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P43618

- CNN1_YEAST

UniProt

P43618 - CNN1_YEAST

Protein

Kinetochore-associated protein CNN1

Gene

CNN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. centromeric DNA binding Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. chromosome segregation Source: SGD
    2. mitotic nuclear division Source: UniProtKB-KW

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30493-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinetochore-associated protein CNN1
    Alternative name(s):
    Co-purified with NNF1 protein 1
    Gene namesi
    Name:CNN1
    Ordered Locus Names:YFR046C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR046c.
    SGDiS000001942. CNN1.

    Subcellular locationi

    Nucleus 1 Publication. Chromosomecentromerekinetochore 1 Publication

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. kinetochore Source: SGD
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Kinetochore-associated protein CNN1PRO_0000202697Add
    BLAST

    Proteomic databases

    PaxDbiP43618.

    Expressioni

    Gene expression databases

    GenevestigatoriP43618.

    Interactioni

    Subunit structurei

    Component of the kinetochore. Interacts with NNF1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NUF2P338952EBI-23036,EBI-12377

    Protein-protein interaction databases

    BioGridi31204. 39 interactions.
    DIPiDIP-5186N.
    IntActiP43618. 4 interactions.
    MINTiMINT-557134.
    STRINGi4932.YFR046C.

    Structurei

    Secondary structure

    1
    361
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi63 – 7816

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GEQX-ray2.01E/F60-84[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG132497.
    OrthoDBiEOG7FBRW8.

    Sequencei

    Sequence statusi: Complete.

    P43618-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTPRKAAGN NENTEVSEIR TPFRERALEE QRLKDEVLIR NTPGYRKLLS    50
    ASTKSHDILN KDPNEVRSFL QDLSQVLARK SQGNDTTTNK TQARNLIDEL 100
    AYEESQPEEN ELLRSRSEKL TDNNIGNETQ PDYTSLSQTV FAKLQERDKG 150
    LKSRKIDPII IQDVPTTGHE DELTVHSPDK ANSISMEVLR TSPSIGMDQV 200
    DEPPVRDPVP ISITQQEEPL SEDLPSDDKE ETEEAENEDY SFENTSDENL 250
    DDIGNDPIRL NVPAVRRSSI KPLQIMDLKH LTRQFLNENR IILPKQTWST 300
    IQEESLNIMD FLKQKIGTLQ KQELVDSFID MGIINNVDDM FELAHELLPL 350
    ELQSRIESYL F 361
    Length:361
    Mass (Da):41,313
    Last modified:November 1, 1995 - v1
    Checksum:i48CEEC087A056D42
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti8 – 81A → T in AAT92741. (PubMed:7670463)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09285.1.
    AY692722 Genomic DNA. Translation: AAT92741.1.
    BK006940 Genomic DNA. Translation: DAA12489.1.
    PIRiS56301.
    RefSeqiNP_116704.1. NM_001180011.1.

    Genome annotation databases

    EnsemblFungiiYFR046C; YFR046C; YFR046C.
    GeneIDi850607.
    KEGGisce:YFR046C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09285.1 .
    AY692722 Genomic DNA. Translation: AAT92741.1 .
    BK006940 Genomic DNA. Translation: DAA12489.1 .
    PIRi S56301.
    RefSeqi NP_116704.1. NM_001180011.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GEQ X-ray 2.01 E/F 60-84 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31204. 39 interactions.
    DIPi DIP-5186N.
    IntActi P43618. 4 interactions.
    MINTi MINT-557134.
    STRINGi 4932.YFR046C.

    Proteomic databases

    PaxDbi P43618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR046C ; YFR046C ; YFR046C .
    GeneIDi 850607.
    KEGGi sce:YFR046C.

    Organism-specific databases

    CYGDi YFR046c.
    SGDi S000001942. CNN1.

    Phylogenomic databases

    eggNOGi NOG132497.
    OrthoDBi EOG7FBRW8.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30493-MONOMER.

    Miscellaneous databases

    NextBioi 966487.

    Gene expression databases

    Genevestigatori P43618.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
      Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
      Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes."
      De Wulf P., McAinsh A.D., Sorger P.K.
      Genes Dev. 17:2902-2921(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NNF1, IDENTIFICATION BY MASS SPECTROMETRY.
    6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCNN1_YEAST
    AccessioniPrimary (citable) accession number: P43618
    Secondary accession number(s): D6VTS9, Q6B2K8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1300 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3