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Protein

Uncharacterized ATP-dependent helicase IRC5

Gene

IRC5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Is probably involved in a pathway contributing to genomic integrity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi247 – 2548ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity Source: SGD
  2. ATP binding Source: UniProtKB-KW
  3. DNA binding Source: UniProtKB-KW
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. mitotic recombination Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30485-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized ATP-dependent helicase IRC5 (EC:3.6.4.-)
Alternative name(s):
Increased recombination centers protein 5
Gene namesi
Name:IRC5
Ordered Locus Names:YFR038W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR038w.
SGDiS000001934. IRC5.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 853853Uncharacterized ATP-dependent helicase IRC5PRO_0000074385Add
BLAST

Proteomic databases

MaxQBiP43610.
PaxDbiP43610.
PRIDEiP43610.

Expressioni

Gene expression databases

GenevestigatoriP43610.

Interactioni

Protein-protein interaction databases

BioGridi31196. 42 interactions.
DIPiDIP-5300N.
MINTiMINT-543614.
STRINGi4932.YFR038W.

Structurei

3D structure databases

ProteinModelPortaliP43610.
SMRiP43610. Positions 213-487, 511-764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini234 – 401168Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini607 – 758152Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili548 – 58033Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi352 – 3554DEGH box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 9151Asp-richAdd
BLAST

Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated
Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00740000115593.
InParanoidiP43610.
OMAiINWKYLI.
OrthoDBiEOG7M98QM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43610-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRCSNAALM TVVEDAVGAR VAARTRNMSN GVNYREKEVN DLTADISDSD
60 70 80 90 100
SDLDSEDNKH GKGDNDTAPI WLQDDVHSDE DIQLDSEDDS DTEAVQAQVV
110 120 130 140 150
DKLAKDTKSE QKSLDDELSE MDTKTVSLKL KKLNEFVRQS QVYSSIIADT
160 170 180 190 200
LLHRSNEVAN ANTKDNSNSD DEEHSSKKRK TKKKSITDFF KKQKKNEDTT
210 220 230 240 250
TQNGAPDDAA IKQPRLLKNC ILKPYQLEGL NWLITLYENG LNGILADEMG
260 270 280 290 300
LGKTVQSIAL LAFIYEMDTK GPFLVTAPLS TLDNWMNEFA KFAPDLPVLK
310 320 330 340 350
YYGTNGYKER SAKLKNFFKQ HGGTGIVITS YEIILRDTDL IMSQNWKFLI
360 370 380 390 400
VDEGHRLKNI NCRLIKELKK INTSNRLLLT GTPLQNNLAE LWSLLNFIMP
410 420 430 440 450
DIFADFEIFN KWFDFDSLNL GSGSNSEALN KLINDELQKN LISNLHTILK
460 470 480 490 500
PFLLRRLKKV VLANILPPKR EYIINCPMTS AQEKFYKAGL NGKLKKTMFK
510 520 530 540 550
ELIKDFFTLN DEYIGHVSNR SIRDFINYKL SGNETSNTDN KINPTLLQMD
560 570 580 590 600
KLYKKNLQME ISNKKLQNMM MQLRQIIDST FLFYFPYLHP EDLTLETLLK
610 620 630 640 650
TSGKLQILQK LIPPLISEGH KVLIYSQFVN MLDLIEDWCD LNSFATFRID
660 670 680 690 700
GSVNNETRKD QLEKFNSSKD KHNIFLLSTR AAGLGINLVG ADTVVLFDSD
710 720 730 740 750
WNPQVDLQAM DRCHRIGQES PVIVYRLCCD NTIEHVILTR AANKRNLERM
760 770 780 790 800
VIQMGKFNNL KKLALNEGSF LKANKAGVNV TNKDLVQELS MLLMSDESNI
810 820 830 840 850
GFENGGQKEN KATEGQLTDK EVEELTNRSL EAYKANRVVD LPHVKLFETT

SGL
Length:853
Mass (Da):96,966
Last modified:December 20, 2005 - v2
Checksum:i91EF0E200197FF28
GO

Sequence cautioni

The sequence BAA09277.1 differs from that shown. Reason: Frameshift at position 769. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09277.1. Frameshift.
BK006940 Genomic DNA. Translation: DAA12481.1.
PIRiS56293.
RefSeqiNP_116696.2. NM_001180003.1.

Genome annotation databases

EnsemblFungiiYFR038W; YFR038W; YFR038W.
GeneIDi850599.
KEGGisce:YFR038W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09277.1. Frameshift.
BK006940 Genomic DNA. Translation: DAA12481.1.
PIRiS56293.
RefSeqiNP_116696.2. NM_001180003.1.

3D structure databases

ProteinModelPortaliP43610.
SMRiP43610. Positions 213-487, 511-764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31196. 42 interactions.
DIPiDIP-5300N.
MINTiMINT-543614.
STRINGi4932.YFR038W.

Proteomic databases

MaxQBiP43610.
PaxDbiP43610.
PRIDEiP43610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYFR038W; YFR038W; YFR038W.
GeneIDi850599.
KEGGisce:YFR038W.

Organism-specific databases

CYGDiYFR038w.
SGDiS000001934. IRC5.

Phylogenomic databases

eggNOGiCOG0553.
GeneTreeiENSGT00740000115593.
InParanoidiP43610.
OMAiINWKYLI.
OrthoDBiEOG7M98QM.

Enzyme and pathway databases

BioCyciYEAST:G3O-30485-MONOMER.

Miscellaneous databases

NextBioi966463.
PROiP43610.

Gene expression databases

GenevestigatoriP43610.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae."
    Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.
    Yeast 12:177-190(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
    Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
    Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
    Strain: ATCC 204511 / S288c / AB972.
  5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
    Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
    Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION OF FRAMESHIFT.
  6. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
    Alvaro D., Lisby M., Rothstein R.
    PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIRC5_YEAST
AccessioniPrimary (citable) accession number: P43610
Secondary accession number(s): D6VTS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 20, 2005
Last modified: January 7, 2015
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.