UniProtKB - P43619 (NADC_YEAST)
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Protein
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Gene
BNA6
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in the catabolism of quinolinic acid (QA).By similarity
Miscellaneous
Present with 2660 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Beta-nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.1 Publication
: NAD(+) biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate.1 PublicationProteins known to be involved in this subpathway in this organism are:
- Nicotinate-nucleotide pyrophosphorylase [carboxylating] (BNA6)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from quinolinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 107 | Substrate1 Publication | 1 | |
Binding sitei | 166 | Substrate1 Publication | 1 | |
Binding sitei | 176 | Substrate1 Publication | 1 | |
Binding sitei | 206 | SubstrateBy similarity | 1 | |
Binding sitei | 227 | Substrate1 Publication | 1 |
GO - Molecular functioni
GO - Biological processi
- 'de novo' NAD biosynthetic process from tryptophan Source: SGD
- quinolinate catabolic process Source: GO_Central
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Biological process | Pyridine nucleotide biosynthesis |
Enzyme and pathway databases
BioCyci | MetaCyc:YFR047C-MONOMER. YEAST:YFR047C-MONOMER. |
BRENDAi | 2.4.2.19. 984. |
Reactomei | R-SCE-196807. Nicotinate metabolism. |
UniPathwayi | UPA00253; UER00331. |
Names & Taxonomyi
Protein namesi | Recommended name: Nicotinate-nucleotide pyrophosphorylase [carboxylating] (EC:2.4.2.19)Alternative name(s): Quinolinate phosphoribosyltransferase [decarboxylating] Short name: QAPRTase |
Gene namesi | Name:BNA6 Synonyms:QPT1 Ordered Locus Names:YFR047C |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YFR047C. |
SGDi | S000001943. BNA6. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000155956 | 1 – 295 | Nicotinate-nucleotide pyrophosphorylase [carboxylating]Add BLAST | 295 |
Proteomic databases
MaxQBi | P43619. |
PaxDbi | P43619. |
PRIDEi | P43619. |
TopDownProteomicsi | P43619. |
PTM databases
iPTMneti | P43619. |
Interactioni
Subunit structurei
Hexamer formed by 3 homodimers.1 Publication
Protein-protein interaction databases
BioGridi | 31205. 41 interactors. |
DIPi | DIP-1569N. |
IntActi | P43619. 4 interactors. |
MINTi | P43619. |
STRINGi | 4932.YFR047C. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 4 – 7 | Combined sources | 4 | |
Beta strandi | 10 – 12 | Combined sources | 3 | |
Helixi | 13 – 25 | Combined sources | 13 | |
Helixi | 31 – 36 | Combined sources | 6 | |
Beta strandi | 40 – 47 | Combined sources | 8 | |
Beta strandi | 49 – 52 | Combined sources | 4 | |
Helixi | 56 – 65 | Combined sources | 10 | |
Beta strandi | 69 – 74 | Combined sources | 6 | |
Helixi | 82 – 84 | Combined sources | 3 | |
Beta strandi | 85 – 88 | Combined sources | 4 | |
Beta strandi | 90 – 98 | Combined sources | 9 | |
Helixi | 99 – 132 | Combined sources | 34 | |
Beta strandi | 137 – 140 | Combined sources | 4 | |
Turni | 147 – 149 | Combined sources | 3 | |
Helixi | 150 – 159 | Combined sources | 10 | |
Turni | 169 – 171 | Combined sources | 3 | |
