Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P43626

- KI2L1_HUMAN

UniProt

P43626 - KI2L1_HUMAN

Protein

Killer cell immunoglobulin-like receptor 2DL1

Gene

KIR2DL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. receptor activity Source: ProtInc

    GO - Biological processi

    1. immune response Source: ProtInc
    2. natural killer cell inhibitory signaling pathway Source: UniProtKB
    3. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Killer cell immunoglobulin-like receptor 2DL1
    Alternative name(s):
    CD158 antigen-like family member A
    MHC class I NK cell receptor
    Natural killer-associated transcript 1
    Short name:
    NKAT-1
    p58 natural killer cell receptor clones CL-42/47.11
    Short name:
    p58 NK receptor CL-42/47.11
    p58.1 MHC class-I-specific NK receptor
    CD_antigen: CD158a
    Gene namesi
    Name:KIR2DL1
    Synonyms:CD158A, NKAT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6329. KIR2DL1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi302 – 3021Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication
    Mutagenesisi332 – 3321Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication

    Organism-specific databases

    PharmGKBiPA30114.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 21211 PublicationAdd
    BLAST
    Chaini22 – 348327Killer cell immunoglobulin-like receptor 2DL1PRO_0000015078Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi49 ↔ 100
    Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi144 – 1441N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi149 ↔ 198
    Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP43626.
    PRIDEiP43626.

    PTM databases

    PhosphoSiteiP43626.

    Expressioni

    Gene expression databases

    CleanExiHS_KIR2DL1.
    GenevestigatoriP43626.

    Organism-specific databases

    HPAiHPA049255.

    Interactioni

    Subunit structurei

    Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PTPN6P293504EBI-8684277,EBI-78260

    Protein-protein interaction databases

    BioGridi110003. 1 interaction.
    IntActiP43626. 3 interactions.
    MINTiMINT-8013645.
    STRINGi9606.ENSP00000336769.

    Structurei

    Secondary structure

    1
    348
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi30 – 356
    Beta strandi37 – 404
    Beta strandi45 – 539
    Beta strandi56 – 6611
    Beta strandi68 – 736
    Beta strandi75 – 773
    Beta strandi80 – 8910
    Helixi92 – 943
    Beta strandi96 – 1049
    Beta strandi118 – 1236
    Beta strandi130 – 1356
    Beta strandi137 – 1404
    Beta strandi144 – 15310
    Beta strandi156 – 1627
    Beta strandi169 – 1724
    Beta strandi174 – 1774
    Beta strandi180 – 18910
    Beta strandi194 – 2029
    Beta strandi205 – 2095
    Beta strandi216 – 2216

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1IM9X-ray2.80D22-245[»]
    1NKRX-ray1.70A22-221[»]
    ProteinModelPortaliP43626.
    SMRiP43626. Positions 27-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43626.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 245224ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini265 – 34884CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei246 – 26419HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 10766Ig-like C2-type 1Add
    BLAST
    Domaini142 – 20564Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG82473.
    HOGENOMiHOG000234396.
    HOVERGENiHBG074353.
    KOiK07981.
    PhylomeDBiP43626.
    TreeFamiTF352669.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view]
    PfamiPF00047. ig. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43626-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW    50
    SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC 100
    YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS 150
    SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG 200
    SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT 250
    SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 300
    TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP 348
    Length:348
    Mass (Da):38,505
    Last modified:November 1, 1995 - v1
    Checksum:i3DFBF2D6FDCE1D1E
    GO
    Isoform 2 (identifier: P43626-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         238-239: TG → TERMFHHVGQACLKLPTSSDPTVSACQS

    Note: No experimental confirmation available.

    Show »
    Length:374
    Mass (Da):41,360
    Checksum:i80C18B19F3A5B394
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti5 – 51V → F.1 Publication
    Corresponds to variant rs2304224 [ dbSNP | Ensembl ].
    VAR_003949
    Natural varianti9 – 91A → V.
    Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
    VAR_061332
    Natural varianti37 – 371P → R.1 Publication
    Corresponds to variant rs35509911 [ dbSNP | Ensembl ].
    VAR_003950
    Natural varianti66 – 661F → Y.
    Corresponds to variant rs673568 [ dbSNP | Ensembl ].
    VAR_056091
    Natural varianti111 – 1111V → L.
    Corresponds to variant rs687885 [ dbSNP | Ensembl ].
    VAR_061333
    Natural varianti135 – 1351P → L.1 Publication
    VAR_003951
    Natural varianti175 – 1751P → T.
    VAR_010331
    Natural varianti184 – 1841D → N.
    VAR_010332
    Natural varianti203 – 2031H → R.
    VAR_010333
    Natural varianti237 – 2371K → E.
    VAR_010334
    Natural varianti266 – 2661R → C.
    VAR_010335

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei238 – 2392TG → TERMFHHVGQACLKLPTSSD PTVSACQS in isoform 2. 1 PublicationVSP_056314

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41267 mRNA. Translation: AAA69868.1.
    U24076 mRNA. Translation: AAC50335.1.
    U24078 mRNA. Translation: AAC50337.1.
    AF022045 mRNA. Translation: AAB95318.1.
    AY789055 mRNA. Translation: AAX23100.1.
    AC011501 Genomic DNA. No translation available.
    BC069344 mRNA. Translation: AAH69344.1.
    CCDSiCCDS12904.1.
    PIRiA56247.
    RefSeqiNP_055033.2. NM_014218.2.
    XP_005258946.1. XM_005258889.1.
    UniGeneiHs.654605.
    Hs.690615.

    Genome annotation databases

    EnsembliENST00000291633; ENSP00000291633; ENSG00000125498.
    ENST00000336077; ENSP00000336769; ENSG00000125498.
    GeneIDi3802.
    KEGGihsa:3802.

    Polymorphism databases

    DMDMi1171726.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L41267 mRNA. Translation: AAA69868.1 .
    U24076 mRNA. Translation: AAC50335.1 .
    U24078 mRNA. Translation: AAC50337.1 .
    AF022045 mRNA. Translation: AAB95318.1 .
    AY789055 mRNA. Translation: AAX23100.1 .
    AC011501 Genomic DNA. No translation available.
    BC069344 mRNA. Translation: AAH69344.1 .
    CCDSi CCDS12904.1.
    PIRi A56247.
    RefSeqi NP_055033.2. NM_014218.2.
    XP_005258946.1. XM_005258889.1.
    UniGenei Hs.654605.
    Hs.690615.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1IM9 X-ray 2.80 D 22-245 [» ]
    1NKR X-ray 1.70 A 22-221 [» ]
    ProteinModelPortali P43626.
    SMRi P43626. Positions 27-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110003. 1 interaction.
    IntActi P43626. 3 interactions.
    MINTi MINT-8013645.
    STRINGi 9606.ENSP00000336769.

    PTM databases

    PhosphoSitei P43626.

    Polymorphism databases

    DMDMi 1171726.

    Proteomic databases

    PaxDbi P43626.
    PRIDEi P43626.

    Protocols and materials databases

    DNASUi 3802.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000291633 ; ENSP00000291633 ; ENSG00000125498 .
    ENST00000336077 ; ENSP00000336769 ; ENSG00000125498 .
    GeneIDi 3802.
    KEGGi hsa:3802.

    Organism-specific databases

    CTDi 3802.
    GeneCardsi GC19P055283.
    HGNCi HGNC:6329. KIR2DL1.
    HPAi HPA049255.
    MIMi 604936. gene.
    neXtProti NX_P43626.
    PharmGKBi PA30114.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG82473.
    HOGENOMi HOG000234396.
    HOVERGENi HBG074353.
    KOi K07981.
    PhylomeDBi P43626.
    TreeFami TF352669.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    EvolutionaryTracei P43626.
    GeneWikii KIR2DL1.
    GenomeRNAii 3802.
    NextBioi 14935.
    PROi P43626.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_KIR2DL1.
    Genevestigatori P43626.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013151. Immunoglobulin.
    [Graphical view ]
    Pfami PF00047. ig. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
      Colonna M., Samaridis J.
      Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Natural killer cell.
    2. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
      Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
      Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 22-45.
      Tissue: Natural killer cell.
    3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANTS.
    4. "Variants of KIR identified in Japanese donors."
      Yawata N., Yawata M., Parham P.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PHE-5.
    5. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS ARG-37 AND LEU-135.
    7. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
      Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
      Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ARRB2; PTPN6 AND PTPN11, MUTAGENESIS OF TYR-302 AND TYR-332.
    8. "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."
      Fan Q.R., Mosyak L., Winter C.C., Wagtmann N., Long E.O., Wiley D.C.
      Nature 389:96-100(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-221.

    Entry informationi

    Entry nameiKI2L1_HUMAN
    AccessioniPrimary (citable) accession number: P43626
    Secondary accession number(s): O43470, Q32WE6, Q6IST4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 138 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3