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Protein

Casein kinase II subunit beta

Gene

CKB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity

GO - Molecular functioni

  • protein kinase regulator activity Source: SGD
  • protein serine/threonine kinase inhibitor activity Source: SGD

GO - Biological processi

  • cellular response to DNA damage stimulus Source: SGD
  • peptidyl-serine phosphorylation Source: SGD
  • peptidyl-threonine phosphorylation Source: SGD
  • protein phosphorylation Source: SGD
  • regulation of protein serine/threonine phosphatase activity Source: GO_Central
  • regulation of transcription from RNA polymerase III promoter Source: SGD
  • regulation of transcription from RNA polymerase I promoter Source: SGD
  • rRNA methylation Source: Reactome
  • signal transduction Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30539-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Gene namesi
Name:CKB1
Ordered Locus Names:YGL019W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VII

Organism-specific databases

EuPathDBiFungiDB:YGL019W.
SGDiS000002987. CKB1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleoplasm Source: Reactome
  • protein kinase CK2 complex Source: SGD
  • UTP-C complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000682572 – 278Casein kinase II subunit betaAdd BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei2PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP43639.
PRIDEiP43639.

PTM databases

iPTMnetiP43639.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit. Interacts with FACT subunits POB3 and SPT16.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CKA1P157907EBI-9563,EBI-9533
CKA2P194547EBI-9563,EBI-9548
CKB2P389307EBI-9563,EBI-9578

Protein-protein interaction databases

BioGridi33227. 283 interactors.
DIPiDIP-282N.
IntActiP43639. 58 interactors.
MINTiMINT-396457.

Structurei

3D structure databases

ProteinModelPortaliP43639.
SMRiP43639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000039270.
InParanoidiP43639.
KOiK03115.
OMAiHARYIIS.
OrthoDBiEOG092C4DSU.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 2 hits.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 2 hits.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEFVEDYS RTGSSDDEDS GAYDEWIPSF CSRFGHEYFC QVPTEFIEDD
60 70 80 90 100
FNMTSLSQEV PHYRKALDLI LDLEAMSDEE EDEDDVVEED EVDQEMQSND
110 120 130 140 150
GHDEGKRRNK SPVVNKSIIE HAAEQLYGLI HARFILTKPG LQAMAEKFDH
160 170 180 190 200
KEFGTCPRYY CNGMQLLPCG LSDTVGKHTV RLYCPSCQDL YLPQSSRFLC
210 220 230 240 250
LEGAFWGTSF PGVFLKHFKE LEEYVERKSK ESYELKVFGF RINDEAVSGP
260 270
RMKWLRQYPS TEEDWEEFAK CEFETPAV
Length:278
Mass (Da):32,265
Last modified:November 1, 1995 - v1
Checksum:i9ACA8D285E6990AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21283 Genomic DNA. Translation: AAA86829.1.
Z72541 Genomic DNA. Translation: CAA96719.1.
BK006941 Genomic DNA. Translation: DAA08079.1.
PIRiA56421.
RefSeqiNP_011496.3. NM_001180884.3.

Genome annotation databases

EnsemblFungiiYGL019W; YGL019W; YGL019W.
GeneIDi852865.
KEGGisce:YGL019W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21283 Genomic DNA. Translation: AAA86829.1.
Z72541 Genomic DNA. Translation: CAA96719.1.
BK006941 Genomic DNA. Translation: DAA08079.1.
PIRiA56421.
RefSeqiNP_011496.3. NM_001180884.3.

3D structure databases

ProteinModelPortaliP43639.
SMRiP43639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33227. 283 interactors.
DIPiDIP-282N.
IntActiP43639. 58 interactors.
MINTiMINT-396457.

PTM databases

iPTMnetiP43639.

Proteomic databases

MaxQBiP43639.
PRIDEiP43639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYGL019W; YGL019W; YGL019W.
GeneIDi852865.
KEGGisce:YGL019W.

Organism-specific databases

EuPathDBiFungiDB:YGL019W.
SGDiS000002987. CKB1.

Phylogenomic databases

HOGENOMiHOG000039270.
InParanoidiP43639.
KOiK03115.
OMAiHARYIIS.
OrthoDBiEOG092C4DSU.

Enzyme and pathway databases

BioCyciYEAST:G3O-30539-MONOMER.
ReactomeiR-SCE-6790901. rRNA modification in the nucleus and cytosol.

Miscellaneous databases

PROiP43639.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 2 hits.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 2 hits.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSK2B_YEAST
AccessioniPrimary (citable) accession number: P43639
Secondary accession number(s): D6VUB8, Q9URG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.