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Protein

ISWI one complex protein 3

Gene

IOC3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome.2 Publications

GO - Biological processi

  • chromatin remodeling Source: SGD
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30466-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ISWI one complex protein 3
Gene namesi
Name:IOC3
Ordered Locus Names:YFR013W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR013W.
SGDiS000001909. IOC3.

Subcellular locationi

GO - Cellular componenti

  • Isw1a complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026851 – 787ISWI one complex protein 3Add BLAST787

Proteomic databases

MaxQBiP43596.
PRIDEiP43596.

Interactioni

Subunit structurei

Component of the ISW1A complex, which at least consists of ISW1 and IOC3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ISW1P381449EBI-22944,EBI-21087

Protein-protein interaction databases

BioGridi31165. 59 interactors.
DIPiDIP-5446N.
IntActiP43596. 29 interactors.
MINTiMINT-574183.

Structurei

Secondary structure

1787
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi144 – 147Combined sources4
Helixi157 – 159Combined sources3
Helixi179 – 191Combined sources13
Turni192 – 195Combined sources4
Turni198 – 202Combined sources5
Helixi205 – 212Combined sources8
Beta strandi219 – 222Combined sources4
Beta strandi224 – 227Combined sources4
Beta strandi229 – 231Combined sources3
Helixi238 – 241Combined sources4
Helixi245 – 265Combined sources21
Turni266 – 268Combined sources3
Helixi284 – 287Combined sources4
Helixi293 – 305Combined sources13
Turni306 – 309Combined sources4
Turni313 – 315Combined sources3
Beta strandi326 – 328Combined sources3
Turni365 – 367Combined sources3
Helixi369 – 371Combined sources3
Helixi373 – 377Combined sources5
Helixi380 – 382Combined sources3
Helixi385 – 402Combined sources18
Helixi404 – 414Combined sources11
Helixi432 – 435Combined sources4
Helixi437 – 453Combined sources17
Turni454 – 457Combined sources4
Helixi462 – 465Combined sources4
Turni470 – 472Combined sources3
Helixi473 – 481Combined sources9
Helixi483 – 490Combined sources8
Turni491 – 493Combined sources3
Helixi500 – 503Combined sources4
Helixi506 – 513Combined sources8
Beta strandi514 – 516Combined sources3
Helixi525 – 527Combined sources3
Turni529 – 534Combined sources6
Beta strandi539 – 543Combined sources5
Turni544 – 546Combined sources3
Beta strandi547 – 550Combined sources4
Beta strandi557 – 559Combined sources3
Helixi569 – 580Combined sources12
Helixi586 – 591Combined sources6
Helixi594 – 596Combined sources3
Beta strandi604 – 606Combined sources3
Helixi608 – 617Combined sources10
Beta strandi627 – 629Combined sources3
Helixi634 – 643Combined sources10
Helixi645 – 648Combined sources4
Helixi694 – 696Combined sources3
Helixi697 – 726Combined sources30
Beta strandi727 – 729Combined sources3
Helixi735 – 739Combined sources5
Turni740 – 743Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9YX-ray3.25B127-749[»]
2Y9ZX-ray3.60B127-749[»]
ProteinModelPortaliP43596.
SMRiP43596.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43596.

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00530000067641.
HOGENOMiHOG000113086.
InParanoidiP43596.
OMAiYWYEMCH.
OrthoDBiEOG092C32A8.

Family and domain databases

InterProiIPR028942. WHIM1_dom.
[Graphical view]
PfamiPF15612. WHIM1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43596-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSPSNSIQN LQQEAQGSSS AQLADHDHDR VSMAMPLQTD QSVSVSQSSD
60 70 80 90 100
NLRRSRRVPK PRTSIYDEYE EELKERANKP KRKRPAPPKK KAPSTQNSKS
110 120 130 140 150
NDKVEKKKTT SIAKDGKPTL KTNDKKVAPK PKPAHEQVEP ALIPSNWTSV
160 170 180 190 200
IPLLTSDFKN QYSVISRLKN PNMKPVPYAG DIIKLMAFIN KFSSFFHSDL
210 220 230 240 250
QNLSFQDFEV GLDLYPGDPN GSAAGIVKGP EDTSLLLYPD FMAIKDIVYC
260 270 280 290 300
QDKMNLLFLS LLDLTFTENF DGKSAKKKGP LTTWENLKSS SKKVFSNPLY
310 320 330 340 350
RLRLVAREWG YPREWRQQLP SDQDISKPKT ALFEQDEQTP VVDPSHPEIL
360 370 380 390 400
TPNIYTWNAN EPLPLESNPL YNREMDKNGI LALKPMDRVV LLRALTDWCA
410 420 430 440 450
SHSSAIHDEI YKLTHGKKDP VFGIQTQQVP RYTIEGVDNT INQFKKLCSL
460 470 480 490 500
IQSRYEIRSK KKHFVKQLKE GKKPDLSRKL EILKEIKAEL KNAVKSEKDE
510 520 530 540 550
LLFSLYDKWV PLFEGELPDQ PLANPFSERL YKLRLQEFFL GRVPHIGDFY
560 570 580 590 600
MPRLHSYGDS LEMSTFTDLR NLQALLSKFK NNEYNAFTLF ENDGQSMSAQ
610 620 630 640 650
FKLFYHDTPS LAHDVARGRN TSGKVYWYEL CHDSATLLEF LEFLDYKIVK
660 670 680 690 700
PQDEKKEGNE KEKEALNNEA HILEQKSTTD NNPSINTNPL PKDAKYNTAR
710 720 730 740 750
KKLQILKEFL SDYYFILRQF EQMKVQFADM KPGKRQLRRI QRQTVNYNTE
760 770 780
YDSEEYVDDE EDDEADIYDD NDNDSSFDDG RVKRQRT
Length:787
Mass (Da):90,897
Last modified:November 1, 1995 - v1
Checksum:i1919A8A1F58B5340
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09252.1.
BK006940 Genomic DNA. Translation: DAA12454.1.
PIRiS56268.
RefSeqiNP_116668.1. NM_001179978.1.

Genome annotation databases

EnsemblFungiiBAA09252; BAA09252; BAA09252.
YFR013W; YFR013W; YFR013W.
GeneIDi850567.
KEGGisce:YFR013W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09252.1.
BK006940 Genomic DNA. Translation: DAA12454.1.
PIRiS56268.
RefSeqiNP_116668.1. NM_001179978.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2Y9YX-ray3.25B127-749[»]
2Y9ZX-ray3.60B127-749[»]
ProteinModelPortaliP43596.
SMRiP43596.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31165. 59 interactors.
DIPiDIP-5446N.
IntActiP43596. 29 interactors.
MINTiMINT-574183.

Proteomic databases

MaxQBiP43596.
PRIDEiP43596.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09252; BAA09252; BAA09252.
YFR013W; YFR013W; YFR013W.
GeneIDi850567.
KEGGisce:YFR013W.

Organism-specific databases

EuPathDBiFungiDB:YFR013W.
SGDiS000001909. IOC3.

Phylogenomic databases

GeneTreeiENSGT00530000067641.
HOGENOMiHOG000113086.
InParanoidiP43596.
OMAiYWYEMCH.
OrthoDBiEOG092C32A8.

Enzyme and pathway databases

BioCyciYEAST:G3O-30466-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP43596.
PROiP43596.

Family and domain databases

InterProiIPR028942. WHIM1_dom.
[Graphical view]
PfamiPF15612. WHIM1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOC3_YEAST
AccessioniPrimary (citable) accession number: P43596
Secondary accession number(s): D6VTP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.