Beta strandi | 172 – 175 | Combined sources | 4 | |
Helixi | 177 – 183 | Combined sources | 7 | |
Helixi | 186 – 197 | Combined sources | 12 | |
Beta strandi | 199 – 201 | Combined sources | 3 | |
Beta strandi | 203 – 206 | Combined sources | 4 | |
Beta strandi | 208 – 210 | Combined sources | 3 | |
Helixi | 211 – 219 | Combined sources | 9 | |
Beta strandi | 222 – 225 | Combined sources | 4 | |
Beta strandi | 252 – 256 | Combined sources | 5 | |
Beta strandi | 273 – 276 | Combined sources | 4 | |
Helixi | 278 – 280 | Combined sources | 3 | |
Turni | 281 – 283 | Combined sources | 3 | |
Beta strandi | 289 – 293 | Combined sources | 5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3C2E | X-ray | 1.90 | A | 2-295 | [»] | |
3C2F | X-ray | 2.35 | A | 2-295 | [»] | |
3C2O | X-ray | 2.30 | A | 2-295 | [»] | |
3C2R | X-ray | 2.40 | A/B | 1-295 | [»] | |
3C2V | X-ray | 2.29 | A | 2-295 | [»] | |
ProteinModelPortali | P43619. | |||||
SMRi | P43619. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43619. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 144 | Substrate binding | 3 | |
Regioni | 256 – 258 | Substrate binding | 3 |
Sequence similaritiesi
Belongs to the NadC/ModD family.Curated
Phylogenomic databases
GeneTreei | ENSGT00390000002761. |
HOGENOMi | HOG000224023. |
InParanoidi | P43619. |
KOi | K00767. |
OMAi | VIMLDNM. |
OrthoDBi | EOG092C4NJQ. |
Family and domain databases
CDDi | cd01572. QPRTase. 1 hit. |
Gene3Di | 3.20.20.70. 1 hit. 3.90.1170.20. 1 hit. |
InterProi | View protein in InterPro IPR013785. Aldolase_TIM. IPR004393. NadC. IPR027277. NadC/ModD. IPR036068. Nicotinate_pribotase_like_C. IPR037128. Quinolinate_PRibosylTase_N_sf. IPR002638. Quinolinate_PRibosylTrfase_C. IPR022412. Quinolinate_PRibosylTrfase_N. |
PANTHERi | PTHR32179. PTHR32179. 1 hit. |
Pfami | View protein in Pfam PF01729. QRPTase_C. 1 hit. PF02749. QRPTase_N. 1 hit. |
PIRSFi | PIRSF006250. NadC_ModD. 1 hit. |
SUPFAMi | SSF51690. SSF51690. 1 hit. |
TIGRFAMsi | TIGR00078. nadC. 1 hit. |
i Sequence
Sequence statusi: Complete.
P43619-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVYEHLLPV NGAWRQDVTN WLSEDVPSFD FGGYVVGSDL KEANLYCKQD
60 70 80 90 100
GMLCGVPFAQ EVFNQCELQV EWLFKEGSFL EPSKNDSGKI VVAKITGPAK
110 120 130 140 150
NILLAERTAL NILSRSSGIA TASHKIISLA RSTGYKGTIA GTRKTTPGLR
160 170 180 190 200
RLEKYSMLVG GCDTHRYDLS SMVMLKDNHI WATGSITNAV KNARAVCGFA
210 220 230 240 250
VKIEVECLSE DEATEAIEAG ADVIMLDNFK GDGLKMCAQS LKNKWNGKKH
260 270 280 290
FLLECSGGLN LDNLEEYLCD DIDIYSTSSI HQGTPVIDFS LKLAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50617 Genomic DNA. Translation: BAA09286.1. BK006940 Genomic DNA. Translation: DAA12490.1. |
PIRi | S56302. |
RefSeqi | NP_602317.3. NM_001180012.3. |
Genome annotation databases
EnsemblFungii | BAA09286; BAA09286; BAA09286. YFR047C; YFR047C; YFR047C. |
GeneIDi | 850608. |
KEGGi | sce:YFR047C. |
Similar proteinsi
Entry informationi
Entry namei | NADC_YEAST | |
Accessioni | P43619Primary (citable) accession number: P43619 Secondary accession number(s): D6VTT0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | March 28, 2018 | |
This is version 165 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |