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Protein

Killer cell immunoglobulin-like receptor 3DL2

Gene

KIR3DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.

GO - Biological processi

  • cellular defense response Source: ProtInc
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125498-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL2
Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name:
NKAT-4
p70 natural killer cell receptor clone CL-5
Short name:
p70 NK receptor CL-5
CD_antigen: CD158k
Gene namesi
Name:KIR3DL2
Synonyms:CD158K, NKAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6339. KIR3DL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 455CytoplasmicSequence analysisAdd BLAST95

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3812.
OpenTargetsiENSG00000240403.
ENSG00000274722.
ENSG00000275083.
ENSG00000276739.
ENSG00000277181.
ENSG00000278809.
PharmGKBiPA30124.

Polymorphism and mutation databases

BioMutaiKIR3DL2.
DMDMi1171729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001509022 – 455Killer cell immunoglobulin-like receptor 3DL2Add BLAST434

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 95Curated
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43630.
PeptideAtlasiP43630.
PRIDEiP43630.

PTM databases

iPTMnetiP43630.
PhosphoSitePlusiP43630.
SwissPalmiP43630.

Expressioni

Gene expression databases

ExpressionAtlasiP43630. baseline and differential.
GenevisibleiP43630. HS.

Interactioni

Protein-protein interaction databases

BioGridi110013. 21 interactors.
IntActiP43630. 1 interactor.
STRINGi9606.ENSP00000325525.

Structurei

3D structure databases

ProteinModelPortaliP43630.
SMRiP43630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43630.
KOiK07980.
OrthoDBiEOG091G0APE.
PhylomeDBiP43630.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH
60 70 80 90 100
YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP
110 120 130 140 150
HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF
160 170 180 190 200
EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP
210 220 230 240 250
HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY
260 270 280 290 300
DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL
310 320 330 340 350
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF
360 370 380 390 400
LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ
410 420 430 440 450
LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG

LEGVF
Length:455
Mass (Da):50,230
Last modified:November 1, 1995 - v1
Checksum:iDB4BA6BB6B3C2945
GO
Isoform 2 (identifier: P43630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-334: Missing.

Show »
Length:438
Mass (Da):48,517
Checksum:iF762B713D6EB916C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01032540P → A.2 Publications1
Natural variantiVAR_010326113L → V.2 PublicationsCorresponds to variant rs17412418dbSNPEnsembl.1
Natural variantiVAR_049991132P → T.Corresponds to variant rs3745894dbSNPEnsembl.1
Natural variantiVAR_010327158E → D.3 PublicationsCorresponds to variant rs1048270dbSNPEnsembl.1
Natural variantiVAR_010328166R → H.2 PublicationsCorresponds to variant rs1048271dbSNPEnsembl.1
Natural variantiVAR_010329228A → P.1 Publication1
Natural variantiVAR_010330252I → T.1 Publication1
Natural variantiVAR_049992397T → M.Corresponds to variant rs3745902dbSNPEnsembl.1
Natural variantiVAR_049993439K → Q.Corresponds to variant rs3745903dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047374318 – 334Missing in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA. Translation: AAA69871.1.
U30272 mRNA. Translation: AAB52520.1.
X93595 mRNA. Translation: CAA63791.1.
X93596 mRNA. Translation: CAA63792.1.
X94373 mRNA. Translation: CAA64150.1.
X94374 mRNA. Translation: CAA64151.1.
L76665 mRNA. Translation: AAB36593.1.
L76666 mRNA. Translation: AAB36594.1.
AY789067 mRNA. Translation: AAX23112.1.
CCDSiCCDS12906.1. [P43630-1]
CCDS58677.1. [P43630-2]
RefSeqiNP_001229796.1. NM_001242867.1. [P43630-2]
NP_006728.2. NM_006737.3. [P43630-1]
UniGeneiHs.645228.
Hs.645532.
Hs.654605.

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809. [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474.
ENST00000611859; ENSP00000480578; ENSG00000277181. [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722. [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442.
ENST00000613612; ENSP00000482565; ENSG00000275566.
ENST00000614753; ENSP00000479299; ENSG00000276357.
ENST00000617354; ENSP00000482110; ENSG00000274722. [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083. [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361.
ENST00000617957; ENSP00000481579; ENSG00000275083. [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739. [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626.
ENST00000620817; ENSP00000479772; ENSG00000276739. [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416.
ENST00000622024; ENSP00000479425; ENSG00000276004.
ENST00000622453; ENSP00000477516; ENSG00000277181. [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809. [P43630-2]
GeneIDi3812.
KEGGihsa:3812.
UCSCiuc002qho.5. human. [P43630-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA. Translation: AAA69871.1.
U30272 mRNA. Translation: AAB52520.1.
X93595 mRNA. Translation: CAA63791.1.
X93596 mRNA. Translation: CAA63792.1.
X94373 mRNA. Translation: CAA64150.1.
X94374 mRNA. Translation: CAA64151.1.
L76665 mRNA. Translation: AAB36593.1.
L76666 mRNA. Translation: AAB36594.1.
AY789067 mRNA. Translation: AAX23112.1.
CCDSiCCDS12906.1. [P43630-1]
CCDS58677.1. [P43630-2]
RefSeqiNP_001229796.1. NM_001242867.1. [P43630-2]
NP_006728.2. NM_006737.3. [P43630-1]
UniGeneiHs.645228.
Hs.645532.
Hs.654605.

3D structure databases

ProteinModelPortaliP43630.
SMRiP43630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110013. 21 interactors.
IntActiP43630. 1 interactor.
STRINGi9606.ENSP00000325525.

PTM databases

iPTMnetiP43630.
PhosphoSitePlusiP43630.
SwissPalmiP43630.

Polymorphism and mutation databases

BioMutaiKIR3DL2.
DMDMi1171729.

Proteomic databases

PaxDbiP43630.
PeptideAtlasiP43630.
PRIDEiP43630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809. [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474.
ENST00000611859; ENSP00000480578; ENSG00000277181. [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722. [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442.
ENST00000613612; ENSP00000482565; ENSG00000275566.
ENST00000614753; ENSP00000479299; ENSG00000276357.
ENST00000617354; ENSP00000482110; ENSG00000274722. [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083. [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361.
ENST00000617957; ENSP00000481579; ENSG00000275083. [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739. [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626.
ENST00000620817; ENSP00000479772; ENSG00000276739. [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416.
ENST00000622024; ENSP00000479425; ENSG00000276004.
ENST00000622453; ENSP00000477516; ENSG00000277181. [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809. [P43630-2]
GeneIDi3812.
KEGGihsa:3812.
UCSCiuc002qho.5. human. [P43630-1]

Organism-specific databases

CTDi3812.
DisGeNETi3812.
GeneCardsiKIR3DL2.
HGNCiHGNC:6339. KIR3DL2.
MIMi604947. gene.
neXtProtiNX_P43630.
OpenTargetsiENSG00000240403.
ENSG00000274722.
ENSG00000275083.
ENSG00000276739.
ENSG00000277181.
ENSG00000278809.
PharmGKBiPA30124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43630.
KOiK07980.
OrthoDBiEOG091G0APE.
PhylomeDBiP43630.
TreeFamiTF352669.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125498-MONOMER.
ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiKIR3DL2.
GenomeRNAii3812.
PROiP43630.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP43630. baseline and differential.
GenevisibleiP43630. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI3L2_HUMAN
AccessioniPrimary (citable) accession number: P43630
Secondary accession number(s): Q13238
, Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 164 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.