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P43631

- KI2S2_HUMAN

UniProt

P43631 - KI2S2_HUMAN

Protein

Killer cell immunoglobulin-like receptor 2DS2

Gene

KIR2DS2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (21 Feb 2001)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. innate immune response Source: Reactome
    3. regulation of immune response Source: Reactome
    4. signal transduction Source: GOC

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DS2
    Alternative name(s):
    CD158 antigen-like family member J
    MHC class I NK cell receptor
    NK receptor 183 ActI
    Natural killer-associated transcript 5
    Short name:
    NKAT-5
    p58 natural killer cell receptor clone CL-49
    Short name:
    p58 NK receptor CL-49
    CD_antigen: CD158j
    Gene namesi
    Name:KIR2DS2
    Synonyms:CD158J, NKAT5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:6334. KIR2DS2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30119.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 304283Killer cell immunoglobulin-like receptor 2DS2PRO_0000015083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 1001 Publication
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 1981 Publication
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP43631.

    Expressioni

    Gene expression databases

    BgeeiP43631.
    GenevestigatoriP43631.

    Interactioni

    Protein-protein interaction databases

    BioGridi110008. 3 interactions.
    STRINGi9606.ENSP00000342215.

    Structurei

    Secondary structure

    1
    304
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi37 – 404
    Beta strandi45 – 539
    Beta strandi56 – 627
    Beta strandi68 – 736
    Beta strandi75 – 795
    Beta strandi81 – 877
    Helixi92 – 943
    Beta strandi96 – 1038
    Beta strandi105 – 1084
    Beta strandi118 – 1236
    Beta strandi130 – 1356
    Beta strandi137 – 1393
    Beta strandi143 – 16220
    Beta strandi169 – 1724
    Beta strandi180 – 18910
    Beta strandi194 – 2018
    Beta strandi205 – 2095
    Beta strandi216 – 2205

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1M4KX-ray2.30A22-221[»]
    4N8VX-ray2.50G/I22-221[»]
    ProteinModelPortaliP43631.
    SMRiP43631. Positions 29-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43631.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 245224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 30439CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei246 – 26520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10766Ig-like C2-type 1Add
    BLAST
    Domaini142 – 20564Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG074353.
    InParanoidiP43631.
    KOiK07980.
    K07981.
    K07982.
    OMAiEDSSSIC.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43631-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW    50
    SDVRFEHFLL HREGKYKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 100
    YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS 150
    SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG 200
    SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHVLIGT 250
    SVVKIPFTIL LFFLLHRWCS NKKNAAVMDQ EPAGNRTVNS EDSDEQDHQE 300
    VSYA 304
    Length:304
    Mass (Da):33,502
    Last modified:February 21, 2001 - v2
    Checksum:i186C77DD9E86BA28
    GO

    Sequence cautioni

    The sequence AAC50338.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti20 – 201W → G in CAA61983. (PubMed:8627176)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91A → V.
    Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
    VAR_059420
    Natural varianti66 – 661Y → F.
    Corresponds to variant rs673568 [ dbSNP | Ensembl ].
    VAR_059421
    Natural varianti237 – 2371K → E.
    Corresponds to variant rs2262065 [ dbSNP | Ensembl ].
    VAR_020090
    Natural varianti254 – 2541K → N.
    Corresponds to variant rs1063326 [ dbSNP | Ensembl ].
    VAR_059422

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24079 mRNA. Translation: AAC50338.1. Different initiation.
    L41347 mRNA. Translation: AAA65225.1.
    X89893 mRNA. Translation: CAA61983.1.
    AY366243 mRNA. Translation: AAR16201.1.
    AL133414 Genomic DNA. Translation: CAC40717.1.
    RefSeqiNP_001278624.1. NM_001291695.1.
    NP_001278625.1. NM_001291696.1.
    NP_001278629.1. NM_001291700.1.
    NP_001278630.1. NM_001291701.1.
    NP_036444.1. NM_012312.4.
    XP_005277361.1. XM_005277304.2.
    XP_006725489.1. XM_006725426.1.
    XP_006725498.1. XM_006725435.1.
    XP_006725842.1. XM_006725779.1.
    XP_006726219.1. XM_006726156.1.
    UniGeneiHs.512572.
    Hs.645224.
    Hs.654608.
    Hs.731378.

