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Protein

Killer cell immunoglobulin-like receptor 3DL2

Gene

KIR3DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.

GO - Biological processi

  1. cellular defense response Source: ProtInc
  2. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL2
Alternative name(s):
CD158 antigen-like family member K
MHC class I NK cell receptor
Natural killer-associated transcript 4
Short name:
NKAT-4
p70 natural killer cell receptor clone CL-5
Short name:
p70 NK receptor CL-5
CD_antigen: CD158k
Gene namesi
Name:KIR3DL2
Synonyms:CD158K, NKAT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

HGNCiHGNC:6339. KIR3DL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 340319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei341 – 36020HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 45595CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30124.

Polymorphism and mutation databases

BioMutaiKIR3DL2.
DMDMi1171729.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 455434Killer cell immunoglobulin-like receptor 3DL2PRO_0000015090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 95By similarity
Disulfide bondi144 ↔ 195By similarity
Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi244 ↔ 293By similarity
Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43630.
PRIDEiP43630.

PTM databases

PhosphoSiteiP43630.

Expressioni

Gene expression databases

ExpressionAtlasiP43630. baseline.
GenevestigatoriP43630.

Interactioni

Protein-protein interaction databases

BioGridi110013. 2 interactions.
IntActiP43630. 1 interaction.
STRINGi9606.ENSP00000325525.

Structurei

3D structure databases

SMRiP43630. Positions 28-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10261Ig-like C2-type 1Add
BLAST
Domaini137 – 20266Ig-like C2-type 2Add
BLAST
Domaini237 – 30064Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43630.
KOiK07980.
OrthoDBiEOG7H792J.
PhylomeDBiP43630.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH
60 70 80 90 100
YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP
110 120 130 140 150
HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF
160 170 180 190 200
EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP
210 220 230 240 250
HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY
260 270 280 290 300
DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL
310 320 330 340 350
PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF
360 370 380 390 400
LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ
410 420 430 440 450
LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG

LEGVF
Length:455
Mass (Da):50,230
Last modified:November 1, 1995 - v1
Checksum:iDB4BA6BB6B3C2945
GO
Isoform 2 (identifier: P43630-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     318-334: Missing.

Show »
Length:438
Mass (Da):48,517
Checksum:iF762B713D6EB916C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti40 – 401P → A.2 Publications
VAR_010325
Natural varianti113 – 1131L → V.2 Publications
Corresponds to variant rs17412418 [ dbSNP | Ensembl ].
VAR_010326
Natural varianti132 – 1321P → T.
Corresponds to variant rs3745894 [ dbSNP | Ensembl ].
VAR_049991
Natural varianti158 – 1581E → D.3 Publications
Corresponds to variant rs1048270 [ dbSNP | Ensembl ].
VAR_010327
Natural varianti166 – 1661R → H.2 Publications
Corresponds to variant rs1048271 [ dbSNP | Ensembl ].
VAR_010328
Natural varianti228 – 2281A → P.1 Publication
VAR_010329
Natural varianti252 – 2521I → T.1 Publication
VAR_010330
Natural varianti397 – 3971T → M.
Corresponds to variant rs3745902 [ dbSNP | Ensembl ].
VAR_049992
Natural varianti439 – 4391K → Q.
Corresponds to variant rs3745903 [ dbSNP | Ensembl ].
VAR_049993

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei318 – 33417Missing in isoform 2. 1 PublicationVSP_047374Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA. Translation: AAA69871.1.
U30272 mRNA. Translation: AAB52520.1.
X93595 mRNA. Translation: CAA63791.1.
X93596 mRNA. Translation: CAA63792.1.
X94373 mRNA. Translation: CAA64150.1.
X94374 mRNA. Translation: CAA64151.1.
L76665 mRNA. Translation: AAB36593.1.
L76666 mRNA. Translation: AAB36594.1.
AY789067 mRNA. Translation: AAX23112.1.
CCDSiCCDS12906.1. [P43630-1]
CCDS58677.1. [P43630-2]
RefSeqiNP_001229796.1. NM_001242867.1. [P43630-2]
NP_006728.2. NM_006737.3. [P43630-1]
UniGeneiHs.645228.
Hs.645532.
Hs.654605.

