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Protein

LAS seventeen-binding protein 3

Gene

LSB3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin cortical patch localization Source: SGD
  • actin filament bundle assembly Source: GO_Central
  • regulation of ruffle assembly Source: GO_Central

Enzyme and pathway databases

BioCyciYEAST:G3O-30504-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
LAS seventeen-binding protein 3
Short name:
LAS17-binding protein 3
Gene namesi
Name:LSB3
Ordered Locus Names:YFR024C-A
ORF Names:YFR024C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR024C-A.
SGDiS000002968. LSB3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026911 – 459LAS seventeen-binding protein 3Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei227PhosphoserineCombined sources1
Modified residuei298PhosphothreonineCombined sources1
Modified residuei300PhosphoserineCombined sources1
Modified residuei303PhosphoserineCombined sources1
Modified residuei393PhosphothreonineCombined sources1
Modified residuei397PhosphoserineCombined sources1
Modified residuei402PhosphoserineCombined sources1
Modified residuei416PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Ser-397 is induced 2-fold in response to mating pheromone.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43603.
PRIDEiP43603.

PTM databases

iPTMnetiP43603.

Interactioni

Subunit structurei

Interacts with LAS17.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31177. 216 interactors.
DIPiDIP-2753N.
DIP-6259N.
IntActiP43603. 126 interactors.
MINTiMINT-374953.

Structurei

Secondary structure

1459
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi404 – 409Combined sources6
Beta strandi426 – 431Combined sources6
Beta strandi438 – 444Combined sources7
Beta strandi447 – 452Combined sources6
Helixi453 – 455Combined sources3
Beta strandi456 – 458Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OOTX-ray1.39A401-459[»]
1SSHX-ray1.40A401-459[»]
ProteinModelPortaliP43603.
SMRiP43603.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43603.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini400 – 459SH3PROSITE-ProRule annotationAdd BLAST60

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi229 – 284Asp-richAdd BLAST56

Sequence similaritiesi

Belongs to the SH3YL1 family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
InParanoidiP43603.
KOiK20523.
OMAiPPPEWAQ.
OrthoDBiEOG092D3WQU.

Family and domain databases

CDDicd11525. SYLF_SH3YL1_like. 1 hit.
InterProiView protein in InterPro
IPR001452. SH3_domain.
IPR033643. SYLF_SH3YL1-like.
IPR007461. Ysc84_actin-binding.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF04366. Ysc84. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

P43603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGINNPIPRS LKSETKKAAK ILASFVKPNQ VFGADQVIPP DVLKRAKGLA
60 70 80 90 100
IITILKAGFL FSGRAGSGVI VARLKDGTWS APSAIAMAGA GAGGMVGIEL
110 120 130 140 150
TDFVFILNTQ DAVKSFSEFG TITLGGNVSV SAGPLGRSAE AAASASAGGV
160 170 180 190 200
AAVFAYSKSK GLFAGVSVEG SAIIERREAN RKFYGDNCTA KMILSGRIRP
210 220 230 240 250
PPAVDPLFRV LESRAFNYRP SNGGRGSFDD DEDDYYDDDD YYNDIPSSFS
260 270 280 290 300
STDASSTRPN TRSTRRRAQS GSRYTFDDDD DDDDYGTGYS RNSRLAPTNS
310 320 330 340 350
GGSGGKLDDP SGASSYYASH RRSGTAQSRA RSSRNRWADD EYDDYDDDYE
360 370 380 390 400
SGYRRGNGRD RTKDREVDDL SNRFSKSRIS SASTPQTSQG RFTAPTSPST
410 420 430 440 450
SSPKAVALYS FAGEESGDLP FRKGDVITIL KKSDSQNDWW TGRVNGREGI

FPANYVELV
Length:459
Mass (Da):49,344
Last modified:July 22, 2008 - v3
Checksum:iF486C787B5771AAC
GO

Sequence cautioni

The sequence BAA09263 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09263.1. Sequence problems.
BK006940 Genomic DNA. Translation: DAA12464.1.
RefSeqiNP_219497.4. NM_001180865.3.

Genome annotation databases

EnsemblFungiiBAA09263; BAA09263; BAA09263.
YFR024C-A; YFR024C-A; YFR024C-A.
GeneIDi850580.
KEGGisce:YFR024C-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09263.1. Sequence problems.
BK006940 Genomic DNA. Translation: DAA12464.1.
RefSeqiNP_219497.4. NM_001180865.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OOTX-ray1.39A401-459[»]
1SSHX-ray1.40A401-459[»]
ProteinModelPortaliP43603.
SMRiP43603.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31177. 216 interactors.
DIPiDIP-2753N.
DIP-6259N.
IntActiP43603. 126 interactors.
MINTiMINT-374953.

PTM databases

iPTMnetiP43603.

Proteomic databases

MaxQBiP43603.
PRIDEiP43603.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09263; BAA09263; BAA09263.
YFR024C-A; YFR024C-A; YFR024C-A.
GeneIDi850580.
KEGGisce:YFR024C-A.

Organism-specific databases

EuPathDBiFungiDB:YFR024C-A.
SGDiS000002968. LSB3.

Phylogenomic databases

GeneTreeiENSGT00510000048137.
HOGENOMiHOG000215564.
InParanoidiP43603.
KOiK20523.
OMAiPPPEWAQ.
OrthoDBiEOG092D3WQU.

Enzyme and pathway databases

BioCyciYEAST:G3O-30504-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP43603.
PROiP43603.

Family and domain databases

CDDicd11525. SYLF_SH3YL1_like. 1 hit.
InterProiView protein in InterPro
IPR001452. SH3_domain.
IPR033643. SYLF_SH3YL1-like.
IPR007461. Ysc84_actin-binding.
PfamiView protein in Pfam
PF00018. SH3_1. 1 hit.
PF04366. Ysc84. 1 hit.
PRINTSiPR00452. SH3DOMAIN.
SMARTiView protein in SMART
SM00326. SH3. 1 hit.
SUPFAMiSSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS50002. SH3. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLSB3_YEAST
AccessioniPrimary (citable) accession number: P43603
Secondary accession number(s): D6VTQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 22, 2008
Last modified: February 15, 2017
This is version 146 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 18000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.