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P43652

- AFAM_HUMAN

UniProt

P43652 - AFAM_HUMAN

Protein

Afamin

Gene

AFM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier.3 Publications

    GO - Molecular functioni

    1. vitamin E binding Source: UniProtKB

    GO - Biological processi

    1. vitamin transport Source: UniProtKB

    Keywords - Biological processi

    Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Afamin
    Alternative name(s):
    Alpha-albumin
    Short name:
    Alpha-Alb
    Gene namesi
    Name:AFM
    Synonyms:ALB2, ALBA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:316. AFM.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: ProtInc
    3. extracellular space Source: UniProtKB
    4. extracellular vesicular exosome Source: UniProt

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24613.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 599578AfaminPRO_0000001106Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...) (complex)5 Publications
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi99 ↔ 114PROSITE-ProRule annotation
    Glycosylationi109 – 1091N-linked (GlcNAc...) (complex)2 Publications
    Disulfide bondi113 ↔ 124PROSITE-ProRule annotation
    Disulfide bondi148 ↔ 193PROSITE-ProRule annotation
    Disulfide bondi192 ↔ 201PROSITE-ProRule annotation
    Disulfide bondi224 ↔ 270PROSITE-ProRule annotation
    Disulfide bondi269 ↔ 277PROSITE-ProRule annotation
    Disulfide bondi289 ↔ 303PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi340 ↔ 385PROSITE-ProRule annotation
    Glycosylationi383 – 3831N-linked (GlcNAc...) (complex); atypical3 Publications
    Disulfide bondi384 ↔ 393PROSITE-ProRule annotation
    Glycosylationi402 – 4021N-linked (GlcNAc...) (complex)6 Publications
    Disulfide bondi416 ↔ 462PROSITE-ProRule annotation
    Disulfide bondi461 ↔ 470PROSITE-ProRule annotation
    Disulfide bondi483 ↔ 499PROSITE-ProRule annotation
    Glycosylationi488 – 4881N-linked (GlcNAc...)2 Publications
    Disulfide bondi498 ↔ 509PROSITE-ProRule annotation
    Disulfide bondi536 ↔ 581PROSITE-ProRule annotation
    Disulfide bondi580 ↔ 589PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated; more than 90% of the glycans are sialylated.7 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP43652.
    PeptideAtlasiP43652.
    PRIDEiP43652.

    PTM databases

    PhosphoSiteiP43652.

    Expressioni

    Tissue specificityi

    High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).1 Publication

    Gene expression databases

    BgeeiP43652.
    CleanExiHS_AFM.
    GenevestigatoriP43652.

    Organism-specific databases

    HPAiHPA017006.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000226355.

    Structurei

    3D structure databases

    ProteinModelPortaliP43652.
    SMRiP43652. Positions 40-597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 210189Albumin 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini211 – 403193Albumin 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 599196Albumin 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
    Contains 3 albumin domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG47806.
    HOGENOMiHOG000293137.
    HOVERGENiHBG004207.
    InParanoidiP43652.
    OMAiFACVDNL.
    OrthoDBiEOG7DZ8JF.
    PhylomeDBiP43652.
    TreeFamiTF335561.

