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P43610

- IRC5_YEAST

UniProt

P43610 - IRC5_YEAST

Protein

Uncharacterized ATP-dependent helicase IRC5

Gene

IRC5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (20 Dec 2005)
      Previous versions | rss
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    Functioni

    Is probably involved in a pathway contributing to genomic integrity.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi247 – 2548ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW
    3. DNA binding Source: UniProtKB-KW
    4. helicase activity Source: UniProtKB-KW

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. mitotic recombination Source: SGD

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30485-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uncharacterized ATP-dependent helicase IRC5 (EC:3.6.4.-)
    Alternative name(s):
    Increased recombination centers protein 5
    Gene namesi
    Name:IRC5
    Ordered Locus Names:YFR038W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR038w.
    SGDiS000001934. IRC5.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 853853Uncharacterized ATP-dependent helicase IRC5PRO_0000074385Add
    BLAST

    Proteomic databases

    MaxQBiP43610.
    PaxDbiP43610.
    PRIDEiP43610.

    Expressioni

    Gene expression databases

    GenevestigatoriP43610.

    Interactioni

    Protein-protein interaction databases

    BioGridi31196. 42 interactions.
    DIPiDIP-5300N.
    MINTiMINT-543614.
    STRINGi4932.YFR038W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43610.
    SMRiP43610. Positions 213-487, 511-764.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini234 – 401168Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini607 – 758152Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili548 – 58033Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi352 – 3554DEGH box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 9151Asp-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SNF2/RAD54 helicase family.Curated
    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG0553.
    GeneTreeiENSGT00740000115593.
    OMAiINWKYLI.
    OrthoDBiEOG7M98QM.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view]
    PfamiPF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43610-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRCSNAALM TVVEDAVGAR VAARTRNMSN GVNYREKEVN DLTADISDSD    50
    SDLDSEDNKH GKGDNDTAPI WLQDDVHSDE DIQLDSEDDS DTEAVQAQVV 100
    DKLAKDTKSE QKSLDDELSE MDTKTVSLKL KKLNEFVRQS QVYSSIIADT 150
    LLHRSNEVAN ANTKDNSNSD DEEHSSKKRK TKKKSITDFF KKQKKNEDTT 200
    TQNGAPDDAA IKQPRLLKNC ILKPYQLEGL NWLITLYENG LNGILADEMG 250
    LGKTVQSIAL LAFIYEMDTK GPFLVTAPLS TLDNWMNEFA KFAPDLPVLK 300
    YYGTNGYKER SAKLKNFFKQ HGGTGIVITS YEIILRDTDL IMSQNWKFLI 350
    VDEGHRLKNI NCRLIKELKK INTSNRLLLT GTPLQNNLAE LWSLLNFIMP 400
    DIFADFEIFN KWFDFDSLNL GSGSNSEALN KLINDELQKN LISNLHTILK 450
    PFLLRRLKKV VLANILPPKR EYIINCPMTS AQEKFYKAGL NGKLKKTMFK 500
    ELIKDFFTLN DEYIGHVSNR SIRDFINYKL SGNETSNTDN KINPTLLQMD 550
    KLYKKNLQME ISNKKLQNMM MQLRQIIDST FLFYFPYLHP EDLTLETLLK 600
    TSGKLQILQK LIPPLISEGH KVLIYSQFVN MLDLIEDWCD LNSFATFRID 650
    GSVNNETRKD QLEKFNSSKD KHNIFLLSTR AAGLGINLVG ADTVVLFDSD 700
    WNPQVDLQAM DRCHRIGQES PVIVYRLCCD NTIEHVILTR AANKRNLERM 750
    VIQMGKFNNL KKLALNEGSF LKANKAGVNV TNKDLVQELS MLLMSDESNI 800
    GFENGGQKEN KATEGQLTDK EVEELTNRSL EAYKANRVVD LPHVKLFETT 850
    SGL 853
    Length:853
    Mass (Da):96,966
    Last modified:December 20, 2005 - v2
    Checksum:i91EF0E200197FF28
    GO

    Sequence cautioni

    The sequence BAA09277.1 differs from that shown. Reason: Frameshift at position 769.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09277.1. Frameshift.
    BK006940 Genomic DNA. Translation: DAA12481.1.
    PIRiS56293.
    RefSeqiNP_116696.2. NM_001180003.1.

    Genome annotation databases

    EnsemblFungiiYFR038W; YFR038W; YFR038W.
    GeneIDi850599.
    KEGGisce:YFR038W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09277.1 . Frameshift.
    BK006940 Genomic DNA. Translation: DAA12481.1 .
    PIRi S56293.
    RefSeqi NP_116696.2. NM_001180003.1.

    3D structure databases

    ProteinModelPortali P43610.
    SMRi P43610. Positions 213-487, 511-764.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31196. 42 interactions.
    DIPi DIP-5300N.
    MINTi MINT-543614.
    STRINGi 4932.YFR038W.

    Proteomic databases

    MaxQBi P43610.
    PaxDbi P43610.
    PRIDEi P43610.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR038W ; YFR038W ; YFR038W .
    GeneIDi 850599.
    KEGGi sce:YFR038W.

    Organism-specific databases

    CYGDi YFR038w.
    SGDi S000001934. IRC5.

    Phylogenomic databases

    eggNOGi COG0553.
    GeneTreei ENSGT00740000115593.
    OMAi INWKYLI.
    OrthoDBi EOG7M98QM.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30485-MONOMER.

    Miscellaneous databases

    NextBioi 966463.
    PROi P43610.

    Gene expression databases

    Genevestigatori P43610.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000330. SNF2_N.
    [Graphical view ]
    Pfami PF00271. Helicase_C. 1 hit.
    PF00176. SNF2_N. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae."
      Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.
      Yeast 12:177-190(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
      Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
      Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
      Strain: ATCC 204511 / S288c / AB972.
    5. "Sequencing and comparison of yeast species to identify genes and regulatory elements."
      Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
      Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION OF FRAMESHIFT.
    6. "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
      Alvaro D., Lisby M., Rothstein R.
      PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIRC5_YEAST
    AccessioniPrimary (citable) accession number: P43610
    Secondary accession number(s): D6VTS1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: December 20, 2005
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3