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Protein

Beta-1,6-glucan synthesis-associated protein KEG1

Gene

KEG1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of (1->6)-beta-D-glucan polymers of the cell wall. Required for viability. Involved in maintaining chromosome stability.2 Publications

GO - Biological processi

  • (1->6)-beta-D-glucan biosynthetic process Source: SGD
  • cell wall organization Source: UniProtKB-KW
  • chromosome organization Source: SGD
Complete GO annotation...

Keywords - Biological processi

Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciYEAST:G3O-30489-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,6-glucan synthesis-associated protein KEG1
Alternative name(s):
KRE6-binding ER protein responsible for glucan synthesis protein 1
Gene namesi
Name:KEG1
Ordered Locus Names:YFR042W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR042W.
SGDiS000001938. KEG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15LumenalSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 44CytoplasmicSequence analysis8
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 82LumenalSequence analysisAdd BLAST17
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 145CytoplasmicSequence analysisAdd BLAST42
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 173LumenalSequence analysis7
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 200CytoplasmicSequence analysis6

GO - Cellular componenti

  • integral component of endoplasmic reticulum membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi124H → L in KEG1-1; temperature-sensitive. Increased sensitivity to chitin-binding dye Calcofluor white and zymolyase. Shows K1 killer toxin resistance, and reduced content of the cell wall beta-1,6-glucan. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026951 – 200Beta-1,6-glucan synthesis-associated protein KEG1Add BLAST200

Proteomic databases

PRIDEiP43614.

Interactioni

Subunit structurei

Interacts with KRE6.1 Publication

Protein-protein interaction databases

BioGridi31200. 14 interactors.
DIPiDIP-1849N.
IntActiP43614. 5 interactors.
MINTiMINT-394790.

Structurei

3D structure databases

ProteinModelPortaliP43614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000113218.
InParanoidiP43614.
OMAiYDDYEHA.
OrthoDBiEOG092C4QBY.

Sequencei

Sequence statusi: Complete.

P43614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGIKLTHKL YQYYQLATSF LYAALLIRWL ILMPLVGSRF LPGGIHEFLI
60 70 80 90 100
YLMFYSSIME VIWLLRFHGF KYGLLSRTFL KDLNFIYLVS VIHFYDDYEH
110 120 130 140 150
ALILKNASYS SFIISLSLSQ AYCHWCKLFK RKGVKERTLV WKVNTFVTLP
160 170 180 190 200
ILYLSEFALL LLNIQVKNYH STPTLDIINR VVLLAYFPVL LTAYKKLLTK
Length:200
Mass (Da):23,555
Last modified:November 1, 1995 - v1
Checksum:iE471CE48A72C2A61
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti3G → V in strain: KA31a. 1 Publication1
Natural varianti55Y → C in strain: KA31a. 1 Publication1
Natural varianti84N → D in strain: KA31a. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB303676 Genomic DNA. Translation: BAF62429.1.
D50617 Genomic DNA. Translation: BAA09281.1.
BK006940 Genomic DNA. Translation: DAA12485.1.
PIRiS56297.
RefSeqiNP_116700.1. NM_001180007.1.

Genome annotation databases

EnsemblFungiiBAA09281; BAA09281; BAA09281.
YFR042W; YFR042W; YFR042W.
GeneIDi850603.
KEGGisce:YFR042W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB303676 Genomic DNA. Translation: BAF62429.1.
D50617 Genomic DNA. Translation: BAA09281.1.
BK006940 Genomic DNA. Translation: DAA12485.1.
PIRiS56297.
RefSeqiNP_116700.1. NM_001180007.1.

3D structure databases

ProteinModelPortaliP43614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31200. 14 interactors.
DIPiDIP-1849N.
IntActiP43614. 5 interactors.
MINTiMINT-394790.

Proteomic databases

PRIDEiP43614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09281; BAA09281; BAA09281.
YFR042W; YFR042W; YFR042W.
GeneIDi850603.
KEGGisce:YFR042W.

Organism-specific databases

EuPathDBiFungiDB:YFR042W.
SGDiS000001938. KEG1.

Phylogenomic databases

HOGENOMiHOG000113218.
InParanoidiP43614.
OMAiYDDYEHA.
OrthoDBiEOG092C4QBY.

Enzyme and pathway databases

BioCyciYEAST:G3O-30489-MONOMER.

Miscellaneous databases

PROiP43614.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiKEG1_YEAST
AccessioniPrimary (citable) accession number: P43614
Secondary accession number(s): A5A8M3, D6VTS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.