SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P43635

- CISY3_YEAST

UniProt

P43635 - CISY3_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Citrate synthase 3
Gene
CIT3, YPR001W, YP9723.01
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei315 – 3151 By similarity
Active sitei361 – 3611 By similarity
Active sitei419 – 4191 By similarity

GO - Molecular functioni

  1. 2-methylcitrate synthase activity Source: SGD
  2. citrate (Si)-synthase activity Source: SGD

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. propionate catabolic process, 2-methylcitrate cycle Source: SGD
  3. tricarboxylic acid cycle Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMetaCyc:YPR001W-MONOMER.
YEAST:YPR001W-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 3 (EC:2.3.3.16)
Gene namesi
Name:CIT3
Ordered Locus Names:YPR001W
ORF Names:YP9723.01
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR001w.
SGDiS000006205. CIT3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Citrate synthase 3
PRO_0000169985Add
BLAST

Proteomic databases

PaxDbiP43635.

Expressioni

Gene expression databases

GenevestigatoriP43635.

Interactioni

Protein-protein interaction databases

BioGridi36177. 27 interactions.
DIPiDIP-3915N.
MINTiMINT-562112.
STRINGi4932.YPR001W.

Structurei

3D structure databases

ProteinModelPortaliP43635.
SMRiP43635. Positions 29-478.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi484 – 4863Microbody targeting signal Reviewed prediction

Sequence similaritiesi

Belongs to the citrate synthase family.

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00750000118689.
HOGENOMiHOG000130831.
KOiK01647.
OMAiGIHVDHE.
OrthoDBiEOG7WQ82G.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43635-1 [UniParc]FASTAAdd to Basket

« Hide

MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC    50
YGSTFVGPIT ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR 100
LPNTGIDGDN FLPESMLWLL MTGGVPTFQQ AASFRKELAI RGRKLPHYTE 150
KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA TNYQKGLIGK MEFWKDTLED 200
SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC SLLGMTNGTN 250
SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY 300
LSYSSGIMGL AGPLHGLAAQ EVVRFLIEMN SNISSIAREQ EIKDYLWKIL 350
NSNRVIPGYG HAVLRKPDPR FTAMLEFAQK RPIEFENDKN VLLMQKLAEI 400
APKVLLEHGK SKNPFPNVDS ASGILFYHYG IRELLFFTVI FGCSRAMGPL 450
TQLVWDRILG LPIERPKSLN LEGLEALTKA SNVNKL 486
Length:486
Mass (Da):53,811
Last modified:November 1, 1995 - v1
Checksum:iF299CA258B772125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X88846 Genomic DNA. Translation: CAA61299.1.
Z48951 Genomic DNA. Translation: CAA88779.1.
Z71255 Genomic DNA. Translation: CAA95041.1.
U31900 Genomic DNA. Translation: AAA97580.1.
BK006949 Genomic DNA. Translation: DAA11428.1.
PIRiS52814.
RefSeqiNP_015325.1. NM_001184098.1.

Genome annotation databases

EnsemblFungiiYPR001W; YPR001W; YPR001W.
GeneIDi856107.
KEGGisce:YPR001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X88846 Genomic DNA. Translation: CAA61299.1 .
Z48951 Genomic DNA. Translation: CAA88779.1 .
Z71255 Genomic DNA. Translation: CAA95041.1 .
U31900 Genomic DNA. Translation: AAA97580.1 .
BK006949 Genomic DNA. Translation: DAA11428.1 .
PIRi S52814.
RefSeqi NP_015325.1. NM_001184098.1.

3D structure databases

ProteinModelPortali P43635.
SMRi P43635. Positions 29-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36177. 27 interactions.
DIPi DIP-3915N.
MINTi MINT-562112.
STRINGi 4932.YPR001W.

Proteomic databases

PaxDbi P43635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR001W ; YPR001W ; YPR001W .
GeneIDi 856107.
KEGGi sce:YPR001W.

Organism-specific databases

CYGDi YPR001w.
SGDi S000006205. CIT3.

Phylogenomic databases

eggNOGi COG0372.
GeneTreei ENSGT00750000118689.
HOGENOMi HOG000130831.
KOi K01647.
OMAi GIHVDHE.
OrthoDBi EOG7WQ82G.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci MetaCyc:YPR001W-MONOMER.
YEAST:YPR001W-MONOMER.

Miscellaneous databases

NextBioi 981167.

Gene expression databases

Genevestigatori P43635.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jia Y.K., Becam A.-M., Slonimski P.P., Herbert C.J.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CW04.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCISY3_YEAST
AccessioniPrimary (citable) accession number: P43635
Secondary accession number(s): D6W412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3

Similar proteinsi