P43594 (AIM13_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Altered inheritance of mitochondria protein 13, mitochondrial

Gene names

Name:	AIM13
Ordered Locus Names:	YFR011C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	170 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	As a component of the mitochondrial inner membrane organizing system (MINOS/MitOS) complex, important for normal mitochondrial morphology. Ref.8 Ref.9
Subunit structure	Component of the MINOS/MitOS complex, that includes FCJ1, AIM5, AIM13, AIM37, MOS1 and MOS2.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side Ref.4 Ref.6 Ref.8 Ref.9.
Disruption phenotype	Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane. Ref.7 Ref.8 Ref.9
Miscellaneous	Present with 3550 molecules/cell in log phase SD medium.
Sequence similarities	Belongs to the AIM13 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cristae formation Inferred from mutant phenotype Ref.8Ref.9PubMed 22009199. Source: SGD
Cellular_component	extrinsic to mitochondrial inner membrane Inferred from direct assay Ref.8PubMed 22009199. Source: SGD mitochondrial crista junction Inferred from direct assay PubMed 22009199. Source: SGD mitochondrial intermembrane space Inferred from direct assay Ref.9PubMed 22009199. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 170	170	Altered inheritance of mitochondria protein 13, mitochondrial		PRO_0000202684

Sequences

	Sequence		Length	Mass (Da)
	P43594 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 0E6670669D3AD0AA	FASTA	170	18,855
	10 20 30 40 50 60 MGSNTSKVGA GAEKQQVYTP LTQIDFSQSL VSQLDSSKES DYVTKQNAEK FIEKKVSQRL 70 80 90 100 110 120 SNLEVETLKK FEDTLNNSLL SDDDKDAVDG ISSSSLNNQI ESLNKKLTLF DQLELQKLEK 130 140 150 160 170 YGGAKGKSDK KTDNGSISIK AKLTECLLAN KGKPLNCYEE MEEFKKLVMG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[5]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[6]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
[7]	"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis." Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A. PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE.
[8]	"Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis." von der Malsburg K., Muller J.M., Bohnert M., Oeljeklaus S., Kwiatkowska P., Becker T., Loniewska-Lwowska A., Wiese S., Rao S., Milenkovic D., Hutu D.P., Zerbes R.M., Schulze-Specking A., Meyer H.E., Martinou J.C., Rospert S., Rehling P., Meisinger C. , Veenhuis M., Warscheid B., van der Klei I.J., Pfanner N., Chacinska A., van der Laan M. Dev. Cell 21:694-707(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[9]	"A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria." Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J. J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, COMPOSITION OF THE MINOS/MITOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09250.1. AY692683 Genomic DNA. Translation: AAT92702.1. BK006940 Genomic DNA. Translation: DAA12451.1.
PIR	S56266.
RefSeq	NP_116666.1. NM_001179976.1.
3D structure databases
ProteinModelPortal	P43594.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1570N.
IntAct	P43594. 2 interactions.
MINT	MINT-391945.
STRING	4932.YFR011C.
Proteomic databases
PaxDb	P43594.
PeptideAtlas	P43594.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFR011C; YFR011C; YFR011C.
GeneID	850563.
KEGG	sce:YFR011C.
Organism-specific databases
CYGD	YFR011c.
SGD	S000001907. AIM13.
Phylogenomic databases
eggNOG	NOG86925.
OMA	PETKVFT.
OrthoDB	EOG47WRZC.
Gene expression databases
Genevestigator	P43594.
GermOnline	YFR011C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR012471. DUF1690. [Graphical view]
Pfam	PF07956. DUF1690. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966364.

Entry information

Entry name

AIM13_YEAST

Accession

Primary (citable) accession number: P43594
Secondary accession number(s): D6VTP1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program