Killer cell immunoglobulin-like receptor 3DL1 precursor

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P43629 (KI3L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 115. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Killer cell immunoglobulin-like receptor 3DL1

Alternative name(s):
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
MHC class I NK cell receptor
Natural killer-associated transcript 3
Short name=NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
Short name=p70 NK receptor CL-2/CL-11
CD_antigen=CD158e

Gene names

Name:	KIR3DL1
Synonyms:	CD158E, NKAT3, NKB1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	immune response Non-traceable author statement Ref.1. Source: UniProtKB regulation of immune response Traceable author statement. Source: Reactome
Cellular component	integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB
Molecular function	HLA-B specific inhibitory MHC class I receptor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 21

By similarity

Chain

22 – 444

423

Killer cell immunoglobulin-like receptor 3DL1

PRO_0000015087

Regions

Topological domain

22 – 340

319

Extracellular Potential

Transmembrane

341 – 360

Helical; Potential

Topological domain

361 – 444

Cytoplasmic Potential

Domain

42 – 102

Ig-like C2-type 1

Domain

137 – 202

Ig-like C2-type 2

Domain

237 – 300

Ig-like C2-type 3

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

179

N-linked (GlcNAc...) Potential

Glycosylation

273

N-linked (GlcNAc...) Potential

Disulfide bond

49 ↔ 95

By similarity

Disulfide bond

144 ↔ 195

By similarity

Disulfide bond

244 ↔ 293

By similarity

Natural variations

Natural variant

S → L.
Corresponds to variant rs605219 [ dbSNP | Ensembl ].

VAR_010319

Natural variant

L → F.

VAR_010320

Natural variant

M → V.

VAR_010321

Natural variant

I → V.
Corresponds to variant rs45556431 [ dbSNP | Ensembl ].

VAR_010322

Natural variant

I → L.
Corresponds to variant rs1049150 [ dbSNP | Ensembl ].

VAR_010323

Natural variant

203

P → S.
Corresponds to variant rs2273731 [ dbSNP | Ensembl ].

VAR_049987

Natural variant

220

P → L.
Corresponds to variant rs680891 [ dbSNP | Ensembl ].

VAR_049988

Natural variant

259

G → R.
Corresponds to variant rs1049215 [ dbSNP | Ensembl ].

VAR_010336

Natural variant

333

S → C.

VAR_010324

Natural variant

362

L → R.
Corresponds to variant rs1130468 [ dbSNP | Ensembl ].

VAR_049989

Natural variant

394

E → Q.
Corresponds to variant rs1130513 [ dbSNP | Ensembl ].

VAR_049990

Sequences

Sequence

Length

Mass (Da)

Tools

P43629 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 47DEA12BBAFDEC53
Show »

FASTA

444

49,098

        10         20         30         40         50         60 
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 

        70         80         90        100        110        120 
YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 

       130        140        150        160        170        180 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 

       190        200        210        220        230        240 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 

       250        260        270        280        290        300 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 

       310        320        330        340        350        360 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 

       370        380        390        400        410        420 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 

       430        440 
PPTDTILYTE LPNAKPRSKV VSCP

« Hide

References

[1]	"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." Colonna M., Samaridis J. Science 268:405-408(1995) [PubMed: 7716543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Natural killer cell.
[2]	"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer." Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O. Immunity 3:801-809(1995) [PubMed: 8777725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte.
[3]	"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer." Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L. J. Exp. Med. 184:505-518(1996) [PubMed: 8760804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte.
[4]	"Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes." D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L. J. Immunol. 155:2306-2310(1995) [PubMed: 7650366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[5]	"Human diversity in killer cell inhibitory receptor genes." Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P. Immunity 7:753-763(1997) [PubMed: 9430221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.

IPI

IPI00940648.

PIR

G01924.
G01925.

RefSeq

NP_037421.2. NM_013289.2.

UniGene

Hs.645228.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3VH8	X-ray	1.80	G/H	22-320	[»]

ProteinModelPortal

P43629.

SMR

P43629. Positions 25-316.

ModBase

Search...

Protein-protein interaction databases

IntAct

P43629. 1 interaction.

STRING

P43629.

PTM databases

PhosphoSite

P43629.

Polymorphism databases

DMDM

1171728.

Proteomic databases

PRIDE

P43629.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000391728; ENSP00000375608; ENSG00000167633.

GeneID

3811.

KEGG

hsa:3811.

UCSC

uc002qhd.2. human.

Organism-specific databases

CTD

3811.

GeneCards

GC19P055253.

HGNC

HGNC:6338. KIR3DL1.

MIM

604946. gene.

neXtProt

NX_P43629.

PharmGKB

PA30123.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG074353.

InParanoid

P43629.

OMA

RTVNTED.

OrthoDB

EOG4RJG1X.

PhylomeDB

P43629.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P43629.

Bgee

P43629.

CleanEx

HS_KIR3DL1.

Genevestigator

P43629.

GermOnline

ENSG00000167633. Homo sapiens.

Family and domain databases

InterPro

IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

K07980.

Pfam

PF00047. ig. 2 hits.
[Graphical view]

SMART

SM00409. IG. 3 hits.
[Graphical view]

PROSITE

PS50835. IG_LIKE. False negative.
[Graphical view]

ProtoNet

Search...

Other

NextBio

14977.

SOURCE

Search...

Entry information

Entry name

KI3L1_HUMAN

Accession

Primary (citable) accession number: P43629
Secondary accession number(s): O43473, Q16541

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 25, 2012
This is version 115 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.