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P43641

- MTMU_MYCSP

UniProt

P43641 - MTMU_MYCSP

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Protein

Modification methylase MunI

Gene

munIM

Organism
Mycoplasma sp.
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence CAATTG, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the MunI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. nucleic acid binding Source: InterPro
  2. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Restriction system

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi3449. M.MunI.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase MunI (EC:2.1.1.72)
Alternative name(s):
Adenine-specific methyltransferase MunI
Short name:
M.MunI
Gene namesi
Name:munIM
OrganismiMycoplasma sp.
Taxonomic identifieri2108 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Modification methylase MunIPRO_0000207637Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MT-A70-like family.PROSITE-ProRule annotation

Family and domain databases

InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF05063. MT-A70. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43641-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENKVTAYSI YNKKAKKNTK VNPLDEVFPQ LPRKKYQVIY ADPPWDYGGK
60 70 80 90 100
MQYDKSTIKS ENEGFKRDIF ISSASFKYPT LKLKELQQLD VPSITADDCI
110 120 130 140 150
LFMWTTGPQM ANSILLGESW GFEYKTVAFV WDKMVHNPGR YTLSQTEFVL
160 170 180 190 200
VFKKGKIPTP RGARNVRQLL QIHRGQHSEK PYAVIDGITK MFPALDKIEL
210 220 230
FARNNFVGWD NWGLEIPDNK IEIPTQGEID ENK
Length:233
Mass (Da):26,933
Last modified:November 1, 1995 - v1
Checksum:i0BE21A05BB2A3A2E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76192 Genomic DNA. Translation: CAA53786.1.
PIRiS38899.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76192 Genomic DNA. Translation: CAA53786.1 .
PIRi S38899.

3D structure databases

ProteinModelPortali P43641.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 3449. M.MunI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR002052. DNA_methylase_N6_adenine_CS.
IPR007757. MT-A70-like.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF05063. MT-A70. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51143. MT_A70. 1 hit.
PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "CAATTG-specific restriction-modification munI genes from Mycoplasma: sequence similarities between R.MunI and R.EcoRI."
    Siksnys V., Zareckaja N., Vaisvila R., Timinskas A., Stakenas P., Butkus V., Janulaitis A.
    Gene 142:1-8(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiMTMU_MYCSP
AccessioniPrimary (citable) accession number: P43641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3