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P43657

- LPAR6_HUMAN

UniProt

P43657 - LPAR6_HUMAN

Protein

Lysophosphatidic acid receptor 6

Gene

LPAR6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 3 (22 Aug 2003)
      Previous versions | rss
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    Functioni

    Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 6
    Short name:
    LPA receptor 6
    Short name:
    LPA-6
    Alternative name(s):
    Oleoyl-L-alpha-lysophosphatidic acid receptor
    P2Y purinoceptor 5
    Short name:
    P2Y5
    Purinergic receptor 5
    RB intron encoded G-protein coupled receptor
    Gene namesi
    Name:LPAR6
    Synonyms:P2RY5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:15520. LPAR6.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti63 – 631D → V in ARWH1. 1 Publication
    VAR_044326
    Natural varianti188 – 1881I → F in ARWH1. 1 Publication
    VAR_044327
    Natural varianti189 – 1891E → K in ARWH1. 1 Publication
    VAR_044328
    Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Disease mutation, Hypotrichosis

    Organism-specific databases

    MIMi278150. phenotype.
    Orphaneti55654. Hypotrichosis simplex.
    170. Woolly hair.
    PharmGKBiPA165505129.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 344344Lysophosphatidic acid receptor 6PRO_0000070025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
    Lipidationi284 – 2841S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiP43657.
    PRIDEiP43657.

    PTM databases

    PhosphoSiteiP43657.

    Expressioni

    Tissue specificityi

    Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.3 Publications

    Developmental stagei

    Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.1 Publication

    Gene expression databases

    ArrayExpressiP43657.
    BgeeiP43657.
    GenevestigatoriP43657.

    Organism-specific databases

    HPAiHPA028934.

    Interactioni

    Protein-protein interaction databases

    BioGridi115463. 1 interaction.
    IntActiP43657. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP43657.
    SMRiP43657. Positions 23-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 559CytoplasmicSequence Analysis
    Topological domaini80 – 9213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini113 – 13321CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 18127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 22718CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 27219ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 34452CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4627Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7924Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei93 – 11220Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei182 – 20928Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 25326Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG289230.
    HOVERGENiHBG101917.
    InParanoidiP43657.
    KOiK04273.
    OMAiFRIFYFA.
    OrthoDBiEOG71VSSZ.
    PhylomeDBiP43657.
    TreeFamiTF350009.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43657-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN    50
    ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM 100
    YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP 150
    AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN 200
    VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI 250
    LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 300
    SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA 344
    Length:344
    Mass (Da):39,392
    Last modified:August 22, 2003 - v3
    Checksum:i699212F3C1249433
    GO

    Sequence cautioni

    The sequence L11910 differs from that shown. Reason: Frameshift at position 31.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421F → I in BAD97109. 1 PublicationCurated
    Sequence conflicti303 – 3031K → I in CAD97680. (PubMed:17974005)Curated
    Sequence conflicti344 – 3441A → G in CAD97687. (PubMed:17974005)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331I → V.
    Corresponds to variant rs1060585 [ dbSNP | Ensembl ].
    VAR_022636
    Natural varianti63 – 631D → V in ARWH1. 1 Publication
    VAR_044326
    Natural varianti137 – 1371C → W.1 Publication
    Corresponds to variant rs4151553 [ dbSNP | Ensembl ].
    VAR_016253
    Natural varianti188 – 1881I → F in ARWH1. 1 Publication
    VAR_044327
    Natural varianti189 – 1891E → K in ARWH1. 1 Publication
    VAR_044328
    Natural varianti307 – 3071W → C.
    Corresponds to variant rs17071686 [ dbSNP | Ensembl ].
    VAR_049430

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11910 Genomic DNA. No translation available.
    L78805 Genomic DNA. Translation: AAL40065.1.
    AF000546 mRNA. Translation: AAB62190.1.
    BX537392 mRNA. Translation: CAD97634.1.
    BX537438 mRNA. Translation: CAD97680.1.
    BX537445 mRNA. Translation: CAD97687.1.
    AK122856 mRNA. Translation: BAG53764.1.
    AK223389 mRNA. Translation: BAD97109.1.
    HQ995530 mRNA. Translation: ADZ31975.1.
    JF810890 mRNA. Translation: AEP43757.1.
    AF551763 Genomic DNA. Translation: AAN64134.1.
    AL392048 Genomic DNA. Translation: CAH72247.1.
    CH471075 Genomic DNA. Translation: EAX08796.1.
    BC040850 mRNA. Translation: AAH40850.1.
    BC045651 mRNA. Translation: AAH45651.1.
    BC070295 mRNA. Translation: AAH70295.1.
    BC106756 mRNA. Translation: AAI06757.1.
    CCDSiCCDS9410.1.
    PIRiT09508.
    RefSeqiNP_001155969.1. NM_001162497.1.
    NP_001155970.1. NM_001162498.1.
    NP_005758.2. NM_005767.5.
    UniGeneiHs.123464.

