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P43635

- CISY3_YEAST

UniProt

P43635 - CISY3_YEAST

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Protein

Citrate synthase 3

Gene

CIT3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei315 – 3151PROSITE-ProRule annotation
Active sitei361 – 3611PROSITE-ProRule annotation
Active sitei419 – 4191PROSITE-ProRule annotation

GO - Molecular functioni

  1. 2-methylcitrate synthase activity Source: SGD
  2. citrate (Si)-synthase activity Source: SGD

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. propionate catabolic process, 2-methylcitrate cycle Source: SGD
  3. tricarboxylic acid cycle Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciMetaCyc:YPR001W-MONOMER.
YEAST:YPR001W-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 3 (EC:2.3.3.16)
Gene namesi
Name:CIT3
Ordered Locus Names:YPR001W
ORF Names:YP9723.01
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

CYGDiYPR001w.
SGDiS000006205. CIT3.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Citrate synthase 3PRO_0000169985Add
BLAST

Proteomic databases

PaxDbiP43635.

Expressioni

Gene expression databases

GenevestigatoriP43635.

Interactioni

Protein-protein interaction databases

BioGridi36177. 27 interactions.
DIPiDIP-3915N.
MINTiMINT-562112.
STRINGi4932.YPR001W.

Structurei

3D structure databases

ProteinModelPortaliP43635.
SMRiP43635. Positions 29-478.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi484 – 4863Microbody targeting signalSequence Analysis

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Phylogenomic databases

eggNOGiCOG0372.
GeneTreeiENSGT00760000120118.
HOGENOMiHOG000130831.
InParanoidiP43635.
KOiK01647.
OMAiGIHVDHE.
OrthoDBiEOG7WQ82G.

Family and domain databases

Gene3Di1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43635-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC
60 70 80 90 100
YGSTFVGPIT ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR
110 120 130 140 150
LPNTGIDGDN FLPESMLWLL MTGGVPTFQQ AASFRKELAI RGRKLPHYTE
160 170 180 190 200
KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA TNYQKGLIGK MEFWKDTLED
210 220 230 240 250
SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC SLLGMTNGTN
260 270 280 290 300
SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY
310 320 330 340 350
LSYSSGIMGL AGPLHGLAAQ EVVRFLIEMN SNISSIAREQ EIKDYLWKIL
360 370 380 390 400
NSNRVIPGYG HAVLRKPDPR FTAMLEFAQK RPIEFENDKN VLLMQKLAEI
410 420 430 440 450
APKVLLEHGK SKNPFPNVDS ASGILFYHYG IRELLFFTVI FGCSRAMGPL
460 470 480
TQLVWDRILG LPIERPKSLN LEGLEALTKA SNVNKL
Length:486
Mass (Da):53,811
Last modified:November 1, 1995 - v1
Checksum:iF299CA258B772125
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X88846 Genomic DNA. Translation: CAA61299.1.
Z48951 Genomic DNA. Translation: CAA88779.1.
Z71255 Genomic DNA. Translation: CAA95041.1.
U31900 Genomic DNA. Translation: AAA97580.1.
BK006949 Genomic DNA. Translation: DAA11428.1.
PIRiS52814.
RefSeqiNP_015325.1. NM_001184098.1.

Genome annotation databases

EnsemblFungiiYPR001W; YPR001W; YPR001W.
GeneIDi856107.
KEGGisce:YPR001W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X88846 Genomic DNA. Translation: CAA61299.1 .
Z48951 Genomic DNA. Translation: CAA88779.1 .
Z71255 Genomic DNA. Translation: CAA95041.1 .
U31900 Genomic DNA. Translation: AAA97580.1 .
BK006949 Genomic DNA. Translation: DAA11428.1 .
PIRi S52814.
RefSeqi NP_015325.1. NM_001184098.1.

3D structure databases

ProteinModelPortali P43635.
SMRi P43635. Positions 29-478.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36177. 27 interactions.
DIPi DIP-3915N.
MINTi MINT-562112.
STRINGi 4932.YPR001W.

Proteomic databases

PaxDbi P43635.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YPR001W ; YPR001W ; YPR001W .
GeneIDi 856107.
KEGGi sce:YPR001W.

Organism-specific databases

CYGDi YPR001w.
SGDi S000006205. CIT3.

Phylogenomic databases

eggNOGi COG0372.
GeneTreei ENSGT00760000120118.
HOGENOMi HOG000130831.
InParanoidi P43635.
KOi K01647.
OMAi GIHVDHE.
OrthoDBi EOG7WQ82G.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci MetaCyc:YPR001W-MONOMER.
YEAST:YPR001W-MONOMER.

Miscellaneous databases

NextBioi 981167.

Gene expression databases

Genevestigatori P43635.

Family and domain databases

Gene3Di 1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Jia Y.K., Becam A.-M., Slonimski P.P., Herbert C.J.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CW04.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiCISY3_YEAST
AccessioniPrimary (citable) accession number: P43635
Secondary accession number(s): D6W412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3