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P43635

- CISY3_YEAST

UniProt

P43635 - CISY3_YEAST

Protein

Citrate synthase 3

Gene

CIT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei315 – 3151PROSITE-ProRule annotation
    Active sitei361 – 3611PROSITE-ProRule annotation
    Active sitei419 – 4191PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 2-methylcitrate synthase activity Source: SGD
    2. citrate (Si)-synthase activity Source: SGD

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. propionate catabolic process, 2-methylcitrate cycle Source: SGD
    3. tricarboxylic acid cycle Source: SGD

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciMetaCyc:YPR001W-MONOMER.
    YEAST:YPR001W-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase 3 (EC:2.3.3.16)
    Gene namesi
    Name:CIT3
    Ordered Locus Names:YPR001W
    ORF Names:YP9723.01
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XVI

    Organism-specific databases

    CYGDiYPR001w.
    SGDiS000006205. CIT3.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Citrate synthase 3PRO_0000169985Add
    BLAST

    Proteomic databases

    PaxDbiP43635.

    Expressioni

    Gene expression databases

    GenevestigatoriP43635.

    Interactioni

    Protein-protein interaction databases

    BioGridi36177. 27 interactions.
    DIPiDIP-3915N.
    MINTiMINT-562112.
    STRINGi4932.YPR001W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43635.
    SMRiP43635. Positions 29-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi484 – 4863Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0372.
    GeneTreeiENSGT00750000118689.
    HOGENOMiHOG000130831.
    KOiK01647.
    OMAiGIHVDHE.
    OrthoDBiEOG7WQ82G.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43635-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC    50
    YGSTFVGPIT ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR 100
    LPNTGIDGDN FLPESMLWLL MTGGVPTFQQ AASFRKELAI RGRKLPHYTE 150
    KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA TNYQKGLIGK MEFWKDTLED 200
    SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC SLLGMTNGTN 250
    SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY 300
    LSYSSGIMGL AGPLHGLAAQ EVVRFLIEMN SNISSIAREQ EIKDYLWKIL 350
    NSNRVIPGYG HAVLRKPDPR FTAMLEFAQK RPIEFENDKN VLLMQKLAEI 400
    APKVLLEHGK SKNPFPNVDS ASGILFYHYG IRELLFFTVI FGCSRAMGPL 450
    TQLVWDRILG LPIERPKSLN LEGLEALTKA SNVNKL 486
    Length:486
    Mass (Da):53,811
    Last modified:November 1, 1995 - v1
    Checksum:iF299CA258B772125
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X88846 Genomic DNA. Translation: CAA61299.1.
    Z48951 Genomic DNA. Translation: CAA88779.1.
    Z71255 Genomic DNA. Translation: CAA95041.1.
    U31900 Genomic DNA. Translation: AAA97580.1.
    BK006949 Genomic DNA. Translation: DAA11428.1.
    PIRiS52814.
    RefSeqiNP_015325.1. NM_001184098.1.

    Genome annotation databases

    EnsemblFungiiYPR001W; YPR001W; YPR001W.
    GeneIDi856107.
    KEGGisce:YPR001W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X88846 Genomic DNA. Translation: CAA61299.1 .
    Z48951 Genomic DNA. Translation: CAA88779.1 .
    Z71255 Genomic DNA. Translation: CAA95041.1 .
    U31900 Genomic DNA. Translation: AAA97580.1 .
    BK006949 Genomic DNA. Translation: DAA11428.1 .
    PIRi S52814.
    RefSeqi NP_015325.1. NM_001184098.1.

    3D structure databases

    ProteinModelPortali P43635.
    SMRi P43635. Positions 29-478.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36177. 27 interactions.
    DIPi DIP-3915N.
    MINTi MINT-562112.
    STRINGi 4932.YPR001W.

    Proteomic databases

    PaxDbi P43635.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YPR001W ; YPR001W ; YPR001W .
    GeneIDi 856107.
    KEGGi sce:YPR001W.

    Organism-specific databases

    CYGDi YPR001w.
    SGDi S000006205. CIT3.

    Phylogenomic databases

    eggNOGi COG0372.
    GeneTreei ENSGT00750000118689.
    HOGENOMi HOG000130831.
    KOi K01647.
    OMAi GIHVDHE.
    OrthoDBi EOG7WQ82G.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci MetaCyc:YPR001W-MONOMER.
    YEAST:YPR001W-MONOMER.

    Miscellaneous databases

    NextBioi 981167.

    Gene expression databases

    Genevestigatori P43635.

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jia Y.K., Becam A.-M., Slonimski P.P., Herbert C.J.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CW04.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
      Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
      , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
      Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiCISY3_YEAST
    AccessioniPrimary (citable) accession number: P43635
    Secondary accession number(s): D6W412
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XVI
      Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

    External Data

    Dasty 3