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Protein

ABC transporter ATP-binding protein uup

Gene

uup

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi352 – 359ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: EcoCyc
  • ATP binding Source: UniProtKB-KW
  • DNA binding Source: EcoCyc

GO - Biological processi

  • regulation of transposon integration Source: EcoCyc
  • transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:UUP-MONOMER.
ECOL316407:JW0932-MONOMER.

Protein family/group databases

TCDBi3.A.1.120.6. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter ATP-binding protein uup
Gene namesi
Name:uup
Synonyms:ycbH, ycbI
Ordered Locus Names:b0949, JW0932
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG13134. uup.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: EcoCyc
  • plasma membrane Source: EcoCyc
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000930291 – 635ABC transporter ATP-binding protein uupAdd BLAST635

Proteomic databases

PaxDbiP43672.
PRIDEiP43672.

Interactioni

Protein-protein interaction databases

BioGridi4260026. 4 interactors.
DIPiDIP-11099N.
IntActiP43672. 13 interactors.
MINTiMINT-1228036.
STRINGi511145.b0949.

Structurei

Secondary structure

1635
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi556 – 559Combined sources4
Helixi564 – 592Combined sources29
Helixi596 – 598Combined sources3
Helixi601 – 633Combined sources33

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW1NMR-A528-635[»]
ProteinModelPortaliP43672.
SMRiP43672.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 253ABC transporter 1PROSITE-ProRule annotationAdd BLAST253
Domaini320 – 546ABC transporter 2PROSITE-ProRule annotationAdd BLAST227

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi547 – 552Poly-Ala6

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105C5H. Bacteria.
COG0488. LUCA.
HOGENOMiHOG000271635.
InParanoidiP43672.
KOiK15738.
OMAiRHDEIEM.
PhylomeDBiP43672.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032524. ABC_tran_C.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF16326. ABC_tran_CTD. 1 hit.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43672-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLISMHGAW LSFSDAPLLD NAELHIEDNE RVCLVGRNGA GKSTLMKILN
60 70 80 90 100
REQGLDDGRI IYEQDLIVAR LQQDPPRNVE GSVYDFVAEG IEEQAEYLKR
110 120 130 140 150
YHDISRLVMN DPSEKNLNEL AKVQEQLDHH NLWQLENRIN EVLAQLGLDP
160 170 180 190 200
NVALSSLSGG WLRKAALGRA LVSNPRVLLL DEPTNHLDIE TIDWLEGFLK
210 220 230 240 250
TFNGTIIFIS HDRSFIRNMA TRIVDLDRGK LVTYPGNYDQ YLLEKEEALR
260 270 280 290 300
VEELQNAEFD RKLAQEEVWI RQGIKARRTR NEGRVRALKA MRRERGERRE
310 320 330 340 350
VMGTAKMQVE EASRSGKIVF EMEDVCYQVN GKQLVKDFSA QVLRGDKIAL
360 370 380 390 400
IGPNGCGKTT LLKLMLGQLQ ADSGRIHVGT KLEVAYFDQH RAELDPDKTV
410 420 430 440 450
MDNLAEGKQE VMVNGKPRHV LGYLQDFLFH PKRAMTPVRA LSGGERNRLL
460 470 480 490 500
LARLFLKPSN LLILDEPTND LDVETLELLE ELIDSYQGTV LLVSHDRQFV
510 520 530 540 550
DNTVTECWIF EGGGKIGRYV GGYHDARGQQ EQYVALKQPA VKKTEEAAAA
560 570 580 590 600
KAETVKRSSS KLSYKLQREL EQLPQLLEDL EAKLEALQTQ VADASFFSQP
610 620 630
HEQTQKVLAD MAAAEQELEQ AFERWEYLEA LKNGG
Length:635
Mass (Da):72,067
Last modified:November 1, 1997 - v2
Checksum:iB1EAC2086BE193D2
GO

Sequence cautioni

The sequence X81561 differs from that shown. Reason: Frameshift at positions 407, 437, 541 and 617.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74035.1.
AP009048 Genomic DNA. Translation: BAA35707.1.
Y09439 Genomic DNA. Translation: CAA70589.1.
X81561 Genomic DNA. No translation available.
PIRiD64835.
RefSeqiNP_415469.1. NC_000913.3.
WP_000053099.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC74035; AAC74035; b0949.
BAA35707; BAA35707; BAA35707.
GeneIDi945566.
KEGGiecj:JW0932.
eco:b0949.
PATRICi32117117. VBIEscCol129921_0983.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA. Translation: AAC74035.1.
AP009048 Genomic DNA. Translation: BAA35707.1.
Y09439 Genomic DNA. Translation: CAA70589.1.
X81561 Genomic DNA. No translation available.
PIRiD64835.
RefSeqiNP_415469.1. NC_000913.3.
WP_000053099.1. NZ_LN832404.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LW1NMR-A528-635[»]
ProteinModelPortaliP43672.
SMRiP43672.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260026. 4 interactors.
DIPiDIP-11099N.
IntActiP43672. 13 interactors.
MINTiMINT-1228036.
STRINGi511145.b0949.

Protein family/group databases

TCDBi3.A.1.120.6. the atp-binding cassette (abc) superfamily.

Proteomic databases

PaxDbiP43672.
PRIDEiP43672.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74035; AAC74035; b0949.
BAA35707; BAA35707; BAA35707.
GeneIDi945566.
KEGGiecj:JW0932.
eco:b0949.
PATRICi32117117. VBIEscCol129921_0983.

Organism-specific databases

EchoBASEiEB2933.
EcoGeneiEG13134. uup.

Phylogenomic databases

eggNOGiENOG4105C5H. Bacteria.
COG0488. LUCA.
HOGENOMiHOG000271635.
InParanoidiP43672.
KOiK15738.
OMAiRHDEIEM.
PhylomeDBiP43672.

Enzyme and pathway databases

BioCyciEcoCyc:UUP-MONOMER.
ECOL316407:JW0932-MONOMER.

Miscellaneous databases

PROiP43672.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR032524. ABC_tran_C.
IPR032781. ABC_tran_Xtn.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00005. ABC_tran. 2 hits.
PF16326. ABC_tran_CTD. 1 hit.
PF12848. ABC_tran_Xtn. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUUP_ECOLI
AccessioniPrimary (citable) accession number: P43672
Secondary accession number(s): O05662, P43673, P75865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.