Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ER-localized J domain-containing protein 5

Gene

ERJ5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

DnaJ-like chaperone required for the folding capacity of the endoplasmic reticulum.1 Publication

GO - Biological processi

  • protein folding Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Enzyme and pathway databases

BioCyciYEAST:G3O-30488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ER-localized J domain-containing protein 5
Gene namesi
Name:ERJ5
Ordered Locus Names:YFR041C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome VI

Organism-specific databases

CYGDiYFR041c.
EuPathDBiFungiDB:YFR041C.
SGDiS000001937. ERJ5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 130110LumenalAdd
BLAST
Transmembranei131 – 15121HelicalSequence AnalysisAdd
BLAST
Topological domaini152 – 295144CytoplasmicAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Add
BLAST
Chaini21 – 295275ER-localized J domain-containing protein 5PRO_0000007272Add
BLAST

Proteomic databases

MaxQBiP43613.
PaxDbiP43613.
PeptideAtlasiP43613.

Interactioni

Protein-protein interaction databases

BioGridi31199. 21 interactions.
IntActiP43613. 2 interactions.
MINTiMINT-4485237.
STRINGi4932.YFR041C.

Structurei

3D structure databases

ProteinModelPortaliP43613.
SMRiP43613. Positions 40-107.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 11069JPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DnaJ family.Curated
Contains 1 J domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2214.
HOGENOMiHOG000142085.
InParanoidiP43613.
OMAiYSKFRPG.
OrthoDBiEOG75QRG3.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43613-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNGYWKPALV VLGLVSLSYA FTTIETEIFQ LQNEISTKYG PDMNFYKFLK
60 70 80 90 100
LPKLQNSSTK EITKNLRKLS KKYHPDKNPK YRKLYERLNL ATQILSNSSN
110 120 130 140 150
RKIYDYYLQN GFPNYDFHKG GFYFSRMKPK TWFLLAFIWI VVNIGQYIIS
160 170 180 190 200
IIQYRSQRSR IENFISQCKQ QDDTNGLGVK QLTFKQHEKD EGKSLVVRFS
210 220 230 240 250
DVYVVEPDGS ETLISPDTLD KPSVKNCLFW RIPASVWNMT FGKSVGSAGK
260 270 280 290
EEIITDSKKY DGNQTKKGNK VKKGSAKKGQ KKMELPNGKV IYSRK
Length:295
Mass (Da):34,191
Last modified:November 1, 1995 - v1
Checksum:i4541BF6C353DB8AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09280.1.
BK006940 Genomic DNA. Translation: DAA12484.1.
PIRiS56296.
RefSeqiNP_116699.3. NM_001180006.3.

Genome annotation databases

EnsemblFungiiYFR041C; YFR041C; YFR041C.
GeneIDi850602.
KEGGisce:YFR041C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09280.1.
BK006940 Genomic DNA. Translation: DAA12484.1.
PIRiS56296.
RefSeqiNP_116699.3. NM_001180006.3.

3D structure databases

ProteinModelPortaliP43613.
SMRiP43613. Positions 40-107.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31199. 21 interactions.
IntActiP43613. 2 interactions.
MINTiMINT-4485237.
STRINGi4932.YFR041C.

Proteomic databases

MaxQBiP43613.
PaxDbiP43613.
PeptideAtlasiP43613.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFR041C; YFR041C; YFR041C.
GeneIDi850602.
KEGGisce:YFR041C.

Organism-specific databases

CYGDiYFR041c.
EuPathDBiFungiDB:YFR041C.
SGDiS000001937. ERJ5.

Phylogenomic databases

eggNOGiCOG2214.
HOGENOMiHOG000142085.
InParanoidiP43613.
OMAiYSKFRPG.
OrthoDBiEOG75QRG3.

Enzyme and pathway databases

BioCyciYEAST:G3O-30488-MONOMER.

Miscellaneous databases

NextBioi966472.
PROiP43613.

Family and domain databases

Gene3Di1.10.287.110. 1 hit.
InterProiIPR001623. DnaJ_domain.
IPR018253. DnaJ_domain_CS.
[Graphical view]
PfamiPF00226. DnaJ. 1 hit.
[Graphical view]
SMARTiSM00271. DnaJ. 1 hit.
[Graphical view]
SUPFAMiSSF46565. SSF46565. 1 hit.
PROSITEiPS00636. DNAJ_1. 1 hit.
PS50076. DNAJ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of a 36.2 kb DNA sequence including the right telomere of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.
    Yeast 12:149-167(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.
  6. "The Saccharomyces cerevisiae YFR041C/ERJ5 gene encoding a type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum."
    Carla Fama M., Raden D., Zacchi N., Lemos D.R., Robinson A.S., Silberstein S.
    Biochim. Biophys. Acta 1773:232-242(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SIGNAL SEQUENCE CLEAVAGE, TOPOLOGY, FUNCTION.

Entry informationi

Entry nameiERJ5_YEAST
AccessioniPrimary (citable) accession number: P43613
Secondary accession number(s): D6VTS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.