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P43629

- KI3L1_HUMAN

UniProt

P43629 - KI3L1_HUMAN

Protein

Killer cell immunoglobulin-like receptor 3DL1

Gene

KIR3DL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 141 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

    GO - Molecular functioni

    1. HLA-B specific inhibitory MHC class I receptor activity Source: UniProtKB

    GO - Biological processi

    1. immune response Source: UniProtKB
    2. regulation of immune response Source: Reactome
    3. signal transduction Source: GOC

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 3DL1
    Alternative name(s):
    CD158 antigen-like family member E
    HLA-BW4-specific inhibitory NK cell receptor
    MHC class I NK cell receptor
    Natural killer-associated transcript 3
    Short name:
    NKAT-3
    p70 natural killer cell receptor clones CL-2/CL-11
    Short name:
    p70 NK receptor CL-2/CL-11
    CD_antigen: CD158e
    Gene namesi
    Name:KIR3DL1
    Synonyms:CD158E, NKAT3, NKB1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6338. KIR3DL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30123.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 444423Killer cell immunoglobulin-like receptor 3DL1PRO_0000015087Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 951 Publication
    Glycosylationi92 – 921N-linked (GlcNAc...)1 Publication
    Disulfide bondi144 ↔ 1951 Publication
    Glycosylationi179 – 1791N-linked (GlcNAc...)1 Publication
    Disulfide bondi244 ↔ 2931 Publication
    Glycosylationi273 – 2731N-linked (GlcNAc...)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP43629.
    PRIDEiP43629.

    PTM databases

    PhosphoSiteiP43629.

    Expressioni

    Gene expression databases

    ArrayExpressiP43629.
    BgeeiP43629.
    CleanExiHS_KIR3DL1.
    GenevestigatoriP43629.

    Interactioni

    Protein-protein interaction databases

    BioGridi110012. 2 interactions.
    IntActiP43629. 2 interactions.
    STRINGi9606.ENSP00000375608.

    Structurei

    Secondary structure

    1
    444
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi37 – 404
    Beta strandi45 – 517
    Beta strandi57 – 648
    Beta strandi66 – 683
    Helixi70 – 734
    Beta strandi76 – 783
    Beta strandi80 – 823
    Helixi87 – 893
    Beta strandi91 – 988
    Beta strandi100 – 1067
    Beta strandi113 – 1186
    Beta strandi125 – 1306
    Beta strandi132 – 1354
    Beta strandi140 – 1489
    Beta strandi151 – 1577
    Beta strandi165 – 1684
    Beta strandi170 – 1723
    Beta strandi175 – 1828
    Helixi187 – 1893
    Beta strandi191 – 1988
    Beta strandi213 – 2186
    Beta strandi225 – 2306
    Beta strandi241 – 2488
    Beta strandi251 – 2577
    Beta strandi264 – 2674
    Beta strandi276 – 2816
    Beta strandi289 – 2979
    Beta strandi311 – 3133

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3VH8X-ray1.80G/H22-320[»]
    3WUWX-ray2.00G28-313[»]
    ProteinModelPortaliP43629.
    SMRiP43629. Positions 28-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 340319ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini361 – 44484CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei341 – 36020HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10261Ig-like C2-type 1Add
    BLAST
    Domaini137 – 20266Ig-like C2-type 2Add
    BLAST
    Domaini237 – 30064Ig-like C2-type 3Add
    BLAST

    Domaini

    Ig-like C2-type domain 2 mediates specificity through recognition of the Bw4 epitope.1 Publication

