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P43631 (KI2S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 137. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 2DS2
Alternative name(s):
CD158 antigen-like family member J
MHC class I NK cell receptor
NK receptor 183 ActI
Natural killer-associated transcript 5
Short name=NKAT-5
p58 natural killer cell receptor clone CL-49
Short name=p58 NK receptor CL-49
CD_antigen=CD158j
Gene names
Name:KIR2DS2
Synonyms:CD158J, NKAT5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution

The sequence AAC50338.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 304283Killer cell immunoglobulin-like receptor 2DS2
PRO_0000015083

Regions

Topological domain22 – 245224Extracellular Potential
Transmembrane246 – 26520Helical; Potential
Topological domain266 – 30439Cytoplasmic Potential
Domain42 – 10766Ig-like C2-type 1
Domain142 – 20564Ig-like C2-type 2

Amino acid modifications

Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Glycosylation2111N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 100 Ref.6
Disulfide bond149 ↔ 198 Ref.6

Natural variations

Natural variant91A → V.
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
VAR_059420
Natural variant661Y → F.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].
VAR_059421
Natural variant2371K → E.
Corresponds to variant rs2262065 [ dbSNP | Ensembl ].
VAR_020090
Natural variant2541K → N.
Corresponds to variant rs1063326 [ dbSNP | Ensembl ].
VAR_059422

Experimental info

Sequence conflict201W → G in CAA61983. Ref.3

Secondary structure

..................................... 304
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43631 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 186C77DD9E86BA28

FASTA30433,502
        10         20         30         40         50         60 
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL 

        70         80         90        100        110        120 
HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI 

       130        140        150        160        170        180 
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT 

       190        200        210        220        230        240 
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 

       250        260        270        280        290        300 
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 


VSYA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-304.
Tissue: Natural killer cell.
[2]"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Colonna M., Samaridis J.
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L.
J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lymphoid tissue.
[4]"Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M.
J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)."
Saulquin X., Gastinel L.N., Vivier E.
J. Exp. Med. 197:933-938(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-221, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U24079 mRNA. Translation: AAC50338.1. Different initiation.
L41347 mRNA. Translation: AAA65225.1.
X89893 mRNA. Translation: CAA61983.1.
AY366243 mRNA. Translation: AAR16201.1.
AL133414 Genomic DNA. Translation: CAC40717.1.
RefSeqNP_036444.1. NM_012312.3.
XP_005277361.1. XM_005277304.2.
UniGeneHs.512572.
Hs.654608.
Hs.731378.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4KX-ray2.30A22-221[»]
4N8VX-ray2.50G/I22-221[»]
ProteinModelPortalP43631.
SMRP43631. Positions 29-249.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110008. 3 interactions.
STRING9606.ENSP00000342215.

Polymorphism databases

DMDM13124793.

Proteomic databases

PRIDEP43631.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000573129; ENSP00000460718; ENSG00000263233.
GeneID100132285.
3804.
KEGGhsa:100132285.
hsa:3804.
UCSCuc002qun.2. human.

Organism-specific databases

CTD100132285.
3804.
GeneCardsGC19P9W0464.
HGNCHGNC:6334. KIR2DS2.
MIM604953. gene.
neXtProtNX_P43631.
PharmGKBPA30119.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG074353.
InParanoidP43631.
KOK07981.
K07982.
OMAEDSSSIC.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

BgeeP43631.
GenevestigatorP43631.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43631.
NextBio20789272.
PROP43631.
SOURCESearch...

Entry information

Entry nameKI2S2_HUMAN
AccessionPrimary (citable) accession number: P43631
Secondary accession number(s): Q14955, Q6H2G9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 21, 2001
Last modified: April 16, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries