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Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

KIR3DL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  • HLA-B specific inhibitory MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  • immune response Source: UniProtKB
  • natural killer cell mediated cytotoxicity Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SIGNORiP43629.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
MHC class I NK cell receptor
Natural killer-associated transcript 3
Short name:
NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
Short name:
p70 NK receptor CL-2/CL-11
CD_antigen: CD158e
Gene namesi
Name:KIR3DL1
Synonyms:CD158E, NKAT3, NKB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6338. KIR3DL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 340ExtracellularSequence analysisAdd BLAST319
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Topological domaini361 – 444CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3811.
MalaCardsiKIR3DL1.
OpenTargetsiENSG00000167633.
ENSG00000274036.
ENSG00000275288.
ENSG00000276423.
PharmGKBiPA30123.

Polymorphism and mutation databases

BioMutaiKIR3DL1.
DMDMi1171728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508722 – 444Killer cell immunoglobulin-like receptor 3DL1Add BLAST423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 951 Publication
Glycosylationi92N-linked (GlcNAc...)1 Publication1
Disulfide bondi144 ↔ 1951 Publication
Glycosylationi179N-linked (GlcNAc...)1 Publication1
Disulfide bondi244 ↔ 2931 Publication
Glycosylationi273N-linked (GlcNAc...)1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43629.
PeptideAtlasiP43629.
PRIDEiP43629.

PTM databases

iPTMnetiP43629.
PhosphoSitePlusiP43629.

Expressioni

Gene expression databases

BgeeiENSG00000167633.
CleanExiHS_KIR3DL1.
ExpressionAtlasiP43629. baseline and differential.
GenevisibleiP43629. HS.

Organism-specific databases

HPAiCAB032997.
CAB032999.

Interactioni

Protein-protein interaction databases

BioGridi110012. 5 interactors.
IntActiP43629. 2 interactors.
STRINGi9606.ENSP00000375608.

Structurei

Secondary structure

1444
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 51Combined sources7
Beta strandi52 – 54Combined sources3
Beta strandi57 – 64Combined sources8
Beta strandi66 – 68Combined sources3
Helixi70 – 73Combined sources4
Beta strandi76 – 78Combined sources3
Beta strandi80 – 82Combined sources3
Helixi87 – 89Combined sources3
Beta strandi91 – 98Combined sources8
Beta strandi100 – 106Combined sources7
Beta strandi113 – 118Combined sources6
Beta strandi125 – 130Combined sources6
Beta strandi132 – 135Combined sources4
Beta strandi140 – 148Combined sources9
Beta strandi151 – 157Combined sources7
Beta strandi165 – 168Combined sources4
Beta strandi170 – 172Combined sources3
Beta strandi175 – 182Combined sources8
Helixi187 – 189Combined sources3
Beta strandi191 – 198Combined sources8
Beta strandi213 – 218Combined sources6
Beta strandi225 – 230Combined sources6
Beta strandi241 – 248Combined sources8
Beta strandi251 – 257Combined sources7
Turni258 – 260Combined sources3
Beta strandi264 – 267Combined sources4
Beta strandi276 – 281Combined sources6
Beta strandi289 – 297Combined sources9
Beta strandi311 – 313Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
3WUWX-ray2.00G28-313[»]
5B38X-ray2.30G22-320[»]
5B39X-ray2.50G22-320[»]
ProteinModelPortaliP43629.
SMRiP43629.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 102Ig-like C2-type 1Add BLAST61
Domaini137 – 202Ig-like C2-type 2Add BLAST66
Domaini237 – 300Ig-like C2-type 3Add BLAST64

