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P43596

- IOC3_YEAST

UniProt

P43596 - IOC3_YEAST

Protein

ISWI one complex protein 3

Gene

IOC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. chromatin remodeling Source: SGD
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30466-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ISWI one complex protein 3
    Gene namesi
    Name:IOC3
    Ordered Locus Names:YFR013W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR013w.
    SGDiS000001909. IOC3.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. Isw1a complex Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 787787ISWI one complex protein 3PRO_0000202685Add
    BLAST

    Proteomic databases

    MaxQBiP43596.
    PaxDbiP43596.
    PeptideAtlasiP43596.

    Expressioni

    Gene expression databases

    GenevestigatoriP43596.

    Interactioni

    Subunit structurei

    Component of the ISW1A complex, which at least consists of ISW1 and IOC3.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ISW1P381449EBI-22944,EBI-21087

    Protein-protein interaction databases

    BioGridi31165. 55 interactions.
    DIPiDIP-5446N.
    IntActiP43596. 29 interactions.
    MINTiMINT-574183.
    STRINGi4932.YFR013W.

    Structurei

    Secondary structure

    1
    787
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi144 – 1474
    Helixi157 – 1593
    Helixi179 – 19113
    Turni192 – 1954
    Turni198 – 2025
    Helixi205 – 2128
    Beta strandi219 – 2224
    Beta strandi224 – 2274
    Beta strandi229 – 2313
    Helixi238 – 2414
    Helixi245 – 26521
    Turni266 – 2683
    Helixi284 – 2874
    Helixi293 – 30513
    Turni306 – 3094
    Turni313 – 3153
    Beta strandi326 – 3283
    Turni365 – 3673
    Helixi369 – 3713
    Helixi373 – 3775
    Helixi380 – 3823
    Helixi385 – 40218
    Helixi404 – 41411
    Helixi432 – 4354
    Helixi437 – 45317
    Turni454 – 4574
    Helixi462 – 4654
    Turni470 – 4723
    Helixi473 – 4819
    Helixi483 – 4908
    Turni491 – 4933
    Helixi500 – 5034
    Helixi506 – 5138
    Beta strandi514 – 5163
    Helixi525 – 5273
    Turni529 – 5346
    Beta strandi539 – 5435
    Turni544 – 5463
    Beta strandi547 – 5504
    Beta strandi557 – 5593
    Helixi569 – 58012
    Helixi586 – 5916
    Helixi594 – 5963
    Beta strandi604 – 6063
    Helixi608 – 61710
    Beta strandi627 – 6293
    Helixi634 – 64310
    Helixi645 – 6484
    Helixi694 – 6963
    Helixi697 – 72630
    Beta strandi727 – 7293
    Helixi735 – 7395
    Turni740 – 7434

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2Y9YX-ray3.25B127-749[»]
    2Y9ZX-ray3.60B127-749[»]
    ProteinModelPortaliP43596.
    SMRiP43596. Positions 134-748.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43596.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG45620.
    GeneTreeiENSGT00530000067641.
    HOGENOMiHOG000113086.
    OMAiFTLFEND.
    OrthoDBiEOG7XH70P.

    Family and domain databases

    InterProiIPR028942. WHIM1_dom.
    [Graphical view]
    PfamiPF15612. WHIM1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43596-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSPSNSIQN LQQEAQGSSS AQLADHDHDR VSMAMPLQTD QSVSVSQSSD    50
    NLRRSRRVPK PRTSIYDEYE EELKERANKP KRKRPAPPKK KAPSTQNSKS 100
    NDKVEKKKTT SIAKDGKPTL KTNDKKVAPK PKPAHEQVEP ALIPSNWTSV 150
    IPLLTSDFKN QYSVISRLKN PNMKPVPYAG DIIKLMAFIN KFSSFFHSDL 200
    QNLSFQDFEV GLDLYPGDPN GSAAGIVKGP EDTSLLLYPD FMAIKDIVYC 250
    QDKMNLLFLS LLDLTFTENF DGKSAKKKGP LTTWENLKSS SKKVFSNPLY 300
    RLRLVAREWG YPREWRQQLP SDQDISKPKT ALFEQDEQTP VVDPSHPEIL 350
    TPNIYTWNAN EPLPLESNPL YNREMDKNGI LALKPMDRVV LLRALTDWCA 400
    SHSSAIHDEI YKLTHGKKDP VFGIQTQQVP RYTIEGVDNT INQFKKLCSL 450
    IQSRYEIRSK KKHFVKQLKE GKKPDLSRKL EILKEIKAEL KNAVKSEKDE 500
    LLFSLYDKWV PLFEGELPDQ PLANPFSERL YKLRLQEFFL GRVPHIGDFY 550
    MPRLHSYGDS LEMSTFTDLR NLQALLSKFK NNEYNAFTLF ENDGQSMSAQ 600
    FKLFYHDTPS LAHDVARGRN TSGKVYWYEL CHDSATLLEF LEFLDYKIVK 650
    PQDEKKEGNE KEKEALNNEA HILEQKSTTD NNPSINTNPL PKDAKYNTAR 700
    KKLQILKEFL SDYYFILRQF EQMKVQFADM KPGKRQLRRI QRQTVNYNTE 750
    YDSEEYVDDE EDDEADIYDD NDNDSSFDDG RVKRQRT 787
    Length:787
    Mass (Da):90,897
    Last modified:November 1, 1995 - v1
    Checksum:i1919A8A1F58B5340
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09252.1.
    BK006940 Genomic DNA. Translation: DAA12454.1.
    PIRiS56268.
    RefSeqiNP_116668.1. NM_001179978.1.

    Genome annotation databases

    EnsemblFungiiYFR013W; YFR013W; YFR013W.
    GeneIDi850567.
    KEGGisce:YFR013W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09252.1 .
    BK006940 Genomic DNA. Translation: DAA12454.1 .
    PIRi S56268.
    RefSeqi NP_116668.1. NM_001179978.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2Y9Y X-ray 3.25 B 127-749 [» ]
    2Y9Z X-ray 3.60 B 127-749 [» ]
    ProteinModelPortali P43596.
    SMRi P43596. Positions 134-748.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31165. 55 interactions.
    DIPi DIP-5446N.
    IntActi P43596. 29 interactions.
    MINTi MINT-574183.
    STRINGi 4932.YFR013W.

    Proteomic databases

    MaxQBi P43596.
    PaxDbi P43596.
    PeptideAtlasi P43596.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR013W ; YFR013W ; YFR013W .
    GeneIDi 850567.
    KEGGi sce:YFR013W.

    Organism-specific databases

    CYGDi YFR013w.
    SGDi S000001909. IOC3.

    Phylogenomic databases

    eggNOGi NOG45620.
    GeneTreei ENSGT00530000067641.
    HOGENOMi HOG000113086.
    OMAi FTLFEND.
    OrthoDBi EOG7XH70P.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30466-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei P43596.
    NextBioi 966375.

    Gene expression databases

    Genevestigatori P43596.

    Family and domain databases

    InterProi IPR028942. WHIM1_dom.
    [Graphical view ]
    Pfami PF15612. WHIM1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
      Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
      Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE ISW1A COMPLEX.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION IN THE ISW1A COMPLEX, FUNCTION OF THE ISW1A COMPLEX.

    Entry informationi

    Entry nameiIOC3_YEAST
    AccessioniPrimary (citable) accession number: P43596
    Secondary accession number(s): D6VTP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1770 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3