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Protein

Increased recombination centers protein 6

Gene

IRC6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in gross chromosomal rearrangements (GCRs) and telomere healing.1 Publication

GO - Molecular functioni

  • protein binding, bridging Source: SGD

GO - Biological processi

  • vesicle-mediated transport Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30490-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Increased recombination centers protein 6
Gene namesi
Name:IRC6
Ordered Locus Names:YFR043C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR043C.
SGDiS000001939. IRC6.

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 237237Increased recombination centers protein 6PRO_0000202696Add
BLAST

Proteomic databases

MaxQBiP43615.

Interactioni

GO - Molecular functioni

  • protein binding, bridging Source: SGD

Protein-protein interaction databases

BioGridi31201. 23 interactions.
DIPiDIP-1851N.
IntActiP43615. 4 interactions.
MINTiMINT-409440.

Structurei

Secondary structure

1
237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Helixi16 – 183Combined sources
Helixi19 – 3012Combined sources
Beta strandi39 – 468Combined sources
Beta strandi51 – 6212Combined sources
Helixi64 – 718Combined sources
Helixi74 – 763Combined sources
Helixi77 – 815Combined sources
Beta strandi83 – 908Combined sources
Helixi92 – 954Combined sources
Helixi97 – 993Combined sources
Helixi101 – 1077Combined sources
Beta strandi113 – 1186Combined sources
Helixi125 – 13511Combined sources
Beta strandi138 – 1414Combined sources
Beta strandi143 – 1475Combined sources
Helixi165 – 17511Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UC9X-ray1.80A1-213[»]
ProteinModelPortaliP43615.
SMRiP43615. Positions 2-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IRC6 family.Curated

Phylogenomic databases

InParanoidiP43615.
OMAiGQINISP.
OrthoDBiEOG76X6CG.

Sequencei

Sequence statusi: Complete.

P43615-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLQYPQNKI LVLSDHPHNF LKTQFLQDLF HCSSTGISIV KDQTWENRYY
60 70 80 90 100
KVHFDLYIDS CKEIPVWVEE FITPECEPLR NVMAGIILIT DIRQTKPQEL
110 120 130 140 150
LHQFMIAAHR NTFVVLANVN EEVEQDEIDE LNEIWSNAFT NVIEFVNWKR
160 170 180 190 200
SKPTVNHNDY GEKLGLDRIQ EIIDTHDWLN CEVQPATKIR EEIPNEMPLE
210 220 230
QIIRNLQSAR LKYKSIENSS EADAFANEMA DELSRYL
Length:237
Mass (Da):27,879
Last modified:November 1, 1995 - v1
Checksum:iD1F36471AEF1FD3C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09282.1.
BK006940 Genomic DNA. Translation: DAA12486.1.
PIRiS56298.
RefSeqiNP_116701.3. NM_001180008.3.

Genome annotation databases

EnsemblFungiiBAA09282; BAA09282; BAA09282.
YFR043C; YFR043C; YFR043C.
GeneIDi850604.
KEGGisce:YFR043C.

Keywords - Coding sequence diversityi

Chromosomal rearrangement

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09282.1.
BK006940 Genomic DNA. Translation: DAA12486.1.
PIRiS56298.
RefSeqiNP_116701.3. NM_001180008.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UC9X-ray1.80A1-213[»]
ProteinModelPortaliP43615.
SMRiP43615. Positions 2-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31201. 23 interactions.
DIPiDIP-1851N.
IntActiP43615. 4 interactions.
MINTiMINT-409440.

Proteomic databases

MaxQBiP43615.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09282; BAA09282; BAA09282.
YFR043C; YFR043C; YFR043C.
GeneIDi850604.
KEGGisce:YFR043C.

Organism-specific databases

EuPathDBiFungiDB:YFR043C.
SGDiS000001939. IRC6.

Phylogenomic databases

InParanoidiP43615.
OMAiGQINISP.
OrthoDBiEOG76X6CG.

Enzyme and pathway databases

BioCyciYEAST:G3O-30490-MONOMER.

Miscellaneous databases

NextBioi966478.
PROiP43615.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
    Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
    Alvaro D., Lisby M., Rothstein R.
    PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks."
    Zhang W., Durocher D.
    Genes Dev. 24:502-515(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIRC6_YEAST
AccessioniPrimary (citable) accession number: P43615
Secondary accession number(s): D6VTS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.