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P43594

- MIC19_YEAST

UniProt

P43594 - MIC19_YEAST

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Protein

MICOS complex subunit MIC19

Gene

MIC19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

GO - Biological processi

  1. cristae formation Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-30464-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC19
Alternative name(s):
Altered inheritance of mitochondria protein 13, mitochondrial
Mitochondrial contact site complex 19 kDa subunit
Gene namesi
Name:MIC19
Synonyms:AIM13, MCS19
Ordered Locus Names:YFR011C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFR011c.
SGDiS000001907. MIC19.

Subcellular locationi

Mitochondrion inner membrane 5 Publications; Peripheral membrane protein 5 Publications; Intermembrane side 5 Publications
Note: Enriched at crista junctions.

GO - Cellular componenti

  1. MICOS complex Source: SGD
  2. mitochondrial crista junction Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170MICOS complex subunit MIC19PRO_0000202684Add
BLAST

Proteomic databases

MaxQBiP43594.
PaxDbiP43594.
PeptideAtlasiP43594.

Expressioni

Gene expression databases

GenevestigatoriP43594.

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Protein-protein interaction databases

BioGridi31161. 55 interactions.
DIPiDIP-1570N.
IntActiP43594. 10 interactions.
MINTiMINT-391945.
STRINGi4932.YFR011C.

Structurei

3D structure databases

ProteinModelPortaliP43594.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic19 family.Curated

Phylogenomic databases

eggNOGiNOG86925.
InParanoidiP43594.
KOiK17788.
OMAiCYEEMEE.
OrthoDBiEOG7N37RD.

Family and domain databases

InterProiIPR012471. DUF1690.
[Graphical view]
PfamiPF07956. DUF1690. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43594-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSNTSKVGA GAEKQQVYTP LTQIDFSQSL VSQLDSSKES DYVTKQNAEK
60 70 80 90 100
FIEKKVSQRL SNLEVETLKK FEDTLNNSLL SDDDKDAVDG ISSSSLNNQI
110 120 130 140 150
ESLNKKLTLF DQLELQKLEK YGGAKGKSDK KTDNGSISIK AKLTECLLAN
160 170
KGKPLNCYEE MEEFKKLVMG
Length:170
Mass (Da):18,855
Last modified:November 1, 1995 - v1
Checksum:i0E6670669D3AD0AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09250.1.
AY692683 Genomic DNA. Translation: AAT92702.1.
BK006940 Genomic DNA. Translation: DAA12451.1.
PIRiS56266.
RefSeqiNP_116666.1. NM_001179976.1.

Genome annotation databases

EnsemblFungiiYFR011C; YFR011C; YFR011C.
GeneIDi850563.
KEGGisce:YFR011C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09250.1 .
AY692683 Genomic DNA. Translation: AAT92702.1 .
BK006940 Genomic DNA. Translation: DAA12451.1 .
PIRi S56266.
RefSeqi NP_116666.1. NM_001179976.1.

3D structure databases

ProteinModelPortali P43594.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31161. 55 interactions.
DIPi DIP-1570N.
IntActi P43594. 10 interactions.
MINTi MINT-391945.
STRINGi 4932.YFR011C.

Proteomic databases

MaxQBi P43594.
PaxDbi P43594.
PeptideAtlasi P43594.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFR011C ; YFR011C ; YFR011C .
GeneIDi 850563.
KEGGi sce:YFR011C.

Organism-specific databases

CYGDi YFR011c.
SGDi S000001907. MIC19.

Phylogenomic databases

eggNOGi NOG86925.
InParanoidi P43594.
KOi K17788.
OMAi CYEEMEE.
OrthoDBi EOG7N37RD.

Enzyme and pathway databases

BioCyci YEAST:G3O-30464-MONOMER.

Miscellaneous databases

NextBioi 966364.

Gene expression databases

Genevestigatori P43594.

Family and domain databases

InterProi IPR012471. DUF1690.
[Graphical view ]
Pfami PF07956. DUF1690. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
    Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
    J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  7. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
    Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
    PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  10. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
    Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
    EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  11. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
    Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
    J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  12. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMIC19_YEAST
AccessioniPrimary (citable) accession number: P43594
Secondary accession number(s): D6VTP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3