ID   KI2L3_HUMAN             Reviewed;         341 AA.
AC   P43628; O43472; P78402; Q14944; Q14945; Q9UM51; Q9UQ70;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   27-MAR-2024, entry version 210.
DE   RecName: Full=Killer cell immunoglobulin-like receptor 2DL3 {ECO:0000305};
DE   AltName: Full=CD158 antigen-like family member B2;
DE   AltName: Full=KIR-023GB;
DE   AltName: Full=Killer inhibitory receptor cl 2-3;
DE   AltName: Full=NKAT2a;
DE   AltName: Full=NKAT2b;
DE   AltName: Full=Natural killer-associated transcript 2;
DE            Short=NKAT-2;
DE   AltName: Full=p58 natural killer cell receptor clone CL-6;
DE            Short=p58 NK receptor CL-6;
DE   AltName: Full=p58.2 MHC class-I-specific NK receptor;
DE   AltName: CD_antigen=CD158b2;
DE   Flags: Precursor;
GN   Name=KIR2DL3 {ECO:0000312|HGNC:HGNC:6331};
GN   Synonyms=CD158B2, KIRCL23, NKAT2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Natural killer cell;
RX   PubMed=7716543; DOI=10.1126/science.7716543;
RA   Colonna M., Samaridis J.;
RT   "Cloning of immunoglobulin-superfamily members associated with HLA-C and
RT   HLA-B recognition by human natural killer cells.";
RL   Science 268:405-408(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Natural killer cell;
RX   PubMed=7749980; DOI=10.1016/1074-7613(95)90025-x;
RA   Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M.,
RA   Bottino C., Moretta L., Moretta A., Long E.O.;
RT   "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related
RT   molecules with diversity in both the extra- and intracellular domains.";
RL   Immunity 2:439-449(1995).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS LEU-229;
RP   THR-304 AND HIS-318.
RX   PubMed=8662091; DOI=10.1007/bf02602590;
RA   Doehring C., Samaridis J., Colonna M.;
RT   "Alternatively spliced forms of human killer inhibitory receptors.";
RL   Immunogenetics 44:227-230(1996).
RN   [4]
RP   NUCLEOTIDE SEQUENCE (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56; ARG-71
RP   AND HIS-318.
RX   PubMed=9430221; DOI=10.1016/s1074-7613(00)80394-5;
RA   Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K.,
RA   Corliss B., Tyan D., Lanier L.L., Parham P.;
RT   "Human diversity in killer cell inhibitory receptor genes.";
RL   Immunity 7:753-763(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS ALA-9; ARG-32; GLU-56;
RP   ARG-71; ILE-242 AND HIS-318.
RX   PubMed=9059894; DOI=10.1111/j.1600-065x.1997.tb00951.x;
RA   Selvakumar A., Steffens U., Dupont B.;
RT   "Polymorphism and domain variability of human killer cell inhibitory
RT   receptors.";
RL   Immunol. Rev. 155:183-196(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS LEU-229
RP   AND HIS-318.
RC   TISSUE=Blood;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1), AND VARIANT
RP   LEU-229.
RX   PubMed=9234478; DOI=10.1111/j.1399-0039.1997.tb02804.x;
RA   Wilson M.J., Torkar M., Trowsdale J.;
RT   "Genomic organization of a human killer cell inhibitory receptor gene.";
RL   Tissue Antigens 49:574-579(1997).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341, AND VARIANT GLN-34.
RC   TISSUE=Placenta;
RA   Chae J.H., Kim Y.M., Ahn J.M., Kim C.G., Kim J., Kim S.J., Park J.H.;
RT   "Genomic organization of novel genes encoding human killer inhibitory
RT   receptors.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [9]
RP   INTERACTION WITH ARRB2.
RX   PubMed=18604210; DOI=10.1038/ni.1635;
RA   Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L.,
RA   Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.;
RT   "An essential function for beta-arrestin 2 in the inhibitory signaling of
RT   natural killer cells.";
RL   Nat. Immunol. 9:898-907(2008).
RN   [10]
RP   X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245.
RX   PubMed=10196125; DOI=10.1016/s0969-2126(99)80052-5;
RA   Maenaka K., Juji T., Stuart D.I., Jones E.Y.;
RT   "Crystal structure of the human p58 killer cell inhibitory receptor
RT   (KIR2DL3) specific for HLA-Cw3-related MHC class I.";
RL   Structure 7:391-398(1999).
CC   -!- FUNCTION: Receptor on natural killer (NK) cells for HLA-C alleles (HLA-
CC       Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus
CC       preventing cell lysis.
CC   -!- SUBUNIT: Interacts with ARRB2. {ECO:0000269|PubMed:18604210}.
CC   -!- INTERACTION:
CC       P43628; Q9UHX3: ADGRE2; NbExp=3; IntAct=EBI-8632435, EBI-11277970;
CC       P43628; Q6RW13-2: AGTRAP; NbExp=3; IntAct=EBI-8632435, EBI-11522760;
CC       P43628; Q9NVV5-2: AIG1; NbExp=3; IntAct=EBI-8632435, EBI-11957045;
CC       P43628; Q86W74-2: ANKRD46; NbExp=3; IntAct=EBI-8632435, EBI-12109402;
CC       P43628; P02652: APOA2; NbExp=3; IntAct=EBI-8632435, EBI-1171525;
CC       P43628; P05090: APOD; NbExp=3; IntAct=EBI-8632435, EBI-715495;
CC       P43628; Q96PS8: AQP10; NbExp=3; IntAct=EBI-8632435, EBI-12820279;
CC       P43628; P07306: ASGR1; NbExp=3; IntAct=EBI-8632435, EBI-1172335;
CC       P43628; O15342: ATP6V0E1; NbExp=3; IntAct=EBI-8632435, EBI-12935759;
CC       P43628; O95393: BMP10; NbExp=3; IntAct=EBI-8632435, EBI-3922513;
CC       P43628; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-8632435, EBI-12244618;
CC       P43628; Q8WVV5: BTN2A2; NbExp=3; IntAct=EBI-8632435, EBI-8648738;
CC       P43628; O14735: CDIPT; NbExp=3; IntAct=EBI-8632435, EBI-358858;
CC       P43628; Q8N5K1: CISD2; NbExp=3; IntAct=EBI-8632435, EBI-1045797;
CC       P43628; Q8N6F1-2: CLDN19; NbExp=3; IntAct=EBI-8632435, EBI-12256978;
CC       P43628; Q9NWW5: CLN6; NbExp=3; IntAct=EBI-8632435, EBI-6165897;
CC       P43628; O75208: COQ9; NbExp=3; IntAct=EBI-8632435, EBI-724524;
CC       P43628; Q07325: CXCL9; NbExp=3; IntAct=EBI-8632435, EBI-3911467;
CC       P43628; O43169: CYB5B; NbExp=3; IntAct=EBI-8632435, EBI-1058710;
CC       P43628; Q9BQA9: CYBC1; NbExp=3; IntAct=EBI-8632435, EBI-2680384;
CC       P43628; P50402: EMD; NbExp=3; IntAct=EBI-8632435, EBI-489887;
CC       P43628; Q5JX71: FAM209A; NbExp=3; IntAct=EBI-8632435, EBI-18304435;
CC       P43628; Q92520: FAM3C; NbExp=3; IntAct=EBI-8632435, EBI-2876774;
CC       P43628; Q9BWH2: FUNDC2; NbExp=3; IntAct=EBI-8632435, EBI-714482;
CC       P43628; P01350: GAST; NbExp=3; IntAct=EBI-8632435, EBI-3436637;
CC       P43628; P48165: GJA8; NbExp=3; IntAct=EBI-8632435, EBI-17458373;
CC       P43628; Q9NPR9: GPR108; NbExp=3; IntAct=EBI-8632435, EBI-11343451;
CC       P43628; Q8TED1: GPX8; NbExp=3; IntAct=EBI-8632435, EBI-11721746;
CC       P43628; P01889: HLA-B; NbExp=2; IntAct=EBI-8632435, EBI-1046513;
CC       P43628; P10321: HLA-C; NbExp=9; IntAct=EBI-8632435, EBI-1051396;
CC       P43628; Q53YP1: HLA-C; NbExp=2; IntAct=EBI-8632435, EBI-13917186;
