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Protein

Lysophosphatidic acid receptor 6

Gene

LPAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139679-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
SIGNORiP43657.

Chemistry databases

SwissLipidsiSLP:000001579.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
RB intron encoded G-protein coupled receptor
Gene namesi
Name:LPAR6
Synonyms:P2RY5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15520. LPAR6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19ExtracellularSequence analysisAdd BLAST19
Transmembranei20 – 46Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini47 – 55CytoplasmicSequence analysis9
Transmembranei56 – 79Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini80 – 92ExtracellularSequence analysisAdd BLAST13
Transmembranei93 – 112Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini113 – 133CytoplasmicSequence analysisAdd BLAST21
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 181ExtracellularSequence analysisAdd BLAST27
Transmembranei182 – 209Helical; Name=5Sequence analysisAdd BLAST28
Topological domaini210 – 227CytoplasmicSequence analysisAdd BLAST18
Transmembranei228 – 253Helical; Name=6Sequence analysisAdd BLAST26
Topological domaini254 – 272ExtracellularSequence analysisAdd BLAST19
Transmembranei273 – 292Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini293 – 344CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.
See also OMIM:278150
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04432663D → V in ARWH1. 1 Publication1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant rs121434307dbSNPEnsembl.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant rs121434309dbSNPEnsembl.1
Hypotrichosis 8 (HYPT8)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.
See also OMIM:278150

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

DisGeNETi10161.
MalaCardsiLPAR6.
MIMi278150. phenotype.
OpenTargetsiENSG00000139679.
Orphaneti55654. Hypotrichosis simplex.
170. Woolly hair.
PharmGKBiPA165505129.

Chemistry databases

ChEMBLiCHEMBL2331058.
GuidetoPHARMACOLOGYi163.

Polymorphism and mutation databases

BioMutaiLPAR6.
DMDMi34223726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700251 – 344Lysophosphatidic acid receptor 6Add BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Lipidationi284S-palmitoyl cysteineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP43657.
PRIDEiP43657.

PTM databases

PhosphoSitePlusiP43657.

Expressioni

Tissue specificityi

Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.3 Publications

Developmental stagei

Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.1 Publication

Gene expression databases

BgeeiENSG00000139679.
ExpressionAtlasiP43657. baseline and differential.
GenevisibleiP43657. HS.

Organism-specific databases

HPAiHPA028934.

Interactioni

Protein-protein interaction databases

BioGridi115463. 57 interactors.
IntActiP43657. 1 interactor.
STRINGi9606.ENSP00000344353.

Chemistry databases

BindingDBiP43657.

Structurei

3D structure databases

ProteinModelPortaliP43657.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOVERGENiHBG101917.
InParanoidiP43657.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG091G0D67.
PhylomeDBiP43657.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP
160 170 180 190 200
AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA
Length:344
Mass (Da):39,392
Last modified:August 22, 2003 - v3
Checksum:i699212F3C1249433
GO

Sequence cautioni

The sequence L11910 differs from that shown. Reason: Frameshift at position 31.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242F → I in BAD97109 (Ref. 6) Curated1
Sequence conflicti303K → I in CAD97680 (PubMed:17974005).Curated1
Sequence conflicti344A → G in CAD97687 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02263633I → V.Corresponds to variant rs1060585dbSNPEnsembl.1
Natural variantiVAR_04432663D → V in ARWH1. 1 Publication1
Natural variantiVAR_016253137C → W.1 PublicationCorresponds to variant rs4151553dbSNPEnsembl.1
Natural variantiVAR_044327188I → F in ARWH1. 1 PublicationCorresponds to variant rs121434307dbSNPEnsembl.1
Natural variantiVAR_044328189E → K in ARWH1. 1 PublicationCorresponds to variant rs121434309dbSNPEnsembl.1
Natural variantiVAR_049430307W → C.Corresponds to variant rs17071686dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA. No translation available.
L78805 Genomic DNA. Translation: AAL40065.1.
AF000546 mRNA. Translation: AAB62190.1.
BX537392 mRNA. Translation: CAD97634.1.
BX537438 mRNA. Translation: CAD97680.1.
BX537445 mRNA. Translation: CAD97687.1.
AK122856 mRNA. Translation: BAG53764.1.
AK223389 mRNA. Translation: BAD97109.1.
HQ995530 mRNA. Translation: ADZ31975.1.
JF810890 mRNA. Translation: AEP43757.1.
AF551763 Genomic DNA. Translation: AAN64134.1.
AL392048 Genomic DNA. Translation: CAH72247.1.
CH471075 Genomic DNA. Translation: EAX08796.1.
BC040850 mRNA. Translation: AAH40850.1.
BC045651 mRNA. Translation: AAH45651.1.
BC070295 mRNA. Translation: AAH70295.1.
BC106756 mRNA. Translation: AAI06757.1.
CCDSiCCDS9410.1.
PIRiT09508.
RefSeqiNP_001155969.1. NM_001162497.1.
NP_001155970.1. NM_001162498.1.
NP_005758.2. NM_005767.5.
UniGeneiHs.123464.

