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P43630 (KI3L2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 142. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 3DL2
Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name=NKAT-4
p70 natural killer cell receptor clone CL-5
Short name=p70 NK receptor CL-5
CD_antigen=CD158k
Gene names
Name:KIR3DL2
Synonyms:CD158K, NKAT4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P43630-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P43630-2)

The sequence of this isoform differs from the canonical sequence as follows:
     318-334: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 455434Killer cell immunoglobulin-like receptor 3DL2
PRO_0000015090

Regions

Topological domain22 – 340319Extracellular Potential
Transmembrane341 – 36020Helical; Potential
Topological domain361 – 45595Cytoplasmic Potential
Domain42 – 10261Ig-like C2-type 1
Domain137 – 20266Ig-like C2-type 2
Domain237 – 30064Ig-like C2-type 3

Amino acid modifications

Glycosylation1791N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2731N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 95 By similarity
Disulfide bond144 ↔ 195 By similarity
Disulfide bond244 ↔ 293 By similarity

Natural variations

Alternative sequence318 – 33417Missing in isoform 2.
VSP_047374
Natural variant401P → A. Ref.3 Ref.6
VAR_010325
Natural variant1131L → V. Ref.3 Ref.6
Corresponds to variant rs17412418 [ dbSNP | Ensembl ].
VAR_010326
Natural variant1321P → T.
Corresponds to variant rs3745894 [ dbSNP | Ensembl ].
VAR_049991
Natural variant1581E → D. Ref.3 Ref.5 Ref.6
Corresponds to variant rs1048270 [ dbSNP | Ensembl ].
VAR_010327
Natural variant1661R → H. Ref.3 Ref.6
Corresponds to variant rs1048271 [ dbSNP | Ensembl ].
VAR_010328
Natural variant2281A → P. Ref.6
VAR_010329
Natural variant2521I → T. Ref.6
VAR_010330
Natural variant3971T → M.
Corresponds to variant rs3745902 [ dbSNP | Ensembl ].
VAR_049992
Natural variant4391K → Q.
Corresponds to variant rs3745903 [ dbSNP | Ensembl ].
VAR_049993

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: DB4BA6BB6B3C2945

FASTA45550,230
        10         20         30         40         50         60 
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH YRRGFNNFML 

        70         80         90        100        110        120 
YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP HSLTGWSAPS NPLVIMVTGN 

       130        140        150        160        170        180 
HRKPSLLAHP GPLLKSGETV ILQCWSDVMF EHFFLHREGI SEDPSRLVGQ IHDGVSKANF 

       190        200        210        220        230        240 
SIGPLMPVLA GTYRCYGSVP HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV 

       250        260        270        280        290        300 
TLSCSSWSSY DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL 

       310        320        330        340        350        360 
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF LFILLLFFLL 

       370        380        390        400        410        420 
YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ LDHCVFIQRK ISRPSQRPKT 

       430        440        450 
PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG LEGVF 

« Hide

Isoform 2 [UniParc].

Checksum: F762B713D6EB916C
Show »

FASTA43848,517

References

[1]"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Colonna M., Samaridis J.
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Natural killer cell.
[2]"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Peripheral blood lymphocyte.
[3]"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-40; VAL-113; ASP-158 AND HIS-166.
Tissue: Lymphoid tissue.
[4]"Alternatively spliced forms of human killer inhibitory receptors."
Doehring C., Samaridis J., Colonna M.
Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Variants of KIR identified in Japanese donors."
Yawata N., Yawata M., Parham P.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-158.
[6]"Human diversity in killer cell inhibitory receptor genes."
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS ALA-40; VAL-113; ASP-158; HIS-166; PRO-228 AND THR-252.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41270 mRNA. Translation: AAA69871.1.
U30272 mRNA. Translation: AAB52520.1.
X93595 mRNA. Translation: CAA63791.1.
X93596 mRNA. Translation: CAA63792.1.
X94373 mRNA. Translation: CAA64150.1.
X94374 mRNA. Translation: CAA64151.1.
L76665 mRNA. Translation: AAB36593.1.
L76666 mRNA. Translation: AAB36594.1.
AY789067 mRNA. Translation: AAX23112.1.
CCDSCCDS12906.1. [P43630-1]
CCDS58677.1. [P43630-2]
RefSeqNP_001229796.1. NM_001242867.1. [P43630-2]
NP_006728.2. NM_006737.3. [P43630-1]
UniGeneHs.645228.
Hs.645532.
Hs.654605.

3D structure databases

ProteinModelPortalP43630.
SMRP43630. Positions 28-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110013. 2 interactions.
IntActP43630. 1 interaction.
STRING9606.ENSP00000325525.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteP43630.

Polymorphism databases

DMDM1171729.

Proteomic databases

PaxDbP43630.
PRIDEP43630.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
ENST00000575378; ENSP00000461377; ENSG00000262007. [P43630-2]
ENST00000576605; ENSP00000459298; ENSG00000263184.
ENST00000576676; ENSP00000460012; ENSG00000262007. [P43630-1]
ENST00000603789; ENSP00000474216; ENSG00000271613. [P43630-1]
ENST00000604891; ENSP00000474315; ENSG00000271613. [P43630-2]
GeneID3812.
KEGGhsa:3812.
UCSCuc002qho.4. human. [P43630-1]

Organism-specific databases

CTD3812.
GeneCardsGC19P055361.
HGNCHGNC:6339. KIR3DL2.
MIM604947. gene.
neXtProtNX_P43630.
PharmGKBPA30124.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25862.
HOGENOMHOG000234396.
HOVERGENHBG074353.
KOK07980.
OMAEDAHESW.
OrthoDBEOG7H792J.
PhylomeDBP43630.
TreeFamTF352669.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

GenevestigatorP43630.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIR3DL2.
GenomeRNAi3812.
NextBio14981.
PROP43630.
SOURCESearch...

Entry information

Entry nameKI3L2_HUMAN
AccessionPrimary (citable) accession number: P43630
Secondary accession number(s): Q13238 expand/collapse secondary AC list , Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries