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P43629 (KI3L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 3DL1
Alternative name(s):
CD158 antigen-like family member E
HLA-BW4-specific inhibitory NK cell receptor
MHC class I NK cell receptor
Natural killer-associated transcript 3
Short name=NKAT-3
p70 natural killer cell receptor clones CL-2/CL-11
Short name=p70 NK receptor CL-2/CL-11
CD_antigen=CD158e
Gene names
Name:KIR3DL1
Synonyms:CD158E, NKAT3, NKB1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length444 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Ref.8

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Domain

Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope (Ref.8).

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P43629-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P43629-2)

The sequence of this isoform differs from the canonical sequence as follows:
     25-119: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 By similarity
Chain22 – 444423Killer cell immunoglobulin-like receptor 3DL1
PRO_0000015087

Regions

Topological domain22 – 340319Extracellular Potential
Transmembrane341 – 36020Helical; Potential
Topological domain361 – 44484Cytoplasmic Potential
Domain42 – 10261Ig-like C2-type 1
Domain137 – 20266Ig-like C2-type 2
Domain237 – 30064Ig-like C2-type 3

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Ref.8
Glycosylation1791N-linked (GlcNAc...) Ref.8
Glycosylation2731N-linked (GlcNAc...) Ref.8
Disulfide bond49 ↔ 95 Ref.8
Disulfide bond144 ↔ 195 Ref.8
Disulfide bond244 ↔ 293 Ref.8

Natural variations

Alternative sequence25 – 11995Missing in isoform 2.
VSP_047633
Natural variant21S → L.
Corresponds to variant rs605219 [ dbSNP | Ensembl ].
VAR_010319
Natural variant131L → F.
VAR_010320
Natural variant231M → V.
VAR_010321
Natural variant681I → V.
Corresponds to variant rs45556431 [ dbSNP | Ensembl ].
VAR_010322
Natural variant751I → L.
Corresponds to variant rs1049150 [ dbSNP | Ensembl ].
VAR_010323
Natural variant2031P → S.
Corresponds to variant rs2273731 [ dbSNP | Ensembl ].
VAR_049987
Natural variant2201P → L.
Corresponds to variant rs680891 [ dbSNP | Ensembl ].
VAR_049988
Natural variant2591G → R.
Corresponds to variant rs1049215 [ dbSNP | Ensembl ].
VAR_010336
Natural variant3331S → C.
VAR_010324
Natural variant3621L → R.
Corresponds to variant rs1130468 [ dbSNP | Ensembl ].
VAR_049989
Natural variant3941E → Q.
Corresponds to variant rs1130513 [ dbSNP | Ensembl ].
VAR_049990

Secondary structure

........................................................... 444
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 47DEA12BBAFDEC53

FASTA44449,098
        10         20         30         40         50         60 
MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH YRHRFNNFML 

        70         80         90        100        110        120 
YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP HSPTGWSAPS NPVVIMVTGN 

       130        140        150        160        170        180 
HRKPSLLAHP GPLVKSGERV ILQCWSDIMF EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF 

       190        200        210        220        230        240 
SIGPMMLALA GTYRCYGSVT HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV 

       250        260        270        280        290        300 
TLSCSSRSSY DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 

       310        320        330        340        350        360 
PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII LFILLLFFLL 

       370        380        390        400        410        420 
HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ LDHCVFTQRK ITRPSQRPKT 

       430        440 
PPTDTILYTE LPNAKPRSKV VSCP 

« Hide

Isoform 2 [UniParc].

Checksum: 250F6C7D25DC0A13
Show »

FASTA34938,403

References

« Hide 'large scale' references
[1]"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Colonna M., Samaridis J.
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Natural killer cell.
[2]"Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Peripheral blood lymphocyte.
[3]"The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Peripheral blood lymphocyte.
[4]"Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes."
D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L.
J. Immunol. 155:2306-2310(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Blood.
[5]"Human diversity in killer cell inhibitory receptor genes."
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS.
[6]"Alternatively spliced forms of human killer inhibitory receptors."
Doehring C., Samaridis J., Colonna M.
Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
[7]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B."
Vivian J.P., Duncan R.C., Berry R., O'Connor G.M., Reid H.H., Beddoe T., Gras S., Saunders P.M., Olshina M.A., Widjaja J.M., Harpur C.M., Lin J., Maloveste S.M., Price D.A., Lafont B.A., McVicar D.W., Clements C.S., Brooks A.G., Rossjohn J.
Nature 479:401-405(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-320 IN COMPLEX WITH PEPTIDE-LOADED HLA-B, FUNCTION, GLYCOSYLATION AT ASN-92; ASN-179 AND ASN-273, DISULFIDE BONDS.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41269 mRNA. Translation: AAA69870.1.
U30273 mRNA. Translation: AAB52521.1.
U30274 mRNA. Translation: AAB52522.1.
X94262 mRNA. Translation: CAA63938.1.
U31416 mRNA. Translation: AAC23725.1.
AF022049 mRNA. Translation: AAB95322.1.
L76664 mRNA. Translation: AAB36592.1.
AC006293 Genomic DNA. No translation available.
AC011501 Genomic DNA. No translation available.
CCDSCCDS42621.1. [P43629-1]
PIRG01924.
G01925.
RefSeqNP_037421.2. NM_013289.2. [P43629-1]
UniGeneHs.645228.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VH8X-ray1.80G/H22-320[»]
ProteinModelPortalP43629.
SMRP43629. Positions 28-313.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110012. 2 interactions.
IntActP43629. 2 interactions.
STRING9606.ENSP00000375608.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteP43629.

Polymorphism databases

DMDM1171728.

Proteomic databases

PaxDbP43629.
PRIDEP43629.

Protocols and materials databases

DNASU3811.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
ENST00000538269; ENSP00000443350; ENSG00000167633. [P43629-1]
ENST00000603295; ENSP00000474733; ENSG00000271039. [P43629-1]
ENST00000603483; ENSP00000474290; ENSG00000271039. [P43629-1]
ENST00000605257; ENSP00000474945; ENSG00000271039. [P43629-2]
GeneID3811.
KEGGhsa:3811.
UCSCuc002qhk.4. human. [P43629-1]

Organism-specific databases

CTD3811.
GeneCardsGC19P055274.
HGNCHGNC:6338. KIR3DL1.
MIM604946. gene.
neXtProtNX_P43629.
PharmGKBPA30123.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25862.
HOGENOMHOG000234396.
HOVERGENHBG074353.
InParanoidP43629.
KOK07980.
OMARTVNTED.
OrthoDBEOG7H792J.
PhylomeDBP43629.
TreeFamTF352669.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

ArrayExpressP43629.
BgeeP43629.
CleanExHS_KIR3DL1.
GenevestigatorP43629.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 2 hits.
[Graphical view]
SMARTSM00409. IG. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiKIR3DL1.
GenomeRNAi3811.
NextBio14977.
PROP43629.
SOURCESearch...

Entry information

Entry nameKI3L1_HUMAN
AccessionPrimary (citable) accession number: P43629
Secondary accession number(s): O43473, Q14946, Q16541
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries