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Protein

Uncharacterized mitochondrial carrier YFR045W

Gene

YFR045W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  • transporter activity Source: SGD

GO - Biological processi

  • transmembrane transport Source: InterPro
  • transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30492-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized mitochondrial carrier YFR045W
Gene namesi
Ordered Locus Names:YFR045W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFR045w.
EuPathDBiFungiDB:YFR045W.
SGDiS000001941. YFR045W.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei47 – 6721Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei222 – 24221Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=6Sequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Uncharacterized mitochondrial carrier YFR045WPRO_0000090695Add
BLAST

Proteomic databases

MaxQBiP43617.
PaxDbiP43617.
PeptideAtlasiP43617.

Interactioni

Protein-protein interaction databases

BioGridi31203. 18 interactions.
DIPiDIP-5570N.
MINTiMINT-472522.

Structurei

3D structure databases

ProteinModelPortaliP43617.
SMRiP43617. Positions 142-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 8378Solcar 1Add
BLAST
Repeati97 – 211115Solcar 2Add
BLAST
Repeati216 – 30287Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG269632.
HOGENOMiHOG000168307.
InParanoidiP43617.
OMAiFITFTRQ.
OrthoDBiEOG71K6CH.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43617-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANQNSDLYK QITAGSVAAV FQTTMTYPFE YLKTGLQLQP KGTAFEIILP
60 70 80 90 100
QIKSYFVGCS ALNVAAFGKT ILRFVTFDKL CHSLNNNIDN NDNFQRLTGY
110 120 130 140 150
NLLIAGTLTG IVESLFIIPF ENIKTTLIQS AMIDHKKLEK NQPVVNAKAT
160 170 180 190 200
FHKVATKSTP VARIEKLLPA VKHMYQTRGP AAFVQGTTAT IFRQIANTSI
210 220 230 240 250
QFTAYTAFKR LLQARNDKAS SVITGLATSF TLVAMTQPID VVKTRMMSQN
260 270 280 290 300
AKTEYKNTLN CMYRIFVQEG MATFWKGSIF RFMKVGISGG LTFTVYEQVS

LLLGFSSRS
Length:309
Mass (Da):34,391
Last modified:June 16, 2009 - v3
Checksum:i3E91A548BD4634EC
GO

Sequence cautioni

The sequence AAL26494.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAA09284.1 differs from that shown. Reason: Frameshift at position 41. Curated
The sequence BAA09284.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09284.1. Sequence problems.
AF419345 Genomic DNA. Translation: AAL26494.1. Different initiation.
AY558474 Genomic DNA. Translation: AAS56800.1.
BK006940 Genomic DNA. Translation: DAA12488.1.
PIRiS56300.
RefSeqiNP_116703.5. NM_001180010.3.

Genome annotation databases

EnsemblFungiiYFR045W; YFR045W; YFR045W.
GeneIDi850606.
KEGGisce:YFR045W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09284.1. Sequence problems.
AF419345 Genomic DNA. Translation: AAL26494.1. Different initiation.
AY558474 Genomic DNA. Translation: AAS56800.1.
BK006940 Genomic DNA. Translation: DAA12488.1.
PIRiS56300.
RefSeqiNP_116703.5. NM_001180010.3.

3D structure databases

ProteinModelPortaliP43617.
SMRiP43617. Positions 142-308.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31203. 18 interactions.
DIPiDIP-5570N.
MINTiMINT-472522.

Proteomic databases

MaxQBiP43617.
PaxDbiP43617.
PeptideAtlasiP43617.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFR045W; YFR045W; YFR045W.
GeneIDi850606.
KEGGisce:YFR045W.

Organism-specific databases

CYGDiYFR045w.
EuPathDBiFungiDB:YFR045W.
SGDiS000001941. YFR045W.

Phylogenomic databases

eggNOGiNOG269632.
HOGENOMiHOG000168307.
InParanoidiP43617.
OMAiFITFTRQ.
OrthoDBiEOG71K6CH.

Enzyme and pathway databases

BioCyciYEAST:G3O-30492-MONOMER.

Miscellaneous databases

NextBioi966484.
PROiP43617.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
    Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins."
    Belenkiy R., Haefele A., Eisen M.B., Wohlrab H.
    Biochim. Biophys. Acta 1467:207-218(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-309, IDENTIFICATION OF FRAMESHIFT.
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-309.
    Strain: ATCC 204508 / S288c.
  6. "A large-scale full-length cDNA analysis to explore the budding yeast transcriptome."
    Miura F., Kawaguchi N., Sese J., Toyoda A., Hattori M., Morishita S., Ito T.
    Proc. Natl. Acad. Sci. U.S.A. 103:17846-17851(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF INTRON.

Entry informationi

Entry nameiYFL5_YEAST
AccessioniPrimary (citable) accession number: P43617
Secondary accession number(s): D6VTS8, Q96US0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 16, 2009
Last modified: July 22, 2015
This is version 126 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.