P43630 (KI3L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Killer cell immunoglobulin-like receptor 3DL2

Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name=NKAT-4
p70 natural killer cell receptor clone CL-5
Short name=p70 NK receptor CL-5
CD_antigen=CD158k

Gene names

Name:	KIR3DL2
Synonyms:	CD158K, NKAT4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular defense response Traceable author statement Ref.1. Source: ProtInc regulation of immune response Traceable author statement. Source: Reactome
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 455	434	Killer cell immunoglobulin-like receptor 3DL2		PRO_0000015090
Regions
	Topological domain	22 – 340	319	Extracellular Potential
	Transmembrane	341 – 360	20	Helical; Potential
	Topological domain	361 – 455	95	Cytoplasmic Potential
	Domain	42 – 102	61	Ig-like C2-type 1
	Domain	137 – 202	66	Ig-like C2-type 2
	Domain	237 – 300	64	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	239	1	N-linked (GlcNAc...) Potential
	Glycosylation	273	1	N-linked (GlcNAc...) Potential
	Glycosylation	306	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 95		By similarity
	Disulfide bond	144 ↔ 195		By similarity
	Disulfide bond	244 ↔ 293		By similarity
Natural variations
	Natural variant	40	1	P → A. Ref.6		VAR_010325
	Natural variant	113	1	L → V. Ref.3 Ref.6 Corresponds to variant rs17412418 [ dbSNP | Ensembl ].		VAR_010326
	Natural variant	132	1	P → T. Corresponds to variant rs3745894 [ dbSNP | Ensembl ].		VAR_049991
	Natural variant	158	1	E → D. Ref.3 Ref.5 Ref.6 Corresponds to variant rs1048270 [ dbSNP | Ensembl ].		VAR_010327
	Natural variant	166	1	R → H. Ref.6 Corresponds to variant rs1048271 [ dbSNP | Ensembl ].		VAR_010328
	Natural variant	228	1	A → P. Ref.6		VAR_010329
	Natural variant	252	1	I → T. Ref.6		VAR_010330
	Natural variant	397	1	T → M. Corresponds to variant rs3745902 [ dbSNP | Ensembl ].		VAR_049992
	Natural variant	439	1	K → Q. Corresponds to variant rs3745903 [ dbSNP | Ensembl ].		VAR_049993

Sequences

	Sequence		Length	Mass (Da)
	P43630 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: DB4BA6BB6B3C2945	FASTA	455	50,230
	10 20 30 40 50 60 MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML 70 80 90 100 110 120 YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN 130 140 150 160 170 180 HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF 190 200 210 220 230 240 SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV 250 260 270 280 290 300 TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL 310 320 330 340 350 360 PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL 370 380 390 400 410 420 YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT 430 440 450 PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF

References

[1]	"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." Colonna M., Samaridis J. Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Natural killer cell.
[2]	"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer." Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O. Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte.
[3]	"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer." Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L. J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-113 AND ASP-158. Tissue: Lymphoid tissue.
[4]	"Alternatively spliced forms of human killer inhibitory receptors." Doehring C., Samaridis J., Colonna M. Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[5]	"Variants of KIR identified in Japanese donors." Yawata N., Yawata M., Parham P. Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-158.
[6]	"Human diversity in killer cell inhibitory receptor genes." Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P. Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS ALA-40; VAL-113; ASP-158; HIS-166; PRO-228 AND THR-252.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L41270 mRNA. Translation: AAA69871.1. U30272 mRNA. Translation: AAB52520.1. X93595 mRNA. Translation: CAA63791.1. X94373 mRNA. Translation: CAA64150.1. X94374 mRNA. Translation: CAA64151.1. L76665 mRNA. Translation: AAB36593.1. L76666 mRNA. Translation: AAB36594.1. AY789067 mRNA. Translation: AAX23112.1.
IPI	IPI00302352.
RefSeq	NP_001229796.1. NM_001242867.1. NP_006728.2. NM_006737.3.
UniGene	Hs.645228. Hs.645532. Hs.654605.
3D structure databases
ProteinModelPortal	P43630.
ModBase	Search...
Protein-protein interaction databases
IntAct	P43630. 1 interaction.
STRING	9606.ENSP00000325525.
Protein family/group databases
MEROPS	I43.001.
PTM databases
PhosphoSite	P43630.
Polymorphism databases
DMDM	1171729.
Proteomic databases
PaxDb	P43630.
PRIDE	P43630.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326321; ENSP00000325525; ENSG00000240403. ENST00000576605; ENSP00000459298; ENSG00000263184. ENST00000576676; ENSP00000460012; ENSG00000262007.
GeneID	3812.
KEGG	hsa:3812.
UCSC	uc002qho.4. human.
Organism-specific databases
CTD	3812.
GeneCards	GC19P055361.
HGNC	HGNC:6339. KIR3DL2.
MIM	604947. gene.
neXtProt	NX_P43630.
PharmGKB	PA30124.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG25862.
HOGENOM	HOG000234396.
HOVERGEN	HBG074353.
KO	K07980.
OMA	YKEDRSH.
OrthoDB	EOG4RJG1X.
PhylomeDB	P43630.
Enzyme and pathway databases
Reactome	REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P43630.
Genevestigator	P43630.
GermOnline	ENSG00000125498. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3812.
NextBio	14981.
SOURCE	Search...

Entry information

Entry name

KI3L2_HUMAN

Accession

Primary (citable) accession number: P43630
Secondary accession number(s): Q13238 , Q14947, Q14948, Q92684, Q95367, Q95368

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.