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P43596

- IOC3_YEAST

UniProt

P43596 - IOC3_YEAST

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Protein

ISWI one complex protein 3

Gene
IOC3, YFR013W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. chromatin remodeling Source: SGD
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30466-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ISWI one complex protein 3
Gene namesi
Name:IOC3
Ordered Locus Names:YFR013W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR013w.
SGDiS000001909. IOC3.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Isw1a complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 787787ISWI one complex protein 3PRO_0000202685Add
BLAST

Proteomic databases

MaxQBiP43596.
PaxDbiP43596.
PeptideAtlasiP43596.

Expressioni

Gene expression databases

GenevestigatoriP43596.

Interactioni

Subunit structurei

Component of the ISW1A complex, which at least consists of ISW1 and IOC3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ISW1P381449EBI-22944,EBI-21087

Protein-protein interaction databases

BioGridi31165. 55 interactions.
DIPiDIP-5446N.
IntActiP43596. 29 interactions.
MINTiMINT-574183.
STRINGi4932.YFR013W.

Structurei

Secondary structure

1
787
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi144 – 1474
Helixi157 – 1593
Helixi179 – 19113
Turni192 – 1954
Turni198 – 2025
Helixi205 – 2128
Beta strandi219 – 2224
Beta strandi224 – 2274
Beta strandi229 – 2313
Helixi238 – 2414
Helixi245 – 26521
Turni266 – 2683
Helixi284 – 2874
Helixi293 – 30513
Turni306 – 3094
Turni313 – 3153
Beta strandi326 – 3283
Turni365 – 3673
Helixi369 – 3713
Helixi373 – 3775
Helixi380 – 3823
Helixi385 – 40218
Helixi404 – 41411
Helixi432 – 4354
Helixi437 – 45317
Turni454 – 4574
Helixi462 – 4654
Turni470 – 4723
Helixi473 – 4819
Helixi483 – 4908
Turni491 – 4933
Helixi500 – 5034
Helixi506 – 5138
Beta strandi514 – 5163
Helixi525 – 5273
Turni529 – 5346
Beta strandi539 – 5435
Turni544 – 5463
Beta strandi547 – 5504
Beta strandi557 – 5593
Helixi569 – 58012
Helixi586 – 5916
Helixi594 – 5963
Beta strandi604 – 6063
Helixi608 – 61710
Beta strandi627 – 6293
Helixi634 – 64310
Helixi645 – 6484
Helixi694 – 6963
Helixi697 – 72630
Beta strandi727 – 7293
Helixi735 – 7395
Turni740 – 7434

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y9YX-ray3.25B127-749[»]
2Y9ZX-ray3.60B127-749[»]
ProteinModelPortaliP43596.
SMRiP43596. Positions 134-748.

Miscellaneous databases

EvolutionaryTraceiP43596.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG45620.
GeneTreeiENSGT00530000067641.
HOGENOMiHOG000113086.
OMAiFTLFEND.
OrthoDBiEOG7XH70P.

Family and domain databases

InterProiIPR028942. WHIM1_dom.
[Graphical view]
PfamiPF15612. WHIM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43596-1 [UniParc]FASTAAdd to Basket

« Hide

MDSPSNSIQN LQQEAQGSSS AQLADHDHDR VSMAMPLQTD QSVSVSQSSD    50
NLRRSRRVPK PRTSIYDEYE EELKERANKP KRKRPAPPKK KAPSTQNSKS 100
NDKVEKKKTT SIAKDGKPTL KTNDKKVAPK PKPAHEQVEP ALIPSNWTSV 150
IPLLTSDFKN QYSVISRLKN PNMKPVPYAG DIIKLMAFIN KFSSFFHSDL 200
QNLSFQDFEV GLDLYPGDPN GSAAGIVKGP EDTSLLLYPD FMAIKDIVYC 250
QDKMNLLFLS LLDLTFTENF DGKSAKKKGP LTTWENLKSS SKKVFSNPLY 300
RLRLVAREWG YPREWRQQLP SDQDISKPKT ALFEQDEQTP VVDPSHPEIL 350
TPNIYTWNAN EPLPLESNPL YNREMDKNGI LALKPMDRVV LLRALTDWCA 400
SHSSAIHDEI YKLTHGKKDP VFGIQTQQVP RYTIEGVDNT INQFKKLCSL 450
IQSRYEIRSK KKHFVKQLKE GKKPDLSRKL EILKEIKAEL KNAVKSEKDE 500
LLFSLYDKWV PLFEGELPDQ PLANPFSERL YKLRLQEFFL GRVPHIGDFY 550
MPRLHSYGDS LEMSTFTDLR NLQALLSKFK NNEYNAFTLF ENDGQSMSAQ 600
FKLFYHDTPS LAHDVARGRN TSGKVYWYEL CHDSATLLEF LEFLDYKIVK 650
PQDEKKEGNE KEKEALNNEA HILEQKSTTD NNPSINTNPL PKDAKYNTAR 700
KKLQILKEFL SDYYFILRQF EQMKVQFADM KPGKRQLRRI QRQTVNYNTE 750
YDSEEYVDDE EDDEADIYDD NDNDSSFDDG RVKRQRT 787
Length:787
Mass (Da):90,897
Last modified:November 1, 1995 - v1
Checksum:i1919A8A1F58B5340
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09252.1.
BK006940 Genomic DNA. Translation: DAA12454.1.
PIRiS56268.
RefSeqiNP_116668.1. NM_001179978.1.

Genome annotation databases

EnsemblFungiiYFR013W; YFR013W; YFR013W.
GeneIDi850567.
KEGGisce:YFR013W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09252.1 .
BK006940 Genomic DNA. Translation: DAA12454.1 .
PIRi S56268.
RefSeqi NP_116668.1. NM_001179978.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Y9Y X-ray 3.25 B 127-749 [» ]
2Y9Z X-ray 3.60 B 127-749 [» ]
ProteinModelPortali P43596.
SMRi P43596. Positions 134-748.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31165. 55 interactions.
DIPi DIP-5446N.
IntActi P43596. 29 interactions.
MINTi MINT-574183.
STRINGi 4932.YFR013W.

Proteomic databases

MaxQBi P43596.
PaxDbi P43596.
PeptideAtlasi P43596.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR013W ; YFR013W ; YFR013W .
GeneIDi 850567.
KEGGi sce:YFR013W.

Organism-specific databases

CYGDi YFR013w.
SGDi S000001909. IOC3.

Phylogenomic databases

eggNOGi NOG45620.
GeneTreei ENSGT00530000067641.
HOGENOMi HOG000113086.
OMAi FTLFEND.
OrthoDBi EOG7XH70P.

Enzyme and pathway databases

BioCyci YEAST:G3O-30466-MONOMER.

Miscellaneous databases

EvolutionaryTracei P43596.
NextBioi 966375.

Gene expression databases

Genevestigatori P43596.

Family and domain databases

InterProi IPR028942. WHIM1_dom.
[Graphical view ]
Pfami PF15612. WHIM1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
    Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
    Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION OF THE ISW1A COMPLEX.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION IN THE ISW1A COMPLEX, FUNCTION OF THE ISW1A COMPLEX.

Entry informationi

Entry nameiIOC3_YEAST
AccessioniPrimary (citable) accession number: P43596
Secondary accession number(s): D6VTP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

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