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Protein

Killer cell immunoglobulin-like receptor 2DS4

Gene

KIR2DS4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS4
Alternative name(s):
CD158 antigen-like family member I
MHC class I NK cell receptor
Natural killer-associated transcript 8
Short name:
NKAT-8
P58 natural killer cell receptor clones CL-39/CL-17
Short name:
p58 NK receptor CL-39/CL-17
CD_antigen: CD158i
Gene namesi
Name:KIR2DS4
Synonyms:CD158I, KKA3, NKAT8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6336. KIR2DS4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224ExtracellularSequence analysisAdd
BLAST
Transmembranei246 – 26520HelicalSequence analysisAdd
BLAST
Topological domaini266 – 30439CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30121.

Polymorphism and mutation databases

BioMutaiKIR2DS4.
DMDMi2828511.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS4PRO_0000015085Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 1001 Publication
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence analysis
Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence analysis
Disulfide bondi149 ↔ 1981 Publication
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43632.

Expressioni

Gene expression databases

CleanExiHS_KIR2DS4.

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 539Combined sources
Beta strandi56 – 627Combined sources
Beta strandi68 – 725Combined sources
Beta strandi80 – 878Combined sources
Beta strandi96 – 10611Combined sources
Beta strandi118 – 1247Combined sources
Beta strandi130 – 1356Combined sources
Beta strandi137 – 1393Combined sources
Beta strandi144 – 15310Combined sources
Beta strandi156 – 1627Combined sources
Beta strandi169 – 1724Combined sources
Beta strandi181 – 1899Combined sources
Beta strandi194 – 2018Combined sources
Beta strandi216 – 2205Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H8NX-ray2.50A27-221[»]
ProteinModelPortaliP43632.
SMRiP43632. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43632.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43632.
KOiK07982.
OMAiEAEPRTY.
PhylomeDBiP43632.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVIIMAC VGFFLLQGAW PQEGVHRKPS FLALPGHLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGKFNNTL HLIGEHHDGV SKANFSIGPM MPVLAGTYRC
110 120 130 140 150
YGSVPHSPYQ LSAPSDPLDM VIIGLYEKPS LSAQPGPTVQ AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAVRSINGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDAPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT
260 270 280 290 300
SVVKIPFTIL LFFLLHRWCS DKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE

VSYA
Length:304
Mass (Da):33,583
Last modified:November 1, 1997 - v2
Checksum:iCEFDAFF3FD679A3F
GO

Sequence cautioni

The sequence AAC50336.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651K → M.
Corresponds to variant rs1130480 [ dbSNP | Ensembl ].
VAR_049980
Natural varianti68 – 681N → D.
Corresponds to variant rs1130481 [ dbSNP | Ensembl ].
VAR_049981
Natural varianti71 – 711H → R.
Corresponds to variant rs1130482 [ dbSNP | Ensembl ].
VAR_049982
Natural varianti89 – 891P → R.
Corresponds to variant rs1130487 [ dbSNP | Ensembl ].
VAR_049983
Natural varianti92 – 921P → H.
Corresponds to variant rs1143508 [ dbSNP | Ensembl ].
VAR_049984
Natural varianti93 – 931V → D.
Corresponds to variant rs1130491 [ dbSNP | Ensembl ].
VAR_049985
Natural varianti103 – 1031S → C.
Corresponds to variant rs10406301 [ dbSNP | Ensembl ].
VAR_049986
Natural varianti178 – 1781N → H.
Corresponds to variant rs4806591 [ dbSNP | Ensembl ].
VAR_059423
Natural varianti205 – 2051A → S.
Corresponds to variant rs1049290 [ dbSNP | Ensembl ].
VAR_059424
Natural varianti254 – 2541K → N.
Corresponds to variant rs1063326 [ dbSNP | Ensembl ].
VAR_059425

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24077 mRNA. Translation: AAC50336.1. Different initiation.
L76671 mRNA. Translation: AAB36599.1.
X94609 mRNA. Translation: CAA64317.1.
AY366245 mRNA. Translation: AAR16203.1.
AF002255 mRNA. Translation: AAB61281.1.
BC101977 mRNA. Translation: AAI01978.1.
BC103693 mRNA. Translation: AAI03694.1.
RefSeqiNP_001268900.1. NM_001281971.1.
NP_001268901.1. NM_001281972.1.
NP_036446.3. NM_012314.5.
UniGeneiHs.654608.
Hs.744319.

