ABC transporter ATP-binding protein uup - Escherichia coli (strain K12)

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P43672 (UUP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 109. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
ABC transporter ATP-binding protein uup

Gene names

Name:	uup
Synonyms:	ycbH, ycbI
Ordered Locus Names:	b0949, JW0932

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.

Contains 2 ABC transporter domains.

Sequence caution

The sequence X81561 differs from that shown. Reason: Frameshift at positions 407, 437, 541 and 617.

Ontologies

Keywords
Biological process	Transport
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transposon integration Inferred from mutant phenotype PubMed 6294054. Source: EcoCyc transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 16407313. Source: EcoCyc
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity Inferred from direct assay PubMed 16407313. Source: EcoCyc DNA binding Inferred from direct assay PubMed 16407313. Source: EcoCyc
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 635

635

ABC transporter ATP-binding protein uup

PRO_0000093029

Regions

Domain

1 – 253

253

ABC transporter 1

Domain

320 – 546

227

ABC transporter 2

Nucleotide binding

36 – 43

ATP 1 Potential

Nucleotide binding

352 – 359

ATP 2 Potential

Compositional bias

547 – 552

Poly-Ala

Secondary structure

635

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P43672 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: B1EAC2086BE193D2
Show »

FASTA

635

72,067

        10         20         30         40         50         60 
MSLISMHGAW LSFSDAPLLD NAELHIEDNE RVCLVGRNGA GKSTLMKILN REQGLDDGRI 

        70         80         90        100        110        120 
IYEQDLIVAR LQQDPPRNVE GSVYDFVAEG IEEQAEYLKR YHDISRLVMN DPSEKNLNEL 

       130        140        150        160        170        180 
AKVQEQLDHH NLWQLENRIN EVLAQLGLDP NVALSSLSGG WLRKAALGRA LVSNPRVLLL 

       190        200        210        220        230        240 
DEPTNHLDIE TIDWLEGFLK TFNGTIIFIS HDRSFIRNMA TRIVDLDRGK LVTYPGNYDQ 

       250        260        270        280        290        300 
YLLEKEEALR VEELQNAEFD RKLAQEEVWI RQGIKARRTR NEGRVRALKA MRRERGERRE 

       310        320        330        340        350        360 
VMGTAKMQVE EASRSGKIVF EMEDVCYQVN GKQLVKDFSA QVLRGDKIAL IGPNGCGKTT 

       370        380        390        400        410        420 
LLKLMLGQLQ ADSGRIHVGT KLEVAYFDQH RAELDPDKTV MDNLAEGKQE VMVNGKPRHV 

       430        440        450        460        470        480 
LGYLQDFLFH PKRAMTPVRA LSGGERNRLL LARLFLKPSN LLILDEPTND LDVETLELLE 

       490        500        510        520        530        540 
ELIDSYQGTV LLVSHDRQFV DNTVTECWIF EGGGKIGRYV GGYHDARGQQ EQYVALKQPA 

       550        560        570        580        590        600 
VKKTEEAAAA KAETVKRSSS KLSYKLQREL EQLPQLLEDL EAKLEALQTQ VADASFFSQP 

       610        620        630 
HEQTQKVLAD MAAAEQELEQ AFERWEYLEA LKNGG

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A., Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K., Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K. Horiuchi T. DNA Res. 3:137-155(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Identification and characterization of ssb and uup mutants with increased frequency of precise excision of transposon Tn10 derivatives: nucleotide sequence of uup in Escherichia coli." Reddy M., Gowrishankar J. J. Bacteriol. 179:2892-2899(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-614. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[5]	"Isolation of a novel paraquat-inducible (pqi) gene regulated by the soxRS locus in Escherichia coli." Koh Y.-S., Roe J.-H. J. Bacteriol. 177:2673-2678(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 395-635. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[6]	Rudd K.E. Unpublished observations (JUL-1995) Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U00096 Genomic DNA. Translation: AAC74035.1.
AP009048 Genomic DNA. Translation: BAA35707.1.
Y09439 Genomic DNA. Translation: CAA70589.1.
X81561 Genomic DNA. No translation available.

PIR

D64835.

RefSeq

NP_415469.1. NC_000913.2.
YP_489221.1. NC_007779.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LW1	NMR	-	A	551-635	[»]

ProteinModelPortal

P43672.

SMR

P43672. Positions 11-635.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-11099N.

IntAct

P43672. 13 interactions.

MINT

MINT-1228036.

STRING

511145.b0949.

Protein family/group databases

TCDB

3.A.1.120.6. ATP-binding cassette (ABC) superfamily.

Proteomic databases

PaxDb

P43672.

PRIDE

P43672.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAC74035; AAC74035; b0949.
BAA35707; BAA35707; BAA35707.

GeneID

12931032.
945566.

KEGG

ecj:Y75_p0921.
eco:b0949.

PATRIC

32117117. VBIEscCol129921_0983.

Organism-specific databases

EchoBASE

EB2933.

EcoGene

EG13134. uup.

Phylogenomic databases

eggNOG

COG0488.

HOGENOM

HOG000271635.

K15738.

OMA

AYHAISH.

ProtClustDB

PRK11147.

Enzyme and pathway databases

BioCyc

EcoCyc:UUP-MONOMER.
ECOL316407:JW0932-MONOMER.

Gene expression databases

Genevestigator

P43672.

Family and domain databases

InterPro

IPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
[Graphical view]

Pfam

PF00005. ABC_tran. 2 hits.
[Graphical view]

SMART

SM00382. AAA. 2 hits.
[Graphical view]

PROSITE

PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

UUP_ECOLI

Accession

Primary (citable) accession number: P43672
Secondary accession number(s): O05662, P43673, P75865

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents