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P43610

- IRC5_YEAST

UniProt

P43610 - IRC5_YEAST

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Protein
Uncharacterized ATP-dependent helicase IRC5
Gene
IRC5, YFR038W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Is probably involved in a pathway contributing to genomic integrity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2548ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: SGD
  3. DNA binding Source: UniProtKB-KW
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. mitotic recombination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized ATP-dependent helicase IRC5 (EC:3.6.4.-)
Alternative name(s):
Increased recombination centers protein 5
Gene namesi
Name:IRC5
Ordered Locus Names:YFR038W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR038w.
SGDiS000001934. IRC5.

Subcellular locationi

Nucleus Reviewed prediction

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Uncharacterized ATP-dependent helicase IRC5
PRO_0000074385Add
BLAST

Proteomic databases

MaxQBiP43610.
PaxDbiP43610.
PRIDEiP43610.

Expressioni

Gene expression databases

GenevestigatoriP43610.

Interactioni

Protein-protein interaction databases

BioGridi31196. 42 interactions.
DIPiDIP-5300N.
MINTiMINT-543614.
STRINGi4932.YFR038W.

Structurei

3D structure databases

ProteinModelPortaliP43610.
SMRiP43610. Positions 213-487, 511-764.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 401168Helicase ATP-binding
Add
BLAST
Domaini607 – 758152Helicase C-terminal
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili548 – 58033 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi352 – 3554DEGH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 9151Asp-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00740000115593.
OMAiINWKYLI.
OrthoDBiEOG7M98QM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43610-1 [UniParc]FASTAAdd to Basket

« Hide

MSRCSNAALM TVVEDAVGAR VAARTRNMSN GVNYREKEVN DLTADISDSD    50
SDLDSEDNKH GKGDNDTAPI WLQDDVHSDE DIQLDSEDDS DTEAVQAQVV 100
DKLAKDTKSE QKSLDDELSE MDTKTVSLKL KKLNEFVRQS QVYSSIIADT 150
LLHRSNEVAN ANTKDNSNSD DEEHSSKKRK TKKKSITDFF KKQKKNEDTT 200
TQNGAPDDAA IKQPRLLKNC ILKPYQLEGL NWLITLYENG LNGILADEMG 250
LGKTVQSIAL LAFIYEMDTK GPFLVTAPLS TLDNWMNEFA KFAPDLPVLK 300
YYGTNGYKER SAKLKNFFKQ HGGTGIVITS YEIILRDTDL IMSQNWKFLI 350
VDEGHRLKNI NCRLIKELKK INTSNRLLLT GTPLQNNLAE LWSLLNFIMP 400
DIFADFEIFN KWFDFDSLNL GSGSNSEALN KLINDELQKN LISNLHTILK 450
PFLLRRLKKV VLANILPPKR EYIINCPMTS AQEKFYKAGL NGKLKKTMFK 500
ELIKDFFTLN DEYIGHVSNR SIRDFINYKL SGNETSNTDN KINPTLLQMD 550
KLYKKNLQME ISNKKLQNMM MQLRQIIDST FLFYFPYLHP EDLTLETLLK 600
TSGKLQILQK LIPPLISEGH KVLIYSQFVN MLDLIEDWCD LNSFATFRID 650
GSVNNETRKD QLEKFNSSKD KHNIFLLSTR AAGLGINLVG ADTVVLFDSD 700
WNPQVDLQAM DRCHRIGQES PVIVYRLCCD NTIEHVILTR AANKRNLERM 750
VIQMGKFNNL KKLALNEGSF LKANKAGVNV TNKDLVQELS MLLMSDESNI 800
GFENGGQKEN KATEGQLTDK EVEELTNRSL EAYKANRVVD LPHVKLFETT 850
SGL 853
Length:853
Mass (Da):96,966
Last modified:December 20, 2005 - v2
Checksum:i91EF0E200197FF28
GO

Sequence cautioni

The sequence BAA09277.1 differs from that shown. Reason: Frameshift at position 769.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09277.1. Frameshift.
BK006940 Genomic DNA. Translation: DAA12481.1.
PIRiS56293.
RefSeqiNP_116696.2. NM_001180003.1.

Genome annotation databases

EnsemblFungiiYFR038W; YFR038W; YFR038W.
GeneIDi850599.
KEGGisce:YFR038W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09277.1 . Frameshift.
BK006940 Genomic DNA. Translation: DAA12481.1 .
PIRi S56293.
RefSeqi NP_116696.2. NM_001180003.1.

3D structure databases

ProteinModelPortali P43610.
SMRi P43610. Positions 213-487, 511-764.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31196. 42 interactions.
DIPi DIP-5300N.
MINTi MINT-543614.
STRINGi 4932.YFR038W.

Proteomic databases

MaxQBi P43610.
PaxDbi P43610.
PRIDEi P43610.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR038W ; YFR038W ; YFR038W .
GeneIDi 850599.
KEGGi sce:YFR038W.

Organism-specific databases

CYGDi YFR038w.
SGDi S000001934. IRC5.

Phylogenomic databases

eggNOGi COG0553.
GeneTreei ENSGT00740000115593.
OMAi INWKYLI.
OrthoDBi EOG7M98QM.

Enzyme and pathway databases

BioCyci YEAST:G3O-30485-MONOMER.

Miscellaneous databases

NextBioi 966463.
PROi P43610.

Gene expression databases

Genevestigatori P43610.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.
    Yeast 12:177-190(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
    Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
    Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
    Strain: ATCC 204511 / S288c / AB972.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  6. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
    Alvaro D., Lisby M., Rothstein R.
    PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIRC5_YEAST
AccessioniPrimary (citable) accession number: P43610
Secondary accession number(s): D6VTS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi