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P43630

- KI3L2_HUMAN

UniProt

P43630 - KI3L2_HUMAN

Protein

Killer cell immunoglobulin-like receptor 3DL2

Gene

KIR3DL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.

    GO - Biological processi

    1. cellular defense response Source: ProtInc
    2. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL2
    Alternative name(s):
    CD158 antigen-like family member K
    MHC class I NK cell receptor
    Natural killer-associated transcript 4
    Short name:
    NKAT-4
    p70 natural killer cell receptor clone CL-5
    Short name:
    p70 NK receptor CL-5
    CD_antigen: CD158k
    Gene namesi
    Name:KIR3DL2
    Synonyms:CD158K, NKAT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6339. KIR3DL2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30124.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 455434Killer cell immunoglobulin-like receptor 3DL2PRO_0000015090Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 95By similarity
    Disulfide bondi144 ↔ 195By similarity
    Glycosylationi179 – 1791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi244 ↔ 293By similarity
    Glycosylationi273 – 2731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP43630.
    PRIDEiP43630.

    PTM databases

    PhosphoSiteiP43630.

    Expressioni

    Gene expression databases

    GenevestigatoriP43630.

    Interactioni

    Protein-protein interaction databases

    BioGridi110013. 2 interactions.
    IntActiP43630. 1 interaction.
    STRINGi9606.ENSP00000325525.

    Structurei

    3D structure databases

    ProteinModelPortaliP43630.
    SMRiP43630. Positions 28-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 340319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 45595CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei341 – 36020HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10261Ig-like C2-type 1Add
    BLAST
    Domaini137 – 20266Ig-like C2-type 2Add
    BLAST
    Domaini237 – 30064Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25862.
    HOGENOMiHOG000234396.
    HOVERGENiHBG074353.
    KOiK07980.
    OMAiEDAHESW.
    OrthoDBiEOG7H792J.
    PhylomeDBiP43630.
    TreeFamiTF352669.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43630-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLTVVSMAC VGFFLLQGAW PLMGGQDKPF LSARPSTVVP RGGHVALQCH    50
    YRRGFNNFML YKEDRSHVPI FHGRIFQESF IMGPVTPAHA GTYRCRGSRP 100
    HSLTGWSAPS NPLVIMVTGN HRKPSLLAHP GPLLKSGETV ILQCWSDVMF 150
    EHFFLHREGI SEDPSRLVGQ IHDGVSKANF SIGPLMPVLA GTYRCYGSVP 200
    HSPYQLSAPS DPLDIVITGL YEKPSLSAQP GPTVQAGENV TLSCSSWSSY 250
    DIYHLSREGE AHERRLRAVP KVNRTFQADF PLGPATHGGT YRCFGSFRAL 300
    PCVWSNSSDP LLVSVTGNPS SSWPSPTEPS SKSGICRHLH VLIGTSVVIF 350
    LFILLLFFLL YRWCSNKKNA AVMDQEPAGD RTVNRQDSDE QDPQEVTYAQ 400
    LDHCVFIQRK ISRPSQRPKT PLTDTSVYTE LPNAEPRSKV VSCPRAPQSG 450
    LEGVF 455
    Length:455
    Mass (Da):50,230
    Last modified:November 1, 1995 - v1
    Checksum:iDB4BA6BB6B3C2945
    GO
    Isoform 2 (identifier: P43630-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         318-334: Missing.

    Show »
    Length:438
    Mass (Da):48,517
    Checksum:iF762B713D6EB916C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401P → A.2 Publications
    VAR_010325
    Natural varianti113 – 1131L → V.2 Publications
    Corresponds to variant rs17412418 [ dbSNP | Ensembl ].
    VAR_010326
    Natural varianti132 – 1321P → T.
    Corresponds to variant rs3745894 [ dbSNP | Ensembl ].
    VAR_049991
    Natural varianti158 – 1581E → D.3 Publications
    Corresponds to variant rs1048270 [ dbSNP | Ensembl ].
    VAR_010327
    Natural varianti166 – 1661R → H.2 Publications
    Corresponds to variant rs1048271 [ dbSNP | Ensembl ].
    VAR_010328
    Natural varianti228 – 2281A → P.1 Publication
    VAR_010329
    Natural varianti252 – 2521I → T.1 Publication
    VAR_010330
    Natural varianti397 – 3971T → M.
    Corresponds to variant rs3745902 [ dbSNP | Ensembl ].
    VAR_049992
    Natural varianti439 – 4391K → Q.
    Corresponds to variant rs3745903 [ dbSNP | Ensembl ].
    VAR_049993

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei318 – 33417Missing in isoform 2. 1 PublicationVSP_047374Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41270 mRNA. Translation: AAA69871.1.
    U30272 mRNA. Translation: AAB52520.1.
    X93595 mRNA. Translation: CAA63791.1.
    X93596 mRNA. Translation: CAA63792.1.
    X94373 mRNA. Translation: CAA64150.1.
    X94374 mRNA. Translation: CAA64151.1.
    L76665 mRNA. Translation: AAB36593.1.
    L76666 mRNA. Translation: AAB36594.1.
    AY789067 mRNA. Translation: AAX23112.1.
    CCDSiCCDS12906.1. [P43630-1]
    CCDS58677.1. [P43630-2]
    RefSeqiNP_001229796.1. NM_001242867.1. [P43630-2]
    NP_006728.2. NM_006737.3. [P43630-1]
    UniGeneiHs.645228.
    Hs.645532.
    Hs.654605.

    Genome annotation databases

    EnsembliENST00000270442; ENSP00000270442; ENSG00000240403. [P43630-2]
    ENST00000326321; ENSP00000325525; ENSG00000240403. [P43630-1]
    GeneIDi3812.
    KEGGihsa:3812.
    UCSCiuc002qho.4. human. [P43630-1]

    Polymorphism databases

    DMDMi1171729.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41270 mRNA. Translation: AAA69871.1 .
    U30272 mRNA. Translation: AAB52520.1 .
    X93595 mRNA. Translation: CAA63791.1 .
    X93596 mRNA. Translation: CAA63792.1 .
    X94373 mRNA. Translation: CAA64150.1 .
    X94374 mRNA. Translation: CAA64151.1 .
    L76665 mRNA. Translation: AAB36593.1 .
    L76666 mRNA. Translation: AAB36594.1 .
    AY789067 mRNA. Translation: AAX23112.1 .
    CCDSi CCDS12906.1. [P43630-1 ]
    CCDS58677.1. [P43630-2 ]
    RefSeqi NP_001229796.1. NM_001242867.1. [P43630-2 ]
    NP_006728.2. NM_006737.3. [P43630-1 ]
    UniGenei Hs.645228.
    Hs.645532.
    Hs.654605.

    3D structure databases

    ProteinModelPortali P43630.
    SMRi P43630. Positions 28-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110013. 2 interactions.
    IntActi P43630. 1 interaction.
    STRINGi 9606.ENSP00000325525.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P43630.

    Polymorphism databases

    DMDMi 1171729.

    Proteomic databases

    PaxDbi P43630.
    PRIDEi P43630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270442 ; ENSP00000270442 ; ENSG00000240403 . [P43630-2 ]
    ENST00000326321 ; ENSP00000325525 ; ENSG00000240403 . [P43630-1 ]
    GeneIDi 3812.
    KEGGi hsa:3812.
    UCSCi uc002qho.4. human. [P43630-1 ]

    Organism-specific databases

    CTDi 3812.
    GeneCardsi GC19P055361.
    HGNCi HGNC:6339. KIR3DL2.
    MIMi 604947. gene.
    neXtProti NX_P43630.
    PharmGKBi PA30124.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25862.
    HOGENOMi HOG000234396.
    HOVERGENi HBG074353.
    KOi K07980.
    OMAi EDAHESW.
    OrthoDBi EOG7H792J.
    PhylomeDBi P43630.
    TreeFami TF352669.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii KIR3DL2.
    GenomeRNAii 3812.
    NextBioi 14981.
    PROi P43630.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P43630.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M., Samaridis J.
      Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Natural killer cell.
    2. "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
      Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
      Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Peripheral blood lymphocyte.
    3. "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
      Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
      J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS ALA-40; VAL-113; ASP-158 AND HIS-166.
      Tissue: Lymphoid tissue.
    4. "Alternatively spliced forms of human killer inhibitory receptors."
      Doehring C., Samaridis J., Colonna M.
      Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. "Variants of KIR identified in Japanese donors."
      Yawata N., Yawata M., Parham P.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT ASP-158.
    6. Cited for: VARIANTS ALA-40; VAL-113; ASP-158; HIS-166; PRO-228 AND THR-252.

    Entry informationi

    Entry nameiKI3L2_HUMAN
    AccessioniPrimary (citable) accession number: P43630
    Secondary accession number(s): Q13238
    , Q14947, Q14948, Q92684, Q95366, Q95367, Q95368
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 144 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3