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P43626 (KI2L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Killer cell immunoglobulin-like receptor 2DL1
Alternative name(s):
CD158 antigen-like family member A
MHC class I NK cell receptor
Natural killer-associated transcript 1
Short name=NKAT-1
p58 natural killer cell receptor clones CL-42/47.11
Short name=p58 NK receptor CL-42/47.11
p58.1 MHC class-I-specific NK receptor
CD_antigen=CD158a
Gene names
Name:KIR2DL1
Synonyms:CD158A, NKAT1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Ref.5

Subunit structure

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Ref.5

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Sequence similarities

Belongs to the immunoglobulin superfamily.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PTPN6P293504EBI-8684277,EBI-78260

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Ref.2
Chain22 – 348327Killer cell immunoglobulin-like receptor 2DL1
PRO_0000015078

Regions

Topological domain22 – 245224Extracellular Potential
Transmembrane246 – 26419Helical; Potential
Topological domain265 – 34884Cytoplasmic Potential
Domain42 – 10766Ig-like C2-type 1
Domain142 – 20564Ig-like C2-type 2

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation1441N-linked (GlcNAc...) Potential
Glycosylation1781N-linked (GlcNAc...) Potential
Disulfide bond49 ↔ 100
Disulfide bond149 ↔ 198

Natural variations

Natural variant51V → F. Ref.4
Corresponds to variant rs2304224 [ dbSNP | Ensembl ].
VAR_003949
Natural variant91A → V.
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
VAR_061332
Natural variant371P → R.
Corresponds to variant rs35509911 [ dbSNP | Ensembl ].
VAR_003950
Natural variant661F → Y.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].
VAR_056091
Natural variant1111V → L.
Corresponds to variant rs687885 [ dbSNP | Ensembl ].
VAR_061333
Natural variant1351P → L.
VAR_003951
Natural variant1751P → T.
VAR_010331
Natural variant1841D → N.
VAR_010332
Natural variant2031H → R.
VAR_010333
Natural variant2371K → E.
VAR_010334
Natural variant2661R → C.
VAR_010335

Experimental info

Mutagenesis3021Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. Ref.5
Mutagenesis3321Y → A: Abolishes interaction with ARRB2; when associated with A-302. Ref.5

Secondary structure

......................................... 348
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43626 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 3DFBF2D6FDCE1D1E

FASTA34838,505
        10         20         30         40         50         60 
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW SDVMFEHFLL 

        70         80         90        100        110        120 
HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC YGSVTHSPYQ VSAPSDPLDI 

       130        140        150        160        170        180 
VIIGLYEKPS LSAQPGPTVL AGENVTLSCS SRSSYDMYHL SREGEAHERR LPAGPKVNGT 

       190        200        210        220        230        240 
FQADFPLGPA THGGTYRCFG SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN 

       250        260        270        280        290        300 
PRHLHILIGT SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 

       310        320        330        340 
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP 

« Hide

References

[1]"Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
Colonna M., Samaridis J.
Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Natural killer cell.
[2]"Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-45.
Tissue: Natural killer cell.
[3]"Human diversity in killer cell inhibitory receptor genes."
Uhrberg M., Valiante N.M., Shum B.P., Shilling H.G., Lienert-Weidenbach K., Corliss B., Tyan D., Lanier L.L., Parham P.
Immunity 7:753-763(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
[4]"Variants of KIR identified in Japanese donors."
Yawata N., Yawata M., Parham P.
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-5.
[5]"An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ARRB2; PTPN6 AND PTPN11, MUTAGENESIS OF TYR-302 AND TYR-332.
[6]"Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."
Fan Q.R., Mosyak L., Winter C.C., Wagtmann N., Long E.O., Wiley D.C.
Nature 389:96-100(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-221.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L41267 mRNA. Translation: AAA69868.1.
U24076 mRNA. Translation: AAC50335.1.
U24078 mRNA. Translation: AAC50337.1.
AF022045 mRNA. Translation: AAB95318.1.
AY789055 mRNA. Translation: AAX23100.1.
CCDSCCDS12904.1.
PIRA56247.
RefSeqNP_055033.2. NM_014218.2.
UniGeneHs.654605.
Hs.690615.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IM9X-ray2.80D22-245[»]
1NKRX-ray1.70A22-221[»]
ProteinModelPortalP43626.
SMRP43626. Positions 27-259.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110003. 1 interaction.
IntActP43626. 3 interactions.
MINTMINT-8013645.
STRING9606.ENSP00000336769.

PTM databases

PhosphoSiteP43626.

Polymorphism databases

DMDM1171726.

Proteomic databases

PaxDbP43626.
PRIDEP43626.

Protocols and materials databases

DNASU3802.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000336077; ENSP00000336769; ENSG00000125498.
ENST00000576294; ENSP00000458867; ENSG00000263208.
GeneID3802.
KEGGhsa:3802.

Organism-specific databases

CTD3802.
GeneCardsGC19P055283.
HGNCHGNC:6329. KIR2DL1.
HPAHPA049255.
MIM604936. gene.
neXtProtNX_P43626.
PharmGKBPA30114.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG82473.
HOGENOMHOG000234396.
HOVERGENHBG074353.
KOK07981.
PhylomeDBP43626.
TreeFamTF352669.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.

Gene expression databases

CleanExHS_KIR2DL1.
GenevestigatorP43626.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamPF00047. ig. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43626.
GeneWikiKIR2DL1.
GenomeRNAi3802.
NextBio14935.
PROP43626.
SOURCESearch...

Entry information

Entry nameKI2L1_HUMAN
AccessionPrimary (citable) accession number: P43626
Secondary accession number(s): O43470, Q32WE6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 9, 2014
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries