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P43628

- KI2L3_HUMAN

UniProt

P43628 - KI2L3_HUMAN

Protein

Killer cell immunoglobulin-like receptor 2DL3

Gene

KIR2DL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 150 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

    GO - Molecular functioni

    1. antigen binding Source: ProtInc
    2. protein binding Source: UniProtKB
    3. receptor activity Source: ProtInc

    GO - Biological processi

    1. immune response Source: ProtInc
    2. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL3
    Alternative name(s):
    CD158 antigen-like family member B2
    KIR-023GB
    Killer inhibitory receptor cl 2-3
    MHC class I NK cell receptor
    NKAT2a
    NKAT2b
    Natural killer-associated transcript 2
    Short name:
    NKAT-2
    p58 natural killer cell receptor clone CL-6
    Short name:
    p58 NK receptor CL-6
    p58.2 MHC class-I-specific NK receptor
    CD_antigen: CD158b2
    Gene namesi
    Name:KIR2DL3
    Synonyms:CD158B2, KIRCL23, NKAT2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6331. KIR2DL3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: ProtInc
    2. integral component of plasma membrane Source: ProtInc
    3. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30116.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121By similarityAdd
    BLAST
    Chaini22 – 341320Killer cell immunoglobulin-like receptor 2DL3PRO_0000015080Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 100By similarity
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 198By similarity
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP43628.

    Expressioni

    Gene expression databases

    GenevestigatoriP43628.

    Interactioni

    Subunit structurei

    Interacts with ARRB2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PTPN11Q061244EBI-8632435,EBI-297779
    PTPN6P2935013EBI-8632435,EBI-78260

    Protein-protein interaction databases

    BioGridi110005. 2 interactions.
    IntActiP43628. 3 interactions.
    MINTiMINT-1523646.

    Structurei

    Secondary structure

    1
    341
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi37 – 426
    Beta strandi45 – 539
    Beta strandi56 – 649
    Beta strandi68 – 736
    Beta strandi81 – 877
    Turni92 – 943
    Beta strandi96 – 1038
    Beta strandi118 – 1236
    Beta strandi130 – 1323
    Beta strandi144 – 1507
    Beta strandi156 – 1627
    Beta strandi177 – 1793
    Beta strandi182 – 1898
    Beta strandi194 – 2018
    Beta strandi216 – 2183

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1B6UX-ray3.00A22-245[»]
    ProteinModelPortaliP43628.
    SMRiP43628. Positions 26-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43628.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 245224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini266 – 34176CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei246 – 26520HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10766Ig-like C2-type 1Add
    BLAST
    Domaini142 – 20564Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG074353.
    InParanoidiP43628.
    KOiK07981.
    OMAiKATVSCN.
    PhylomeDBiP43628.
    TreeFamiTF352669.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW    50
    SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC 100
    YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS 150
    SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG 200
    SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT 250
    SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE 300
    VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P 341
    Length:341
    Mass (Da):37,886
    Last modified:November 1, 1995 - v1
    Checksum:iC21EAFF80EA9AAB2
    GO
    Isoform 2 (identifier: P43628-2) [UniParc]FASTAAdd to Basket

    Also known as: NKAT2a-delta-Ig2

    The sequence of this isoform differs from the canonical sequence as follows:
         117-214: Missing.

    Show »
    Length:243
    Mass (Da):27,269
    Checksum:i86E3E532F7335609
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti9 – 91V → A.2 Publications
    Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
    VAR_010313
    Natural varianti32 – 321L → R.2 Publications
    VAR_010314
    Natural varianti34 – 341H → Q.1 Publication
    VAR_015967
    Natural varianti37 – 371P → R.
    Corresponds to variant rs613240 [ dbSNP | Ensembl ].
    VAR_049978
    Natural varianti56 – 561Q → E.2 Publications
    Corresponds to variant rs35719984 [ dbSNP | Ensembl ].
    VAR_010315
    Natural varianti66 – 661F → Y.
    Corresponds to variant rs673568 [ dbSNP | Ensembl ].
    VAR_049979
    Natural varianti71 – 711H → R.2 Publications
    Corresponds to variant rs138897134 [ dbSNP | Ensembl ].
    VAR_010316
    Natural varianti229 – 2291P → L.3 Publications
    Corresponds to variant rs35861855 [ dbSNP | Ensembl ].
    VAR_015968
    Natural varianti242 – 2421R → I.1 Publication
    VAR_015969
    Natural varianti304 – 3041A → T.1 Publication
    Corresponds to variant rs4020187 [ dbSNP | Ensembl ].
    VAR_015970
    Natural varianti318 – 3181R → H.4 Publications
    Corresponds to variant rs1049267 [ dbSNP | Ensembl ].
    VAR_010317

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei117 – 21498Missing in isoform 2. 1 PublicationVSP_007814Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41268 mRNA. Translation: AAA69869.1.
    U24074 mRNA. Translation: AAC50333.1.
    L76662 mRNA. Translation: AAB36590.1.
    L76663 mRNA. Translation: AAB36591.1.
    AF022048 mRNA. Translation: AAB95321.1.
    U73395 mRNA. Translation: AAC51147.1.
    BC032422 mRNA. Translation: AAH32422.1.
    BC050730 mRNA. Translation: AAH50730.1.
    AH006692 Genomic DNA. Translation: AAC51651.1.
    AH007572 Genomic DNA. Translation: AAD24477.1.
    CCDSiCCDS33107.1. [P43628-1]
    PIRiI61725.
    RefSeqiNP_056952.2. NM_015868.2. [P43628-1]
    UniGeneiHs.654608.
    Hs.731378.

    Genome annotation databases

    EnsembliENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
    GeneIDi3804.
    KEGGihsa:3804.
    UCSCiuc002qgx.3. human. [P43628-1]

    Polymorphism databases

    DMDMi1171727.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41268 mRNA. Translation: AAA69869.1 .
    U24074 mRNA. Translation: AAC50333.1 .
    L76662 mRNA. Translation: AAB36590.1 .
    L76663 mRNA. Translation: AAB36591.1 .
    AF022048 mRNA. Translation: AAB95321.1 .
    U73395 mRNA. Translation: AAC51147.1 .
    BC032422 mRNA. Translation: AAH32422.1 .
    BC050730 mRNA. Translation: AAH50730.1 .
    AH006692 Genomic DNA. Translation: AAC51651.1 .
    AH007572 Genomic DNA. Translation: AAD24477.1 .
    CCDSi CCDS33107.1. [P43628-1 ]
    PIRi I61725.
    RefSeqi NP_056952.2. NM_015868.2. [P43628-1 ]
    UniGenei Hs.654608.
    Hs.731378.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1B6U X-ray 3.00 A 22-245 [» ]
    ProteinModelPortali P43628.
    SMRi P43628. Positions 26-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110005. 2 interactions.
    IntActi P43628. 3 interactions.
    MINTi MINT-1523646.

    Polymorphism databases

    DMDMi 1171727.

    Proteomic databases

    PRIDEi P43628.

    Protocols and materials databases

    DNASUi 3804.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342376 ; ENSP00000342215 ; ENSG00000243772 . [P43628-1 ]
    GeneIDi 3804.
    KEGGi hsa:3804.
    UCSCi uc002qgx.3. human. [P43628-1 ]

    Organism-specific databases

    CTDi 3804.
    GeneCardsi GC19P055273.
    HGNCi HGNC:6331. KIR2DL3.
    MIMi 604938. gene.
    neXtProti NX_P43628.
    PharmGKBi PA30116.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG074353.
    InParanoidi P43628.
    KOi K07981.
    OMAi KATVSCN.
    PhylomeDBi P43628.
    TreeFami TF352669.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    EvolutionaryTracei P43628.
    NextBioi 14943.
    PROi P43628.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P43628.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M., Samaridis J.
      Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Natural killer cell.
    2. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
      Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
      Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Natural killer cell.
    3. "Alternatively spliced forms of human killer inhibitory receptors."
      Doehring C., Samaridis J., Colonna M.
      Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-229; THR-304 AND HIS-318.
    4. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), VARIANTS ALA-9; ARG-32; GLU-56; ARG-71 AND HIS-318.
    5. "Polymorphism and domain variability of human killer cell inhibitory receptors."
      Selvakumar A., Steffens U., Dupont B.
      Immunol. Rev. 155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-9; ARG-32; GLU-56; ARG-71; ILE-242 AND HIS-318.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-229 AND HIS-318.
      Tissue: Blood.
    7. "Genomic organization of a human killer cell inhibitory receptor gene."
      Wilson M.J., Torkar M., Trowsdale J.
      Tissue Antigens 49:574-579(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1), VARIANT LEU-229.
    8. "Genomic organization of novel genes encoding human killer inhibitory receptors."
      Chae J.H., Kim Y.M., Ahn J.M., Kim C.G., Kim J., Kim S.J., Park J.H.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341, VARIANT GLN-34.
      Tissue: Placenta.
    9. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
      Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
      Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ARRB2.
    10. "Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I."
      Maenaka K., Juji T., Stuart D.I., Jones E.Y.
      Structure 7:391-398(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245.

    Entry informationi

    Entry nameiKI2L3_HUMAN
    AccessioniPrimary (citable) accession number: P43628
    Secondary accession number(s): O43472
    , P78402, Q14944, Q14945, Q9UM51, Q9UQ70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3