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P43639

- CSK2B_YEAST

UniProt

P43639 - CSK2B_YEAST

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Protein

Casein kinase II subunit beta

Gene

CKB1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a complex role in regulating the basal catalytic activity of the alpha subunit.By similarity

GO - Molecular functioni

  1. protein kinase regulator activity Source: SGD
  2. protein serine/threonine kinase inhibitor activity Source: SGD

GO - Biological processi

  1. cellular response to DNA damage stimulus Source: SGD
  2. negative regulation of protein serine/threonine kinase activity Source: GOC
  3. protein phosphorylation Source: SGD
  4. regulation of protein kinase activity Source: GOC
  5. regulation of transcription from RNA polymerase III promoter Source: SGD
  6. regulation of transcription from RNA polymerase I promoter Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30539-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase II subunit beta
Short name:
CK II beta
Gene namesi
Name:CKB1
Ordered Locus Names:YGL019W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VII

Organism-specific databases

CYGDiYGL019w.
SGDiS000002987. CKB1.

Subcellular locationi

GO - Cellular componenti

  1. protein kinase CK2 complex Source: SGD
  2. UTP-C complex Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 278277Casein kinase II subunit betaPRO_0000068257Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine2 Publications
Modified residuei2 – 21Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated by alpha subunit.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP43639.
PaxDbiP43639.
PeptideAtlasiP43639.

Expressioni

Gene expression databases

GenevestigatoriP43639.

Interactioni

Subunit structurei

Tetramer composed of an alpha subunit, an alpha' subunit, one beta subunit and one beta' subunit. Interacts with FACT subunits POB3 and SPT16.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CKA1P157907EBI-9563,EBI-9533
CKA2P194547EBI-9563,EBI-9548
CKB2P389307EBI-9563,EBI-9578

Protein-protein interaction databases

BioGridi33227. 287 interactions.
DIPiDIP-282N.
IntActiP43639. 56 interactions.
MINTiMINT-396457.
STRINGi4932.YGL019W.

Structurei

3D structure databases

ProteinModelPortaliP43639.
SMRiP43639. Positions 26-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG5041.
HOGENOMiHOG000039270.
InParanoidiP43639.
KOiK03115.
OMAiGHDYFVE.
OrthoDBiEOG7K6Q6G.

Family and domain databases

Gene3Di1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProiIPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view]
PANTHERiPTHR11740. PTHR11740. 1 hit.
PfamiPF01214. CK_II_beta. 1 hit.
[Graphical view]
PRINTSiPR00472. CASNKINASEII.
SMARTiSM01085. CK_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF57798. SSF57798. 2 hits.
PROSITEiPS01101. CK2_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43639-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQEFVEDYS RTGSSDDEDS GAYDEWIPSF CSRFGHEYFC QVPTEFIEDD
60 70 80 90 100
FNMTSLSQEV PHYRKALDLI LDLEAMSDEE EDEDDVVEED EVDQEMQSND
110 120 130 140 150
GHDEGKRRNK SPVVNKSIIE HAAEQLYGLI HARFILTKPG LQAMAEKFDH
160 170 180 190 200
KEFGTCPRYY CNGMQLLPCG LSDTVGKHTV RLYCPSCQDL YLPQSSRFLC
210 220 230 240 250
LEGAFWGTSF PGVFLKHFKE LEEYVERKSK ESYELKVFGF RINDEAVSGP
260 270
RMKWLRQYPS TEEDWEEFAK CEFETPAV
Length:278
Mass (Da):32,265
Last modified:November 1, 1995 - v1
Checksum:i9ACA8D285E6990AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21283 Genomic DNA. Translation: AAA86829.1.
Z72541 Genomic DNA. Translation: CAA96719.1.
BK006941 Genomic DNA. Translation: DAA08079.1.
PIRiA56421.
RefSeqiNP_011496.3. NM_001180884.3.

