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Protein

Activatory protein CHA4

Gene

CHA4

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activates the CHA1 gene for L-serine dehydratase. Binds to the DNA sequence 5'-GVGGARAYRTRATTCCRC-3'.1 Publication

Miscellaneous

Present with 396 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi44 – 70Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

  • cellular amino acid catabolic process Source: SGD
  • positive regulation of transcription, DNA-templated Source: SGD
  • regulation of transcription by RNA polymerase II Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-32248-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Activatory protein CHA4
Gene namesi
Name:CHA4
Synonyms:SIL2, SIL3
Ordered Locus Names:YLR098C
ORF Names:L8004.8
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR098C
SGDiS000004088 CHA4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001149421 – 648Activatory protein CHA4Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei164PhosphoserineCombined sources1
Modified residuei166PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43634
PaxDbiP43634
PRIDEiP43634

PTM databases

iPTMnetiP43634

Interactioni

Protein-protein interaction databases

BioGridi31371, 124 interactors
DIPiDIP-1798N
IntActiP43634, 11 interactors
MINTiP43634
STRINGi4932.YLR098C

Structurei

3D structure databases

ProteinModelPortaliP43634
SMRiP43634
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Asn4
Compositional biasi48 – 52Poly-Arg5
Compositional biasi105 – 109Poly-Ser5
Compositional biasi195 – 198Poly-Gln4
Compositional biasi302 – 306Poly-Ser5

Phylogenomic databases

GeneTreeiENSGT00530000067248
HOGENOMiHOG000074724
InParanoidiP43634
OMAiKRAKCDG
OrthoDBiEOG092C2WW6

Family and domain databases

CDDicd00067 GAL4, 1 hit
Gene3Di4.10.240.10, 1 hit
InterProiView protein in InterPro
IPR007219 Transcription_factor_dom_fun
IPR001138 Zn2-C6_fun-type_DNA-bd
IPR036864 Zn2-C6_fun-type_DNA-bd_sf
PfamiView protein in Pfam
PF04082 Fungal_trans, 1 hit
PF00172 Zn_clus, 1 hit
SMARTiView protein in SMART
SM00906 Fungal_trans, 1 hit
SM00066 GAL4, 1 hit
SUPFAMiSSF57701 SSF57701, 1 hit
PROSITEiView protein in PROSITE
PS00463 ZN2_CY6_FUNGAL_1, 1 hit
PS50048 ZN2_CY6_FUNGAL_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLEPSPPPL TTTVTPSLPS SLKKSVTDND QNNNNVPRKR KLACQNCRRR
60 70 80 90 100
RRKCNMEKPC SNCIKFRTEC VFTQQDLRNK RYSTTYVEAL QSQIRSLKEQ
110 120 130 140 150
LQILSSSSST IASNALSSLK NNSDHGDAPN EKILKYGETA QSALPSSESN
160 170 180 190 200
DENESDAFTK KMPSESPPPV GTNSIYPSNS LSIIKKKTDG STRYQQQQVS
210 220 230 240 250
LKNLSRSPLI LRSLSLFFKW LYPGHYLFIH RETFLSAFFG DTNTKSYYCS
260 270 280 290 300
EELVFAIAAL GSLISYKSET ELFQQSEVFY QRAKTIVLKK IFQLEDSSLA
310 320 330 340 350
ESSSSSKLAI IQTLLCLAFY DIGSGENPMA WYLSGLAFRI AHEIGLHLNP
360 370 380 390 400
EAWSNVYEDE LSIMDFEVRS RIYWGCYIAD HLIAILFGRS TSLRLSNSTV
410 420 430 440 450
PETDELPEIE TGIEEYIYDP KVILSTANPL KKLIVLSRIT EIFASKIFSP
460 470 480 490 500
NETLLQRSEY LAKFNLEVYN WRRDLPPELQ WTKRSLMEMT DFNPTIAYVW
510 520 530 540 550
FHYYIVLISY NKPFIYEIKQ SRELVEGYVD ELYYLLKVWK NKFKTFEKAT
560 570 580 590 600
IYMIYSAILA IQCMKSNLIK KDRKQDFLNF LSAPTLNYEL ARKFIENSED
610 620 630 640
ALHNSETMDL LGTLSHGNDF ALEYNFDFTL LNEIDMLIGG NTNDGLSK
Length:648
Mass (Da):74,393
Last modified:November 1, 1995 - v1
Checksum:iCF3381B4C0356F82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49975 Genomic DNA Translation: CAA90276.1
U53876 Genomic DNA Translation: AAB67542.1
Z73270 Genomic DNA Translation: CAA97662.1
BK006945 Genomic DNA Translation: DAA09414.1
PIRiS59723
RefSeqiNP_013199.1, NM_001181985.1

Genome annotation databases

EnsemblFungiiYLR098C; YLR098C; YLR098C
GeneIDi850787
KEGGisce:YLR098C

Similar proteinsi

Entry informationi

Entry nameiCHA4_YEAST
AccessioniPrimary (citable) accession number: P43634
Secondary accession number(s): D6VY98
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health