Reviewed, UniProtKB/Swiss-Prot P43629 (KI3L1_HUMAN)

Names and origin

Protein names

Recommended name:
    Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
    MHC class I NK cell receptor
    Natural killer-associated transcript 3
      Short name=NKAT-3
    p70 natural killer cell receptor clones CL-2/CL-11
    HLA-BW4-specific inhibitory NK cell receptor
    CD158 antigen-like family member E
    CD_antigen=CD158e

Gene names

Name:	KIR3DL1
Synonyms:	CD158E, NKAT3, NKB1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	444 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the immunoglobulin superfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	immune response Ref.1 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.1 Non-traceable author statement. Source: UniProtKB
Molecular function	HLA-B specific inhibitory MHC class I receptor activity Ref.4 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	By similarity
	Chain	22 – 444	423	Killer cell immunoglobulin-like receptor 3DL1		PRO_0000015087
Regions
	Topological domain	22 – 340	319	Extracellular Potential
	Transmembrane	341 – 360	20	Potential
	Topological domain	361 – 444	84	Cytoplasmic Potential
	Domain	42 – 102	61	Ig-like C2-type 1
	Domain	137 – 202	66	Ig-like C2-type 2
	Domain	237 – 300	64	Ig-like C2-type 3
Amino acid modifications
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
	Glycosylation	179	1	N-linked (GlcNAc...) Potential
	Glycosylation	273	1	N-linked (GlcNAc...) Potential
	Disulfide bond	49 ↔ 95		By similarity
	Disulfide bond	144 ↔ 195		By similarity
	Disulfide bond	244 ↔ 293		By similarity
Natural variations
	Natural variant	2	1	S → L: dbSNP rs605219.		VAR_010319
	Natural variant	13	1	L → F		VAR_010320
	Natural variant	23	1	M → V		VAR_010321
	Natural variant	68	1	I → V: dbSNP rs45556431.		VAR_010322
	Natural variant	75	1	I → L: dbSNP rs1049150.		VAR_010323
	Natural variant	203	1	P → S: dbSNP rs2273731.		VAR_049987
	Natural variant	220	1	P → L: dbSNP rs680891.		VAR_049988
	Natural variant	259	1	G → R: dbSNP rs1049215.		VAR_010336
	Natural variant	333	1	S → C		VAR_010324
	Natural variant	362	1	L → R: dbSNP rs1130468.		VAR_049989
	Natural variant	394	1	E → Q: dbSNP rs1130513.		VAR_049990

Sequences

	Sequence		Length	Mass (Da)
	P43629-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 47DEA12BBAFDEC53	FASTA	444	49,098
	10 20 30 40 50 60 MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 70 80 90 100 110 120 YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 130 140 150 160 170 180 HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 190 200 210 220 230 240 SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 250 260 270 280 290 300 TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 310 320 330 340 350 360 PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 370 380 390 400 410 420 HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 430 440 PPTDTILYTE LPNAKPRSKV VSCP

References

[1]	"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells." Colonna M., Samaridis J. Science 268:405-408(1995) [PubMed: 7716543] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Natural killer cell.
[2]	"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer." Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O. Immunity 3:801-809(1995) [PubMed: 8777725] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte.
[3]	"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer." Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L. J. Exp. Med. 184:505-518(1996) [PubMed: 8760804] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Peripheral blood lymphocyte.
[4]	"Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes." D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L. J. Immunol. 155:2306-2310(1995) [PubMed: 7650366] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[5]	"Human diversity in killer cell inhibitory receptor genes." Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P. Immunity 7:753-763(1997) [PubMed: 9430221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L41269 mRNA. Translation: AAA69870.1. U30273 mRNA. Translation: AAB52521.1. U30274 mRNA. Translation: AAB52522.1. X94262 mRNA. Translation: CAA63938.1. U31416 mRNA. Translation: AAC23725.1. AF022049 mRNA. Translation: AAB95322.1.
IPI	IPI00940648.
PIR	G01924. G01925.
RefSeq	NP_037421.2.
UniGene	Hs.645228
3D structure databases
HSSP	HSSP built from PDB template 1B6U based on UniProtKB P43628.
SMR	P43629. Positions 121-319.
ModBase	Search...
Protein-protein interaction databases
STRING	P43629.
PTM databases
PhosphoSite	P43629.
Genome annotation databases
Ensembl	ENST00000270442; ENSP00000270442; ENSG00000167633; Homo sapiens. [Genome view] ENST00000326321; ENSP00000325525; ENSG00000167633; Homo sapiens. [Genome view] ENST00000326542; ENSP00000326868; ENSG00000167633; Homo sapiens. [Genome view] ENST00000355608; ENSP00000347819; ENSG00000167633; Homo sapiens. [Genome view] ENST00000358178; ENSP00000350901; ENSG00000167633; Homo sapiens. [Genome view] ENST00000391728; ENSP00000375608; ENSG00000167633; Homo sapiens. [Genome view]
GeneID	3811.
KEGG	hsa:3811.
UCSC	uc002qhd.2. human.
Organism-specific databases
CTD	3811.
GeneCards	GC19P060019.
HGNC	HGNC:6338. KIR3DL1.
MIM	604946. gene.
PharmGKB	PA30123.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P43629.
OMA	ESFNMSP.
Enzyme and pathway databases
Reactome	REACT_6900. Signaling in Immune system.
Gene expression databases
Bgee	P43629.
CleanEx	HS_KIR3DL1.
Genevestigator	P43629.
GermOnline	ENSG00000167633. Homo sapiens.
Family and domain databases
InterPro	IPR013151. Ig. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF00047. ig. 3 hits. [Graphical view]
SMART	SM00409. IG. 3 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	14977.
SOURCE	Search...

Entry information

Entry name

KI3L1_HUMAN

Accession

Primary (citable) accession number: P43629
Secondary accession number(s): O43473, Q16541

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 3, 2009
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.