Domaini

Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.1 Publication

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43629.
KOiK07980.
PhylomeDBiP43629.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII
360 370 380 390 400
LFILLLFFLL HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ
410 420 430 440
LDHCVFTQRK ITRPSQRPKT PPTDTILYTE LPNAKPRSKV VSCP
Length:444
Mass (Da):49,098
Last modified:November 1, 1995 - v1
Checksum:i47DEA12BBAFDEC53
GO
Isoform 2 (identifier: P43629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Show »
Length:349
Mass (Da):38,403
Checksum:i250F6C7D25DC0A13
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0103192S → L.Corresponds to variant rs605219dbSNPEnsembl.1
Natural variantiVAR_01032013L → F.Corresponds to variant rs1142881dbSNPEnsembl.1
Natural variantiVAR_01032123M → V.Corresponds to variant rs1142882dbSNPEnsembl.1
Natural variantiVAR_01032268I → V.Corresponds to variant rs45556431dbSNPEnsembl.1
Natural variantiVAR_01032375I → L.Corresponds to variant rs1049150dbSNPEnsembl.1
Natural variantiVAR_049987203P → S.Corresponds to variant rs2273731dbSNPEnsembl.1
Natural variantiVAR_049988220P → L.Corresponds to variant rs680891dbSNPEnsembl.1
Natural variantiVAR_010336259G → R.Corresponds to variant rs1049215dbSNPEnsembl.1
Natural variantiVAR_010324333S → C.1
Natural variantiVAR_049989362L → R.Corresponds to variant rs1130468dbSNPEnsembl.1
Natural variantiVAR_049990394E → Q.Corresponds to variant rs1130513dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04763325 – 119Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.
L76664 mRNA. Translation: AAB36592.1.
AC006293 Genomic DNA. No translation available.
AC011501 Genomic DNA. No translation available.
CCDSiCCDS42621.1. [P43629-1]
PIRiG01924.
G01925.
RefSeqiNP_001309097.1. NM_001322168.1.
NP_037421.2. NM_013289.2. [P43629-1]
UniGeneiHs.645228.

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036. [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288. [P43629-1]
ENST00000616945; ENSP00000481802; ENSG00000274036. [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423. [P43629-1]
ENST00000621398; ENSP00000479009; ENSG00000275288. [P43629-1]
GeneIDi3811.
KEGGihsa:3811.
UCSCiuc010esf.4. human. [P43629-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.
L76664 mRNA. Translation: AAB36592.1.
AC006293 Genomic DNA. No translation available.
AC011501 Genomic DNA. No translation available.
CCDSiCCDS42621.1. [P43629-1]
PIRiG01924.
G01925.
RefSeqiNP_001309097.1. NM_001322168.1.
NP_037421.2. NM_013289.2. [P43629-1]
UniGeneiHs.645228.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
3WUWX-ray2.00G28-313[»]
5B38X-ray2.30G22-320[»]
5B39X-ray2.50G22-320[»]
ProteinModelPortaliP43629.
SMRiP43629.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110012. 5 interactors.
IntActiP43629. 2 interactors.
STRINGi9606.ENSP00000375608.

PTM databases

iPTMnetiP43629.
PhosphoSitePlusiP43629.

Polymorphism and mutation databases

BioMutaiKIR3DL1.
DMDMi1171728.

Proteomic databases

PaxDbiP43629.
PeptideAtlasiP43629.
PRIDEiP43629.

Protocols and materials databases

DNASUi3811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036. [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288. [P43629-1]
ENST00000616945; ENSP00000481802; ENSG00000274036. [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423. [P43629-1]
ENST00000621398; ENSP00000479009; ENSG00000275288. [P43629-1]
GeneIDi3811.
KEGGihsa:3811.
UCSCiuc010esf.4. human. [P43629-1]

Organism-specific databases

CTDi3811.
DisGeNETi3811.
GeneCardsiKIR3DL1.
HGNCiHGNC:6338. KIR3DL1.
HPAiCAB032997.
CAB032999.
MalaCardsiKIR3DL1.
MIMi604946. gene.
neXtProtiNX_P43629.
OpenTargetsiENSG00000167633.
ENSG00000274036.
ENSG00000275288.
ENSG00000276423.
PharmGKBiPA30123.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JAMM. Eukaryota.
ENOG410ZT7K. LUCA.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43629.
KOiK07980.
PhylomeDBiP43629.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SIGNORiP43629.

Miscellaneous databases

GeneWikiiKIR3DL1.
GenomeRNAii3811.
PROiP43629.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167633.
CleanExiHS_KIR3DL1.
ExpressionAtlasiP43629. baseline and differential.
GenevisibleiP43629. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 3 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI3L1_HUMAN
AccessioniPrimary (citable) accession number: P43629
Secondary accession number(s): O43473, Q14946, Q16541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 159 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.