    Family and domain databases

    InterProiIPR000264. ALB/AFP/VDB.
    IPR001703. Alpha-fetoprotein.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view]
    PfamiPF00273. Serum_albumin. 3 hits.
    [Graphical view]
    PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSiPR00803. AFETOPROTEIN.
    PR00802. SERUMALBUMIN.
    SMARTiSM00103. ALBUMIN. 3 hits.
    [Graphical view]
    SUPFAMiSSF48552. SSF48552. 3 hits.
    PROSITEiPS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43652-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLKLTGFI FFLFFLTESL TLPTQPRDIE NFNSTQKFIE DNIEYITIIA    50
    FAQYVQEATF EEMEKLVKDM VEYKDRCMAD KTLPECSKLP NNVLQEKICA 100
    MEGLPQKHNF SHCCSKVDAQ RRLCFFYNKK SDVGFLPPFP TLDPEEKCQA 150
    YESNRESLLN HFLYEVARRN PFVFAPTLLT VAVHFEEVAK SCCEEQNKVN 200
    CLQTRAIPVT QYLKAFSSYQ KHVCGALLKF GTKVVHFIYI AILSQKFPKI 250
    EFKELISLVE DVSSNYDGCC EGDVVQCIRD TSKVMNHICS KQDSISSKIK 300
    ECCEKKIPER GQCIINSNKD DRPKDLSLRE GKFTDSENVC QERDADPDTF 350
    FAKFTFEYSR RHPDLSIPEL LRIVQIYKDL LRNCCNTENP PGCYRYAEDK 400
    FNETTEKSLK MVQQECKHFQ NLGKDGLKYH YLIRLTKIAP QLSTEELVSL 450
    GEKMVTAFTT CCTLSEEFAC VDNLADLVFG ELCGVNENRT INPAVDHCCK 500
    TNFAFRRPCF ESLKADKTYV PPPFSQDLFT FHADMCQSQN EELQRKTDRF 550
    LVNLVKLKHE LTDEELQSLF TNFANVVDKC CKAESPEVCF NEESPKIGN 599
    Length:599
    Mass (Da):69,069
    Last modified:November 1, 1995 - v1
    Checksum:iD594E75E20D308AB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti395 – 3951R → H.
    Corresponds to variant rs41265665 [ dbSNP | Ensembl ].
    VAR_061003
    Natural varianti404 – 4041T → S.
    Corresponds to variant rs2276444 [ dbSNP | Ensembl ].
    VAR_048218

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32140 mRNA. Translation: AAA21612.1.
    U51243 Genomic DNA. Translation: AAC50720.1.
    AK290556 mRNA. Translation: BAF83245.1.
    AC108157 Genomic DNA. No translation available.
    AC110752 Genomic DNA. Translation: AAY41051.1.
    CH471057 Genomic DNA. Translation: EAX05682.1.
    BC109020 mRNA. Translation: AAI09021.1.
    BC109021 mRNA. Translation: AAI09022.1.
    L35486 mRNA. Translation: AAA68197.1.
    L35497 mRNA. Translation: AAA68198.1.
    L35498 mRNA. Translation: AAA68199.1.
    CCDSiCCDS3557.1.
    PIRiA54906.
    I39424.
    I39426.
    RefSeqiNP_001124.1. NM_001133.2.
    UniGeneiHs.168718.

    Genome annotation databases

    EnsembliENST00000226355; ENSP00000226355; ENSG00000079557.
    GeneIDi173.
    KEGGihsa:173.
    UCSCiuc003hhb.3. human.

    Polymorphism databases

    DMDMi1168366.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L32140 mRNA. Translation: AAA21612.1 .
    U51243 Genomic DNA. Translation: AAC50720.1 .
    AK290556 mRNA. Translation: BAF83245.1 .
    AC108157 Genomic DNA. No translation available.
    AC110752 Genomic DNA. Translation: AAY41051.1 .
    CH471057 Genomic DNA. Translation: EAX05682.1 .
    BC109020 mRNA. Translation: AAI09021.1 .
    BC109021 mRNA. Translation: AAI09022.1 .
    L35486 mRNA. Translation: AAA68197.1 .
    L35497 mRNA. Translation: AAA68198.1 .
    L35498 mRNA. Translation: AAA68199.1 .
    CCDSi CCDS3557.1.
    PIRi A54906.
    I39424.
    I39426.
    RefSeqi NP_001124.1. NM_001133.2.
    UniGenei Hs.168718.

    3D structure databases

    ProteinModelPortali P43652.
    SMRi P43652. Positions 40-597.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000226355.

    PTM databases

    PhosphoSitei P43652.

    Polymorphism databases

    DMDMi 1168366.

    Proteomic databases

    PaxDbi P43652.
    PeptideAtlasi P43652.
    PRIDEi P43652.

