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P43641

- MTMU_MYCSP

UniProt

P43641 - MTMU_MYCSP

Protein

Modification methylase MunI

Gene

munIM

Organism
Mycoplasma sp.
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence CAATTG, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the MunI endonuclease.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. nucleic acid binding Source: InterPro
    2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA restriction-modification system Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Restriction system

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi3449. M.MunI.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase MunI (EC:2.1.1.72)
    Alternative name(s):
    Adenine-specific methyltransferase MunI
    Short name:
    M.MunI
    Gene namesi
    Name:munIM
    OrganismiMycoplasma sp.
    Taxonomic identifieri2108 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Modification methylase MunIPRO_0000207637Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43641.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MT-A70-like family.PROSITE-ProRule annotation

    Family and domain databases

    InterProiIPR002052. DNA_methylase_N6_adenine_CS.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF05063. MT-A70. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51143. MT_A70. 1 hit.
    PS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43641-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENKVTAYSI YNKKAKKNTK VNPLDEVFPQ LPRKKYQVIY ADPPWDYGGK    50
    MQYDKSTIKS ENEGFKRDIF ISSASFKYPT LKLKELQQLD VPSITADDCI 100
    LFMWTTGPQM ANSILLGESW GFEYKTVAFV WDKMVHNPGR YTLSQTEFVL 150
    VFKKGKIPTP RGARNVRQLL QIHRGQHSEK PYAVIDGITK MFPALDKIEL 200
    FARNNFVGWD NWGLEIPDNK IEIPTQGEID ENK 233
    Length:233
    Mass (Da):26,933
    Last modified:November 1, 1995 - v1
    Checksum:i0BE21A05BB2A3A2E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76192 Genomic DNA. Translation: CAA53786.1.
    PIRiS38899.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76192 Genomic DNA. Translation: CAA53786.1 .
    PIRi S38899.

    3D structure databases

    ProteinModelPortali P43641.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 3449. M.MunI.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR002052. DNA_methylase_N6_adenine_CS.
    IPR007757. MT-A70-like.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF05063. MT-A70. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51143. MT_A70. 1 hit.
    PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "CAATTG-specific restriction-modification munI genes from Mycoplasma: sequence similarities between R.MunI and R.EcoRI."
      Siksnys V., Zareckaja N., Vaisvila R., Timinskas A., Stakenas P., Butkus V., Janulaitis A.
      Gene 142:1-8(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiMTMU_MYCSP
    AccessioniPrimary (citable) accession number: P43641
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. Restriction enzymes and methylases
      Classification of restriction enzymes and methylases and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3