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P43628

- KI2L3_HUMAN

UniProt

P43628 - KI2L3_HUMAN

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Protein

Killer cell immunoglobulin-like receptor 2DL3

Gene

KIR2DL3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.

GO - Molecular functioni

  1. antigen binding Source: ProtInc
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. immune response Source: ProtInc
  2. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL3
Alternative name(s):
CD158 antigen-like family member B2
KIR-023GB
Killer inhibitory receptor cl 2-3
MHC class I NK cell receptor
NKAT2a
NKAT2b
Natural killer-associated transcript 2
Short name:
NKAT-2
p58 natural killer cell receptor clone CL-6
Short name:
p58 NK receptor CL-6
p58.2 MHC class-I-specific NK receptor
CD_antigen: CD158b2
Gene namesi
Name:KIR2DL3
Synonyms:CD158B2, KIRCL23, NKAT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6331. KIR2DL3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: ProtInc
  2. integral component of plasma membrane Source: ProtInc
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30116.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 341320Killer cell immunoglobulin-like receptor 2DL3PRO_0000015080Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100By similarity
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi149 ↔ 198By similarity
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43628.

Expressioni

Gene expression databases

ExpressionAtlasiP43628. baseline.
GenevestigatoriP43628.

Interactioni

Subunit structurei

Interacts with ARRB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN11Q061244EBI-8632435,EBI-297779
PTPN6P2935013EBI-8632435,EBI-78260

Protein-protein interaction databases

BioGridi110005. 2 interactions.
IntActiP43628. 3 interactions.
MINTiMINT-1523646.

Structurei

Secondary structure

1
341
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 426
Beta strandi45 – 539
Beta strandi56 – 649
Beta strandi68 – 736
Beta strandi81 – 877
Turni92 – 943
Beta strandi96 – 1038
Beta strandi118 – 1236
Beta strandi130 – 1323
Beta strandi144 – 1507
Beta strandi156 – 1627
Beta strandi177 – 1793
Beta strandi182 – 1898
Beta strandi194 – 2018
Beta strandi216 – 2183

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1B6UX-ray3.00A22-245[»]
ProteinModelPortaliP43628.
SMRiP43628. Positions 26-224.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43628.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224ExtracellularSequence AnalysisAdd
BLAST
Topological domaini266 – 34176CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei246 – 26520HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119033.
HOVERGENiHBG074353.
InParanoidiP43628.
KOiK07981.
OMAiKATVSCN.
PhylomeDBiP43628.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P43628-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLMVVSMVC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVRFQHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV TGNPSNSWPS PTEPSSETGN PRHLHVLIGT
260 270 280 290 300
SVVIILFILL LFFLLHRWCC NKKNAVVMDQ EPAGNRTVNR EDSDEQDPQE
310 320 330 340
VTYAQLNHCV FTQRKITRPS QRPKTPPTDI IVYTELPNAE P
Length:341
Mass (Da):37,886
Last modified:November 1, 1995 - v1
Checksum:iC21EAFF80EA9AAB2
GO
Isoform 2 (identifier: P43628-2) [UniParc]FASTAAdd to Basket

Also known as: NKAT2a-delta-Ig2

The sequence of this isoform differs from the canonical sequence as follows:
     117-214: Missing.

Show »
Length:243
Mass (Da):27,269
Checksum:i86E3E532F7335609
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti9 – 91V → A.2 Publications
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
VAR_010313
Natural varianti32 – 321L → R.2 Publications
VAR_010314
Natural varianti34 – 341H → Q.1 Publication
VAR_015967
Natural varianti37 – 371P → R.
Corresponds to variant rs613240 [ dbSNP | Ensembl ].
VAR_049978
Natural varianti56 – 561Q → E.2 Publications
Corresponds to variant rs35719984 [ dbSNP | Ensembl ].
VAR_010315
Natural varianti66 – 661F → Y.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].
VAR_049979
Natural varianti71 – 711H → R.2 Publications
Corresponds to variant rs138897134 [ dbSNP | Ensembl ].
VAR_010316
Natural varianti229 – 2291P → L.3 Publications
Corresponds to variant rs35861855 [ dbSNP | Ensembl ].
VAR_015968
Natural varianti242 – 2421R → I.1 Publication
VAR_015969
Natural varianti304 – 3041A → T.1 Publication
Corresponds to variant rs4020187 [ dbSNP | Ensembl ].
VAR_015970
Natural varianti318 – 3181R → H.4 Publications
Corresponds to variant rs1049267 [ dbSNP | Ensembl ].
VAR_010317

