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Protein

Killer cell immunoglobulin-like receptor 2DL1

Gene

KIR2DL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  • receptor activity Source: ProtInc

GO - Biological processi

  • immune response Source: ProtInc
  • natural killer cell inhibitory signaling pathway Source: UniProtKB
  • regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL1
Alternative name(s):
CD158 antigen-like family member A
MHC class I NK cell receptor
Natural killer-associated transcript 1
Short name:
NKAT-1
p58 natural killer cell receptor clones CL-42/47.11
Short name:
p58 NK receptor CL-42/47.11
p58.1 MHC class-I-specific NK receptor
CD_antigen: CD158a
Gene namesi
Name:KIR2DL1
Synonyms:CD158A, NKAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6329. KIR2DL1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 245ExtracellularSequence analysisAdd BLAST224
Transmembranei246 – 264HelicalSequence analysisAdd BLAST19
Topological domaini265 – 348CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi302Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication1
Mutagenesisi332Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication1

Organism-specific databases

DisGeNETi3802.
PharmGKBiPA30114.

Polymorphism and mutation databases

BioMutaiKIR2DL1.
DMDMi1171726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001507822 – 348Killer cell immunoglobulin-like receptor 2DL1Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi49 ↔ 100Combined sources1 Publication
Glycosylationi67N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi144N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi149 ↔ 198Combined sources1 Publication
Glycosylationi178N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43626.
PeptideAtlasiP43626.
PRIDEiP43626.

PTM databases

iPTMnetiP43626.
PhosphoSitePlusiP43626.

Expressioni

Gene expression databases

CleanExiHS_KIR2DL1.
ExpressionAtlasiP43626. baseline and differential.
GenevisibleiP43626. HS.

Interactioni

Subunit structurei

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN6P293504EBI-8684277,EBI-78260

Protein-protein interaction databases

BioGridi110003. 1 interactor.
IntActiP43626. 3 interactors.
MINTiMINT-8013645.
STRINGi9606.ENSP00000336769.

Structurei

Secondary structure

1348
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 35Combined sources6
Beta strandi37 – 40Combined sources4
Beta strandi45 – 53Combined sources9
Beta strandi56 – 66Combined sources11
Beta strandi68 – 73Combined sources6
Beta strandi75 – 77Combined sources3
Beta strandi80 – 89Combined sources10
Helixi92 – 94Combined sources3
Beta strandi96 – 104Combined sources9
Beta strandi118 – 123Combined sources6
Beta strandi130 – 135Combined sources6
Beta strandi137 – 140Combined sources4
Beta strandi144 – 153Combined sources10
Beta strandi156 – 162Combined sources7
Beta strandi169 – 172Combined sources4
Beta strandi174 – 177Combined sources4
Beta strandi180 – 189Combined sources10
Beta strandi194 – 202Combined sources9
Beta strandi205 – 209Combined sources5
Beta strandi216 – 221Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM9X-ray2.80D22-245[»]
1NKRX-ray1.70A22-221[»]
ProteinModelPortaliP43626.
SMRiP43626.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43626.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 107Ig-like C2-type 1Add BLAST66
Domaini142 – 205Ig-like C2-type 2Add BLAST64

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410KCDN. Eukaryota.
ENOG4110P2R. LUCA.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43626.
KOiK07981.
OrthoDBiEOG091G0APE.
PhylomeDBiP43626.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43626-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW
60 70 80 90 100
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC
110 120 130 140 150
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS
160 170 180 190 200
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG
210 220 230 240 250
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT
260 270 280 290 300
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV
310 320 330 340
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP
Length:348
Mass (Da):38,505
Last modified:November 1, 1995 - v1
Checksum:i3DFBF2D6FDCE1D1E
GO
Isoform 2 (identifier: P43626-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     238-239: TG → TERMFHHVGQACLKLPTSSDPTVSACQS

Note: No experimental confirmation available.
Show »
Length:374
Mass (Da):41,360
Checksum:i80C18B19F3A5B394
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0039495V → F.1 PublicationCorresponds to variant rs2304224dbSNPEnsembl.1
Natural variantiVAR_0613329A → V.Corresponds to variant rs3810343dbSNPEnsembl.1
Natural variantiVAR_00395037P → R.1 PublicationCorresponds to variant rs35509911dbSNPEnsembl.1
Natural variantiVAR_05609166F → Y.Corresponds to variant rs673568dbSNPEnsembl.1
Natural variantiVAR_061333111V → L.Corresponds to variant rs687885dbSNPEnsembl.1
Natural variantiVAR_003951135P → L.1 Publication1
Natural variantiVAR_010331175P → T.1
Natural variantiVAR_010332184D → N.1
Natural variantiVAR_010333203H → R.1
Natural variantiVAR_010334237K → E.1
Natural variantiVAR_010335266R → C.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056314238 – 239TG → TERMFHHVGQACLKLPTSSD PTVSACQS in isoform 2. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41267 mRNA. Translation: AAA69868.1.
U24076 mRNA. Translation: AAC50335.1.
U24078 mRNA. Translation: AAC50337.1.
AF022045 mRNA. Translation: AAB95318.1.
AY789055 mRNA. Translation: AAX23100.1.
AC011501 Genomic DNA. No translation available.
BC069344 mRNA. Translation: AAH69344.1.
CCDSiCCDS12904.1. [P43626-1]
PIRiA56247.
RefSeqiNP_055033.2. NM_014218.2.
UniGeneiHs.654605.
Hs.690615.

Genome annotation databases

EnsembliENST00000291633; ENSP00000291633; ENSG00000125498.
ENST00000611611; ENSP00000478232; ENSG00000278738.
ENST00000615920; ENSP00000482120; ENSG00000273794.
ENST00000617376; ENSP00000484559; ENSG00000278821.
ENST00000618563; ENSP00000484361; ENSG00000276625.
ENST00000620449; ENSP00000478263; ENSG00000277833.
ENST00000622463; ENSP00000479363; ENSG00000278495.
GeneIDi3802.
KEGGihsa:3802.
UCSCiuc010erz.2. human. [P43626-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41267 mRNA. Translation: AAA69868.1.
U24076 mRNA. Translation: AAC50335.1.
U24078 mRNA. Translation: AAC50337.1.
AF022045 mRNA. Translation: AAB95318.1.
AY789055 mRNA. Translation: AAX23100.1.
AC011501 Genomic DNA. No translation available.
BC069344 mRNA. Translation: AAH69344.1.
CCDSiCCDS12904.1. [P43626-1]
PIRiA56247.
RefSeqiNP_055033.2. NM_014218.2.
UniGeneiHs.654605.
Hs.690615.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IM9X-ray2.80D22-245[»]
1NKRX-ray1.70A22-221[»]
ProteinModelPortaliP43626.
SMRiP43626.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110003. 1 interactor.
IntActiP43626. 3 interactors.
MINTiMINT-8013645.
STRINGi9606.ENSP00000336769.

PTM databases

iPTMnetiP43626.
PhosphoSitePlusiP43626.

Polymorphism and mutation databases

BioMutaiKIR2DL1.
DMDMi1171726.

Proteomic databases

PaxDbiP43626.
PeptideAtlasiP43626.
PRIDEiP43626.

Protocols and materials databases

DNASUi3802.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291633; ENSP00000291633; ENSG00000125498.
ENST00000611611; ENSP00000478232; ENSG00000278738.
ENST00000615920; ENSP00000482120; ENSG00000273794.
ENST00000617376; ENSP00000484559; ENSG00000278821.
ENST00000618563; ENSP00000484361; ENSG00000276625.
ENST00000620449; ENSP00000478263; ENSG00000277833.
ENST00000622463; ENSP00000479363; ENSG00000278495.
GeneIDi3802.
KEGGihsa:3802.
UCSCiuc010erz.2. human. [P43626-1]

Organism-specific databases

CTDi3802.
DisGeNETi3802.
GeneCardsiKIR2DL1.
HGNCiHGNC:6329. KIR2DL1.
MIMi604936. gene.
neXtProtiNX_P43626.
PharmGKBiPA30114.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410KCDN. Eukaryota.
ENOG4110P2R. LUCA.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
InParanoidiP43626.
KOiK07981.
OrthoDBiEOG091G0APE.
PhylomeDBiP43626.
TreeFamiTF352669.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTraceiP43626.
GeneWikiiKIR2DL1.
GenomeRNAii3802.
PROiP43626.
SOURCEiSearch...

Gene expression databases

CleanExiHS_KIR2DL1.
ExpressionAtlasiP43626. baseline and differential.
GenevisibleiP43626. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiKI2L1_HUMAN
AccessioniPrimary (citable) accession number: P43626
Secondary accession number(s): O43470, Q32WE6, Q6IST4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.