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Protein

Killer cell immunoglobulin-like receptor 2DS4

Gene

KIR2DS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS4
Alternative name(s):
CD158 antigen-like family member I
MHC class I NK cell receptor
Natural killer-associated transcript 8
Short name:
NKAT-8
P58 natural killer cell receptor clones CL-39/CL-17
Short name:
p58 NK receptor CL-39/CL-17
CD_antigen: CD158i
Gene namesi
Name:KIR2DS4
Synonyms:CD158I, KKA3, NKAT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6336. KIR2DS4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 304CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3809.
OpenTargetsiENSG00000274406.
ENSG00000274947.
ENSG00000274957.
ENSG00000275353.
ENSG00000276154.
ENSG00000276395.
ENSG00000276634.
ENSG00000276885.
PharmGKBiPA30121.

Polymorphism and mutation databases

BioMutaiKIR2DS4.
DMDMi2828511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508522 – 304Killer cell immunoglobulin-like receptor 2DS4Add BLAST283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 1001 Publication
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 1981 Publication
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP43632.
PRIDEiP43632.

Expressioni

Gene expression databases

CleanExiHS_KIR2DS4.

Structurei

Secondary structure

1304
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 53Combined sources9
Beta strandi56 – 62Combined sources7
Beta strandi68 – 72Combined sources5
Beta strandi80 – 87Combined sources8
Beta strandi96 – 106Combined sources11
Beta strandi118 – 124Combined sources7
Beta strandi130 – 135Combined sources6
Beta strandi137 – 139Combined sources3
Beta strandi144 – 153Combined sources10
Beta strandi156 – 162Combined sources7
Beta strandi169 – 172Combined sources4
Beta strandi181 – 189Combined sources9
Beta strandi194 – 201Combined sources8
Beta strandi216 – 220Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8NX-ray2.50A27-221[»]
ProteinModelPortaliP43632.
SMRiP43632.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43632.
KOiK07982.
OMAiRCYGSLP.
OrthoDBiEOG091G0APE.
PhylomeDBiP43632.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC
110 120 130 140 150
YGSVPHSPYQ LSAPSDPLDM VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAVRSINGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,583
Last modified:November 1, 1997 - v2
Checksum:iCEFDAFF3FD679A3F
GO

Sequence cautioni

The sequence AAC50336 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04998065K → M.Corresponds to variant rs1130480dbSNPEnsembl.1
Natural variantiVAR_04998168N → D.Corresponds to variant rs1130481dbSNPEnsembl.1
Natural variantiVAR_04998271H → R.Corresponds to variant rs1130482dbSNPEnsembl.1
Natural variantiVAR_04998389P → R.Corresponds to variant rs1130487dbSNPEnsembl.1
Natural variantiVAR_04998492P → H.Corresponds to variant rs1143508dbSNPEnsembl.1
Natural variantiVAR_04998593V → D.Corresponds to variant rs1130491dbSNPEnsembl.1
Natural variantiVAR_049986103S → C.Corresponds to variant rs10406301dbSNPEnsembl.1
Natural variantiVAR_059423178N → H.Corresponds to variant rs4806591dbSNPEnsembl.1
Natural variantiVAR_059424205A → S.Corresponds to variant rs1049290dbSNPEnsembl.1
Natural variantiVAR_059425254K → N.Corresponds to variant rs1063326dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24077 mRNA. Translation: AAC50336.1. Different initiation.
L76671 mRNA. Translation: AAB36599.1.
X94609 mRNA. Translation: CAA64317.1.
AY366245 mRNA. Translation: AAR16203.1.
AF002255 mRNA. Translation: AAB61281.1.
BC101977 mRNA. Translation: AAI01978.1.
BC103693 mRNA. Translation: AAI03694.1.
RefSeqiNP_001268900.1. NM_001281971.1.
NP_001268901.1. NM_001281972.1.
NP_036446.3. NM_012314.5.
UniGeneiHs.654608.
Hs.744319.

Genome annotation databases

EnsembliENST00000611311; ENSP00000484123; ENSG00000276885.
ENST00000612783; ENSP00000481753; ENSG00000274957.
ENST00000613654; ENSP00000483112; ENSG00000276634.
ENST00000614639; ENSP00000481319; ENSG00000275731.
ENST00000617469; ENSP00000477744; ENSG00000276395.
ENST00000617825; ENSP00000483274; ENSG00000275353.
ENST00000619771; ENSP00000478241; ENSG00000274947.
ENST00000620669; ENSP00000480062; ENSG00000274406.
ENST00000621436; ENSP00000479843; ENSG00000276154.
GeneIDi3809.
KEGGihsa:3809.
UCSCiuc061emp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24077 mRNA. Translation: AAC50336.1. Different initiation.
L76671 mRNA. Translation: AAB36599.1.
X94609 mRNA. Translation: CAA64317.1.
AY366245 mRNA. Translation: AAR16203.1.
AF002255 mRNA. Translation: AAB61281.1.
BC101977 mRNA. Translation: AAI01978.1.
BC103693 mRNA. Translation: AAI03694.1.
RefSeqiNP_001268900.1. NM_001281971.1.
NP_001268901.1. NM_001281972.1.
NP_036446.3. NM_012314.5.
UniGeneiHs.654608.
Hs.744319.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3H8NX-ray2.50A27-221[»]
ProteinModelPortaliP43632.
SMRiP43632.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiKIR2DS4.
DMDMi2828511.

Proteomic databases

PeptideAtlasiP43632.
PRIDEiP43632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611311; ENSP00000484123; ENSG00000276885.
ENST00000612783; ENSP00000481753; ENSG00000274957.
ENST00000613654; ENSP00000483112; ENSG00000276634.
ENST00000614639; ENSP00000481319; ENSG00000275731.
ENST00000617469; ENSP00000477744; ENSG00000276395.
ENST00000617825; ENSP00000483274; ENSG00000275353.
ENST00000619771; ENSP00000478241; ENSG00000274947.
ENST00000620669; ENSP00000480062; ENSG00000274406.
ENST00000621436; ENSP00000479843; ENSG00000276154.
GeneIDi3809.
KEGGihsa:3809.
UCSCiuc061emp.1. human.

Organism-specific databases

CTDi3809.
DisGeNETi3809.
GeneCardsiKIR2DS4.
HGNCiHGNC:6336. KIR2DS4.
MIMi604955. gene.
neXtProtiNX_P43632.
OpenTargetsiENSG00000274406.
ENSG00000274947.
ENSG00000274957.
ENSG00000275353.
ENSG00000276154.
ENSG00000276395.
ENSG00000276634.
ENSG00000276885.
PharmGKBiPA30121.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43632.
KOiK07982.
OMAiRCYGSLP.
OrthoDBiEOG091G0APE.
PhylomeDBiP43632.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiP43632.
GeneWikiiKIR2DS4.
GenomeRNAii3809.
PROiP43632.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DS4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2S4_HUMAN
AccessioniPrimary (citable) accession number: P43632
Secondary accession number(s): Q6H2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.