CC       P43628; Q01628: IFITM3; NbExp=3; IntAct=EBI-8632435, EBI-7932862;
CC       P43628; Q9Y5U4: INSIG2; NbExp=3; IntAct=EBI-8632435, EBI-8503746;
CC       P43628; P11215: ITGAM; NbExp=3; IntAct=EBI-8632435, EBI-2568251;
CC       P43628; Q8N5M9: JAGN1; NbExp=3; IntAct=EBI-8632435, EBI-10266796;
CC       P43628; P43628: KIR2DL3; NbExp=3; IntAct=EBI-8632435, EBI-8632435;
CC       P43628; Q86UP2-3: KTN1; NbExp=3; IntAct=EBI-8632435, EBI-12007212;
CC       P43628; O43561-2: LAT; NbExp=3; IntAct=EBI-8632435, EBI-8070286;
CC       P43628; A8MZ59: LEUTX; NbExp=3; IntAct=EBI-8632435, EBI-17490413;
CC       P43628; Q8TAF8: LHFPL5; NbExp=3; IntAct=EBI-8632435, EBI-2820517;
CC       P43628; Q9NZG7: NINJ2; NbExp=3; IntAct=EBI-8632435, EBI-10317425;
CC       P43628; Q8IXM6: NRM; NbExp=3; IntAct=EBI-8632435, EBI-10262547;
CC       P43628; P42857: NSG1; NbExp=3; IntAct=EBI-8632435, EBI-6380741;
CC       P43628; Q6UX06: OLFM4; NbExp=3; IntAct=EBI-8632435, EBI-2804156;
CC       P43628; P26678: PLN; NbExp=3; IntAct=EBI-8632435, EBI-692836;
CC       P43628; Q96GM1: PLPPR2; NbExp=3; IntAct=EBI-8632435, EBI-12955265;
CC       P43628; Q06124: PTPN11; NbExp=4; IntAct=EBI-8632435, EBI-297779;
CC       P43628; P29350: PTPN6; NbExp=13; IntAct=EBI-8632435, EBI-78260;
CC       P43628; Q8N8N0: RNF152; NbExp=3; IntAct=EBI-8632435, EBI-2129725;
CC       P43628; Q5QGT7: RTP2; NbExp=3; IntAct=EBI-8632435, EBI-10244780;
CC       P43628; O75396: SEC22B; NbExp=3; IntAct=EBI-8632435, EBI-1058865;
CC       P43628; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-8632435, EBI-10314552;
CC       P43628; B2RUZ4: SMIM1; NbExp=3; IntAct=EBI-8632435, EBI-12188413;
CC       P43628; Q6UX34: SNORC; NbExp=3; IntAct=EBI-8632435, EBI-11957067;
CC       P43628; P07204: THBD; NbExp=3; IntAct=EBI-8632435, EBI-941422;
CC       P43628; A2RU14: TMEM218; NbExp=3; IntAct=EBI-8632435, EBI-10173151;
CC       P43628; Q9H0R3: TMEM222; NbExp=3; IntAct=EBI-8632435, EBI-347385;
CC       P43628; Q9BU79: TMEM243; NbExp=3; IntAct=EBI-8632435, EBI-12887458;
CC       P43628; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-8632435, EBI-2548832;
CC       P43628; Q5BJF2: TMEM97; NbExp=3; IntAct=EBI-8632435, EBI-12111910;
CC       P43628; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-8632435, EBI-765817;
CC       P43628; Q5BVD1: TTMP; NbExp=3; IntAct=EBI-8632435, EBI-10243654;
CC       P43628; O75841: UPK1B; NbExp=3; IntAct=EBI-8632435, EBI-12237619;
CC       P43628; O00526: UPK2; NbExp=3; IntAct=EBI-8632435, EBI-10179682;
CC       P43628; O95183: VAMP5; NbExp=3; IntAct=EBI-8632435, EBI-10191195;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
CC       protein.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P43628-1; Sequence=Displayed;
CC       Name=2; Synonyms=NKAT2a-delta-Ig2;
CC         IsoId=P43628-2; Sequence=VSP_007814;
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. {ECO:0000305}.
