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P43602 (ROG3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein ROG3
Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 3
Gene names
Name:ROG3
Ordered Locus Names:YFR022W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length733 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in resistance to GST substrate o-dinitrobenzene (o-DNB). Ref.3

Subunit structure

Interacts with RSP5 via its 2 PY-motifs. Ref.3

Domain

The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase. Ref.3

Sequence similarities

Belongs to the arrestin family.

Ontologies

Keywords
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent endocytosis

Inferred from sequence alignment PubMed 18976803. Source: SGD

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

RSP5P399403EBI-22976,EBI-16219

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 733733Protein ROG3
PRO_0000202690

Regions

Motif460 – 4634PY-motif
Motif625 – 6284PY-motif
Compositional bias641 – 71070Ser-rich

Amino acid modifications

Modified residue821Phosphoserine Ref.4
Modified residue1261Phosphoserine Ref.4
Modified residue1271Phosphoserine Ref.4
Modified residue1391Phosphoserine Ref.4
Modified residue4731Phosphoserine Ref.4
Modified residue4751Phosphoserine Ref.4
Modified residue5371Phosphoserine Ref.4
Modified residue5731Phosphoserine Ref.4

Experimental info

Mutagenesis460 – 4612PP → QA: Reduced binding to RSP5. Ref.3
Mutagenesis625 – 6262PP → QA: Reduced binding to RSP5. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P43602 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2BC6F7F24B9806A5

FASTA73379,709
        10         20         30         40         50         60 
MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI NEPMQIKSIS 

        70         80         90        100        110        120 
LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN YAWDNVNLKE YLSGLRGQSG 

       130        140        150        160        170        180 
LAGSSSSSNI LGTRQRAQST SSLKSLKGSS SPSSCTLDKG NYDFPFSAIL PGSLPESVES 

       190        200        210        220        230        240 
LPNCFVTYSM ESVIERSKNY SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI 

       250        260        270        280        290        300 
SVPNKAVAIG SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL 

       310        320        330        340        350        360 
EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ DCDVRSNIKV 

       370        380        390        400        410        420 
RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP LSSSNLYSLF STTNQKDENS 

       430        440        450        460        470        480 
SQEEEEEYLF SRSASVTGLE LLADMRSGGS VPTISDLMTP PNYEMHVYDR LYSGSFTRTA 

       490        500        510        520        530        540 
VETSGTCTPL GSECSTVEDQ QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL 

       550        560        570        580        590        600 
NVPAPEDGTE RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP 

       610        620        630        640        650        660 
ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST TLSSSIPTSF 

       670        680        690        700        710        720 
HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN NPSSNSMKRS PTRRRATSLA 

       730 
GFMGGFLSKG NKR

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance."
Andoh T., Hirata Y., Kikuchi A.
FEBS Lett. 525:131-134(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAIN, INTERACTION WITH RSP5, MUTAGENESIS OF 460-PRO-PRO-461 AND 625-PRO-PRO-626.
[4]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-82; SER-126; SER-127; SER-139; SER-473; SER-475; SER-537 AND SER-573, MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D50617 Genomic DNA. Translation: BAA09261.1.
BK006940 Genomic DNA. Translation: DAA12462.1.
PIRS56277.
RefSeqNP_116677.3. NM_001179987.3.

3D structure databases

ProteinModelPortalP43602.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-4111N.
IntActP43602. 1 interaction.
MINTMINT-506352.
STRING4932.YFR022W.

Proteomic databases

PaxDbP43602.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFR022W; YFR022W; YFR022W.
GeneID850578.
KEGGsce:YFR022W.
sce:YFR024C-A.

Organism-specific databases

CYGDYFR022w.
SGDS000001918. ROG3.

Phylogenomic databases

eggNOGNOG250259.
GeneTreeENSGT00530000067129.
HOGENOMHOG000248143.
OMAPPNYEMH.
OrthoDBEOG4KSST1.

Gene expression databases

GenevestigatorP43602.
GermOnlineYFR022W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view]
PfamPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTSM01017. Arrestin_C. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966403.

Entry information

Entry nameROG3_YEAST
AccessionPrimary (citable) accession number: P43602
Secondary accession number(s): D6VTQ2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families

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