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Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

KIR3DL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  1. HLA-B specific inhibitory MHC class I receptor activity Source: UniProtKB

GO - Biological processi

  1. immune response Source: UniProtKB
  2. natural killer cell mediated cytotoxicity Source: UniProtKB
  3. regulation of immune response Source: Reactome
  4. signal transduction Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
MHC class I NK cell receptor
Natural killer-associated transcript 3
Short name:
NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
Short name:
p70 NK receptor CL-2/CL-11
CD_antigen: CD158e
Gene namesi
Name:KIR3DL1
Synonyms:CD158E, NKAT3, NKB1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 19, Unplaced

Organism-specific databases

HGNCiHGNC:6338. KIR3DL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 340319ExtracellularSequence AnalysisAdd
BLAST
Transmembranei341 – 36020HelicalSequence AnalysisAdd
BLAST
Topological domaini361 – 44484CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30123.

Polymorphism and mutation databases

BioMutaiKIR3DL1.
DMDMi1171728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 444423Killer cell immunoglobulin-like receptor 3DL1PRO_0000015087Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 951 Publication
Glycosylationi92 – 921N-linked (GlcNAc...)1 Publication
Disulfide bondi144 ↔ 1951 Publication
Glycosylationi179 – 1791N-linked (GlcNAc...)1 Publication
Disulfide bondi244 ↔ 2931 Publication
Glycosylationi273 – 2731N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43629.
PRIDEiP43629.

PTM databases

PhosphoSiteiP43629.

Expressioni

Gene expression databases

BgeeiP43629.
CleanExiHS_KIR3DL1.
ExpressionAtlasiP43629. baseline and differential.
GenevestigatoriP43629.

Interactioni

Protein-protein interaction databases

BioGridi110012. 5 interactions.
IntActiP43629. 2 interactions.
STRINGi9606.ENSP00000375608.

Structurei

Secondary structure

1
444
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356Combined sources
Beta strandi37 – 404Combined sources
Beta strandi45 – 517Combined sources
Beta strandi57 – 648Combined sources
Beta strandi66 – 683Combined sources
Helixi70 – 734Combined sources
Beta strandi76 – 783Combined sources
Beta strandi80 – 823Combined sources
Helixi87 – 893Combined sources
Beta strandi91 – 988Combined sources
Beta strandi100 – 1067Combined sources
Beta strandi113 – 1186Combined sources
Beta strandi125 – 1306Combined sources
Beta strandi132 – 1354Combined sources
Beta strandi140 – 1489Combined sources
Beta strandi151 – 1577Combined sources
Beta strandi165 – 1684Combined sources
Beta strandi170 – 1723Combined sources
Beta strandi175 – 1828Combined sources
Helixi187 – 1893Combined sources
Beta strandi191 – 1988Combined sources
Beta strandi213 – 2186Combined sources
Beta strandi225 – 2306Combined sources
Beta strandi241 – 2488Combined sources
Beta strandi251 – 2577Combined sources
Turni258 – 2603Combined sources
Beta strandi264 – 2674Combined sources
Beta strandi276 – 2816Combined sources
Beta strandi289 – 2979Combined sources
Beta strandi311 – 3133Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
3WUWX-ray2.00G28-313[»]
ProteinModelPortaliP43629.
SMRiP43629. Positions 28-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10261Ig-like C2-type 1Add
BLAST
Domaini137 – 20266Ig-like C2-type 2Add
BLAST
Domaini237 – 30064Ig-like C2-type 3Add
BLAST

Domaini

Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.1 Publication

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43629.
KOiK07980.
OMAiEGEAREY.
OrthoDBiEOG7H792J.
PhylomeDBiP43629.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43629-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH
60 70 80 90 100
YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP
110 120 130 140 150
HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF
160 170 180 190 200
EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT
210 220 230 240 250
HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY
260 270 280 290 300
DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS
310 320 330 340 350
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII
360 370 380 390 400
LFILLLFFLL HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ
410 420 430 440
LDHCVFTQRK ITRPSQRPKT PPTDTILYTE LPNAKPRSKV VSCP
Length:444
Mass (Da):49,098
Last modified:November 1, 1995 - v1
Checksum:i47DEA12BBAFDEC53
GO
Isoform 2 (identifier: P43629-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Show »
Length:349
Mass (Da):38,403
Checksum:i250F6C7D25DC0A13
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21S → L.
Corresponds to variant rs605219 [ dbSNP | Ensembl ].
VAR_010319
Natural varianti13 – 131L → F.
VAR_010320
Natural varianti23 – 231M → V.
VAR_010321
Natural varianti68 – 681I → V.
Corresponds to variant rs45556431 [ dbSNP | Ensembl ].
VAR_010322
Natural varianti75 – 751I → L.
Corresponds to variant rs1049150 [ dbSNP | Ensembl ].
VAR_010323
Natural varianti203 – 2031P → S.
Corresponds to variant rs2273731 [ dbSNP | Ensembl ].
VAR_049987
Natural varianti220 – 2201P → L.
Corresponds to variant rs680891 [ dbSNP | Ensembl ].
VAR_049988
Natural varianti259 – 2591G → R.
Corresponds to variant rs1049215 [ dbSNP | Ensembl ].
VAR_010336
Natural varianti333 – 3331S → C.
VAR_010324
Natural varianti362 – 3621L → R.
Corresponds to variant rs1130468 [ dbSNP | Ensembl ].
VAR_049989
Natural varianti394 – 3941E → Q.
Corresponds to variant rs1130513 [ dbSNP | Ensembl ].
VAR_049990

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei25 – 11995Missing in isoform 2. 1 PublicationVSP_047633Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.
L76664 mRNA. Translation: AAB36592.1.
AC006293 Genomic DNA. No translation available.
AC011501 Genomic DNA. No translation available.
CCDSiCCDS42621.1. [P43629-1]
PIRiG01924.
G01925.
RefSeqiNP_037421.2. NM_013289.2. [P43629-1]
UniGeneiHs.645228.

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036. [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288. [P43629-1]
ENST00000616945; ENSP00000481802; ENSG00000274036. [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423. [P43629-1]
ENST00000621398; ENSP00000479009; ENSG00000275288. [P43629-1]
GeneIDi3811.
KEGGihsa:3811.
UCSCiuc002qhk.4. human. [P43629-1]
uc010esf.3. human.

Polymorphism and mutation databases

BioMutaiKIR3DL1.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.
L76664 mRNA. Translation: AAB36592.1.
AC006293 Genomic DNA. No translation available.
AC011501 Genomic DNA. No translation available.
CCDSiCCDS42621.1. [P43629-1]
PIRiG01924.
G01925.
RefSeqiNP_037421.2. NM_013289.2. [P43629-1]
UniGeneiHs.645228.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
3WUWX-ray2.00G28-313[»]
ProteinModelPortaliP43629.
SMRiP43629. Positions 28-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110012. 5 interactions.
IntActiP43629. 2 interactions.
STRINGi9606.ENSP00000375608.

PTM databases

PhosphoSiteiP43629.

Polymorphism and mutation databases

BioMutaiKIR3DL1.
DMDMi1171728.

Proteomic databases

PaxDbiP43629.
PRIDEiP43629.

Protocols and materials databases

DNASUi3811.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
ENST00000612668; ENSP00000484488; ENSG00000274036. [P43629-1]
ENST00000616188; ENSP00000484036; ENSG00000275288. [P43629-1]
ENST00000616945; ENSP00000481802; ENSG00000274036. [P43629-1]
ENST00000621353; ENSP00000484972; ENSG00000276423. [P43629-1]
ENST00000621398; ENSP00000479009; ENSG00000275288. [P43629-1]
GeneIDi3811.
KEGGihsa:3811.
UCSCiuc002qhk.4. human. [P43629-1]
uc010esf.3. human.

Organism-specific databases

CTDi3811.
GeneCardsiGC19P055278.
HGNCiHGNC:6338. KIR3DL1.
MIMi604946. gene.
neXtProtiNX_P43629.
PharmGKBiPA30123.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25862.
GeneTreeiENSGT00760000119033.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43629.
KOiK07980.
OMAiEGEAREY.
OrthoDBiEOG7H792J.
PhylomeDBiP43629.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

GeneWikiiKIR3DL1.
GenomeRNAii3811.
NextBioi14977.
PROiP43629.
SOURCEiSearch...

Gene expression databases

BgeeiP43629.
CleanExiHS_KIR3DL1.
ExpressionAtlasiP43629. baseline and differential.
GenevestigatoriP43629.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
    Colonna M., Samaridis J.
    Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Natural killer cell.
  2. "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
    Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
    Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood lymphocyte.
  3. "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
    Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
    J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Peripheral blood lymphocyte.
  4. "Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes."
    D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L.
    J. Immunol. 155:2306-2310(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Blood.
  5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS.
  6. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-320 IN COMPLEX WITH PEPTIDE-LOADED HLA-B, FUNCTION, GLYCOSYLATION AT ASN-92; ASN-179 AND ASN-273, DISULFIDE BONDS.

Entry informationi

Entry nameiKI3L1_HUMAN
AccessioniPrimary (citable) accession number: P43629
Secondary accession number(s): O43473, Q14946, Q16541
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 29, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.