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DR   EMBL; L41268; AAA69869.1; -; mRNA.
DR   EMBL; U24074; AAC50333.1; -; mRNA.
DR   EMBL; L76662; AAB36590.1; -; mRNA.
DR   EMBL; L76663; AAB36591.1; -; mRNA.
DR   EMBL; AF022048; AAB95321.1; -; mRNA.
DR   EMBL; U73395; AAC51147.1; -; mRNA.
DR   EMBL; BC032422; AAH32422.1; -; mRNA.
DR   EMBL; BC050730; AAH50730.1; -; mRNA.
DR   EMBL; AH006692; AAC51651.1; -; Genomic_DNA.
DR   EMBL; AH007572; AAD24477.1; -; Genomic_DNA.
DR   CCDS; CCDS33107.1; -. [P43628-1]
DR   PIR; I61725; I61725.
DR   RefSeq; NP_056952.2; NM_015868.2. [P43628-1]
DR   PDB; 1B6U; X-ray; 3.00 A; A=22-245.
DR   PDB; 6PAG; X-ray; 2.50 A; D=22-225.
DR   PDB; 8TUI; X-ray; 2.75 A; A=22-245.
DR   PDBsum; 1B6U; -.
DR   PDBsum; 6PAG; -.
DR   PDBsum; 8TUI; -.
DR   AlphaFoldDB; P43628; -.
DR   SMR; P43628; -.
DR   BioGRID; 110005; 63.
DR   IntAct; P43628; 76.
DR   MINT; P43628; -.
DR   STRING; 9606.ENSP00000342215; -.
DR   ChEMBL; CHEMBL3713026; -.
DR   GlyCosmos; P43628; 3 sites, No reported glycans.
DR   GlyGen; P43628; 3 sites.
DR   iPTMnet; P43628; -.
DR   PhosphoSitePlus; P43628; -.
DR   BioMuta; KIR2DL3; -.
DR   DMDM; 1171727; -.
DR   jPOST; P43628; -.
DR   MassIVE; P43628; -.
DR   PaxDb; 9606-ENSP00000342215; -.
DR   PeptideAtlas; P43628; -.
DR   ProteomicsDB; 55641; -. [P43628-1]
DR   ProteomicsDB; 55642; -. [P43628-2]
DR   TopDownProteomics; P43628-1; -. [P43628-1]
DR   ABCD; P43628; 1 sequenced antibody.
DR   Antibodypedia; 35081; 581 antibodies from 32 providers.
DR   DNASU; 3804; -.
DR   Ensembl; ENST00000342376.4; ENSP00000342215.3; ENSG00000243772.8. [P43628-1]
DR   Ensembl; ENST00000610407.4; ENSP00000478848.1; ENSG00000274830.5.
DR   Ensembl; ENST00000611207.4; ENSP00000478657.1; ENSG00000276218.5. [P43628-1]
DR   Ensembl; ENST00000611369.4; ENSP00000483975.1; ENSG00000277484.5. [P43628-1]
DR   Ensembl; ENST00000611821.4; ENSP00000484459.1; ENSG00000276590.5. [P43628-1]
DR   Ensembl; ENST00000611990.4; ENSP00000479121.1; ENSG00000278327.5. [P43628-1]
DR   Ensembl; ENST00000614792.4; ENSP00000481237.1; ENSG00000277554.5. [P43628-1]
DR   Ensembl; ENST00000615091.4; ENSP00000483551.1; ENSG00000275658.5. [P43628-1]
DR   Ensembl; ENST00000615739.1; ENSP00000478136.1; ENSG00000273887.1.
DR   Ensembl; ENST00000617150.4; ENSP00000481159.1; ENSG00000274952.5.
DR   Ensembl; ENST00000617242.4; ENSP00000483883.1; ENSG00000274410.5. [P43628-1]
DR   Ensembl; ENST00000617404.1; ENSP00000481478.1; ENSG00000275008.1. [P43628-1]
DR   Ensembl; ENST00000617593.4; ENSP00000483192.1; ENSG00000274108.5. [P43628-1]
DR   Ensembl; ENST00000617790.4; ENSP00000481355.1; ENSG00000275623.5. [P43628-1]
DR   Ensembl; ENST00000619702.1; ENSP00000480464.1; ENSG00000274402.1. [P43628-1]
DR   Ensembl; ENST00000619995.4; ENSP00000480087.1; ENSG00000277317.5. [P43628-1]
DR   Ensembl; ENST00000620549.4; ENSP00000483419.1; ENSG00000277924.5. [P43628-1]
DR   Ensembl; ENST00000622644.4; ENSP00000482830.1; ENSG00000276459.5. [P43628-1]
DR   Ensembl; ENST00000638813.2; ENSP00000492856.1; ENSG00000284333.2. [P43628-1]
DR   Ensembl; ENST00000638851.2; ENSP00000491452.1; ENSG00000283708.2. [P43628-1]
DR   Ensembl; ENST00000639089.2; ENSP00000491264.1; ENSG00000283702.2. [P43628-1]
DR   Ensembl; ENST00000639101.2; ENSP00000492356.1; ENSG00000283790.2. [P43628-1]
DR   Ensembl; ENST00000639176.2; ENSP00000491273.1; ENSG00000284504.2. [P43628-1]
DR   Ensembl; ENST00000640485.2; ENSP00000491955.1; ENSG00000284510.2. [P43628-1]
DR   GeneID; 3804; -.
DR   KEGG; hsa:3804; -.
DR   MANE-Select; ENST00000342376.4; ENSP00000342215.3; NM_015868.3; NP_056952.2.
DR   UCSC; uc002qgx.4; human. [P43628-1]
DR   AGR; HGNC:6331; -.
DR   CTD; 3804; -.
DR   DisGeNET; 3804; -.
DR   GeneCards; KIR2DL3; -.
DR   HGNC; HGNC:6331; KIR2DL3.
DR   HPA; ENSG00000243772; Tissue enhanced (lymphoid).
DR   MIM; 604938; gene.
DR   neXtProt; NX_P43628; -.
DR   OpenTargets; ENSG00000243772; -.
DR   PharmGKB; PA30116; -.
DR   VEuPathDB; HostDB:ENSG00000243772; -.
DR   eggNOG; ENOG502RU21; Eukaryota.
DR   GeneTree; ENSGT01100000263478; -.
DR   InParanoid; P43628; -.
DR   OMA; VACVGEC; -.
DR   OrthoDB; 4802839at2759; -.
DR   PhylomeDB; P43628; -.
DR   TreeFam; TF352669; -.
DR   PathwayCommons; P43628; -.
DR   Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR   SignaLink; P43628; -.
DR   BioGRID-ORCS; 3804; 16 hits in 1039 CRISPR screens.
DR   ChiTaRS; KIR2DL3; human.
DR   EvolutionaryTrace; P43628; -.
DR   GenomeRNAi; 3804; -.
DR   Pharos; P43628; Tbio.
DR   PRO; PR:P43628; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; P43628; Protein.
DR   Bgee; ENSG00000243772; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 33 other cell types or tissues.
DR   ExpressionAtlas; P43628; baseline and differential.
DR   GO; GO:0016020; C:membrane; TAS:ProtInc.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0003823; F:antigen binding; TAS:ProtInc.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0038023; F:signaling receptor activity; TAS:ProtInc.
DR   GO; GO:0006955; P:immune response; TAS:ProtInc.
DR   CDD; cd05711; IgC2_D2_LILR_KIR_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013151; Immunoglobulin.
DR   PANTHER; PTHR11738:SF168; KILLER CELL IMMUNOGLOBULIN-LIKE RECEPTOR 2DL2-RELATED; 1.
DR   PANTHER; PTHR11738; MHC CLASS I NK CELL RECEPTOR; 1.
DR   Pfam; PF00047; ig; 2.
