Killer cell immunoglobulin-like receptor 2DS2 precursor

Contribute

Send feedback

Read comments (?) or add your own

P43631 (KI2S2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 129. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Killer cell immunoglobulin-like receptor 2DS2

Alternative name(s):
CD158 antigen-like family member J
MHC class I NK cell receptor
NK receptor 183 ActI
Natural killer-associated transcript 5
Short name=NKAT-5
p58 natural killer cell receptor clone CL-49
Short name=p58 NK receptor CL-49
CD_antigen=CD158j

Gene names

Name:	KIR2DS2
Synonyms:	CD158J, NKAT5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence AAC50338.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.3. Source: UniProtKB regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Non-traceable author statement Ref.3. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular_function	transmembrane signaling receptor activity Non-traceable author statement Ref.3. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

By similarity

Chain

22 – 304

283

Killer cell immunoglobulin-like receptor 2DS2

PRO_0000015083

Regions

Topological domain

22 – 245

224

Extracellular Potential

Transmembrane

246 – 265

Helical; Potential

Topological domain

266 – 304

Cytoplasmic Potential

Domain

42 – 107

Ig-like C2-type 1

Domain

142 – 205

Ig-like C2-type 2

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

178

N-linked (GlcNAc...) Potential

Glycosylation

211

N-linked (GlcNAc...) Potential

Disulfide bond

Disulfide bond

Natural variations

Natural variant

A → V.
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].

VAR_059420

Natural variant

Y → F.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].

VAR_059421

Natural variant

237

K → E.
Corresponds to variant rs2262065 [ dbSNP | Ensembl ].

VAR_020090

Natural variant

254

K → N.
Corresponds to variant rs1063326 [ dbSNP | Ensembl ].

VAR_059422

Experimental info

Sequence conflict

W → G in CAA61983. Ref.3

Secondary structure

304

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P43631 [UniParc].

Last modified February 21, 2001. Version 2.
Checksum: 186C77DD9E86BA28
Show »

FASTA

304

33,502

        10         20         30         40         50         60 
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFEHFLL 

        70         80         90        100        110        120 
HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI 

       130        140        150        160        170        180 
VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT 

       190        200        210        220        230        240 
FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 

       250        260        270        280        290        300 
PRHLHVLIGT SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 


VSYA

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains." Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O. Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-304. Tissue: Natural killer cell.
[2]	"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." Colonna M., Samaridis J. Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions." Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L. J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoid tissue.
[4]	"Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes." Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M. J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)." Saulquin X., Gastinel L.N., Vivier E. J. Exp. Med. 197:933-938(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-221, DISULFIDE BONDS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U24079 mRNA. Translation: AAC50338.1. Different initiation.
L41347 mRNA. Translation: AAA65225.1.
X89893 mRNA. Translation: CAA61983.1.
AY366243 mRNA. Translation: AAR16201.1.
AL133414 Genomic DNA. Translation: CAC40717.1.

IPI

IPI00956336.

RefSeq

NP_036444.1. NM_012312.2.

UniGene

Hs.512572.
Hs.731378.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1M4K	X-ray	2.30	A	22-221	[»]

ProteinModelPortal

P43631.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000342215.

Polymorphism databases

DMDM

13124793.

Proteomic databases

PRIDE

P43631.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000573129; ENSP00000460718; ENSG00000263233.
ENST00000576413; ENSP00000461341; ENSG00000262596.

GeneID

100132285.

KEGG

hsa:100132285.

UCSC

uc002qun.2. human.

Organism-specific databases

CTD

100132285.

GeneCards

GC19P9I0131.

HGNC

HGNC:6334. KIR2DS2.

MIM

604953. gene.

neXtProt

NX_P43631.

PharmGKB

PA30119.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG074353.

InParanoid

P43631.

K07982.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

Bgee

P43631.

Genevestigator

P43631.

GermOnline

ENSG00000125498. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 2 hits.

InterPro

IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]

Pfam

PF00047. ig. 1 hit.
[Graphical view]

SMART

SM00409. IG. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. False negative.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P43631.

GenomeRNAi

100132285.

NextBio

20789272.

SOURCE

Search...

Entry information

Entry name

KI2S2_HUMAN

Accession

Primary (citable) accession number: P43631
Secondary accession number(s): Q14955, Q6H2G9

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	February 21, 2001
Last modified:	May 1, 2013
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.