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809. [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474.
ENST00000611859; ENSP00000480578; ENSG00000277181. [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722. [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442.
ENST00000613612; ENSP00000482565; ENSG00000275566.
ENST00000614753; ENSP00000479299; ENSG00000276357.
ENST00000617354; ENSP00000482110; ENSG00000274722. [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083. [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361.
ENST00000617957; ENSP00000481579; ENSG00000275083. [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739. [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626.
ENST00000620817; ENSP00000479772; ENSG00000276739. [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416.
ENST00000622024; ENSP00000479425; ENSG00000276004.
ENST00000622453; ENSP00000477516; ENSG00000277181. [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809. [P43630-2]
GeneIDi3812.
KEGGihsa:3812.
UCSCiuc002qho.4. human. [P43630-1]

Polymorphism and mutation databases

BioMutaiKIR3DL2.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41270 mRNA. Translation: AAA69871.1.
U30272 mRNA. Translation: AAB52520.1.
X93595 mRNA. Translation: CAA63791.1.
X93596 mRNA. Translation: CAA63792.1.
X94373 mRNA. Translation: CAA64150.1.
X94374 mRNA. Translation: CAA64151.1.
L76665 mRNA. Translation: AAB36593.1.
L76666 mRNA. Translation: AAB36594.1.
AY789067 mRNA. Translation: AAX23112.1.
CCDSiCCDS12906.1. [P43630-1]
CCDS58677.1. [P43630-2]
RefSeqiNP_001229796.1. NM_001242867.1. [P43630-2]
NP_006728.2. NM_006737.3. [P43630-1]
UniGeneiHs.645228.
Hs.645532.
Hs.654605.

3D structure databases

SMRiP43630. Positions 28-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110013. 2 interactions.
IntActiP43630. 1 interaction.
STRINGi9606.ENSP00000325525.

PTM databases

PhosphoSiteiP43630.

Polymorphism and mutation databases

BioMutaiKIR3DL2.
DMDMi1171729.

Proteomic databases

PaxDbiP43630.
PRIDEiP43630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
ENST00000611608; ENSP00000479903; ENSG00000278809. [P43630-1]
ENST00000611628; ENSP00000481662; ENSG00000278474.
ENST00000611859; ENSP00000480578; ENSG00000277181. [P43630-2]
ENST00000612138; ENSP00000482589; ENSG00000274722. [P43630-2]
ENST00000613610; ENSP00000482301; ENSG00000278442.
ENST00000613612; ENSP00000482565; ENSG00000275566.
ENST00000614753; ENSP00000479299; ENSG00000276357.
ENST00000617354; ENSP00000482110; ENSG00000274722. [P43630-1]
ENST00000617481; ENSP00000481306; ENSG00000275083. [P43630-2]
ENST00000617666; ENSP00000481209; ENSG00000278361.
ENST00000617957; ENSP00000481579; ENSG00000275083. [P43630-1]
ENST00000618273; ENSP00000481871; ENSG00000276739. [P43630-2]
ENST00000619683; ENSP00000478251; ENSG00000275626.
ENST00000620817; ENSP00000479772; ENSG00000276739. [P43630-1]
ENST00000621155; ENSP00000477519; ENSG00000275416.
ENST00000622024; ENSP00000479425; ENSG00000276004.
ENST00000622453; ENSP00000477516; ENSG00000277181. [P43630-1]
ENST00000622579; ENSP00000482655; ENSG00000278809. [P43630-2]
GeneIDi3812.
KEGGihsa:3812.
UCSCiuc002qho.4. human. [P43630-1]

Organism-specific databases

CTDi3812.
GeneCardsiGC19P055361.
HGNCiHGNC:6339. KIR3DL2.
MIMi604947. gene.
neXtProtiNX_P43630.
PharmGKBiPA30124.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43630.
KOiK07980.
OrthoDBiEOG7H792J.
PhylomeDBiP43630.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiKIR3DL2.
GenomeRNAii3812.
NextBioi14981.
PROiP43630.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP43630. baseline.
GenevestigatoriP43630.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
    Colonna M., Samaridis J.
    Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Natural killer cell.
  2. "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
    Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
    Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood lymphocyte.
  3. "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
    Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
    J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-40; VAL-113; ASP-158 AND HIS-166.
    Tissue: Lymphoid tissue.
  4. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  5. "Variants of KIR identified in Japanese donors."
    Yawata N., Yawata M., Parham P.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-158.
  6. Cited for: VARIANTS ALA-40; VAL-113; ASP-158; HIS-166; PRO-228 AND THR-252.

Entry informationi

Entry nameiKI3L2_HUMAN
AccessioniPrimary (citable) accession number: P43630
Secondary accession number(s): Q13238
, Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 148 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.