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P43618

- CNN1_YEAST

UniProt

P43618 - CNN1_YEAST

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Protein

Kinetochore-associated protein CNN1

Gene

CNN1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. centromeric DNA binding Source: SGD

GO - Biological processi

  1. chromosome segregation Source: SGD
  2. mitotic nuclear division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Enzyme and pathway databases

BioCyciYEAST:G3O-30493-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinetochore-associated protein CNN1
Alternative name(s):
Co-purified with NNF1 protein 1
Gene namesi
Name:CNN1
Ordered Locus Names:YFR046C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR046c.
SGDiS000001942. CNN1.

Subcellular locationi

Nucleus 1 Publication. Chromosomecentromerekinetochore 1 Publication

GO - Cellular componenti

  1. kinetochore Source: SGD
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Kinetochore-associated protein CNN1PRO_0000202697Add
BLAST

Proteomic databases

PaxDbiP43618.

Expressioni

Gene expression databases

GenevestigatoriP43618.

Interactioni

Subunit structurei

Component of the kinetochore. Interacts with NNF1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NUF2P338952EBI-23036,EBI-12377

Protein-protein interaction databases

BioGridi31204. 39 interactions.
DIPiDIP-5186N.
IntActiP43618. 4 interactions.
MINTiMINT-557134.
STRINGi4932.YFR046C.

Structurei

Secondary structure

1
361
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi63 – 7816Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GEQX-ray2.01E/F60-84[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG132497.
InParanoidiP43618.
OrthoDBiEOG7FBRW8.

Sequencei

Sequence statusi: Complete.

P43618-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPRKAAGN NENTEVSEIR TPFRERALEE QRLKDEVLIR NTPGYRKLLS
60 70 80 90 100
ASTKSHDILN KDPNEVRSFL QDLSQVLARK SQGNDTTTNK TQARNLIDEL
110 120 130 140 150
AYEESQPEEN ELLRSRSEKL TDNNIGNETQ PDYTSLSQTV FAKLQERDKG
160 170 180 190 200
LKSRKIDPII IQDVPTTGHE DELTVHSPDK ANSISMEVLR TSPSIGMDQV
210 220 230 240 250
DEPPVRDPVP ISITQQEEPL SEDLPSDDKE ETEEAENEDY SFENTSDENL
260 270 280 290 300
DDIGNDPIRL NVPAVRRSSI KPLQIMDLKH LTRQFLNENR IILPKQTWST
310 320 330 340 350
IQEESLNIMD FLKQKIGTLQ KQELVDSFID MGIINNVDDM FELAHELLPL
360
ELQSRIESYL F
Length:361
Mass (Da):41,313
Last modified:November 1, 1995 - v1
Checksum:i48CEEC087A056D42
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81A → T in AAT92741. (PubMed:7670463)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09285.1.
AY692722 Genomic DNA. Translation: AAT92741.1.
BK006940 Genomic DNA. Translation: DAA12489.1.
PIRiS56301.
RefSeqiNP_116704.1. NM_001180011.1.

Genome annotation databases

EnsemblFungiiYFR046C; YFR046C; YFR046C.
GeneIDi850607.
KEGGisce:YFR046C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09285.1 .
AY692722 Genomic DNA. Translation: AAT92741.1 .
BK006940 Genomic DNA. Translation: DAA12489.1 .
PIRi S56301.
RefSeqi NP_116704.1. NM_001180011.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GEQ X-ray 2.01 E/F 60-84 [» ]
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31204. 39 interactions.
DIPi DIP-5186N.
IntActi P43618. 4 interactions.
MINTi MINT-557134.
STRINGi 4932.YFR046C.

Proteomic databases

PaxDbi P43618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR046C ; YFR046C ; YFR046C .
GeneIDi 850607.
KEGGi sce:YFR046C.

Organism-specific databases

CYGDi YFR046c.
SGDi S000001942. CNN1.

Phylogenomic databases

eggNOGi NOG132497.
InParanoidi P43618.
OrthoDBi EOG7FBRW8.

Enzyme and pathway databases

BioCyci YEAST:G3O-30493-MONOMER.

Miscellaneous databases

NextBioi 966487.

Gene expression databases

Genevestigatori P43618.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
    Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes."
    De Wulf P., McAinsh A.D., Sorger P.K.
    Genes Dev. 17:2902-2921(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NNF1, IDENTIFICATION BY MASS SPECTROMETRY.
  6. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNN1_YEAST
AccessioniPrimary (citable) accession number: P43618
Secondary accession number(s): D6VTS9, Q6B2K8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1300 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3