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P43626

- KI2L1_HUMAN

UniProt

P43626 - KI2L1_HUMAN

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Protein

Killer cell immunoglobulin-like receptor 2DL1

Gene
KIR2DL1, CD158A, NKAT1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. receptor activity Source: ProtInc

GO - Biological processi

  1. immune response Source: ProtInc
  2. natural killer cell inhibitory signaling pathway Source: UniProtKB
  3. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Killer cell immunoglobulin-like receptor 2DL1
Alternative name(s):
CD158 antigen-like family member A
MHC class I NK cell receptor
Natural killer-associated transcript 1
Short name:
NKAT-1
p58 natural killer cell receptor clones CL-42/47.11
Short name:
p58 NK receptor CL-42/47.11
p58.1 MHC class-I-specific NK receptor
CD_antigen: CD158a
Gene namesi
Name:KIR2DL1
Synonyms:CD158A, NKAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:6329. KIR2DL1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 245224Extracellular Reviewed predictionAdd
BLAST
Transmembranei246 – 26419Helical; Reviewed predictionAdd
BLAST
Topological domaini265 – 34884Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi302 – 3021Y → A: Abolishes interaction with ARRB2; when associated with A-332. Diminishes interaction with ARRB2. 1 Publication
Mutagenesisi332 – 3321Y → A: Abolishes interaction with ARRB2; when associated with A-302. 1 Publication

Organism-specific databases

PharmGKBiPA30114.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 348327Killer cell immunoglobulin-like receptor 2DL1PRO_0000015078Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi49 ↔ 100
Glycosylationi67 – 671N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi144 – 1441N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi149 ↔ 198
Glycosylationi178 – 1781N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43626.
PRIDEiP43626.

PTM databases

PhosphoSiteiP43626.

Expressioni

Gene expression databases

CleanExiHS_KIR2DL1.
GenevestigatoriP43626.

Organism-specific databases

HPAiHPA049255.

Interactioni

Subunit structurei

Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PTPN6P293504EBI-8684277,EBI-78260

Protein-protein interaction databases

BioGridi110003. 1 interaction.
IntActiP43626. 3 interactions.
MINTiMINT-8013645.
STRINGi9606.ENSP00000336769.

Structurei

Secondary structure

1
348
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi30 – 356
Beta strandi37 – 404
Beta strandi45 – 539
Beta strandi56 – 6611
Beta strandi68 – 736
Beta strandi75 – 773
Beta strandi80 – 8910
Helixi92 – 943
Beta strandi96 – 1049
Beta strandi118 – 1236
Beta strandi130 – 1356
Beta strandi137 – 1404
Beta strandi144 – 15310
Beta strandi156 – 1627
Beta strandi169 – 1724
Beta strandi174 – 1774
Beta strandi180 – 18910
Beta strandi194 – 2029
Beta strandi205 – 2095
Beta strandi216 – 2216

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1IM9X-ray2.80D22-245[»]
1NKRX-ray1.70A22-221[»]
ProteinModelPortaliP43626.
SMRiP43626. Positions 27-259.

Miscellaneous databases

EvolutionaryTraceiP43626.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 10766Ig-like C2-type 1Add
BLAST
Domaini142 – 20564Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG82473.
HOGENOMiHOG000234396.
HOVERGENiHBG074353.
KOiK07981.
PhylomeDBiP43626.
TreeFamiTF352669.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view]
PfamiPF00047. ig. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43626-1 [UniParc]FASTAAdd to Basket

« Hide

MSLLVVSMAC VGFFLLQGAW PHEGVHRKPS LLAHPGPLVK SEETVILQCW    50
SDVMFEHFLL HREGMFNDTL RLIGEHHDGV SKANFSISRM TQDLAGTYRC 100
YGSVTHSPYQ VSAPSDPLDI VIIGLYEKPS LSAQPGPTVL AGENVTLSCS 150
SRSSYDMYHL SREGEAHERR LPAGPKVNGT FQADFPLGPA THGGTYRCFG 200
SFHDSPYEWS KSSDPLLVSV TGNPSNSWPS PTEPSSKTGN PRHLHILIGT 250
SVVIILFILL FFLLHRWCSN KKNAAVMDQE SAGNRTANSE DSDEQDPQEV 300
TYTQLNHCVF TQRKITRPSQ RPKTPPTDII VYTELPNAES RSKVVSCP 348
Length:348
Mass (Da):38,505
Last modified:November 1, 1995 - v1
Checksum:i3DFBF2D6FDCE1D1E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51V → F.1 Publication
Corresponds to variant rs2304224 [ dbSNP | Ensembl ].
VAR_003949
Natural varianti9 – 91A → V.
Corresponds to variant rs3810343 [ dbSNP | Ensembl ].
VAR_061332
Natural varianti37 – 371P → R.
Corresponds to variant rs35509911 [ dbSNP | Ensembl ].
VAR_003950
Natural varianti66 – 661F → Y.
Corresponds to variant rs673568 [ dbSNP | Ensembl ].
VAR_056091
Natural varianti111 – 1111V → L.
Corresponds to variant rs687885 [ dbSNP | Ensembl ].
VAR_061333
Natural varianti135 – 1351P → L.
VAR_003951
Natural varianti175 – 1751P → T.
VAR_010331
Natural varianti184 – 1841D → N.
VAR_010332
Natural varianti203 – 2031H → R.
VAR_010333
Natural varianti237 – 2371K → E.
VAR_010334
Natural varianti266 – 2661R → C.
VAR_010335

