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Protein

Killer cell immunoglobulin-like receptor 2DL2

Gene

KIR2DL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-Cw1, 3, 7, and 8 allotypes. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL2
Alternative name(s):
CD158 antigen-like family member B1
MHC class I NK cell receptor
Natural killer-associated transcript 6
Short name:
NKAT-6
p58 natural killer cell receptor clone CL-43
Short name:
p58 NK receptor CL-43
CD_antigen: CD158b1
Gene namesi
Name:KIR2DL2
Synonyms:CD158B1, NKAT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6330. KIR2DL2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 348CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3803.
OpenTargetsiENSG00000275407.
ENSG00000275546.
ENSG00000275914.
ENSG00000276011.
ENSG00000276731.
ENSG00000278731.
PharmGKBiPA30115.

Polymorphism and mutation databases

DMDMi1171725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001507922 – 348Killer cell immunoglobulin-like receptor 2DL2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources2 Publications
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 198Combined sources2 Publications
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP43627.
PRIDEiP43627.

PTM databases

iPTMnetiP43627.
PhosphoSitePlusiP43627.

Expressioni

Gene expression databases

CleanExiHS_KIR2DL2.

Interactioni

Protein-protein interaction databases

BioGridi110004. 3 interactors.

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 32Combined sources3
Beta strandi37 – 40Combined sources4
Beta strandi45 – 53Combined sources9
Beta strandi56 – 61Combined sources6
Beta strandi64 – 66Combined sources3
Beta strandi69 – 72Combined sources4
Beta strandi77 – 87Combined sources11
Turni92 – 94Combined sources3
Beta strandi96 – 103Combined sources8
Beta strandi107 – 109Combined sources3
Beta strandi118 – 123Combined sources6
Beta strandi130 – 135Combined sources6
Beta strandi137 – 140Combined sources4
Beta strandi143 – 150Combined sources8
Beta strandi156 – 161Combined sources6
Beta strandi163 – 165Combined sources3
Beta strandi169 – 172Combined sources4
Beta strandi177 – 179Combined sources3
Beta strandi180 – 182Combined sources3
Beta strandi184 – 189Combined sources6
Beta strandi194 – 201Combined sources8
Beta strandi205 – 209Combined sources5
Beta strandi216 – 219Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFXX-ray3.00D/E22-221[»]
2DL2X-ray3.00A26-221[»]
2DLIX-ray2.90A25-221[»]
ProteinModelPortaliP43627.
SMRiP43627.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43627.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43627.
KOiK07981.
OrthoDBiEOG091G0APE.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43627-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLMVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGRLVK SEETVILQCW
60 70 80 90 100
SDVRFEHFLL HREGKFKDTL HLIGEHHDGV SKANFSIGPM MQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ LSAPSDPLDI VITGLYEKPS LSAQPGPTVL AGESVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHECR FSAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFRDSPYEWS NSSDPLLVSV IGNPSNSWPS PTEPSSKTGN PRHLHILIGT
260 270 280 290 300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
310 320 330 340
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYAELPNAES RSKVVSCP
Length:348
Mass (Da):38,472
Last modified:November 1, 1995 - v1
Checksum:i5B54C548F5CF3FBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289 – 290SE → RQ in AAB36597 (PubMed:8662091).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0594179A → V.Corresponds to variant rs3810343dbSNPEnsembl.1
Natural variantiVAR_02192937R → P.Corresponds to variant rs613240dbSNPEnsembl.1
Natural variantiVAR_05941866F → Y.Corresponds to variant rs673568dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24075 mRNA. Translation: AAC50334.1.
L76669 mRNA. Translation: AAB36597.1.
EU791544 Genomic DNA. Translation: ACI49715.1.
RefSeqiNP_055034.2. NM_014219.2.
UniGeneiHs.743949.

Genome annotation databases

EnsembliENST00000611724; ENSP00000482519; ENSG00000275546.
ENST00000613410; ENSP00000483373; ENSG00000276731.
ENST00000616831; ENSP00000482201; ENSG00000278731.
ENST00000618388; ENSP00000480161; ENSG00000275914.
ENST00000618796; ENSP00000481907; ENSG00000275407.
ENST00000619621; ENSP00000483052; ENSG00000276011.
GeneIDi3803.
KEGGihsa:3803.
UCSCiuc032lsh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24075 mRNA. Translation: AAC50334.1.
L76669 mRNA. Translation: AAB36597.1.
EU791544 Genomic DNA. Translation: ACI49715.1.
RefSeqiNP_055034.2. NM_014219.2.
UniGeneiHs.743949.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EFXX-ray3.00D/E22-221[»]
2DL2X-ray3.00A26-221[»]
2DLIX-ray2.90A25-221[»]
ProteinModelPortaliP43627.
SMRiP43627.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110004. 3 interactors.

PTM databases

iPTMnetiP43627.
PhosphoSitePlusiP43627.

Polymorphism and mutation databases

DMDMi1171725.

Proteomic databases

PeptideAtlasiP43627.
PRIDEiP43627.

Protocols and materials databases

DNASUi3803.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611724; ENSP00000482519; ENSG00000275546.
ENST00000613410; ENSP00000483373; ENSG00000276731.
ENST00000616831; ENSP00000482201; ENSG00000278731.
ENST00000618388; ENSP00000480161; ENSG00000275914.
ENST00000618796; ENSP00000481907; ENSG00000275407.
ENST00000619621; ENSP00000483052; ENSG00000276011.
GeneIDi3803.
KEGGihsa:3803.
UCSCiuc032lsh.2. human.

Organism-specific databases

CTDi3803.
DisGeNETi3803.
GeneCardsiKIR2DL2.
HGNCiHGNC:6330. KIR2DL2.
MIMi604937. gene.
neXtProtiNX_P43627.
OpenTargetsiENSG00000275407.
ENSG00000275546.
ENSG00000275914.
ENSG00000276011.
ENSG00000276731.
ENSG00000278731.
PharmGKBiPA30115.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG074353.
InParanoidiP43627.
KOiK07981.
OrthoDBiEOG091G0APE.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP43627.
GenomeRNAii3803.
PROiP43627.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DL2.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L2_HUMAN
AccessioniPrimary (citable) accession number: P43627
Secondary accession number(s): C6EVR8, Q14951
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.