Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Lysophosphatidic acid receptor 6

Gene

LPAR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 6
Short name:
LPA receptor 6
Short name:
LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name:
P2Y5
Purinergic receptor 5
RB intron encoded G-protein coupled receptor
Gene namesi
Name:LPAR6
Synonyms:P2RY5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:15520. LPAR6.

Subcellular locationi

Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei20 – 4627Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 559CytoplasmicSequence Analysis
Transmembranei56 – 7924Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 9213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei93 – 11220Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini113 – 13321CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 18127ExtracellularSequence AnalysisAdd
BLAST
Transmembranei182 – 20928Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini210 – 22718CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei228 – 25326Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini254 – 27219ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29220Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 34452CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.

See also OMIM:278150
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti63 – 631D → V in ARWH1. 1 Publication
VAR_044326
Natural varianti188 – 1881I → F in ARWH1. 1 Publication
VAR_044327
Natural varianti189 – 1891E → K in ARWH1. 1 Publication
VAR_044328
Hypotrichosis 8 (HYPT8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.

See also OMIM:278150

Keywords - Diseasei

Disease mutation, Hypotrichosis

Organism-specific databases

MIMi278150. phenotype.
Orphaneti55654. Hypotrichosis simplex.
170. Woolly hair.
PharmGKBiPA165505129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344Lysophosphatidic acid receptor 6PRO_0000070025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi89 ↔ 168PROSITE-ProRule annotation
Lipidationi284 – 2841S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP43657.
PRIDEiP43657.

PTM databases

PhosphoSiteiP43657.

Expressioni

Tissue specificityi

Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes.3 Publications

Developmental stagei

Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway.1 Publication

Gene expression databases

BgeeiP43657.
ExpressionAtlasiP43657. baseline and differential.
GenevestigatoriP43657.

Organism-specific databases

HPAiHPA028934.

Interactioni

Protein-protein interaction databases

BioGridi115463. 54 interactions.
IntActiP43657. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP43657.
SMRiP43657. Positions 23-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG289230.
GeneTreeiENSGT00760000118784.
HOVERGENiHBG101917.
InParanoidiP43657.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiP43657.
TreeFamiTF350009.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43657-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN
60 70 80 90 100
ETTTYMINLA MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM
110 120 130 140 150
YGSILFLTCI SVDRFLAIVY PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP
160 170 180 190 200
AVFVQSTHSQ GNNASEACFE NFPEATWKTY LSRIVIFIEI VGFFIPLILN
210 220 230 240 250
VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF CFVPYNINLI
260 270 280 290 300
LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN
310 320 330 340
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA
Length:344
Mass (Da):39,392
Last modified:August 22, 2003 - v3
Checksum:i699212F3C1249433
GO

Sequence cautioni

The sequence L11910 differs from that shown. Reason: Frameshift at position 31. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421F → I in BAD97109 (Ref. 6) Curated
Sequence conflicti303 – 3031K → I in CAD97680 (PubMed:17974005).Curated
Sequence conflicti344 – 3441A → G in CAD97687 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti33 – 331I → V.
Corresponds to variant rs1060585 [ dbSNP | Ensembl ].
VAR_022636
Natural varianti63 – 631D → V in ARWH1. 1 Publication
VAR_044326
Natural varianti137 – 1371C → W.1 Publication
Corresponds to variant rs4151553 [ dbSNP | Ensembl ].
VAR_016253
Natural varianti188 – 1881I → F in ARWH1. 1 Publication
VAR_044327
Natural varianti189 – 1891E → K in ARWH1. 1 Publication
VAR_044328
Natural varianti307 – 3071W → C.
Corresponds to variant rs17071686 [ dbSNP | Ensembl ].
VAR_049430

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA. No translation available.
L78805 Genomic DNA. Translation: AAL40065.1.
AF000546 mRNA. Translation: AAB62190.1.
BX537392 mRNA. Translation: CAD97634.1.
BX537438 mRNA. Translation: CAD97680.1.
BX537445 mRNA. Translation: CAD97687.1.
AK122856 mRNA. Translation: BAG53764.1.
AK223389 mRNA. Translation: BAD97109.1.
HQ995530 mRNA. Translation: ADZ31975.1.
JF810890 mRNA. Translation: AEP43757.1.
AF551763 Genomic DNA. Translation: AAN64134.1.
AL392048 Genomic DNA. Translation: CAH72247.1.
CH471075 Genomic DNA. Translation: EAX08796.1.
BC040850 mRNA. Translation: AAH40850.1.
BC045651 mRNA. Translation: AAH45651.1.
BC070295 mRNA. Translation: AAH70295.1.
BC106756 mRNA. Translation: AAI06757.1.
CCDSiCCDS9410.1.
PIRiT09508.
RefSeqiNP_001155969.1. NM_001162497.1.
NP_001155970.1. NM_001162498.1.
NP_005758.2. NM_005767.5.
UniGeneiHs.123464.