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25862.
    HOGENOMiHOG000234396.
    HOVERGENiHBG074353.
    InParanoidiP43629.
    KOiK07980.
    OMAiRTVNTED.
    OrthoDBiEOG7H792J.
    PhylomeDBiP43629.
    TreeFamiTF352669.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43629-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLMVVSMAC VGLFLVQRAG PHMGGQDKPF LSAWPSAVVP RGGHVTLRCH    50
    YRHRFNNFML YKEDRIHIPI FHGRIFQESF NMSPVTTAHA GNYTCRGSHP 100
    HSPTGWSAPS NPVVIMVTGN HRKPSLLAHP GPLVKSGERV ILQCWSDIMF 150
    EHFFLHKEGI SKDPSRLVGQ IHDGVSKANF SIGPMMLALA GTYRCYGSVT 200
    HTPYQLSAPS DPLDIVVTGP YEKPSLSAQP GPKVQAGESV TLSCSSRSSY 250
    DMYHLSREGG AHERRLPAVR KVNRTFQADF PLGPATHGGT YRCFGSFRHS 300
    PYEWSDPSDP LLVSVTGNPS SSWPSPTEPS SKSGNPRHLH ILIGTSVVII 350
    LFILLLFFLL HLWCSNKKNA AVMDQEPAGN RTANSEDSDE QDPEEVTYAQ 400
    LDHCVFTQRK ITRPSQRPKT PPTDTILYTE LPNAKPRSKV VSCP 444
    Length:444
    Mass (Da):49,098
    Last modified:November 1, 1995 - v1
    Checksum:i47DEA12BBAFDEC53
    GO
    Isoform 2 (identifier: P43629-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         25-119: Missing.

    Show »
    Length:349
    Mass (Da):38,403
    Checksum:i250F6C7D25DC0A13
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21S → L.
    Corresponds to variant rs605219 [ dbSNP | Ensembl ].
    VAR_010319
    Natural varianti13 – 131L → F.
    VAR_010320
    Natural varianti23 – 231M → V.
    VAR_010321
    Natural varianti68 – 681I → V.
    Corresponds to variant rs45556431 [ dbSNP | Ensembl ].
    VAR_010322
    Natural varianti75 – 751I → L.
    Corresponds to variant rs1049150 [ dbSNP | Ensembl ].
    VAR_010323
    Natural varianti203 – 2031P → S.
    Corresponds to variant rs2273731 [ dbSNP | Ensembl ].
    VAR_049987
    Natural varianti220 – 2201P → L.
    Corresponds to variant rs680891 [ dbSNP | Ensembl ].
    VAR_049988
    Natural varianti259 – 2591G → R.
    Corresponds to variant rs1049215 [ dbSNP | Ensembl ].
    VAR_010336
    Natural varianti333 – 3331S → C.
    VAR_010324
    Natural varianti362 – 3621L → R.
    Corresponds to variant rs1130468 [ dbSNP | Ensembl ].
    VAR_049989
    Natural varianti394 – 3941E → Q.
    Corresponds to variant rs1130513 [ dbSNP | Ensembl ].
    VAR_049990

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei25 – 11995Missing in isoform 2. 1 PublicationVSP_047633Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41269 mRNA. Translation: AAA69870.1.
    U30273 mRNA. Translation: AAB52521.1.
    U30274 mRNA. Translation: AAB52522.1.
    X94262 mRNA. Translation: CAA63938.1.
    U31416 mRNA. Translation: AAC23725.1.
    AF022049 mRNA. Translation: AAB95322.1.
    L76664 mRNA. Translation: AAB36592.1.
    AC006293 Genomic DNA. No translation available.
    AC011501 Genomic DNA. No translation available.
    CCDSiCCDS42621.1. [P43629-1]
    PIRiG01924.
    G01925.
    RefSeqiNP_037421.2. NM_013289.2. [P43629-1]
    UniGeneiHs.645228.

    Genome annotation databases

    EnsembliENST00000358178; ENSP00000350901; ENSG00000167633. [P43629-2]
    ENST00000391728; ENSP00000375608; ENSG00000167633. [P43629-1]
    ENST00000538269; ENSP00000443350; ENSG00000167633. [P43629-1]
    GeneIDi3811.
    KEGGihsa:3811.
    UCSCiuc002qhk.4. human. [P43629-1]
    uc010esf.3. human.

