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P43639 (CSK2B_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 130. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Casein kinase II subunit beta

Short name=CK II beta
Gene names
Name:CKB1
Ordered Locus Names:YGL019W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length278 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a complex role in regulating the basal catalytic activity of the alpha subunit By similarity.

Subunit structure

Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit. Interacts with FACT subunits POB3 and SPT16. Ref.5

Post-translational modification

Phosphorylated by alpha subunit By similarity.

Miscellaneous

Present with 8120 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the casein kinase 2 subunit beta family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.7
Chain2 – 278277Casein kinase II subunit beta
PRO_0000068257

Amino acid modifications

Modified residue21N-acetylserine Ref.7 Ref.9
Modified residue21Phosphoserine Ref.7

Sequences

Sequence LengthMass (Da)Tools
P43639 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9ACA8D285E6990AF

FASTA27832,265
        10         20         30         40         50         60 
MSQEFVEDYS RTGSSDDEDS GAYDEWIPSF CSRFGHEYFC QVPTEFIEDD FNMTSLSQEV 

        70         80         90        100        110        120 
PHYRKALDLI LDLEAMSDEE EDEDDVVEED EVDQEMQSND GHDEGKRRNK SPVVNKSIIE 

       130        140        150        160        170        180 
HAAEQLYGLI HARFILTKPG LQAMAEKFDH KEFGTCPRYY CNGMQLLPCG LSDTVGKHTV 

       190        200        210        220        230        240 
RLYCPSCQDL YLPQSSRFLC LEGAFWGTSF PGVFLKHFKE LEEYVERKSK ESYELKVFGF 

       250        260        270 
RINDEAVSGP RMKWLRQYPS TEEDWEEFAK CEFETPAV 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and disruption of CKB1, the gene encoding the 38-kDa beta subunit of Saccharomyces cerevisiae casein kinase II (CKII). Deletion of CKII regulatory subunits elicits a salt-sensitive phenotype."
Bidwai A.P., Reed J.C., Glover C.V.C.
J. Biol. Chem. 270:10395-10404(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E. expand/collapse author list , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Casein kinase II of Saccharomyces cerevisiae contains two distinct regulatory subunits, beta and beta'."
Bidwai A.P., Reed J.C., Glover C.V.C.
Arch. Biochem. Biophys. 309:348-355(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 34-52; 182-196 AND 257-270.
[5]"RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach."
Krogan N.J., Kim M., Ahn S.H., Zhong G., Kobor M.S., Cagney G., Emili A., Shilatifard A., Buratowski S., Greenblatt J.F.
Mol. Cell. Biol. 22:6979-6992(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH POB3 AND SPT16.
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
Strain: YAL6B.
[8]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U21283 Genomic DNA. Translation: AAA86829.1.
Z72541 Genomic DNA. Translation: CAA96719.1.
BK006941 Genomic DNA. Translation: DAA08079.1.
PIRA56421.
RefSeqNP_011496.3. NM_001180884.3.

3D structure databases

ProteinModelPortalP43639.
SMRP43639. Positions 26-246.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid33227. 283 interactions.
DIPDIP-282N.
IntActP43639. 56 interactions.
MINTMINT-396457.
STRING4932.YGL019W.

Proteomic databases

MaxQBP43639.
PaxDbP43639.
PeptideAtlasP43639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYGL019W; YGL019W; YGL019W.
GeneID852865.
KEGGsce:YGL019W.

Organism-specific databases

CYGDYGL019w.
SGDS000002987. CKB1.

Phylogenomic databases

eggNOGCOG5041.
HOGENOMHOG000039270.
KOK03115.
OMAGHDYFVE.
OrthoDBEOG7K6Q6G.

Enzyme and pathway databases

BioCycYEAST:G3O-30539-MONOMER.

Gene expression databases

GenevestigatorP43639.

Family and domain databases

Gene3D1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERPTHR11740. PTHR11740. 1 hit.
PfamPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSPR00472. CASNKINASEII.
SMARTSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMSSF57798. SSF57798. 2 hits.
PROSITEPS01101. CK2_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio972481.

Entry information

Entry nameCSK2B_YEAST
AccessionPrimary (citable) accession number: P43639
Secondary accession number(s): D6VUB8, Q9URG5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VII

Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families