Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P43613

- ERJ5_YEAST

UniProt

P43613 - ERJ5_YEAST

Protein

ER-localized J domain-containing protein 5

Gene

ERJ5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    DnaJ-like chaperone required for the folding capacity of the endoplasmic reticulum.1 Publication

    GO - Biological processi

    1. protein folding Source: SGD

    Keywords - Molecular functioni

    Chaperone

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30488-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER-localized J domain-containing protein 5
    Gene namesi
    Name:ERJ5
    Ordered Locus Names:YFR041C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR041c.
    SGDiS000001937. ERJ5.

    Subcellular locationi

    Endoplasmic reticulum membrane 2 Publications; Single-pass type I membrane protein 2 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum Source: SGD
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 295275ER-localized J domain-containing protein 5PRO_0000007272Add
    BLAST

    Proteomic databases

    MaxQBiP43613.
    PaxDbiP43613.
    PeptideAtlasiP43613.

    Expressioni

    Gene expression databases

    GenevestigatoriP43613.

    Interactioni

    Protein-protein interaction databases

    BioGridi31199. 20 interactions.
    IntActiP43613. 2 interactions.
    MINTiMINT-4485237.
    STRINGi4932.YFR041C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43613.
    SMRiP43613. Positions 40-107.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 130110LumenalAdd
    BLAST
    Topological domaini152 – 295144CytoplasmicAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei131 – 15121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini42 – 11069JPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the DnaJ family.Curated
    Contains 1 J domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2214.
    HOGENOMiHOG000142085.
    OMAiYSKFRPG.
    OrthoDBiEOG75QRG3.

    Family and domain databases

    Gene3Di1.10.287.110. 1 hit.
    InterProiIPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view]
    PfamiPF00226. DnaJ. 1 hit.
    [Graphical view]
    SMARTiSM00271. DnaJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF46565. SSF46565. 1 hit.
    PROSITEiPS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43613-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK    50
    LPKLQNSSTK EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN 100
    RKIYDYYLQN GFPNYDFHKG GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS 150
    IIQYRSQRSR IENFISQCKQ QDDTNGLGVK QLTFKQHEKD EGKSLVVRFS 200
    DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT FGKSVGSAGK 250
    EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK 295
    Length:295
    Mass (Da):34,191
    Last modified:November 1, 1995 - v1
    Checksum:i4541BF6C353DB8AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09280.1.
    BK006940 Genomic DNA. Translation: DAA12484.1.
    PIRiS56296.
    RefSeqiNP_116699.3. NM_001180006.3.

    Genome annotation databases

    EnsemblFungiiYFR041C; YFR041C; YFR041C.
    GeneIDi850602.
    KEGGisce:YFR041C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09280.1 .
    BK006940 Genomic DNA. Translation: DAA12484.1 .
    PIRi S56296.
    RefSeqi NP_116699.3. NM_001180006.3.

    3D structure databases

    ProteinModelPortali P43613.
    SMRi P43613. Positions 40-107.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31199. 20 interactions.
    IntActi P43613. 2 interactions.
    MINTi MINT-4485237.
    STRINGi 4932.YFR041C.

    Proteomic databases

    MaxQBi P43613.
    PaxDbi P43613.
    PeptideAtlasi P43613.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR041C ; YFR041C ; YFR041C .
    GeneIDi 850602.
    KEGGi sce:YFR041C.

    Organism-specific databases

    CYGDi YFR041c.
    SGDi S000001937. ERJ5.

    Phylogenomic databases

    eggNOGi COG2214.
    HOGENOMi HOG000142085.
    OMAi YSKFRPG.
    OrthoDBi EOG75QRG3.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30488-MONOMER.

    Miscellaneous databases

    NextBioi 966472.

    Gene expression databases

    Genevestigatori P43613.

    Family and domain databases

    Gene3Di 1.10.287.110. 1 hit.
    InterProi IPR001623. DnaJ_domain.
    IPR018253. DnaJ_domain_CS.
    [Graphical view ]
    Pfami PF00226. DnaJ. 1 hit.
    [Graphical view ]
    SMARTi SM00271. DnaJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46565. SSF46565. 1 hit.
    PROSITEi PS00636. DNAJ_1. 1 hit.
    PS50076. DNAJ_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
      Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
      Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
      Kim H., Melen K., Oesterberg M., von Heijne G.
      Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
      Strain: ATCC 208353 / W303-1A.
    6. "The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum."
      Carla Fama M., Raden D., Zacchi N., Lemos D.R., Robinson A.S., Silberstein S.
      Biochim. Biophys. Acta 1773:232-242(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE, TOPOLOGY, FUNCTION.

    Entry informationi

    Entry nameiERJ5_YEAST
    AccessioniPrimary (citable) accession number: P43613
    Secondary accession number(s): D6VTS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3