Genome annotation databases

EnsemblFungiiYGL019W; YGL019W; YGL019W.
GeneIDi852865.
KEGGisce:YGL019W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21283 Genomic DNA. Translation: AAA86829.1 .
Z72541 Genomic DNA. Translation: CAA96719.1 .
BK006941 Genomic DNA. Translation: DAA08079.1 .
PIRi A56421.
RefSeqi NP_011496.3. NM_001180884.3.

3D structure databases

ProteinModelPortali P43639.
SMRi P43639. Positions 26-246.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 33227. 287 interactions.
DIPi DIP-282N.
IntActi P43639. 56 interactions.
MINTi MINT-396457.
STRINGi 4932.YGL019W.

Proteomic databases

MaxQBi P43639.
PaxDbi P43639.
PeptideAtlasi P43639.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YGL019W ; YGL019W ; YGL019W .
GeneIDi 852865.
KEGGi sce:YGL019W.

Organism-specific databases

CYGDi YGL019w.
SGDi S000002987. CKB1.

Phylogenomic databases

eggNOGi COG5041.
HOGENOMi HOG000039270.
InParanoidi P43639.
KOi K03115.
OMAi GHDYFVE.
OrthoDBi EOG7K6Q6G.

Enzyme and pathway databases

BioCyci YEAST:G3O-30539-MONOMER.

Miscellaneous databases

NextBioi 972481.

Gene expression databases

Genevestigatori P43639.

Family and domain databases

Gene3Di 1.10.1820.10. 1 hit.
2.20.25.20. 1 hit.
InterProi IPR016149. Casein_kin_II_reg-sub_a-hlx.
IPR016150. Casein_kin_II_reg-sub_b-sht.
IPR000704. Casein_kinase_II_reg-sub.
[Graphical view ]
PANTHERi PTHR11740. PTHR11740. 1 hit.
Pfami PF01214. CK_II_beta. 1 hit.
[Graphical view ]
PRINTSi PR00472. CASNKINASEII.
SMARTi SM01085. CK_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF57798. SSF57798. 2 hits.
PROSITEi PS01101. CK2_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and disruption of CKB1, the gene encoding the 38-kDa beta subunit of Saccharomyces cerevisiae casein kinase II (CKII). Deletion of CKII regulatory subunits elicits a salt-sensitive phenotype."
    Bidwai A.P., Reed J.C., Glover C.V.C.
    J. Biol. Chem. 270:10395-10404(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome VII."
    Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J., Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M., Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L., Coblenz A., Coglievina M., Coissac E.
    , Defoor E., Del Bino S., Delius H., Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P., Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M., Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A., Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K., Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P., Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E., Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K., Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A., Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S., Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M., Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C., Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M., Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M., Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y., Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L., Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D., Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F., Zaccaria P., Zimmermann M., Zollner A., Kleine K.
    Nature 387:81-84(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Casein kinase II of Saccharomyces cerevisiae contains two distinct regulatory subunits, beta and beta'."
    Bidwai A.P., Reed J.C., Glover C.V.C.
    Arch. Biochem. Biophys. 309:348-355(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 34-52; 182-196 AND 257-270.
  5. "RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach."
    Krogan N.J., Kim M., Ahn S.H., Zhong G., Kobor M.S., Cagney G., Emili A., Shilatifard A., Buratowski S., Greenblatt J.F.
    Mol. Cell. Biol. 22:6979-6992(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH POB3 AND SPT16.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics applied to the yeast pheromone signaling pathway."
    Gruhler A., Olsen J.V., Mohammed S., Mortensen P., Faergeman N.J., Mann M., Jensen O.N.
    Mol. Cell. Proteomics 4:310-327(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Strain: YAL6B.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCSK2B_YEAST
AccessioniPrimary (citable) accession number: P43639
Secondary accession number(s): D6VUB8, Q9URG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VII
    Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names

External Data

Dasty 3