    Genome annotation databases

    GeneIDi100132285.
    115653.
    3804.
    KEGGihsa:100132285.
    hsa:115653.
    hsa:3804.
    UCSCiuc002qun.2. human.

    Polymorphism databases

    DMDMi13124793.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U24079 mRNA. Translation: AAC50338.1 . Different initiation.
    L41347 mRNA. Translation: AAA65225.1 .
    X89893 mRNA. Translation: CAA61983.1 .
    AY366243 mRNA. Translation: AAR16201.1 .
    AL133414 Genomic DNA. Translation: CAC40717.1 .
    RefSeqi NP_001278624.1. NM_001291695.1.
    NP_001278625.1. NM_001291696.1.
    NP_001278629.1. NM_001291700.1.
    NP_001278630.1. NM_001291701.1.
    NP_036444.1. NM_012312.4.
    XP_005277361.1. XM_005277304.2.
    XP_006725489.1. XM_006725426.1.
    XP_006725498.1. XM_006725435.1.
    XP_006725842.1. XM_006725779.1.
    XP_006726219.1. XM_006726156.1.
    UniGenei Hs.512572.
    Hs.645224.
    Hs.654608.
    Hs.731378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1M4K X-ray 2.30 A 22-221 [» ]
    4N8V X-ray 2.50 G/I 22-221 [» ]
    ProteinModelPortali P43631.
    SMRi P43631. Positions 29-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110008. 3 interactions.
    STRINGi 9606.ENSP00000342215.

    Polymorphism databases

    DMDMi 13124793.

    Proteomic databases

    PRIDEi P43631.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100132285.
    115653.
    3804.
    KEGGi hsa:100132285.
    hsa:115653.
    hsa:3804.
    UCSCi uc002qun.2. human.

    Organism-specific databases

    CTDi 100132285.
    115653.
    3804.
    GeneCardsi GC19P9W0464.
    HGNCi HGNC:6334. KIR2DS2.
    MIMi 604953. gene.
    neXtProti NX_P43631.
    PharmGKBi PA30119.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG074353.
    InParanoidi P43631.
    KOi K07980.
    K07981.
    K07982.
    OMAi EDSSSIC.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_147694. DAP12 interactions.

    Miscellaneous databases

    EvolutionaryTracei P43631.
    NextBioi 20789272.
    PROi P43631.
    SOURCEi Search...

    Gene expression databases

    Bgeei P43631.
    Genevestigatori P43631.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
      Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
      Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-304.
      Tissue: Natural killer cell.
    2. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M., Samaridis J.
      Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The human leukocyte antigen (HLA)-C-specific 'activatory' or 'inhibitory' natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions."
      Biassoni R., Cantoni C., Falco M., Verdiani S., Bottino C., Vitale M., Conte R., Poggi A., Moretta A., Moretta L.
      J. Exp. Med. 183:645-650(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoid tissue.
    4. "Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes."
      Artavanis-Tsakonas K., Eleme K., McQueen K.L., Cheng N.W., Parham P., Davis D.M., Riley E.M.
      J. Immunol. 171:5396-5405(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Crystal structure of the human natural killer cell activating receptor KIR2DS2 (CD158j)."
      Saulquin X., Gastinel L.N., Vivier E.
      J. Exp. Med. 197:933-938(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 22-221, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKI2S2_HUMAN
    AccessioniPrimary (citable) accession number: P43631
    Secondary accession number(s): Q14955, Q6H2G9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: February 21, 2001
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3