DR   SMART; SM00409; IG; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 2.
DR   Genevisible; P43628; HS.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Cell membrane; Disulfide bond;
KW   Glycoprotein; Immunoglobulin domain; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000250"
FT   CHAIN           22..341
FT                   /note="Killer cell immunoglobulin-like receptor 2DL3"
FT                   /id="PRO_0000015080"
FT   TOPO_DOM        22..245
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        266..341
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          42..107
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          142..205
FT                   /note="Ig-like C2-type 2"
FT   REGION          220..239
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        178
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        211
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        49..100
FT                   /evidence="ECO:0000250|UniProtKB:P43626"
FT   DISULFID        149..198
FT                   /evidence="ECO:0000250|UniProtKB:P43626"
FT   VAR_SEQ         117..214
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:8662091"
FT                   /id="VSP_007814"
FT   VARIANT         9
FT                   /note="V -> A (in dbSNP:rs3810343)"
FT                   /evidence="ECO:0000269|PubMed:9059894,
FT                   ECO:0000269|PubMed:9430221"
FT                   /id="VAR_010313"
FT   VARIANT         32
FT                   /note="L -> R (in dbSNP:rs202032116)"
FT                   /evidence="ECO:0000269|PubMed:9059894,
FT                   ECO:0000269|PubMed:9430221"
FT                   /id="VAR_010314"
FT   VARIANT         34
FT                   /note="H -> Q (in dbSNP:rs683003)"
FT                   /evidence="ECO:0000269|Ref.8"
FT                   /id="VAR_015967"
FT   VARIANT         37
FT                   /note="P -> R (in dbSNP:rs613240)"
FT                   /id="VAR_049978"
FT   VARIANT         56
FT                   /note="Q -> E (in dbSNP:rs35719984)"
FT                   /evidence="ECO:0000269|PubMed:9059894,
FT                   ECO:0000269|PubMed:9430221"
FT                   /id="VAR_010315"
FT   VARIANT         66
FT                   /note="F -> Y (in dbSNP:rs78713511)"
FT                   /id="VAR_049979"
FT   VARIANT         71
FT                   /note="H -> R (in dbSNP:rs138897134)"
FT                   /evidence="ECO:0000269|PubMed:9059894,
FT                   ECO:0000269|PubMed:9430221"
FT                   /id="VAR_010316"
FT   VARIANT         229
FT                   /note="P -> L (in dbSNP:rs35861855)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9234478"
FT                   /id="VAR_015968"
FT   VARIANT         242
FT                   /note="R -> I"
FT                   /evidence="ECO:0000269|PubMed:9059894"
FT                   /id="VAR_015969"
FT   VARIANT         304
FT                   /note="A -> T (in dbSNP:rs4020187)"
FT                   /evidence="ECO:0000269|PubMed:8662091"
FT                   /id="VAR_015970"
FT   VARIANT         318
FT                   /note="R -> H (in dbSNP:rs1049267)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:8662091, ECO:0000269|PubMed:9059894,
FT                   ECO:0000269|PubMed:9430221"
FT                   /id="VAR_010317"
FT   STRAND          30..35
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          37..40
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          45..53
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          56..66
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          68..73
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          75..77
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          80..87
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   HELIX           92..94
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          96..101
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          118..123
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          130..135
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          147..153
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          156..160
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          177..179
FT                   /evidence="ECO:0007829|PDB:1B6U"
FT   STRAND          181..183
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          198..202
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          205..209
FT                   /evidence="ECO:0007829|PDB:6PAG"
FT   STRAND          216..218
FT                   /evidence="ECO:0007829|PDB:1B6U"
SQ   SEQUENCE   341 AA;  37886 MW;  C21EAFF80EA9AAB2 CRC64;
     MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVRFQHFLL
     HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC YGSVTHSPYQ LSAPSDPLDI
     VITGLYEKPS LSAQPGPTVL AGESVTLSCS SRSSYDMYHL SREGEAHERR FSAGPKVNGT
     FQADFPLGPA THGGTYRCFG SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN
     PRHLHVLIGT SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
     VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
//