    Genome annotation databases

    EnsembliENST00000345941; ENSP00000344353; ENSG00000139679.
    ENST00000378434; ENSP00000367691; ENSG00000139679.
    GeneIDi10161.
    KEGGihsa:10161.
    UCSCiuc001vce.3. human.

    Polymorphism databases

    DMDMi34223726.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11910 Genomic DNA. No translation available.
    L78805 Genomic DNA. Translation: AAL40065.1 .
    AF000546 mRNA. Translation: AAB62190.1 .
    BX537392 mRNA. Translation: CAD97634.1 .
    BX537438 mRNA. Translation: CAD97680.1 .
    BX537445 mRNA. Translation: CAD97687.1 .
    AK122856 mRNA. Translation: BAG53764.1 .
    AK223389 mRNA. Translation: BAD97109.1 .
    HQ995530 mRNA. Translation: ADZ31975.1 .
    JF810890 mRNA. Translation: AEP43757.1 .
    AF551763 Genomic DNA. Translation: AAN64134.1 .
    AL392048 Genomic DNA. Translation: CAH72247.1 .
    CH471075 Genomic DNA. Translation: EAX08796.1 .
    BC040850 mRNA. Translation: AAH40850.1 .
    BC045651 mRNA. Translation: AAH45651.1 .
    BC070295 mRNA. Translation: AAH70295.1 .
    BC106756 mRNA. Translation: AAI06757.1 .
    CCDSi CCDS9410.1.
    PIRi T09508.
    RefSeqi NP_001155969.1. NM_001162497.1.
    NP_001155970.1. NM_001162498.1.
    NP_005758.2. NM_005767.5.
    UniGenei Hs.123464.

    3D structure databases

    ProteinModelPortali P43657.
    SMRi P43657. Positions 23-300.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115463. 1 interaction.
    IntActi P43657. 1 interaction.

    Chemistry

    ChEMBLi CHEMBL2331058.
    GuidetoPHARMACOLOGYi 163.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P43657.

    Polymorphism databases

    DMDMi 34223726.

    Proteomic databases

    PaxDbi P43657.
    PRIDEi P43657.

    Protocols and materials databases

    DNASUi 10161.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345941 ; ENSP00000344353 ; ENSG00000139679 .
    ENST00000378434 ; ENSP00000367691 ; ENSG00000139679 .
    GeneIDi 10161.
    KEGGi hsa:10161.
    UCSCi uc001vce.3. human.

    Organism-specific databases

    CTDi 10161.
    GeneCardsi GC13M048963.
    HGNCi HGNC:15520. LPAR6.
    HPAi HPA028934.
    MIMi 278150. phenotype.
    609239. gene.
    neXtProti NX_P43657.
    Orphaneti 55654. Hypotrichosis simplex.
    170. Woolly hair.
    PharmGKBi PA165505129.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG289230.
    HOVERGENi HBG101917.
    InParanoidi P43657.
    KOi K04273.
    OMAi FRIFYFA.
    OrthoDBi EOG71VSSZ.
    PhylomeDBi P43657.
    TreeFami TF350009.

    Enzyme and pathway databases

    Reactomei REACT_18283. G alpha (q) signalling events.
    REACT_18289. P2Y receptors.

    Miscellaneous databases

    GenomeRNAii 10161.
    NextBioi 38470.
    PROi P43657.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43657.
    Bgeei P43657.
    Genevestigatori P43657.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genomic sequence of the human retinoblastoma susceptibility gene."
      Toguchida J., McGee T.L., Paterson J.C., Eagle J.R., Tucker S., Yandell D.W., Dryja T.P.
      Genomics 17:535-543(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene."
      Herzog H., Darby K., Hort Y.J., Shine J.
      Genome Res. 6:858-861(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The human purinergic receptor P2Y5 is encoded in intron 17 of the retinoblastoma gene."
      Bohm S.K., Trumpp A., Khitin L.M., Kong W., Payan D.G., Bunnett N.W.
      Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Endometrium and Heart.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Thymus.
    7. Kaighin V.A., Martin A.L., Aronstam R.S.
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Peripheral blood leukocyte.
    8. NIEHS SNPs program
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TRP-137.
    9. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain, Placenta and Testis.
    12. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
      Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
      Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    13. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."
      Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F., Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P., Noethen M.M., Betz R.C.
      Nat. Genet. 40:329-334(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN HYPT8.
    14. "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."
      Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D., Christiano A.M.
      Nat. Genet. 40:335-339(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARWH1 VAL-63; PHE-188 AND LYS-189, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLPAR6_HUMAN
    AccessioniPrimary (citable) accession number: P43657
    Secondary accession number(s): A4FTW9
    , B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: August 22, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    This is a nested gene within intron 17 of the retinoblastoma gene.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3