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679.
ENST00000378434; ENSP00000367691; ENSG00000139679.
ENST00000620633; ENSP00000482660; ENSG00000139679.
GeneIDi10161.
KEGGihsa:10161.
UCSCiuc001vce.3. human.

Polymorphism databases

DMDMi34223726.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11910 Genomic DNA. No translation available.
L78805 Genomic DNA. Translation: AAL40065.1.
AF000546 mRNA. Translation: AAB62190.1.
BX537392 mRNA. Translation: CAD97634.1.
BX537438 mRNA. Translation: CAD97680.1.
BX537445 mRNA. Translation: CAD97687.1.
AK122856 mRNA. Translation: BAG53764.1.
AK223389 mRNA. Translation: BAD97109.1.
HQ995530 mRNA. Translation: ADZ31975.1.
JF810890 mRNA. Translation: AEP43757.1.
AF551763 Genomic DNA. Translation: AAN64134.1.
AL392048 Genomic DNA. Translation: CAH72247.1.
CH471075 Genomic DNA. Translation: EAX08796.1.
BC040850 mRNA. Translation: AAH40850.1.
BC045651 mRNA. Translation: AAH45651.1.
BC070295 mRNA. Translation: AAH70295.1.
BC106756 mRNA. Translation: AAI06757.1.
CCDSiCCDS9410.1.
PIRiT09508.
RefSeqiNP_001155969.1. NM_001162497.1.
NP_001155970.1. NM_001162498.1.
NP_005758.2. NM_005767.5.
UniGeneiHs.123464.

3D structure databases

ProteinModelPortaliP43657.
SMRiP43657. Positions 23-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115463. 54 interactions.
IntActiP43657. 1 interaction.

Chemistry

BindingDBiP43657.
ChEMBLiCHEMBL2331058.
GuidetoPHARMACOLOGYi163.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP43657.

Polymorphism databases

DMDMi34223726.

Proteomic databases

PaxDbiP43657.
PRIDEiP43657.

Protocols and materials databases

DNASUi10161.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345941; ENSP00000344353; ENSG00000139679.
ENST00000378434; ENSP00000367691; ENSG00000139679.
ENST00000620633; ENSP00000482660; ENSG00000139679.
GeneIDi10161.
KEGGihsa:10161.
UCSCiuc001vce.3. human.

Organism-specific databases

CTDi10161.
GeneCardsiGC13M048963.
HGNCiHGNC:15520. LPAR6.
HPAiHPA028934.
MIMi278150. phenotype.
609239. gene.
neXtProtiNX_P43657.
Orphaneti55654. Hypotrichosis simplex.
170. Woolly hair.
PharmGKBiPA165505129.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG289230.
GeneTreeiENSGT00760000118784.
HOVERGENiHBG101917.
InParanoidiP43657.
KOiK04273.
OMAiFRIFYFA.
OrthoDBiEOG71VSSZ.
PhylomeDBiP43657.
TreeFamiTF350009.

Enzyme and pathway databases

ReactomeiREACT_18283. G alpha (q) signalling events.
REACT_18289. P2Y receptors.

Miscellaneous databases

GenomeRNAii10161.
NextBioi38470.
PROiP43657.
SOURCEiSearch...

Gene expression databases

BgeeiP43657.
ExpressionAtlasiP43657. baseline and differential.
GenevestigatoriP43657.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete genomic sequence of the human retinoblastoma susceptibility gene."
    Toguchida J., McGee T.L., Paterson J.C., Eagle J.R., Tucker S., Yandell D.W., Dryja T.P.
    Genomics 17:535-543(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene."
    Herzog H., Darby K., Hort Y.J., Shine J.
    Genome Res. 6:858-861(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The human purinergic receptor P2Y5 is encoded in intron 17 of the retinoblastoma gene."
    Bohm S.K., Trumpp A., Khitin L.M., Kong W., Payan D.G., Bunnett N.W.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Endometrium and Heart.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  6. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Thymus.
  7. Kaighin V.A., Martin A.L., Aronstam R.S.
    Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Peripheral blood leukocyte.
  8. NIEHS SNPs program
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TRP-137.
  9. "The DNA sequence and analysis of human chromosome 13."
    Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
    Nature 428:522-528(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain, Placenta and Testis.
  12. "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
    Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
    Biochim. Biophys. Acta 1492:127-138(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  13. "G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."
    Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F., Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P., Noethen M.M., Betz R.C.
    Nat. Genet. 40:329-334(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN HYPT8.
  14. "Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."
    Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D., Christiano A.M.
    Nat. Genet. 40:335-339(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARWH1 VAL-63; PHE-188 AND LYS-189, TISSUE SPECIFICITY.

Entry informationi

Entry nameiLPAR6_HUMAN
AccessioniPrimary (citable) accession number: P43657
Secondary accession number(s): A4FTW9
, B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 22, 2003
Last modified: January 7, 2015
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This is a nested gene within intron 17 of the retinoblastoma gene.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.