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P43610 (IRC5_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uncharacterized ATP-dependent helicase IRC5

EC=3.6.4.-
Alternative name(s):
Increased recombination centers protein 5
Gene names
Name:IRC5
Ordered Locus Names:YFR038W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length853 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Is probably involved in a pathway contributing to genomic integrity.

Subcellular location

Nucleus Potential.

Disruption phenotype

Displays increased levels of spontaneous RAD52 foci in proliferating diploid cells. Ref.6

Sequence similarities

Belongs to the SNF2/RAD54 helicase family.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence caution

The sequence BAA09277.1 differs from that shown. Reason: Frameshift at position 769.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 853853Uncharacterized ATP-dependent helicase IRC5
PRO_0000074385

Regions

Domain234 – 401168Helicase ATP-binding
Domain607 – 758152Helicase C-terminal
Nucleotide binding247 – 2548ATP Potential
Coiled coil548 – 58033 Potential
Motif352 – 3554DEGH box
Compositional bias41 – 9151Asp-rich

Sequences

Sequence LengthMass (Da)Tools
P43610 [UniParc].

Last modified December 20, 2005. Version 2.
Checksum: 91EF0E200197FF28

FASTA85396,966
        10         20         30         40         50         60 
MSRCSNAALM TVVEDAVGAR VAARTRNMSN GVNYREKEVN DLTADISDSD SDLDSEDNKH 

        70         80         90        100        110        120 
GKGDNDTAPI WLQDDVHSDE DIQLDSEDDS DTEAVQAQVV DKLAKDTKSE QKSLDDELSE 

       130        140        150        160        170        180 
MDTKTVSLKL KKLNEFVRQS QVYSSIIADT LLHRSNEVAN ANTKDNSNSD DEEHSSKKRK 

       190        200        210        220        230        240 
TKKKSITDFF KKQKKNEDTT TQNGAPDDAA IKQPRLLKNC ILKPYQLEGL NWLITLYENG 

       250        260        270        280        290        300 
LNGILADEMG LGKTVQSIAL LAFIYEMDTK GPFLVTAPLS TLDNWMNEFA KFAPDLPVLK 

       310        320        330        340        350        360 
YYGTNGYKER SAKLKNFFKQ HGGTGIVITS YEIILRDTDL IMSQNWKFLI VDEGHRLKNI 

       370        380        390        400        410        420 
NCRLIKELKK INTSNRLLLT GTPLQNNLAE LWSLLNFIMP DIFADFEIFN KWFDFDSLNL 

       430        440        450        460        470        480 
GSGSNSEALN KLINDELQKN LISNLHTILK PFLLRRLKKV VLANILPPKR EYIINCPMTS 

       490        500        510        520        530        540 
AQEKFYKAGL NGKLKKTMFK ELIKDFFTLN DEYIGHVSNR SIRDFINYKL SGNETSNTDN 

       550        560        570        580        590        600 
KINPTLLQMD KLYKKNLQME ISNKKLQNMM MQLRQIIDST FLFYFPYLHP EDLTLETLLK 

       610        620        630        640        650        660 
TSGKLQILQK LIPPLISEGH KVLIYSQFVN MLDLIEDWCD LNSFATFRID GSVNNETRKD 

       670        680        690        700        710        720 
QLEKFNSSKD KHNIFLLSTR AAGLGINLVG ADTVVLFDSD WNPQVDLQAM DRCHRIGQES 

       730        740        750        760        770        780 
PVIVYRLCCD NTIEHVILTR AANKRNLERM VIQMGKFNNL KKLALNEGSF LKANKAGVNV 

       790        800        810        820        830        840 
TNKDLVQELS MLLMSDESNI GFENGGQKEN KATEGQLTDK EVEELTNRSL EAYKANRVVD 

       850 
LPHVKLFETT SGL 

« Hide

References

« Hide 'large scale' references
[1]"Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VI from Saccharomyces cerevisiae."
Eki T., Naitou M., Hagiwara H., Abe M., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Shibata T., Watanabe K., Ono A., Yamazaki M., Tashiro H., Hanaoka F., Murakami Y.
Yeast 12:177-190(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFT.
Strain: ATCC 204511 / S288c / AB972.
[5]"Sequencing and comparison of yeast species to identify genes and regulatory elements."
Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.
Nature 423:241-254(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION OF FRAMESHIFT.
[6]"Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination."
Alvaro D., Lisby M., Rothstein R.
PLoS Genet. 3:E228-E228(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09277.1. Frameshift.
BK006940 Genomic DNA. Translation: DAA12481.1.
PIRS56293.
RefSeqNP_116696.2. NM_001180003.1.

3D structure databases

ProteinModelPortalP43610.
SMRP43610. Positions 213-487, 511-764.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31196. 42 interactions.
DIPDIP-5300N.
MINTMINT-543614.
STRING4932.YFR038W.

Proteomic databases

MaxQBP43610.
PaxDbP43610.
PRIDEP43610.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFR038W; YFR038W; YFR038W.
GeneID850599.
KEGGsce:YFR038W.

Organism-specific databases

CYGDYFR038w.
SGDS000001934. IRC5.

Phylogenomic databases

eggNOGCOG0553.
GeneTreeENSGT00740000115593.
OMAINWKYLI.
OrthoDBEOG7M98QM.

Enzyme and pathway databases

BioCycYEAST:G3O-30485-MONOMER.

Gene expression databases

GenevestigatorP43610.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000330. SNF2_N.
[Graphical view]
PfamPF00271. Helicase_C. 1 hit.
PF00176. SNF2_N. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
PROSITEPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966463.
PROP43610.

Entry information

Entry nameIRC5_YEAST
AccessionPrimary (citable) accession number: P43610
Secondary accession number(s): D6VTS1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: December 20, 2005
Last modified: June 11, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families