P43617 (YFL5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uncharacterized mitochondrial carrier YFR045W

Gene names

Ordered Locus Names:

YFR045W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification] Contains 3 Solcar repeats.
Sequence caution	The sequence AAL26494.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA09284.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA09284.1 differs from that shown. Reason: Frameshift at position 41.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Repeat Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transmembrane transport Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from sequence model PubMed 12192589. Source: SGD mitochondrial inner membrane Inferred from sequence or structural similarity Ref.4. Source: SGD
Molecular_function	transporter activity Inferred from sequence or structural similarity Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	Uncharacterized mitochondrial carrier YFR045W		PRO_0000090695
Regions
	Transmembrane	12 – 32	21	Helical; Name=1; Potential
	Transmembrane	47 – 67	21	Helical; Name=2; Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Transmembrane	184 – 204	21	Helical; Name=4; Potential
	Transmembrane	222 – 242	21	Helical; Name=5; Potential
	Transmembrane	285 – 305	21	Helical; Name=6; Potential
	Repeat	6 – 83	78	Solcar 1
	Repeat	97 – 211	115	Solcar 2
	Repeat	216 – 302	87	Solcar 3

Sequences

	Sequence		Length	Mass (Da)
	P43617 [UniParc]. Last modified June 16, 2009. Version 3. Checksum: 3E91A548BD4634EC	FASTA	309	34,391
	10 20 30 40 50 60 MANQNSDLYK QITAGSVAAV FQTTMTYPFE YLKTGLQLQP KGTAFEIILP QIKSYFVGCS 70 80 90 100 110 120 ALNVAAFGKT ILRFVTFDKL CHSLNNNIDN NDNFQRLTGY NLLIAGTLTG IVESLFIIPF 130 140 150 160 170 180 ENIKTTLIQS AMIDHKKLEK NQPVVNAKAT FHKVATKSTP VARIEKLLPA VKHMYQTRGP 190 200 210 220 230 240 AAFVQGTTAT IFRQIANTSI QFTAYTAFKR LLQARNDKAS SVITGLATSF TLVAMTQPID 250 260 270 280 290 300 VVKTRMMSQN AKTEYKNTLN CMYRIFVQEG MATFWKGSIF RFMKVGISGG LTFTVYEQVS LLLGFSSRS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae." Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y. Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"The yeast mitochondrial transport proteins: new sequences and consensus residues, lack of direct relation between consensus residues and transmembrane helices, expression patterns of the transport protein genes, and protein-protein interactions with other proteins." Belenkiy R., Haefele A., Eisen M.B., Wohlrab H. Biochim. Biophys. Acta 1467:207-218(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-309, IDENTIFICATION OF FRAMESHIFT.
[5]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-309. Strain: ATCC 204508 / S288c.
[6]	"A large-scale full-length cDNA analysis to explore the budding yeast transcriptome." Miura F., Kawaguchi N., Sese J., Toyoda A., Hattori M., Morishita S., Ito T. Proc. Natl. Acad. Sci. U.S.A. 103:17846-17851(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION OF INTRON.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09284.1. Sequence problems. AF419345 Genomic DNA. Translation: AAL26494.1. Different initiation. AY558474 Genomic DNA. Translation: AAS56800.1. BK006940 Genomic DNA. Translation: DAA12488.1.
PIR	S56300.
RefSeq	NP_116703.5. NM_001180010.3.
3D structure databases
ProteinModelPortal	P43617.
SMR	P43617. Positions 142-308.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5570N.
MINT	MINT-472522.
STRING	4932.YFR045W.
Proteomic databases
PaxDb	P43617.
PeptideAtlas	P43617.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFR045W; YFR045W; YFR045W.
GeneID	850606.
KEGG	sce:YFR045W. sce:YFR047C.
Organism-specific databases
CYGD	YFR045w.
SGD	S000001941. YFR045W.
Phylogenomic databases
eggNOG	NOG269632.
HOGENOM	HOG000168307.
KO	K00767.
OMA	FEFLKTG.
OrthoDB	EOG4R2740.
Gene expression databases
Genevestigator	P43617.
GermOnline	YFR045W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.50.40.10. 1 hit.
InterPro	IPR002067. Mit_carrier. IPR018108. Mitochondrial_sb/sol_carrier. IPR023395. Mt_carrier_dom. [Graphical view]
Pfam	PF00153. Mito_carr. 3 hits. [Graphical view]
PRINTS	PR00926. MITOCARRIER.
SUPFAM	SSF103506. Mitoch_carrier. 1 hit.
PROSITE	PS50920. SOLCAR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	966484.

Entry information

Entry name

YFL5_YEAST

Accession

Primary (citable) accession number: P43617
Secondary accession number(s): D6VTS8, Q96US0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	June 16, 2009
Last modified:	May 1, 2013
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program