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Protein

Killer cell immunoglobulin-like receptor 2DL3

Gene

KIR2DL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

GO - Molecular functioni

  • antigen binding Source: ProtInc
  • receptor activity Source: ProtInc

GO - Biological processi

  • immune response Source: ProtInc
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL3
Alternative name(s):
CD158 antigen-like family member B2
KIR-023GB
Killer inhibitory receptor cl 2-3
MHC class I NK cell receptor
NKAT2a
NKAT2b
Natural killer-associated transcript 2
Short name:
NKAT-2
p58 natural killer cell receptor clone CL-6
Short name:
p58 NK receptor CL-6
p58.2 MHC class-I-specific NK receptor
CD_antigen: CD158b2
Gene namesi
Name:KIR2DL3
Synonyms:CD158B2, KIRCL23, NKAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6331. KIR2DL3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 265HelicalSequence analysisAdd BLAST20
Topological domaini266 – 341CytoplasmicSequence analysisAdd BLAST76

GO - Cellular componenti

  • integral component of membrane Source: ProtInc
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi100132285.
115653.
3804.
OpenTargetsiENSG00000243772.
ENSG00000274108.
ENSG00000274402.
ENSG00000274410.
ENSG00000275008.
ENSG00000275623.
ENSG00000275658.
ENSG00000276218.
ENSG00000276459.
ENSG00000276590.
ENSG00000277317.
ENSG00000277484.
ENSG00000277554.
ENSG00000277924.
ENSG00000278327.
PharmGKBiPA30116.

Polymorphism and mutation databases

BioMutaiKIR2DL3.
DMDMi1171727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001508022 – 341Killer cell immunoglobulin-like receptor 2DL3Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100By similarity
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43628.
PeptideAtlasiP43628.
PRIDEiP43628.
TopDownProteomicsiP43628-1. [P43628-1]

PTM databases

iPTMnetiP43628.
PhosphoSitePlusiP43628.

Expressioni

Gene expression databases

ExpressionAtlasiP43628. baseline and differential.
GenevisibleiP43628. HS.

Interactioni

Subunit structurei

Interacts with ARRB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN11Q061244EBI-8632435,EBI-297779
PTPN6P2935013EBI-8632435,EBI-78260

Protein-protein interaction databases

BioGridi110005. 2 interactors.
IntActiP43628. 3 interactors.
MINTiMINT-1523646.
STRINGi9606.ENSP00000342215.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 42Combined sources6
Beta strandi45 – 53Combined sources9
Beta strandi56 – 64Combined sources9
Beta strandi68 – 73Combined sources6
Beta strandi81 – 87Combined sources7
Turni92 – 94Combined sources3
Beta strandi96 – 103Combined sources8
Beta strandi118 – 123Combined sources6
Beta strandi130 – 132Combined sources3
Beta strandi144 – 150Combined sources7
Beta strandi156 – 162Combined sources7
Beta strandi177 – 179Combined sources3
Beta strandi182 – 189Combined sources8
Beta strandi194 – 201Combined sources8
Beta strandi216 – 218Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6UX-ray3.00A22-245[»]
ProteinModelPortaliP43628.
SMRiP43628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119033.
HOVERGENiHBG074353.
InParanoidiP43628.
KOiK07981.
OrthoDBiEOG091G0APE.
PhylomeDBiP43628.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
310 320 330 340
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Length:341
Mass (Da):37,886
Last modified:November 1, 1995 - v1
Checksum:iC21EAFF80EA9AAB2
GO
Isoform 2 (identifier: P43628-2) [UniParc]FASTAAdd to basket
Also known as: NKAT2a-delta-Ig2

The sequence of this isoform differs from the canonical sequence as follows:
     117-214: Missing.

Show »
Length:243
Mass (Da):27,269
Checksum:i86E3E532F7335609
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0103139V → A.2 PublicationsCorresponds to variant rs3810343dbSNPEnsembl.1
Natural variantiVAR_01031432L → R.2 PublicationsCorresponds to variant rs202032116dbSNPEnsembl.1
Natural variantiVAR_01596734H → Q.1 PublicationCorresponds to variant rs683003dbSNPEnsembl.1
Natural variantiVAR_04997837P → R.Corresponds to variant rs613240dbSNPEnsembl.1
Natural variantiVAR_01031556Q → E.2 PublicationsCorresponds to variant rs35719984dbSNPEnsembl.1
Natural variantiVAR_04997966F → Y.Corresponds to variant rs673568dbSNPEnsembl.1
Natural variantiVAR_01031671H → R.2 PublicationsCorresponds to variant rs138897134dbSNPEnsembl.1
Natural variantiVAR_015968229P → L.3 PublicationsCorresponds to variant rs35861855dbSNPEnsembl.1
Natural variantiVAR_015969242R → I.1 Publication1
Natural variantiVAR_015970304A → T.1 PublicationCorresponds to variant rs4020187dbSNPEnsembl.1
Natural variantiVAR_010317318R → H.4 PublicationsCorresponds to variant rs1049267dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_007814117 – 214Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41268 mRNA. Translation: AAA69869.1.
U24074 mRNA. Translation: AAC50333.1.
L76662 mRNA. Translation: AAB36590.1.
L76663 mRNA. Translation: AAB36591.1.
AF022048 mRNA. Translation: AAB95321.1.
U73395 mRNA. Translation: AAC51147.1.
BC032422 mRNA. Translation: AAH32422.1.
BC050730 mRNA. Translation: AAH50730.1.
AH006692 Genomic DNA. Translation: AAC51651.1.
AH007572 Genomic DNA. Translation: AAD24477.1.
CCDSiCCDS33107.1. [P43628-1]
PIRiI61725.
RefSeqiNP_056952.2. NM_015868.2. [P43628-1]
UniGeneiHs.654608.
Hs.731378.

