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P43602

- ROG3_YEAST

UniProt

P43602 - ROG3_YEAST

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Protein

Protein ROG3

Gene

ROG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).1 Publication

GO - Molecular functioni

  1. ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  1. ubiquitin-dependent endocytosis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ROG3
Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 3
Gene namesi
Name:ROG3
Ordered Locus Names:YFR022W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR022w.
SGDiS000001918. ROG3.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi460 – 4612PP → QA: Reduced binding to RSP5. 1 Publication
Mutagenesisi625 – 6262PP → QA: Reduced binding to RSP5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Protein ROG3PRO_0000202690Add
BLAST

Proteomic databases

MaxQBiP43602.
PaxDbiP43602.

Expressioni

Gene expression databases

GenevestigatoriP43602.

Interactioni

Subunit structurei

Interacts with RSP5 via its 2 PY-motifs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399403EBI-22976,EBI-16219

Protein-protein interaction databases

BioGridi31175. 27 interactions.
DIPiDIP-4111N.
IntActiP43602. 2 interactions.
MINTiMINT-506352.
STRINGi4932.YFR022W.

Structurei

3D structure databases

ProteinModelPortaliP43602.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi460 – 4634PY-motif
Motifi625 – 6284PY-motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi641 – 71070Ser-richAdd
BLAST

Domaini

The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase.1 Publication

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiNOG250259.
GeneTreeiENSGT00730000112717.
HOGENOMiHOG000248143.
InParanoidiP43602.
OMAiPPNYEMH.
OrthoDBiEOG78WM17.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43602-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI
60 70 80 90 100
NEPMQIKSIS LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN
110 120 130 140 150
YAWDNVNLKE YLSGLRGQSG LAGSSSSSNI LGTRQRAQST SSLKSLKGSS
160 170 180 190 200
SPSSCTLDKG NYDFPFSAIL PGSLPESVES LPNCFVTYSM ESVIERSKNY
210 220 230 240 250
SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI SVPNKAVAIG
260 270 280 290 300
SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL
310 320 330 340 350
EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ
360 370 380 390 400
DCDVRSNIKV RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP
410 420 430 440 450
LSSSNLYSLF STTNQKDENS SQEEEEEYLF SRSASVTGLE LLADMRSGGS
460 470 480 490 500
VPTISDLMTP PNYEMHVYDR LYSGSFTRTA VETSGTCTPL GSECSTVEDQ
510 520 530 540 550
QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL NVPAPEDGTE
560 570 580 590 600
RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP
610 620 630 640 650
ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST
660 670 680 690 700
TLSSSIPTSF HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN
710 720 730
NPSSNSMKRS PTRRRATSLA GFMGGFLSKG NKR
Length:733
Mass (Da):79,709
Last modified:November 1, 1995 - v1
Checksum:i2BC6F7F24B9806A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09261.1.
BK006940 Genomic DNA. Translation: DAA12462.1.
PIRiS56277.
RefSeqiNP_116677.3. NM_001179987.3.

Genome annotation databases

EnsemblFungiiYFR022W; YFR022W; YFR022W.
GeneIDi850578.
KEGGisce:YFR022W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09261.1 .
BK006940 Genomic DNA. Translation: DAA12462.1 .
PIRi S56277.
RefSeqi NP_116677.3. NM_001179987.3.

3D structure databases

ProteinModelPortali P43602.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31175. 27 interactions.
DIPi DIP-4111N.
IntActi P43602. 2 interactions.
MINTi MINT-506352.
STRINGi 4932.YFR022W.

Proteomic databases

MaxQBi P43602.
PaxDbi P43602.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR022W ; YFR022W ; YFR022W .
GeneIDi 850578.
KEGGi sce:YFR022W.

Organism-specific databases

CYGDi YFR022w.
SGDi S000001918. ROG3.

Phylogenomic databases

eggNOGi NOG250259.
GeneTreei ENSGT00730000112717.
HOGENOMi HOG000248143.
InParanoidi P43602.
OMAi PPNYEMH.
OrthoDBi EOG78WM17.

Enzyme and pathway databases

BioCyci YEAST:G3O-30473-MONOMER.

Miscellaneous databases

NextBioi 966403.

Gene expression databases

Genevestigatori P43602.

Family and domain databases

InterProi IPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view ]
Pfami PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view ]
SMARTi SM01017. Arrestin_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance."
    Andoh T., Hirata Y., Kikuchi A.
    FEBS Lett. 525:131-134(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, INTERACTION WITH RSP5, MUTAGENESIS OF 460-PRO-PRO-461 AND 625-PRO-PRO-626.
  4. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiROG3_YEAST
AccessioniPrimary (citable) accession number: P43602
Secondary accession number(s): D6VTQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3