucleotide binding352 – 3598ATP 2 Potential
Compositional bias547 – 5526Poly-Ala

Sequences

Sequence LengthMass (Da)Tools
P43672 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: B1EAC2086BE193D2

FASTA63572,067
        10         20         30         40         50         60 
MSLISMHGAW LSFSDAPLLD NAELHIEDNE RVCLVGRNGA GKSTLMKILN REQGLDDGRI 

        70         80         90        100        110        120 
IYEQDLIVAR LQQDPPRNVE GSVYDFVAEG IEEQAEYLKR YHDISRLVMN DPSEKNLNEL 

       130        140        150        160        170        180 
AKVQEQLDHH NLWQLENRIN EVLAQLGLDP NVALSSLSGG WLRKAALGRA LVSNPRVLLL 

       190        200        210        220        230        240 
DEPTNHLDIE TIDWLEGFLK TFNGTIIFIS HDRSFIRNMA TRIVDLDRGK LVTYPGNYDQ 

       250        260        270        280        290        300 
YLLEKEEALR VEELQNAEFD RKLAQEEVWI RQGIKARRTR NEGRVRALKA MRRERGERRE 

       310        320        330        340        350        360 
VMGTAKMQVE EASRSGKIVF EMEDVCYQVN GKQLVKDFSA QVLRGDKIAL IGPNGCGKTT 

       370        380        390        400        410        420 
LLKLMLGQLQ ADSGRIHVGT KLEVAYFDQH RAELDPDKTV MDNLAEGKQE VMVNGKPRHV 

       430        440        450        460        470        480 
LGYLQDFLFH PKRAMTPVRA LSGGERNRLL LARLFLKPSN LLILDEPTND LDVETLELLE 

       490        500        510        520        530        540 
ELIDSYQGTV LLVSHDRQFV DNTVTECWIF EGGGKIGRYV GGYHDARGQQ EQYVALKQPA 

       550        560        570        580        590        600 
VKKTEEAAAA KAETVKRSSS KLSYKLQREL EQLPQLLEDL EAKLEALQTQ VADASFFSQP 

       610        620        630 
HEQTQKVLAD MAAAEQELEQ AFERWEYLEA LKNGG 

« Hide

References

« Hide 'large scale' references
[1]"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map."
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. expand/collapse author list , Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N., Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y., Yano M., Horiuchi T.
DNA Res. 3:137-155(1996) [PubMed: 8905232] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli."
Reddy M., Gowrishankar J.
J. Bacteriol. 179:2892-2899(1997) [PubMed: 9139905] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-614.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]"Isolation of a novel paraquat-inducible (pqi) gene regulated by the soxRS locus in Escherichia coli."
Koh Y.-S., Roe J.-H.
J. Bacteriol. 177:2673-2678(1995) [PubMed: 7751275] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 395-635.
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]Rudd K.E.
Unpublished observations (JUL-1995)
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U00096 Genomic DNA. Translation: AAC74035.1.
AP009048 Genomic DNA. Translation: BAA35707.1.
Y09439 Genomic DNA. Translation: CAA70589.1.
X81561 Genomic DNA. No translation available.
PIRD64835.
RefSeqNP_415469.1. NC_000913.2.

3D structure databases

ProteinModelPortalP43672.
SMRP43672. Positions 1-239, 319-528.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-11099N.
IntActP43672. 13 interactions.
MINTMINT-1228036.

Protein family/group databases

TCDB3.A.1.120.6. ATP-binding cassette (ABC) superfamily.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBESCT00000004261; EBESCP00000004261; EBESCG00000003473.
EBESCT00000014590; EBESCP00000013881; EBESCG00000013651.
GeneID945566.
GenomeReviewsGene locus JW0932 in contig AP009048_GR.
Gene locus b0949 in contig U00096_GR.
KEGGecj:JW0932.
eco:b0949.
PATRIC32117117. VBIEscCol129921_0983.

Organism-specific databases

EchoBASEEB2933.
EcoGeneEG13134. uup.

Phylogenomic databases

eggNOGCOG0488.
GeneTreeEBGT00050000008245.
HOGENOMHBG758042.
OMAAMPELME.
PhylomeDBP43672.
ProtClustDBPRK11147.

Enzyme and pathway databases

BioCycEcoCyc:UUP-MONOMER.

Gene expression databases

GenevestigatorP43672.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
PROSITEPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUUP_ECOLI
AccessionPrimary (citable) accession number: P43672
Secondary accession number(s): O05662, P43673, P75865
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families