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P43596 (IOC3_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ISWI one complex protein 3
Gene names
Name:IOC3
Ordered Locus Names:YFR013W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length787 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Functions as component of the ISW1A complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW1A complex represses gene expression at initiation through specific positioning of a promoter proximal dinucleosome. Ref.3 Ref.6

Subunit structure

Component of the ISW1A complex, which at least consists of ISW1 and IOC3. Ref.6

Subcellular location

Nucleus Ref.4.

Miscellaneous

Present with 1770 molecules/cell in log phase SD medium.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ISW1P381449EBI-22944,EBI-21087

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 787787ISWI one complex protein 3
PRO_0000202685

Secondary structure

............................................................................................... 787
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43596 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 1919A8A1F58B5340

FASTA78790,897
        10         20         30         40         50         60 
MDSPSNSIQN LQQEAQGSSS AQLADHDHDR VSMAMPLQTD QSVSVSQSSD NLRRSRRVPK 

        70         80         90        100        110        120 
PRTSIYDEYE EELKERANKP KRKRPAPPKK KAPSTQNSKS NDKVEKKKTT SIAKDGKPTL 

       130        140        150        160        170        180 
KTNDKKVAPK PKPAHEQVEP ALIPSNWTSV IPLLTSDFKN QYSVISRLKN PNMKPVPYAG 

       190        200        210        220        230        240 
DIIKLMAFIN KFSSFFHSDL QNLSFQDFEV GLDLYPGDPN GSAAGIVKGP EDTSLLLYPD 

       250        260        270        280        290        300 
FMAIKDIVYC QDKMNLLFLS LLDLTFTENF DGKSAKKKGP LTTWENLKSS SKKVFSNPLY 

       310        320        330        340        350        360 
RLRLVAREWG YPREWRQQLP SDQDISKPKT ALFEQDEQTP VVDPSHPEIL TPNIYTWNAN 

       370        380        390        400        410        420 
EPLPLESNPL YNREMDKNGI LALKPMDRVV LLRALTDWCA SHSSAIHDEI YKLTHGKKDP 

       430        440        450        460        470        480 
VFGIQTQQVP RYTIEGVDNT INQFKKLCSL IQSRYEIRSK KKHFVKQLKE GKKPDLSRKL 

       490        500        510        520        530        540 
EILKEIKAEL KNAVKSEKDE LLFSLYDKWV PLFEGELPDQ PLANPFSERL YKLRLQEFFL 

       550        560        570        580        590        600 
GRVPHIGDFY MPRLHSYGDS LEMSTFTDLR NLQALLSKFK NNEYNAFTLF ENDGQSMSAQ 

       610        620        630        640        650        660 
FKLFYHDTPS LAHDVARGRN TSGKVYWYEL CHDSATLLEF LEFLDYKIVK PQDEKKEGNE 

       670        680        690        700        710        720 
KEKEALNNEA HILEQKSTTD NNPSINTNPL PKDAKYNTAR KKLQILKEFL SDYYFILRQF 

       730        740        750        760        770        780 
EQMKVQFADM KPGKRQLRRI QRQTVNYNTE YDSEEYVDDE EDDEADIYDD NDNDSSFDDG 


RVKRQRT 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Isw1 chromatin remodeling ATPase coordinates transcription elongation and termination by RNA polymerase II."
Morillon A., Karabetsou N., O'Sullivan J., Kent N., Proudfoot N., Mellor J.
Cell 115:425-435(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION OF THE ISW1A COMPLEX.
[4]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]"Yeast Isw1p forms two separable complexes in vivo."
Vary J.C. Jr., Gangaraju V.K., Qin J., Landel C.C., Kooperberg C., Bartholomew B., Tsukiyama T.
Mol. Cell. Biol. 23:80-91(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION IN THE ISW1A COMPLEX, FUNCTION OF THE ISW1A COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09252.1.
BK006940 Genomic DNA. Translation: DAA12454.1.
PIRS56268.
RefSeqNP_116668.1. NM_001179978.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2Y9YX-ray3.25B127-749[»]
2Y9ZX-ray3.60B127-749[»]
ProteinModelPortalP43596.
SMRP43596. Positions 134-748.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31165. 55 interactions.
DIPDIP-5446N.
IntActP43596. 29 interactions.
MINTMINT-574183.
STRING4932.YFR013W.

Proteomic databases

PaxDbP43596.
PeptideAtlasP43596.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFR013W; YFR013W; YFR013W.
GeneID850567.
KEGGsce:YFR013W.

Organism-specific databases

CYGDYFR013w.
SGDS000001909. IOC3.

Phylogenomic databases

eggNOGNOG45620.
GeneTreeENSGT00530000067641.
HOGENOMHOG000113086.
OMAFTLFEND.
OrthoDBEOG7XH70P.

Enzyme and pathway databases

BioCycYEAST:G3O-30466-MONOMER.

Gene expression databases

GenevestigatorP43596.

Family and domain databases

InterProIPR028942. WHIM1_dom.
[Graphical view]
PfamPF15612. WHIM1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP43596.
NextBio966375.

Entry information

Entry nameIOC3_YEAST
AccessionPrimary (citable) accession number: P43596
Secondary accession number(s): D6VTP4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

PDB cross-references

Index of Protein Data Bank (PDB) cross-references