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P43613 (ERJ5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER-localized J domain-containing protein 5
Gene names
Name:ERJ5
Ordered Locus Names:YFR041C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length295 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DnaJ-like chaperone required for the folding capacity of the endoplasmic reticulum. Ref.6

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein Ref.4 Ref.6.

Sequence similarities

Belongs to the DnaJ family.

Contains 1 J domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 295275ER-localized J domain-containing protein 5
PRO_0000007272

Regions

Topological domain21 – 130110Lumenal Ref.5 Ref.6
Transmembrane131 – 15121Helical; Potential
Topological domain152 – 295144Cytoplasmic Ref.5 Ref.6
Domain42 – 11069J

Sequences

Sequence LengthMass (Da)Tools
P43613 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 4541BF6C353DB8AC

FASTA29534,191
        10         20         30         40         50         60 
MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK LPKLQNSSTK 

        70         80         90        100        110        120 
EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN RKIYDYYLQN GFPNYDFHKG 

       130        140        150        160        170        180 
GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS IIQYRSQRSR IENFISQCKQ QDDTNGLGVK 

       190        200        210        220        230        240 
QLTFKQHEKD EGKSLVVRFS DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT 

       250        260        270        280        290 
FGKSVGSAGK EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: ATCC 208353 / W303-1A.
[6]"The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum."
Carla Fama M., Raden D., Zacchi N., Lemos D.R., Robinson A.S., Silberstein S.
Biochim. Biophys. Acta 1773:232-242(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE, TOPOLOGY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09280.1.
BK006940 Genomic DNA. Translation: DAA12484.1.
PIRS56296.
RefSeqNP_116699.3. NM_001180006.3.

3D structure databases

ProteinModelPortalP43613.
SMRP43613. Positions 40-107.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31199. 18 interactions.
IntActP43613. 2 interactions.
MINTMINT-4485237.
STRING4932.YFR041C.

Proteomic databases

PaxDbP43613.
PeptideAtlasP43613.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFR041C; YFR041C; YFR041C.
GeneID850602.
KEGGsce:YFR041C.

Organism-specific databases

CYGDYFR041c.
SGDS000001937. ERJ5.

Phylogenomic databases

eggNOGCOG2214.
HOGENOMHOG000142085.
OMAYSKFRPG.
OrthoDBEOG75QRG3.

Enzyme and pathway databases

BioCycYEAST:G3O-30488-MONOMER.

Gene expression databases

GenevestigatorP43613.

Family and domain databases

Gene3D1.10.287.110. 1 hit.
InterProIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMSSF46565. SSF46565. 1 hit.
PROSITEPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966472.

Entry information

Entry nameERJ5_YEAST
AccessionPrimary (citable) accession number: P43613
Secondary accession number(s): D6VTS4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families