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei117 – 21498Missing in isoform 2. 1 PublicationVSP_007814Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41268 mRNA. Translation: AAA69869.1.
U24074 mRNA. Translation: AAC50333.1.
L76662 mRNA. Translation: AAB36590.1.
L76663 mRNA. Translation: AAB36591.1.
AF022048 mRNA. Translation: AAB95321.1.
U73395 mRNA. Translation: AAC51147.1.
BC032422 mRNA. Translation: AAH32422.1.
BC050730 mRNA. Translation: AAH50730.1.
AH006692 Genomic DNA. Translation: AAC51651.1.
AH007572 Genomic DNA. Translation: AAD24477.1.
CCDSiCCDS33107.1. [P43628-1]
PIRiI61725.
RefSeqiNP_056952.2. NM_015868.2. [P43628-1]
UniGeneiHs.654608.
Hs.731378.

Genome annotation databases

EnsembliENST00000342376; ENSP00000342215; ENSG00000243772. [P43628-1]
ENST00000610407; ENSP00000478848; ENSG00000274830.
ENST00000611207; ENSP00000478657; ENSG00000276218. [P43628-1]
ENST00000611369; ENSP00000483975; ENSG00000277484. [P43628-1]
ENST00000611821; ENSP00000484459; ENSG00000276590. [P43628-1]
ENST00000611990; ENSP00000479121; ENSG00000278327. [P43628-1]
ENST00000614792; ENSP00000481237; ENSG00000277554. [P43628-1]
ENST00000615091; ENSP00000483551; ENSG00000275658. [P43628-1]
ENST00000615739; ENSP00000478136; ENSG00000273887.
ENST00000617150; ENSP00000481159; ENSG00000274952.
ENST00000617242; ENSP00000483883; ENSG00000274410. [P43628-1]
ENST00000617404; ENSP00000481478; ENSG00000275008. [P43628-1]
ENST00000617593; ENSP00000483192; ENSG00000274108. [P43628-1]
ENST00000617790; ENSP00000481355; ENSG00000275623. [P43628-1]
ENST00000619702; ENSP00000480464; ENSG00000274402. [P43628-1]
ENST00000619995; ENSP00000480087; ENSG00000277317. [P43628-1]
ENST00000620549; ENSP00000483419; ENSG00000277924. [P43628-1]
ENST00000622644; ENSP00000482830; ENSG00000276459. [P43628-1]
GeneIDi3804.
KEGGihsa:3804.
UCSCiuc002qgx.3. human. [P43628-1]

Polymorphism databases

DMDMi1171727.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41268 mRNA. Translation: AAA69869.1 .
U24074 mRNA. Translation: AAC50333.1 .
L76662 mRNA. Translation: AAB36590.1 .
L76663 mRNA. Translation: AAB36591.1 .
AF022048 mRNA. Translation: AAB95321.1 .
U73395 mRNA. Translation: AAC51147.1 .
BC032422 mRNA. Translation: AAH32422.1 .
BC050730 mRNA. Translation: AAH50730.1 .
AH006692 Genomic DNA. Translation: AAC51651.1 .
AH007572 Genomic DNA. Translation: AAD24477.1 .
CCDSi CCDS33107.1. [P43628-1 ]
PIRi I61725.
RefSeqi NP_056952.2. NM_015868.2. [P43628-1 ]
UniGenei Hs.654608.
Hs.731378.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1B6U X-ray 3.00 A 22-245 [» ]
ProteinModelPortali P43628.
SMRi P43628. Positions 26-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110005. 2 interactions.
IntActi P43628. 3 interactions.
MINTi MINT-1523646.

Polymorphism databases

DMDMi 1171727.

Proteomic databases

PRIDEi P43628.