Genome annotation databases

EnsembliENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
ENST00000610407; ENSP00000478848; ENSG00000274830.
ENST00000611207; ENSP00000478657; ENSG00000276218. [P43628-1]
ENST00000611369; ENSP00000483975; ENSG00000277484. [P43628-1]
ENST00000611821; ENSP00000484459; ENSG00000276590. [P43628-1]
ENST00000611990; ENSP00000479121; ENSG00000278327. [P43628-1]
ENST00000614792; ENSP00000481237; ENSG00000277554. [P43628-1]
ENST00000615091; ENSP00000483551; ENSG00000275658. [P43628-1]
ENST00000615739; ENSP00000478136; ENSG00000273887.
ENST00000617150; ENSP00000481159; ENSG00000274952.
ENST00000617242; ENSP00000483883; ENSG00000274410. [P43628-1]
ENST00000617404; ENSP00000481478; ENSG00000275008. [P43628-1]
ENST00000617593; ENSP00000483192; ENSG00000274108. [P43628-1]
ENST00000617790; ENSP00000481355; ENSG00000275623. [P43628-1]
ENST00000619702; ENSP00000480464; ENSG00000274402. [P43628-1]
ENST00000619995; ENSP00000480087; ENSG00000277317. [P43628-1]
ENST00000620549; ENSP00000483419; ENSG00000277924. [P43628-1]
ENST00000622644; ENSP00000482830; ENSG00000276459. [P43628-1]
GeneIDi3804.
KEGGihsa:3804.
UCSCiuc002qgx.4. human. [P43628-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41268 mRNA. Translation: AAA69869.1.
U24074 mRNA. Translation: AAC50333.1.
L76662 mRNA. Translation: AAB36590.1.
L76663 mRNA. Translation: AAB36591.1.
AF022048 mRNA. Translation: AAB95321.1.
U73395 mRNA. Translation: AAC51147.1.
BC032422 mRNA. Translation: AAH32422.1.
BC050730 mRNA. Translation: AAH50730.1.
AH006692 Genomic DNA. Translation: AAC51651.1.
AH007572 Genomic DNA. Translation: AAD24477.1.
CCDSiCCDS33107.1. [P43628-1]
PIRiI61725.
RefSeqiNP_056952.2. NM_015868.2. [P43628-1]
UniGeneiHs.654608.
Hs.731378.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B6UX-ray3.00A22-245[»]
ProteinModelPortaliP43628.
SMRiP43628.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110005. 2 interactors.
IntActiP43628. 3 interactors.
MINTiMINT-1523646.
STRINGi9606.ENSP00000342215.

PTM databases

iPTMnetiP43628.
PhosphoSitePlusiP43628.

Polymorphism and mutation databases

BioMutaiKIR2DL3.
DMDMi1171727.

Proteomic databases

PaxDbiP43628.
PeptideAtlasiP43628.
PRIDEiP43628.
TopDownProteomicsiP43628-1. [P43628-1]

Protocols and materials databases

DNASUi3804.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
ENST00000610407; ENSP00000478848; ENSG00000274830.
ENST00000611207; ENSP00000478657; ENSG00000276218. [P43628-1]
ENST00000611369; ENSP00000483975; ENSG00000277484. [P43628-1]
ENST00000611821; ENSP00000484459; ENSG00000276590. [P43628-1]
ENST00000611990; ENSP00000479121; ENSG00000278327. [P43628-1]
ENST00000614792; ENSP00000481237; ENSG00000277554. [P43628-1]
ENST00000615091; ENSP00000483551; ENSG00000275658. [P43628-1]
ENST00000615739; ENSP00000478136; ENSG00000273887.
ENST00000617150; ENSP00000481159; ENSG00000274952.
ENST00000617242; ENSP00000483883; ENSG00000274410. [P43628-1]
ENST00000617404; ENSP00000481478; ENSG00000275008. [P43628-1]
ENST00000617593; ENSP00000483192; ENSG00000274108. [P43628-1]
ENST00000617790; ENSP00000481355; ENSG00000275623. [P43628-1]
ENST00000619702; ENSP00000480464; ENSG00000274402. [P43628-1]
ENST00000619995; ENSP00000480087; ENSG00000277317. [P43628-1]
ENST00000620549; ENSP00000483419; ENSG00000277924. [P43628-1]
ENST00000622644; ENSP00000482830; ENSG00000276459. [P43628-1]
GeneIDi3804.
KEGGihsa:3804.
UCSCiuc002qgx.4. human. [P43628-1]

Organism-specific databases

CTDi3804.
DisGeNETi100132285.
115653.
3804.
GeneCardsiKIR2DL3.
HGNCiHGNC:6331. KIR2DL3.
MIMi604938. gene.
neXtProtiNX_P43628.
OpenTargetsiENSG00000243772.
ENSG00000274108.
ENSG00000274402.
ENSG00000274410.
ENSG00000275008.
ENSG00000275623.
ENSG00000275658.
ENSG00000276218.
ENSG00000276459.
ENSG00000276590.
ENSG00000277317.
ENSG00000277484.
ENSG00000277554.
ENSG00000277924.
ENSG00000278327.
PharmGKBiPA30116.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119033.
HOVERGENiHBG074353.
InParanoidiP43628.
KOiK07981.
OrthoDBiEOG091G0APE.
PhylomeDBiP43628.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP43628.
GenomeRNAii3804.
PROiP43628.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP43628. baseline and differential.
GenevisibleiP43628. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L3_HUMAN
AccessioniPrimary (citable) accession number: P43628
Secondary accession number(s): O43472
, P78402, Q14944, Q14945, Q9UM51, Q9UQ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 167 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.