Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P43657 (LPAR6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid receptor 6

Short name=LPA receptor 6
Short name=LPA-6
Alternative name(s):
Oleoyl-L-alpha-lysophosphatidic acid receptor
P2Y purinoceptor 5
Short name=P2Y5
Purinergic receptor 5
RB intron encoded G-protein coupled receptor
Gene names
Name:LPAR6
Synonyms:P2RY5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length344 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. Ref.13

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.13.

Tissue specificity

Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes. Ref.12 Ref.13 Ref.14

Developmental stage

Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway. Ref.12

Involvement in disease

Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.14

Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.13

Miscellaneous

This is a nested gene within intron 17 of the retinoblastoma gene.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence L11910 differs from that shown. Reason: Frameshift at position 31.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 344344Lysophosphatidic acid receptor 6
PRO_0000070025

Regions

Topological domain1 – 1919Extracellular Potential
Transmembrane20 – 4627Helical; Name=1; Potential
Topological domain47 – 559Cytoplasmic Potential
Transmembrane56 – 7924Helical; Name=2; Potential
Topological domain80 – 9213Extracellular Potential
Transmembrane93 – 11220Helical; Name=3; Potential
Topological domain113 – 13321Cytoplasmic Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 18127Extracellular Potential
Transmembrane182 – 20928Helical; Name=5; Potential
Topological domain210 – 22718Cytoplasmic Potential
Transmembrane228 – 25326Helical; Name=6; Potential
Topological domain254 – 27219Extracellular Potential
Transmembrane273 – 29220Helical; Name=7; Potential
Topological domain293 – 34452Cytoplasmic Potential

Amino acid modifications

Lipidation2841S-palmitoyl cysteine By similarity
Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond89 ↔ 168 Potential

Natural variations

Natural variant331I → V.
Corresponds to variant rs1060585 [ dbSNP | Ensembl ].
VAR_022636
Natural variant631D → V in ARWH1. Ref.14
VAR_044326
Natural variant1371C → W. Ref.8
Corresponds to variant rs4151553 [ dbSNP | Ensembl ].
VAR_016253
Natural variant1881I → F in ARWH1. Ref.14
VAR_044327
Natural variant1891E → K in ARWH1. Ref.14
VAR_044328
Natural variant3071W → C.
Corresponds to variant rs17071686 [ dbSNP | Ensembl ].
VAR_049430

Experimental info

Sequence conflict2421F → I in BAD97109. Ref.6
Sequence conflict3031K → I in CAD97680. Ref.4
Sequence conflict3441A → G in CAD97687. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P43657 [UniParc].

Last modified August 22, 2003. Version 3.
Checksum: 699212F3C1249433

FASTA34439,392
        10         20         30         40         50         60 
MVSVNSSHCF YNDSFKYTLY GCMFSMVFVL GLISNCVAIY IFICVLKVRN ETTTYMINLA 

        70         80         90        100        110        120 
MSDLLFVFTL PFRIFYFTTR NWPFGDLLCK ISVMLFYTNM YGSILFLTCI SVDRFLAIVY 

       130        140        150        160        170        180 
PFKSKTLRTK RNAKIVCTGV WLTVIGGSAP AVFVQSTHSQ GNNASEACFE NFPEATWKTY 

       190        200        210        220        230        240 
LSRIVIFIEI VGFFIPLILN VTCSSMVLKT LTKPVTLSRS KINKTKVLKM IFVHLIIFCF 

       250        260        270        280        290        300 
CFVPYNINLI LYSLVRTQTF VNCSVVAAVR TMYPITLCIA VSNCCFDPIV YYFTSDTIQN 

