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P43631

- KI2S2_HUMAN

UniProt

P43631 - KI2S2_HUMAN

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Protein

Killer cell immunoglobulin-like receptor 2DS2

Gene
KIR2DS2, CD158J, NKAT5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
  2. innate immune response Source: Reactome
  3. regulation of immune response Source: Reactome
  4. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DS2
Alternative name(s):
CD158 antigen-like family member J
MHC class I NK cell receptor
NK receptor 183 ActI
Natural killer-associated transcript 5
Short name:
NKAT-5
p58 natural killer cell receptor clone CL-49
Short name:
p58 NK receptor CL-49
CD_antigen: CD158j
Gene namesi
Name:KIR2DS2
Synonyms:CD158J, NKAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:6334. KIR2DS2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224Extracellular Reviewed predictionAdd
BLAST
Transmembranei246 – 26520Helical; Reviewed predictionAdd
BLAST
Topological domaini266 – 30439Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30119.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 By similarityAdd
BLAST
Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS2PRO_0000015083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 1001 Publication
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 1981 Publication
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi211 – 2111N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43631.

Expressioni

Gene expression databases

BgeeiP43631.
GenevestigatoriP43631.

Interactioni

Protein-protein interaction databases

BioGridi110008. 3 interactions.
STRINGi9606.ENSP00000342215.

Structurei

Secondary structure

1
304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356
Beta strandi37 – 404
Beta strandi45 – 539
Beta strandi56 – 627
Beta strandi68 – 736
Beta strandi75 – 795
Beta strandi81 – 877
Helixi92 – 943
Beta strandi96 – 1038
Beta strandi105 – 1084
Beta strandi118 – 1236
Beta strandi130 – 1356
Beta strandi137 – 1393
Beta strandi143 – 16220
Beta strandi169 – 1724
Beta strandi180 – 18910
Beta strandi194 – 2018
Beta strandi205 – 2095
Beta strandi216 – 2205

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1M4KX-ray2.30A22-221[»]
4N8VX-ray2.50G/I22-221[»]
ProteinModelPortaliP43631.
SMRiP43631. Positions 29-221.

Miscellaneous databases

EvolutionaryTraceiP43631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43631.
KOiK07980.
K07981.
K07982.
OMAiEDSSSIC.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43631-1 [UniParc]FASTAAdd to Basket

« Hide

MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW    50
SDVRFEHFLL HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 100
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS 150
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG 200
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT 250
SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 300
VSYA 304
Length:304
Mass (Da):33,502
Last modified:February 21, 2001 - v2
Checksum:i186C77DD9E86BA28
GO

Sequence cautioni

The sequence AAC50338.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91A → V.
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
VAR_059420
Natural varianti66 – 661Y → F.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].
VAR_059421
Natural varianti237 – 2371K → E.
Corresponds to variant rs2262065 [ dbSNP | Ensembl ].
VAR_020090
Natural varianti254 – 2541K → N.
Corresponds to variant rs1063326 [ dbSNP | Ensembl ].
VAR_059422

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201W → G in CAA61983. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24079 mRNA. Translation: AAC50338.1. Different initiation.
L41347 mRNA. Translation: AAA65225.1.
X89893 mRNA. Translation: CAA61983.1.
AY366243 mRNA. Translation: AAR16201.1.
AL133414 Genomic DNA. Translation: CAC40717.1.
RefSeqiNP_001278624.1. NM_001291695.1.
NP_001278625.1. NM_001291696.1.
NP_001278629.1. NM_001291700.1.
NP_001278630.1. NM_001291701.1.
NP_036444.1. NM_012312.4.
XP_005277361.1. XM_005277304.2.
XP_006725489.1. XM_006725426.1.
XP_006725498.1. XM_006725435.1.
XP_006725842.1. XM_006725779.1.
XP_006726219.1. XM_006726156.1.
UniGeneiHs.512572.
Hs.645224.
Hs.654608.
Hs.731378.

Genome annotation databases

EnsembliENST00000573129; ENSP00000460718; ENSG00000263233.
GeneIDi100132285.
115653.
3804.
KEGGihsa:100132285.
hsa:115653.
hsa:3804.
UCSCiuc002qun.2. human.

Polymorphism databases

DMDMi13124793.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U24079 mRNA. Translation: AAC50338.1 . Different initiation.
L41347 mRNA. Translation: AAA65225.1 .
X89893 mRNA. Translation: CAA61983.1 .
AY366243 mRNA. Translation: AAR16201.1 .
AL133414 Genomic DNA. Translation: CAC40717.1 .
RefSeqi NP_001278624.1. NM_001291695.1.
NP_001278625.1. NM_001291696.1.
NP_001278629.1. NM_001291700.1.
NP_001278630.1. NM_001291701.1.
NP_036444.1. NM_012312.4.
XP_005277361.1. XM_005277304.2.
XP_006725489.1. XM_006725426.1.
XP_006725498.1. XM_006725435.1.
XP_006725842.1. XM_006725779.1.
XP_006726219.1. XM_006726156.1.
UniGenei Hs.512572.
Hs.645224.
Hs.654608.
Hs.731378.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1M4K X-ray 2.30 A 22-221 [» ]
4N8V X-ray 2.50 G/I 22-221 [» ]
ProteinModelPortali P43631.
SMRi P43631. Positions 29-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110008. 3 interactions.
STRINGi 9606.ENSP00000342215.

Polymorphism databases

DMDMi 13124793.

Proteomic databases

PRIDEi P43631.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000573129 ; ENSP00000460718 ; ENSG00000263233 .
GeneIDi 100132285.
115653.
3804.
KEGGi hsa:100132285.
hsa:115653.
hsa:3804.
UCSCi uc002qun.2. human.

Organism-specific databases

CTDi 100132285.
115653.
3804.
GeneCardsi GC19P9W0464.
HGNCi HGNC:6334. KIR2DS2.
MIMi 604953. gene.
neXtProti NX_P43631.
PharmGKBi PA30119.
GenAtlasi Search...

Phylogenomic databases

HOVERGENi HBG074353.
InParanoidi P43631.
KOi K07980.
K07981.
K07982.
OMAi EDSSSIC.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_147694. DAP12 interactions.

Miscellaneous databases

EvolutionaryTracei P43631.
NextBioi 20789272.
PROi P43631.
SOURCEi Search...

Gene expression databases

Bgeei P43631.
Genevestigatori P43631.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
    Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
    Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-304.
    Tissue: Natural killer cell.
  2. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
    Colonna M., Samaridis J.
    Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
    Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L.
    J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoid tissue.
  4. "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
    Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M.
    J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)."
    Saulquin X., Gastinel L.N., Vivier E.
    J. Exp. Med. 197:933-938(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-221, DISULFIDE BONDS.

Entry informationi

Entry nameiKI2S2_HUMAN
AccessioniPrimary (citable) accession number: P43631
Secondary accession number(s): Q14955, Q6H2G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 21, 2001
Last modified: September 3, 2014
This is version 141 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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