    Polymorphism databases

    DMDMi1171728.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41269 mRNA. Translation: AAA69870.1 .
    U30273 mRNA. Translation: AAB52521.1 .
    U30274 mRNA. Translation: AAB52522.1 .
    X94262 mRNA. Translation: CAA63938.1 .
    U31416 mRNA. Translation: AAC23725.1 .
    AF022049 mRNA. Translation: AAB95322.1 .
    L76664 mRNA. Translation: AAB36592.1 .
    AC006293 Genomic DNA. No translation available.
    AC011501 Genomic DNA. No translation available.
    CCDSi CCDS42621.1. [P43629-1 ]
    PIRi G01924.
    G01925.
    RefSeqi NP_037421.2. NM_013289.2. [P43629-1 ]
    UniGenei Hs.645228.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3VH8 X-ray 1.80 G/H 22-320 [» ]
    3WUW X-ray 2.00 G 28-313 [» ]
    ProteinModelPortali P43629.
    SMRi P43629. Positions 28-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110012. 2 interactions.
    IntActi P43629. 2 interactions.
    STRINGi 9606.ENSP00000375608.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P43629.

    Polymorphism databases

    DMDMi 1171728.

    Proteomic databases

    PaxDbi P43629.
    PRIDEi P43629.

    Protocols and materials databases

    DNASUi 3811.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000358178 ; ENSP00000350901 ; ENSG00000167633 . [P43629-2 ]
    ENST00000391728 ; ENSP00000375608 ; ENSG00000167633 . [P43629-1 ]
    ENST00000538269 ; ENSP00000443350 ; ENSG00000167633 . [P43629-1 ]
    GeneIDi 3811.
    KEGGi hsa:3811.
    UCSCi uc002qhk.4. human. [P43629-1 ]
    uc010esf.3. human.

    Organism-specific databases

    CTDi 3811.
    GeneCardsi GC19P055274.
    HGNCi HGNC:6338. KIR3DL1.
    MIMi 604946. gene.
    neXtProti NX_P43629.
    PharmGKBi PA30123.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25862.
    HOGENOMi HOG000234396.
    HOVERGENi HBG074353.
    InParanoidi P43629.
    KOi K07980.
    OMAi RTVNTED.
    OrthoDBi EOG7H792J.
    PhylomeDBi P43629.
    TreeFami TF352669.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    GeneWikii KIR3DL1.
    GenomeRNAii 3811.
    NextBioi 14977.
    PROi P43629.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43629.
    Bgeei P43629.
    CleanExi HS_KIR3DL1.
    Genevestigatori P43629.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M., Samaridis J.
      Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Natural killer cell.
    2. "Killer cell inhibitory receptors specific for HLA-C and HLA-B identified by direct binding and by functional transfer."
      Wagtmann N., Rajagopalan S., Winter C.C., Peruzzi M., Long E.O.
      Immunity 3:801-809(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Peripheral blood lymphocyte.
    3. "The natural killer cell receptor specific for HLA-A allotypes: a novel member of the p58/p70 family of inhibitory receptors that is characterized by three immunoglobulin-like domains and is expressed as a 140-kD disulphide-linked dimer."
      Pende D., Biassoni R., Cantoni C., Verdiani S., Falco M., di Donato C., Accame L., Bottino C., Moretta A., Moretta L.
      J. Exp. Med. 184:505-518(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Peripheral blood lymphocyte.
    4. "Molecular cloning of NKB1. A natural killer cell receptor for HLA-B allotypes."
      D'Andrea A., Chang C., Franz-Bacon K., McClanahan T., Phillips J.H., Lanier L.L.
      J. Immunol. 155:2306-2310(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Blood.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS.
    6. "Alternatively spliced forms of human killer inhibitory receptors."
      Doehring C., Samaridis J., Colonna M.
      Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    7. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 22-320 IN COMPLEX WITH PEPTIDE-LOADED HLA-B, FUNCTION, GLYCOSYLATION AT ASN-92; ASN-179 AND ASN-273, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKI3L1_HUMAN
    AccessioniPrimary (citable) accession number: P43629
    Secondary accession number(s): O43473, Q14946, Q16541
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 141 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3