Protocols and materials databases

DNASUi 3804.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342376 ; ENSP00000342215 ; ENSG00000243772 . [P43628-1 ]
ENST00000610407 ; ENSP00000478848 ; ENSG00000274830 .
ENST00000611207 ; ENSP00000478657 ; ENSG00000276218 . [P43628-1 ]
ENST00000611369 ; ENSP00000483975 ; ENSG00000277484 . [P43628-1 ]
ENST00000611821 ; ENSP00000484459 ; ENSG00000276590 . [P43628-1 ]
ENST00000611990 ; ENSP00000479121 ; ENSG00000278327 . [P43628-1 ]
ENST00000614792 ; ENSP00000481237 ; ENSG00000277554 . [P43628-1 ]
ENST00000615091 ; ENSP00000483551 ; ENSG00000275658 . [P43628-1 ]
ENST00000615739 ; ENSP00000478136 ; ENSG00000273887 .
ENST00000617150 ; ENSP00000481159 ; ENSG00000274952 .
ENST00000617242 ; ENSP00000483883 ; ENSG00000274410 . [P43628-1 ]
ENST00000617404 ; ENSP00000481478 ; ENSG00000275008 . [P43628-1 ]
ENST00000617593 ; ENSP00000483192 ; ENSG00000274108 . [P43628-1 ]
ENST00000617790 ; ENSP00000481355 ; ENSG00000275623 . [P43628-1 ]
ENST00000619702 ; ENSP00000480464 ; ENSG00000274402 . [P43628-1 ]
ENST00000619995 ; ENSP00000480087 ; ENSG00000277317 . [P43628-1 ]
ENST00000620549 ; ENSP00000483419 ; ENSG00000277924 . [P43628-1 ]
ENST00000622644 ; ENSP00000482830 ; ENSG00000276459 . [P43628-1 ]
GeneIDi 3804.
KEGGi hsa:3804.
UCSCi uc002qgx.3. human. [P43628-1 ]

Organism-specific databases

CTDi 3804.
GeneCardsi GC19P055277.
HGNCi HGNC:6331. KIR2DL3.
MIMi 604938. gene.
neXtProti NX_P43628.
PharmGKBi PA30116.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00760000119033.
HOVERGENi HBG074353.
InParanoidi P43628.
KOi K07981.
OMAi KATVSCN.
PhylomeDBi P43628.
TreeFami TF352669.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTracei P43628.
GenomeRNAii 3804.
NextBioi 14943.
PROi P43628.
SOURCEi Search...

Gene expression databases

ExpressionAtlasi P43628. baseline.
Genevestigatori P43628.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
    Colonna M., Samaridis J.
    Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Natural killer cell.
  2. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
    Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
    Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Natural killer cell.
  3. "Alternatively spliced forms of human killer inhibitory receptors."
    Doehring C., Samaridis J., Colonna M.
    Immunogenetics 44:227-230(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANTS LEU-229; THR-304 AND HIS-318.
  4. Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1), VARIANTS ALA-9; ARG-32; GLU-56; ARG-71 AND HIS-318.
  5. "Polymorphism and domain variability of human killer cell inhibitory receptors."
    Selvakumar A., Steffens U., Dupont B.
    Immunol. Rev. 155:183-196(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS ALA-9; ARG-32; GLU-56; ARG-71; ILE-242 AND HIS-318.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS LEU-229 AND HIS-318.
    Tissue: Blood.
  7. "Genomic organization of a human killer cell inhibitory receptor gene."
    Wilson M.J., Torkar M., Trowsdale J.
    Tissue Antigens 49:574-579(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-298 (ISOFORM 1), VARIANT LEU-229.
  8. "Genomic organization of novel genes encoding human killer inhibitory receptors."
    Chae J.H., Kim Y.M., Ahn J.M., Kim C.G., Kim J., Kim S.J., Park J.H.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341, VARIANT GLN-34.
    Tissue: Placenta.
  9. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
    Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
    Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARRB2.
  10. "Crystal structure of the human p58 killer cell inhibitory receptor (KIR2DL3) specific for HLA-Cw3-related MHC class I."
    Maenaka K., Juji T., Stuart D.I., Jones E.Y.
    Structure 7:391-398(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 22-245.

Entry informationi

Entry nameiKI2L3_HUMAN
AccessioniPrimary (citable) accession number: P43628
Secondary accession number(s): O43472
, P78402, Q14944, Q14945, Q9UM51, Q9UQ70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 151 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3