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Protein

Protein ROG3

Gene

ROG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).1 Publication

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

GO - Biological processi

  • adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion Source: SGD
  • positive regulation of receptor internalization Source: SGD
  • ubiquitin-dependent endocytosis Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30473-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ROG3
Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 3
Gene namesi
Name:ROG3
Ordered Locus Names:YFR022W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR022W
SGDiS000001918 ROG3

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi460 – 461PP → QA: Reduced binding to RSP5. 1 Publication2
Mutagenesisi625 – 626PP → QA: Reduced binding to RSP5. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026901 – 733Protein ROG3Add BLAST733

Proteomic databases

MaxQBiP43602
PaxDbiP43602
PRIDEiP43602

PTM databases

iPTMnetiP43602

Interactioni

Subunit structurei

Interacts with RSP5 via its 2 PY-motifs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399403EBI-22976,EBI-16219

GO - Molecular functioni

  • ubiquitin protein ligase binding Source: SGD

Protein-protein interaction databases

BioGridi31175, 49 interactors
DIPiDIP-4111N
IntActiP43602, 5 interactors
MINTiP43602
STRINGi4932.YFR022W

Structurei

3D structure databases

ProteinModelPortaliP43602
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi460 – 463PY-motif4
Motifi625 – 628PY-motif4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi641 – 710Ser-richAdd BLAST70

Domaini

The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase.1 Publication

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

GeneTreeiENSGT00730000112717
HOGENOMiHOG000248143
InParanoidiP43602
KOiK20062
OMAiPPNYEMH
OrthoDBiEOG092C0NX0

Family and domain databases

InterProiView protein in InterPro
IPR011021 Arrestin-like_N
IPR011022 Arrestin_C-like
PfamiView protein in Pfam
PF02752 Arrestin_C, 1 hit
PF00339 Arrestin_N, 1 hit
SMARTiView protein in SMART
SM01017 Arrestin_C, 1 hit

Sequencei

Sequence statusi: Complete.

P43602-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI
60 70 80 90 100
NEPMQIKSIS LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN
110 120 130 140 150
YAWDNVNLKE YLSGLRGQSG LAGSSSSSNI LGTRQRAQST SSLKSLKGSS
160 170 180 190 200
SPSSCTLDKG NYDFPFSAIL PGSLPESVES LPNCFVTYSM ESVIERSKNY
210 220 230 240 250
SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI SVPNKAVAIG
260 270 280 290 300
SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL
310 320 330 340 350
EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ
360 370 380 390 400
DCDVRSNIKV RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP
410 420 430 440 450
LSSSNLYSLF STTNQKDENS SQEEEEEYLF SRSASVTGLE LLADMRSGGS
460 470 480 490 500
VPTISDLMTP PNYEMHVYDR LYSGSFTRTA VETSGTCTPL GSECSTVEDQ
510 520 530 540 550
QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL NVPAPEDGTE
560 570 580 590 600
RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP
610 620 630 640 650
ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST
660 670 680 690 700
TLSSSIPTSF HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN
710 720 730
NPSSNSMKRS PTRRRATSLA GFMGGFLSKG NKR
Length:733
Mass (Da):79,709
Last modified:November 1, 1995 - v1
Checksum:i2BC6F7F24B9806A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09261.1
BK006940 Genomic DNA Translation: DAA12462.1
PIRiS56277
RefSeqiNP_116677.3, NM_001179987.3

Genome annotation databases

EnsemblFungiiBAA09261; BAA09261; BAA09261
YFR022W; YFR022W; YFR022W
GeneIDi850578
KEGGisce:YFR022W

Similar proteinsi

Entry informationi

Entry nameiROG3_YEAST
AccessioniPrimary (citable) accession number: P43602
Secondary accession number(s): D6VTQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health