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41267 mRNA. Translation: AAA69868.1.
U24076 mRNA. Translation: AAC50335.1.
U24078 mRNA. Translation: AAC50337.1.
AF022045 mRNA. Translation: AAB95318.1.
AY789055 mRNA. Translation: AAX23100.1.
CCDSiCCDS12904.1.
PIRiA56247.
RefSeqiNP_055033.2. NM_014218.2.
UniGeneiHs.654605.
Hs.690615.

Genome annotation databases

EnsembliENST00000336077; ENSP00000336769; ENSG00000125498.
ENST00000576294; ENSP00000458867; ENSG00000263208.
GeneIDi3802.
KEGGihsa:3802.

Polymorphism databases

DMDMi1171726.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41267 mRNA. Translation: AAA69868.1 .
U24076 mRNA. Translation: AAC50335.1 .
U24078 mRNA. Translation: AAC50337.1 .
AF022045 mRNA. Translation: AAB95318.1 .
AY789055 mRNA. Translation: AAX23100.1 .
CCDSi CCDS12904.1.
PIRi A56247.
RefSeqi NP_055033.2. NM_014218.2.
UniGenei Hs.654605.
Hs.690615.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1IM9 X-ray 2.80 D 22-245 [» ]
1NKR X-ray 1.70 A 22-221 [» ]
ProteinModelPortali P43626.
SMRi P43626. Positions 27-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110003. 1 interaction.
IntActi P43626. 3 interactions.
MINTi MINT-8013645.
STRINGi 9606.ENSP00000336769.

PTM databases

PhosphoSitei P43626.

Polymorphism databases

DMDMi 1171726.

Proteomic databases

PaxDbi P43626.
PRIDEi P43626.

Protocols and materials databases

DNASUi 3802.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336077 ; ENSP00000336769 ; ENSG00000125498 .
ENST00000576294 ; ENSP00000458867 ; ENSG00000263208 .
GeneIDi 3802.
KEGGi hsa:3802.

Organism-specific databases

CTDi 3802.
GeneCardsi GC19P055283.
HGNCi HGNC:6329. KIR2DL1.
HPAi HPA049255.
MIMi 604936. gene.
neXtProti NX_P43626.
PharmGKBi PA30114.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG82473.
HOGENOMi HOG000234396.
HOVERGENi HBG074353.
KOi K07981.
PhylomeDBi P43626.
TreeFami TF352669.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

EvolutionaryTracei P43626.
GeneWikii KIR2DL1.
GenomeRNAii 3802.
NextBioi 14935.
PROi P43626.
SOURCEi Search...

Gene expression databases

CleanExi HS_KIR2DL1.
Genevestigatori P43626.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013151. Immunoglobulin.
[Graphical view ]
Pfami PF00047. ig. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells."
    Colonna M., Samaridis J.
    Science 268:405-408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Natural killer cell.
  2. "Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains."
    Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M.S., Vitale M., Bottino C., Moretta L., Moretta A., Long E.O.
    Immunity 2:439-449(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 22-45.
    Tissue: Natural killer cell.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS.
  4. "Variants of KIR identified in Japanese donors."
    Yawata N., Yawata M., Parham P.
    Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT PHE-5.
  5. "An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells."
    Yu M.-C., Su L.-L., Zou L., Liu Y., Wu N., Kong L., Zhuang Z.-H., Sun L., Liu H.P., Hu J.-H., Li D., Strominger J.L., Zang J.-W., Pei G., Ge B.-X.
    Nat. Immunol. 9:898-907(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ARRB2; PTPN6 AND PTPN11, MUTAGENESIS OF TYR-302 AND TYR-332.
  6. "Structure of the inhibitory receptor for human natural killer cells resembles haematopoietic receptors."
    Fan Q.R., Mosyak L., Winter C.C., Wagtmann N., Long E.O., Wiley D.C.
    Nature 389:96-100(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 27-221.

Entry informationi

Entry nameiKI2L1_HUMAN
AccessioniPrimary (citable) accession number: P43626
Secondary accession number(s): O43470, Q32WE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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