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P43602

- ROG3_YEAST

UniProt

P43602 - ROG3_YEAST

Protein

Protein ROG3

Gene

ROG3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. ubiquitin protein ligase binding Source: SGD

    GO - Biological processi

    1. ubiquitin-dependent endocytosis Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30473-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ROG3
    Alternative name(s):
    Revertant of glycogen synthase kinase mutation protein 3
    Gene namesi
    Name:ROG3
    Ordered Locus Names:YFR022W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR022w.
    SGDiS000001918. ROG3.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi460 – 4612PP → QA: Reduced binding to RSP5. 1 Publication
    Mutagenesisi625 – 6262PP → QA: Reduced binding to RSP5. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 733733Protein ROG3PRO_0000202690Add
    BLAST

    Proteomic databases

    MaxQBiP43602.
    PaxDbiP43602.

    Expressioni

    Gene expression databases

    GenevestigatoriP43602.

    Interactioni

    Subunit structurei

    Interacts with RSP5 via its 2 PY-motifs.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    RSP5P399403EBI-22976,EBI-16219

    Protein-protein interaction databases

    BioGridi31175. 22 interactions.
    DIPiDIP-4111N.
    IntActiP43602. 2 interactions.
    MINTiMINT-506352.
    STRINGi4932.YFR022W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43602.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi460 – 4634PY-motif
    Motifi625 – 6284PY-motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi641 – 71070Ser-richAdd
    BLAST

    Domaini

    The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase.1 Publication

    Sequence similaritiesi

    Belongs to the arrestin family.Curated

    Phylogenomic databases

    eggNOGiNOG250259.
    GeneTreeiENSGT00730000112717.
    HOGENOMiHOG000248143.
    OMAiPPNYEMH.
    OrthoDBiEOG78WM17.

    Family and domain databases

    InterProiIPR011021. Arrestin-like_N.
    IPR011022. Arrestin_C-like.
    [Graphical view]
    PfamiPF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view]
    SMARTiSM01017. Arrestin_C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43602-1 [UniParc]FASTAAdd to Basket

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    MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI    50
    NEPMQIKSIS LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN 100
    YAWDNVNLKE YLSGLRGQSG LAGSSSSSNI LGTRQRAQST SSLKSLKGSS 150
    SPSSCTLDKG NYDFPFSAIL PGSLPESVES LPNCFVTYSM ESVIERSKNY 200
    SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI SVPNKAVAIG 250
    SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL 300
    EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ 350
    DCDVRSNIKV RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP 400
    LSSSNLYSLF STTNQKDENS SQEEEEEYLF SRSASVTGLE LLADMRSGGS 450
    VPTISDLMTP PNYEMHVYDR LYSGSFTRTA VETSGTCTPL GSECSTVEDQ 500
    QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL NVPAPEDGTE 550
    RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP 600
    ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST 650
    TLSSSIPTSF HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN 700
    NPSSNSMKRS PTRRRATSLA GFMGGFLSKG NKR 733
    Length:733
    Mass (Da):79,709
    Last modified:November 1, 1995 - v1
    Checksum:i2BC6F7F24B9806A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09261.1.
    BK006940 Genomic DNA. Translation: DAA12462.1.
    PIRiS56277.
    RefSeqiNP_116677.3. NM_001179987.3.

    Genome annotation databases

    EnsemblFungiiYFR022W; YFR022W; YFR022W.
    GeneIDi850578.
    KEGGisce:YFR022W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09261.1 .
    BK006940 Genomic DNA. Translation: DAA12462.1 .
    PIRi S56277.
    RefSeqi NP_116677.3. NM_001179987.3.

    3D structure databases

    ProteinModelPortali P43602.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31175. 22 interactions.
    DIPi DIP-4111N.
    IntActi P43602. 2 interactions.
    MINTi MINT-506352.
    STRINGi 4932.YFR022W.

    Proteomic databases

    MaxQBi P43602.
    PaxDbi P43602.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR022W ; YFR022W ; YFR022W .
    GeneIDi 850578.
    KEGGi sce:YFR022W.

    Organism-specific databases

    CYGDi YFR022w.
    SGDi S000001918. ROG3.

    Phylogenomic databases

    eggNOGi NOG250259.
    GeneTreei ENSGT00730000112717.
    HOGENOMi HOG000248143.
    OMAi PPNYEMH.
    OrthoDBi EOG78WM17.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30473-MONOMER.

    Miscellaneous databases

    NextBioi 966403.

    Gene expression databases

    Genevestigatori P43602.

    Family and domain databases

    InterProi IPR011021. Arrestin-like_N.
    IPR011022. Arrestin_C-like.
    [Graphical view ]
    Pfami PF02752. Arrestin_C. 1 hit.
    PF00339. Arrestin_N. 1 hit.
    [Graphical view ]
    SMARTi SM01017. Arrestin_C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance."
      Andoh T., Hirata Y., Kikuchi A.
      FEBS Lett. 525:131-134(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN, INTERACTION WITH RSP5, MUTAGENESIS OF 460-PRO-PRO-461 AND 625-PRO-PRO-626.
    4. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiROG3_YEAST
    AccessioniPrimary (citable) accession number: P43602
    Secondary accession number(s): D6VTQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3