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Protein

ER-localized J domain-containing protein 5

Gene

ERJ5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DnaJ-like chaperone required for the folding capacity of the endoplasmic reticulum.1 Publication

GO - Biological processi

  • protein folding Source: SGD

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-localized J domain-containing protein 5
Gene namesi
Name:ERJ5
Ordered Locus Names:YFR041C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR041C.
SGDiS000001937. ERJ5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 130LumenalAdd BLAST110
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 295CytoplasmicAdd BLAST144

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000727221 – 295ER-localized J domain-containing protein 5Add BLAST275

Proteomic databases

MaxQBiP43613.
PRIDEiP43613.

Interactioni

Protein-protein interaction databases

BioGridi31199. 40 interactors.
IntActiP43613. 2 interactors.
MINTiMINT-4485237.
STRINGi4932.YFR041C.

Structurei

3D structure databases

ProteinModelPortaliP43613.
SMRiP43613.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 110JPROSITE-ProRule annotationAdd BLAST69

Sequence similaritiesi

Belongs to the DnaJ family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000142085.
InParanoidiP43613.
OMAiYSKFRPG.
OrthoDBiEOG092C4Q4V.

Family and domain databases

CDDicd06257. DnaJ. 1 hit.
Gene3Di1.10.287.110. 1 hit.
InterProiView protein in InterPro
IPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
PfamiView protein in Pfam
PF00226. DnaJ. 1 hit.
SMARTiView protein in SMART
SM00271. DnaJ. 1 hit.
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiView protein in PROSITE
PS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK
60 70 80 90 100
LPKLQNSSTK EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN
110 120 130 140 150
RKIYDYYLQN GFPNYDFHKG GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS
160 170 180 190 200
IIQYRSQRSR IENFISQCKQ QDDTNGLGVK QLTFKQHEKD EGKSLVVRFS
210 220 230 240 250
DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT FGKSVGSAGK
260 270 280 290
EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK
Length:295
Mass (Da):34,191
Last modified:November 1, 1995 - v1
Checksum:i4541BF6C353DB8AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09280.1.
BK006940 Genomic DNA. Translation: DAA12484.1.
PIRiS56296.
RefSeqiNP_116699.3. NM_001180006.3.

Genome annotation databases

EnsemblFungiiBAA09280; BAA09280; BAA09280.
YFR041C; YFR041C; YFR041C.
GeneIDi850602.
KEGGisce:YFR041C.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiERJ5_YEAST
AccessioniPrimary (citable) accession number: P43613
Secondary accession number(s): D6VTS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 5, 2017
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names