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P43635 (CISY3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Citrate synthase 3

EC=2.3.3.1
Gene names
Name:CIT3
Ordered Locus Names:YPR001W
ORF Names:YP9723.01
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length486 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Sequence similarities

Belongs to the citrate synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 486486Citrate synthase 3
PRO_0000169985

Regions

Motif484 – 4863Microbody targeting signal Potential

Sites

Active site3151 By similarity
Active site3611 By similarity
Active site4191 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43635 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F299CA258B772125

FASTA48653,811
        10         20         30         40         50         60 
MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC YGSTFVGPIT 

        70         80         90        100        110        120 
ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR LPNTGIDGDN FLPESMLWLL 

       130        140        150        160        170        180 
MTGGVPTFQQ AASFRKELAI RGRKLPHYTE KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA 

       190        200        210        220        230        240 
TNYQKGLIGK MEFWKDTLED SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC 

       250        260        270        280        290        300 
SLLGMTNGTN SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY 

       310        320        330        340        350        360 
LSYSSGIMGL AGPLHGLAAQ EVVRFLIEMN SNISSIAREQ EIKDYLWKIL NSNRVIPGYG 

       370        380        390        400        410        420 
HAVLRKPDPR FTAMLEFAQK RPIEFENDKN VLLMQKLAEI APKVLLEHGK SKNPFPNVDS 

       430        440        450        460        470        480 
ASGILFYHYG IRELLFFTVI FGCSRAMGPL TQLVWDRILG LPIERPKSLN LEGLEALTKA 


SNVNKL 

« Hide

References

« Hide 'large scale' references
[1]Jia Y.K., Becam A.-M., Slonimski P.P., Herbert C.J.
Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CW04.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M. expand/collapse author list , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X88846 Genomic DNA. Translation: CAA61299.1.
Z48951 Genomic DNA. Translation: CAA88779.1.
Z71255 Genomic DNA. Translation: CAA95041.1.
U31900 Genomic DNA. Translation: AAA97580.1.
BK006949 Genomic DNA. Translation: DAA11428.1.
PIRS52814.
RefSeqNP_015325.1. NM_001184098.1.

3D structure databases

ProteinModelPortalP43635.
SMRP43635. Positions 29-478.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36177. 27 interactions.
DIPDIP-3915N.
MINTMINT-562112.
STRING4932.YPR001W.

Proteomic databases

PaxDbP43635.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYPR001W; YPR001W; YPR001W.
GeneID856107.
KEGGsce:YPR001W.

Organism-specific databases

CYGDYPR001w.
SGDS000006205. CIT3.

Phylogenomic databases

eggNOGCOG0372.
GeneTreeENSGT00750000118689.
HOGENOMHOG000130831.
KOK01647.
OMAGIHVDHE.
OrthoDBEOG7WQ82G.

Enzyme and pathway databases

BioCycYEAST:YPR001W-MONOMER.
UniPathwayUPA00223; UER00717.

Gene expression databases

GenevestigatorP43635.

Family and domain databases

Gene3D1.10.580.10. 1 hit.
InterProIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981167.

Entry information

Entry nameCISY3_YEAST
AccessionPrimary (citable) accession number: P43635
Secondary accession number(s): D6W412
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XVI

Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways