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P43602

- ROG3_YEAST

UniProt

P43602 - ROG3_YEAST

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Protein
Protein ROG3
Gene
ROG3, YFR022W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in resistance to GST substrate o-dinitrobenzene (o-DNB).1 Publication

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. ubiquitin protein ligase binding Source: SGD
Complete GO annotation...

GO - Biological processi

  1. ubiquitin-dependent endocytosis Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30473-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ROG3
Alternative name(s):
Revertant of glycogen synthase kinase mutation protein 3
Gene namesi
Name:ROG3
Ordered Locus Names:YFR022W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR022w.
SGDiS000001918. ROG3.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi460 – 4612PP → QA: Reduced binding to RSP5. 1 Publication
Mutagenesisi625 – 6262PP → QA: Reduced binding to RSP5. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 733733Protein ROG3
PRO_0000202690Add
BLAST

Proteomic databases

MaxQBiP43602.
PaxDbiP43602.

Expressioni

Gene expression databases

GenevestigatoriP43602.

Interactioni

Subunit structurei

Interacts with RSP5 via its 2 PY-motifs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSP5P399403EBI-22976,EBI-16219

Protein-protein interaction databases

BioGridi31175. 22 interactions.
DIPiDIP-4111N.
IntActiP43602. 2 interactions.
MINTiMINT-506352.
STRINGi4932.YFR022W.

Structurei

3D structure databases

ProteinModelPortaliP43602.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi460 – 4634PY-motif
Motifi625 – 6284PY-motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi641 – 71070Ser-rich
Add
BLAST

Domaini

The PY-motifs are required for the interaction with RSP5 ubiquitin-ligase.1 Publication

Sequence similaritiesi

Belongs to the arrestin family.

Phylogenomic databases

eggNOGiNOG250259.
GeneTreeiENSGT00730000112717.
HOGENOMiHOG000248143.
OMAiPPNYEMH.
OrthoDBiEOG78WM17.

Family and domain databases

InterProiIPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view]
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43602-1 [UniParc]FASTAAdd to Basket

« Hide

MGFSSGKSTK KKPLLFDIRL KNVDNDVILL KGPPNEAPSV LLSGCIVLSI    50
NEPMQIKSIS LRLYGKIQID VPLERPQDAS SSSLSSSPPK IRKYNKVFYN 100
YAWDNVNLKE YLSGLRGQSG LAGSSSSSNI LGTRQRAQST SSLKSLKGSS 150
SPSSCTLDKG NYDFPFSAIL PGSLPESVES LPNCFVTYSM ESVIERSKNY 200
SDLICRKNIR VLRTISPAAV ELSETVCVDN SWPDKVDYSI SVPNKAVAIG 250
SATPINISIV PLSKGLKLGS IKVVLFENYQ YCDPFPPVIS ENRQVTELNL 300
EDPLNESSGE FNGNGCFVNN PFFQPDHSFQ DKWEIDTILQ IPNSLSNCVQ 350
DCDVRSNIKV RHKLKFFIIL INPDGHKSEL RASLPIQLFI SPFVALSIKP 400
LSSSNLYSLF STTNQKDENS SQEEEEEYLF SRSASVTGLE LLADMRSGGS 450
VPTISDLMTP PNYEMHVYDR LYSGSFTRTA VETSGTCTPL GSECSTVEDQ 500
QQDLEDLRIR LTKIRNQRDN LGLPPSASSA AASRSLSPLL NVPAPEDGTE 550
RILPQSALGP NSGSVPGVHS NVSPVLLSRS PAPSVSAHEV LPVPSGLNYP 600
ETQNLNKVPS YGKAMKYDII GEDLPPSYPC AIQNVQPRKP SRVHSRNSST 650
TLSSSIPTSF HSSSFMSSTA SPISIINGSR SSSSGVSLNT LNELTSKTSN 700
NPSSNSMKRS PTRRRATSLA GFMGGFLSKG NKR 733
Length:733
Mass (Da):79,709
Last modified:November 1, 1995 - v1
Checksum:i2BC6F7F24B9806A5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09261.1.
BK006940 Genomic DNA. Translation: DAA12462.1.
PIRiS56277.
RefSeqiNP_116677.3. NM_001179987.3.

Genome annotation databases

EnsemblFungiiYFR022W; YFR022W; YFR022W.
GeneIDi850578.
KEGGisce:YFR022W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09261.1 .
BK006940 Genomic DNA. Translation: DAA12462.1 .
PIRi S56277.
RefSeqi NP_116677.3. NM_001179987.3.

3D structure databases

ProteinModelPortali P43602.
ModBasei Search...

Protein-protein interaction databases

BioGridi 31175. 22 interactions.
DIPi DIP-4111N.
IntActi P43602. 2 interactions.
MINTi MINT-506352.
STRINGi 4932.YFR022W.

Proteomic databases

MaxQBi P43602.
PaxDbi P43602.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR022W ; YFR022W ; YFR022W .
GeneIDi 850578.
KEGGi sce:YFR022W.

Organism-specific databases

CYGDi YFR022w.
SGDi S000001918. ROG3.

Phylogenomic databases

eggNOGi NOG250259.
GeneTreei ENSGT00730000112717.
HOGENOMi HOG000248143.
OMAi PPNYEMH.
OrthoDBi EOG78WM17.

Enzyme and pathway databases

BioCyci YEAST:G3O-30473-MONOMER.

Miscellaneous databases

NextBioi 966403.

Gene expression databases

Genevestigatori P43602.

Family and domain databases

InterProi IPR011021. Arrestin-like_N.
IPR011022. Arrestin_C-like.
[Graphical view ]
Pfami PF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view ]
SMARTi SM01017. Arrestin_C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "PY motifs of Rod1 are required for binding to Rsp5 and for drug resistance."
    Andoh T., Hirata Y., Kikuchi A.
    FEBS Lett. 525:131-134(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, INTERACTION WITH RSP5, MUTAGENESIS OF 460-PRO-PRO-461 AND 625-PRO-PRO-626.
  4. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiROG3_YEAST
AccessioniPrimary (citable) accession number: P43602
Secondary accession number(s): D6VTQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

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