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679.
ENST00000378434; ENSP00000367691; ENSG00000139679.
ENST00000620633; ENSP00000482660; ENSG00000139679.
GeneIDi10161.
KEGGihsa:10161.
UCSCiuc001vce.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA. No translation available.
L78805 Genomic DNA. Translation: AAL40065.1.
AF000546 mRNA. Translation: AAB62190.1.
BX537392 mRNA. Translation: CAD97634.1.
BX537438 mRNA. Translation: CAD97680.1.
BX537445 mRNA. Translation: CAD97687.1.
AK122856 mRNA. Translation: BAG53764.1.
AK223389 mRNA. Translation: BAD97109.1.
HQ995530 mRNA. Translation: ADZ31975.1.
JF810890 mRNA. Translation: AEP43757.1.
AF551763 Genomic DNA. Translation: AAN64134.1.
AL392048 Genomic DNA. Translation: CAH72247.1.
CH471075 Genomic DNA. Translation: EAX08796.1.
BC040850 mRNA. Translation: AAH40850.1.
BC045651 mRNA. Translation: AAH45651.1.
BC070295 mRNA. Translation: AAH70295.1.
BC106756 mRNA. Translation: AAI06757.1.
CCDSiCCDS9410.1.
PIRiT09508.
RefSeqiNP_001155969.1. NM_001162497.1.
NP_001155970.1. NM_001162498.1.
NP_005758.2. NM_005767.5.
UniGeneiHs.123464.

3D structure databases

ProteinModelPortaliP43657.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115463. 57 interactors.
IntActiP43657. 1 interactor.
STRINGi9606.ENSP00000344353.

Chemistry databases

BindingDBiP43657.
ChEMBLiCHEMBL2331058.
GuidetoPHARMACOLOGYi163.
SwissLipidsiSLP:000001579.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP43657.

Polymorphism and mutation databases

BioMutaiLPAR6.
DMDMi34223726.

Proteomic databases

PaxDbiP43657.
PRIDEiP43657.

Protocols and materials databases

DNASUi10161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679.
ENST00000378434; ENSP00000367691; ENSG00000139679.
ENST00000620633; ENSP00000482660; ENSG00000139679.
GeneIDi10161.
KEGGihsa:10161.
UCSCiuc001vce.4. human.

Organism-specific databases

CTDi10161.
DisGeNETi10161.
GeneCardsiLPAR6.
HGNCiHGNC:15520. LPAR6.
HPAiHPA028934.
MalaCardsiLPAR6.
MIMi278150. phenotype.
609239. gene.
neXtProtiNX_P43657.
OpenTargetsiENSG00000139679.
Orphaneti55654. Hypotrichosis simplex.
170. Woolly hair.
PharmGKBiPA165505129.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFM0. Eukaryota.
ENOG41115C6. LUCA.
GeneTreeiENSGT00760000118784.
HOVERGENiHBG101917.
InParanoidiP43657.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG091G0D67.
PhylomeDBiP43657.
TreeFamiTF350009.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139679-MONOMER.
ReactomeiR-HSA-416476. G alpha (q) signalling events.
R-HSA-417957. P2Y receptors.
SIGNORiP43657.

Miscellaneous databases

GenomeRNAii10161.
PROiP43657.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139679.
ExpressionAtlasiP43657. baseline and differential.
GenevisibleiP43657. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPAR6_HUMAN
AccessioniPrimary (citable) accession number: P43657
Secondary accession number(s): A4FTW9
, B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 22, 2003
Last modified: November 30, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This is a nested gene within intron 17 of the retinoblastoma gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.