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P43614

- KEG1_YEAST

UniProt

P43614 - KEG1_YEAST

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Protein
Beta-1,6-glucan synthesis-associated protein KEG1
Gene
KEG1, YFR042W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability.2 Publications

GO - Biological processi

  1. (1->6)-beta-D-glucan biosynthetic process Source: SGD
  2. chromosome organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-30489-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,6-glucan synthesis-associated protein KEG1
Alternative name(s):
KRE6-binding ER protein responsible for glucan synthesis protein 1
Gene namesi
Name:KEG1
Ordered Locus Names:YFR042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR042w.
SGDiS000001938. KEG1.

Subcellular locationi

Endoplasmic reticulum membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Lumenal Reviewed prediction
Add
BLAST
Transmembranei16 – 3621Helical; Reviewed prediction
Add
BLAST
Topological domaini37 – 448Cytoplasmic Reviewed prediction
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Topological domaini66 – 8217Lumenal Reviewed prediction
Add
BLAST
Transmembranei83 – 10321Helical; Reviewed prediction
Add
BLAST
Topological domaini104 – 14542Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei146 – 16621Helical; Reviewed prediction
Add
BLAST
Topological domaini167 – 1737Lumenal Reviewed prediction
Transmembranei174 – 19421Helical; Reviewed prediction
Add
BLAST
Topological domaini195 – 2006Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. integral component of endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi124 – 1241H → L in KEG1-1; temperature-sensitive. Increased sensitivity to chitin-binding dye Calcofluor white and zymolyase. Shows K1 killer toxin resistance, and reduced content of the cell wall beta-1,6-glucan. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Beta-1,6-glucan synthesis-associated protein KEG1
PRO_0000202695Add
BLAST

Proteomic databases

PaxDbiP43614.

Expressioni

Gene expression databases

GenevestigatoriP43614.

Interactioni

Subunit structurei

Interacts with KRE6.1 Publication

Protein-protein interaction databases

BioGridi31200. 14 interactions.
DIPiDIP-1849N.
IntActiP43614. 5 interactions.
MINTiMINT-394790.
STRINGi4932.YFR042W.

Structurei

3D structure databases

ProteinModelPortaliP43614.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40874.
HOGENOMiHOG000113218.
OMAiYDDYEHA.
OrthoDBiEOG7V4B9K.

Sequencei

Sequence statusi: Complete.

P43614-1 [UniParc]FASTAAdd to Basket

« Hide

MAGIKLTHKL YQYYQLATSF LYAALLIRWL ILMPLVGSRF LPGGIHEFLI    50
YLMFYSSIME VIWLLRFHGF KYGLLSRTFL KDLNFIYLVS VIHFYDDYEH 100
ALILKNASYS SFIISLSLSQ AYCHWCKLFK RKGVKERTLV WKVNTFVTLP 150
ILYLSEFALL LLNIQVKNYH STPTLDIINR VVLLAYFPVL LTAYKKLLTK 200
Length:200
Mass (Da):23,555
Last modified:November 1, 1995 - v1
Checksum:iE471CE48A72C2A61
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31G → V in strain: KA31a. 1 Publication
Natural varianti55 – 551Y → C in strain: KA31a. 1 Publication
Natural varianti84 – 841N → D in strain: KA31a. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB303676 Genomic DNA. Translation: BAF62429.1.
D50617 Genomic DNA. Translation: BAA09281.1.
BK006940 Genomic DNA. Translation: DAA12485.1.
PIRiS56297.
RefSeqiNP_116700.1. NM_001180007.1.

Genome annotation databases

EnsemblFungiiYFR042W; YFR042W; YFR042W.
GeneIDi850603.
KEGGisce:YFR042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB303676 Genomic DNA. Translation: BAF62429.1 .
D50617 Genomic DNA. Translation: BAA09281.1 .
BK006940 Genomic DNA. Translation: DAA12485.1 .
PIRi S56297.
RefSeqi NP_116700.1. NM_001180007.1.

3D structure databases

ProteinModelPortali P43614.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31200. 14 interactions.
DIPi DIP-1849N.
IntActi P43614. 5 interactions.
MINTi MINT-394790.
STRINGi 4932.YFR042W.

Proteomic databases

PaxDbi P43614.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR042W ; YFR042W ; YFR042W .
GeneIDi 850603.
KEGGi sce:YFR042W.

Organism-specific databases

CYGDi YFR042w.
SGDi S000001938. KEG1.

Phylogenomic databases

eggNOGi NOG40874.
HOGENOMi HOG000113218.
OMAi YDDYEHA.
OrthoDBi EOG7V4B9K.

Enzyme and pathway databases

BioCyci YEAST:G3O-30489-MONOMER.

Miscellaneous databases

NextBioi 966475.

Gene expression databases

Genevestigatori P43614.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae."
    Nakamata K., Kurita T., Bhuiyan M.S.A., Sato K., Noda Y., Yoda K.
    J. Biol. Chem. 282:34315-34324(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], GENE NAME, FUNCTION, INTERACTION WITH KRE6, SUBCELLULAR LOCATION, VARIANTS VAL-3; CYS-55 AND ASP-84, MUTAGENESIS OF HIS-124.
    Strain: KA31a.
  2. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
    Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae."
    Ben-Aroya S., Coombes C., Kwok T., O'Donnell K.A., Boeke J.D., Hieter P.
    Mol. Cell 30:248-258(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKEG1_YEAST
AccessioniPrimary (citable) accession number: P43614
Secondary accession number(s): A5A8M3, D6VTS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

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