Genome annotation databases

EnsembliENST00000611311; ENSP00000484123; ENSG00000276885.
ENST00000612783; ENSP00000481753; ENSG00000274957.
ENST00000613654; ENSP00000483112; ENSG00000276634.
ENST00000614639; ENSP00000481319; ENSG00000275731.
ENST00000617469; ENSP00000477744; ENSG00000276395.
ENST00000617825; ENSP00000483274; ENSG00000275353.
ENST00000619771; ENSP00000478241; ENSG00000274947.
ENST00000620669; ENSP00000480062; ENSG00000274406.
ENST00000621436; ENSP00000479843; ENSG00000276154.
GeneIDi3809.
KEGGihsa:3809.
UCSCiuc061emp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24077 mRNA. Translation: AAC50336.1. Different initiation.
L76671 mRNA. Translation: AAB36599.1.
X94609 mRNA. Translation: CAA64317.1.
AY366245 mRNA. Translation: AAR16203.1.
AF002255 mRNA. Translation: AAB61281.1.
BC101977 mRNA. Translation: AAI01978.1.
BC103693 mRNA. Translation: AAI03694.1.
RefSeqiNP_001268900.1. NM_001281971.1.
NP_001268901.1. NM_001281972.1.
NP_036446.3. NM_012314.5.
UniGeneiHs.654608.
Hs.744319.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3H8NX-ray2.50A27-221[»]
ProteinModelPortaliP43632.
SMRiP43632. Positions 27-221.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism and mutation databases

BioMutaiKIR2DS4.
DMDMi2828511.

Proteomic databases

PRIDEiP43632.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611311; ENSP00000484123; ENSG00000276885.
ENST00000612783; ENSP00000481753; ENSG00000274957.
ENST00000613654; ENSP00000483112; ENSG00000276634.
ENST00000614639; ENSP00000481319; ENSG00000275731.
ENST00000617469; ENSP00000477744; ENSG00000276395.
ENST00000617825; ENSP00000483274; ENSG00000275353.
ENST00000619771; ENSP00000478241; ENSG00000274947.
ENST00000620669; ENSP00000480062; ENSG00000274406.
ENST00000621436; ENSP00000479843; ENSG00000276154.
GeneIDi3809.
KEGGihsa:3809.
UCSCiuc061emp.1. human.

Organism-specific databases

CTDi3809.
GeneCardsiKIR2DS4.
HGNCiHGNC:6336. KIR2DS4.
MIMi604955. gene.
neXtProtiNX_P43632.
PharmGKBiPA30121.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43632.
KOiK07982.
OMAiEAEPRTY.
PhylomeDBiP43632.

Enzyme and pathway databases

ReactomeiR-HSA-2172127. DAP12 interactions.

Miscellaneous databases

EvolutionaryTraceiP43632.
GeneWikiiKIR2DS4.
GenomeRNAii3809.
NextBioi14969.
PROiP43632.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DS4.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
    Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
    Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Natural killer cell.
  2. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "A novel surface molecule homologous to the p58/p50 family of receptors is selectively expressed on a subset of human natural killer cells and induces both triggering of cell functions and proliferation."
    Bottino C., Sivori S., Vitale M., Cantoni C., Falco M., Pende D., Morelli L., Augugliaro R., Semenzato G., Biassoni R., Moretta L., Moretta A.
    Eur. J. Immunol. 26:1816-1824(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoid tissue.
  4. "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
    Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M.
    J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. Chan H.W., Salter R.D.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C."
    Graef T., Moesta A.K., Norman P.J., Abi-Rached L., Vago L., Older Aguilar A.M., Gleimer M., Hammond J.A., Guethlein L.A., Bushnell D.A., Robinson P.J., Parham P.
    J. Exp. Med. 206:2557-2572(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 27-221, FUNCTION, DISULFIDE BONDS.

Entry informationi

Entry nameiKI2S4_HUMAN
AccessioniPrimary (citable) accession number: P43632
Secondary accession number(s): Q6H2G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: May 11, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.