    Protocols and materials databases

    DNASUi 173.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000226355 ; ENSP00000226355 ; ENSG00000079557 .
    GeneIDi 173.
    KEGGi hsa:173.
    UCSCi uc003hhb.3. human.

    Organism-specific databases

    CTDi 173.
    GeneCardsi GC04P074336.
    HGNCi HGNC:316. AFM.
    HPAi HPA017006.
    MIMi 104145. gene.
    neXtProti NX_P43652.
    PharmGKBi PA24613.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47806.
    HOGENOMi HOG000293137.
    HOVERGENi HBG004207.
    InParanoidi P43652.
    OMAi FACVDNL.
    OrthoDBi EOG7DZ8JF.
    PhylomeDBi P43652.
    TreeFami TF335561.

    Miscellaneous databases

    ChiTaRSi AFM. human.
    GeneWikii Afamin.
    GenomeRNAii 173.
    NextBioi 694.
    PROi P43652.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43652.
    CleanExi HS_AFM.
    Genevestigatori P43652.

    Family and domain databases

    InterProi IPR000264. ALB/AFP/VDB.
    IPR001703. Alpha-fetoprotein.
    IPR020858. Serum_albumin-like.
    IPR021177. Serum_albumin/AFP.
    IPR020857. Serum_albumin_CS.
    IPR014760. Serum_albumin_N.
    [Graphical view ]
    Pfami PF00273. Serum_albumin. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF002520. Serum_albumin_subgroup. 1 hit.
    PRINTSi PR00803. AFETOPROTEIN.
    PR00802. SERUMALBUMIN.
    SMARTi SM00103. ALBUMIN. 3 hits.
    [Graphical view ]
    SUPFAMi SSF48552. SSF48552. 3 hits.
    PROSITEi PS00212. ALBUMIN_1. 3 hits.
    PS51438. ALBUMIN_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family."
      Lichenstein H.S., Lyons D.E., Wurfel M.M., Johnson D.A., McGinley M.D., Leidli J.C., Trollinger D.B., Mayer J.P., Wright S.D., Zukowski M.M.
      J. Biol. Chem. 269:18149-18154(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family."
      Nishio H., Dugaiczyk A.
      Proc. Natl. Acad. Sci. U.S.A. 93:7557-7561(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.
    4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Identification of rat alpha-albumin and cDNA cloning of its human ortholog."
      Allard D., Gilbert S., Lamontagne A., Hamel D., Belanger L.
      Gene 153:287-288(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-69; 105-207 AND 560-599.
      Tissue: Liver.
    8. Cited for: PROTEIN SEQUENCE OF 22-45, GLYCOSYLATION, TISSUE SPECIFICITY, FUNCTION.
    9. "Characterization of the vitamin E-binding properties of human plasma afamin."
      Voegele A.F., Jerkovic L., Wellenzohn B., Eller P., Kronenberg F., Liedl K.R., Dieplinger H.
      Biochemistry 41:14532-14538(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
      Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-402.
      Tissue: Plasma.
    11. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33; ASN-402 AND ASN-488.
      Tissue: Plasma.
    12. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
      Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
      J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33.
      Tissue: Saliva.
    13. "Afamin is synthesized by cerebrovascular endothelial cells and mediates alpha-tocopherol transport across an in vitro model of the blood-brain barrier."
      Kratzer I., Bernhart E., Wintersperger A., Hammer A., Waltl S., Malle E., Sperk G., Wietzorrek G., Dieplinger H., Sattler W.
      J. Neurochem. 108:707-718(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-33 AND ASN-402.
      Tissue: Liver.
    15. Cited for: GLYCOSYLATION AT ASN-33; ASN-383 AND ASN-402.
    16. "Enrichment of glycopeptides for glycan structure and attachment site identification."
      Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
      Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-109; ASN-383 AND ASN-402, STRUCTURE OF CARBOHYDRATES.
      Tissue: Cerebrospinal fluid.
    17. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAFAM_HUMAN
    AccessioniPrimary (citable) accession number: P43652
    Secondary accession number(s): A8K3E1, Q32MR3, Q4W5C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3