       310        320        330        340 
SIKMKNWSVR RSDFRFSEVH GAENFIQHNL QTLKSKIFDN ESAA 

« Hide

References

« Hide 'large scale' references
[1]"Complete genomic sequence of the human retinoblastoma susceptibility gene."
Toguchida J., McGee T.L., Paterson J.C., Eagle J.R., Tucker S., Yandell D.W., Dryja T.P.
Genomics 17:535-543(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene."
Herzog H., Darby K., Hort Y.J., Shine J.
Genome Res. 6:858-861(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The human purinergic receptor P2Y5 is encoded in intron 17 of the retinoblastoma gene."
Bohm S.K., Trumpp A., Khitin L.M., Kong W., Payan D.G., Bunnett N.W.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Endometrium and Heart.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Subthalamic nucleus.
[6]Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Thymus.
[7]Kaighin V.A., Martin A.L., Aronstam R.S.
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Peripheral blood leukocyte.
[8]NIEHS SNPs program
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT TRP-137.
[9]"The DNA sequence and analysis of human chromosome 13."
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. expand/collapse author list , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[10]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[11]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain, Placenta and Testis.
[12]"Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells."
Adrian K., Bernhard M.K., Breitinger H.-G., Ogilvie A.
Biochim. Biophys. Acta 1492:127-138(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[13]"G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth."
Pasternack S.M., von Kuegelgen I., Aboud K.A., Lee Y.-A., Rueschendorf F., Voss K., Hillmer A.M., Molderings G.J., Franz T., Ramirez A., Nuernberg P., Noethen M.M., Betz R.C.
Nat. Genet. 40:329-334(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INVOLVEMENT IN HYPT8.
[14]"Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair."
Shimomura Y., Wajid M., Ishii Y., Shapiro L., Petukhova L., Gordon D., Christiano A.M.
Nat. Genet. 40:335-339(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ARWH1 VAL-63; PHE-188 AND LYS-189, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11910 Genomic DNA. No translation available.
L78805 Genomic DNA. Translation: AAL40065.1.
AF000546 mRNA. Translation: AAB62190.1.
BX537392 mRNA. Translation: CAD97634.1.
BX537438 mRNA. Translation: CAD97680.1.
BX537445 mRNA. Translation: CAD97687.1.
AK122856 mRNA. Translation: BAG53764.1.
AK223389 mRNA. Translation: BAD97109.1.
HQ995530 mRNA. Translation: ADZ31975.1.
JF810890 mRNA. Translation: AEP43757.1.
AF551763 Genomic DNA. Translation: AAN64134.1.
AL392048 Genomic DNA. Translation: CAH72247.1.
CH471075 Genomic DNA. Translation: EAX08796.1.
BC040850 mRNA. Translation: AAH40850.1.
BC045651 mRNA. Translation: AAH45651.1.
BC070295 mRNA. Translation: AAH70295.1.
BC106756 mRNA. Translation: AAI06757.1.
PIRT09508.
RefSeqNP_001155969.1. NM_001162497.1.
NP_001155970.1. NM_001162498.1.
NP_005758.2. NM_005767.5.
UniGeneHs.123464.

3D structure databases

ProteinModelPortalP43657.
SMRP43657. Positions 23-300.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115463. 1 interaction.
IntActP43657. 1 interaction.

Chemistry

ChEMBLCHEMBL2331058.
GuidetoPHARMACOLOGY163.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP43657.

Polymorphism databases

DMDM34223726.

Proteomic databases

PaxDbP43657.
PRIDEP43657.

Protocols and materials databases

DNASU10161.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000345941; ENSP00000344353; ENSG00000139679.
ENST00000378434; ENSP00000367691; ENSG00000139679.
GeneID10161.
KEGGhsa:10161.
UCSCuc001vce.3. human.

Organism-specific databases

CTD10161.
GeneCardsGC13M048963.
HGNCHGNC:15520. LPAR6.
HPAHPA028934.
MIM278150. phenotype.
609239. gene.
neXtProtNX_P43657.
Orphanet55654. Hypotrichosis simplex.
170. Woolly hair.
PharmGKBPA165505129.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG289230.
HOVERGENHBG101917.
InParanoidP43657.
KOK04273.
OMAFRIFYFA.
OrthoDBEOG71VSSZ.
PhylomeDBP43657.
TreeFamTF350009.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP43657.
BgeeP43657.
GenevestigatorP43657.

Family and domain databases

InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10161.
NextBio38470.
PROP43657.
SOURCESearch...

Entry information

Entry nameLPAR6_HUMAN
AccessionPrimary (citable) accession number: P43657
Secondary accession number(s): A4FTW9 expand/collapse secondary AC list , B3KVF2, F2YGU4, O15133, Q3KPF5, Q53FA0, Q5VW44, Q7Z3S0, Q7Z3S6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 22, 2003
Last modified: March 19, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 13

Human chromosome 13: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries