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P43594

- MIC19_YEAST

UniProt

P43594 - MIC19_YEAST

Protein

MICOS complex subunit MIC19

Gene

MIC19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

    GO - Biological processi

    1. cristae formation Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30464-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MICOS complex subunit MIC19
    Alternative name(s):
    Altered inheritance of mitochondria protein 13, mitochondrial
    Mitochondrial contact site complex 19 kDa subunit
    Gene namesi
    Name:MIC19
    Synonyms:AIM13, MCS19
    Ordered Locus Names:YFR011C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFR011c.
    SGDiS000001907. MIC19.

    Subcellular locationi

    Mitochondrion inner membrane 5 Publications; Peripheral membrane protein 5 Publications; Intermembrane side 5 Publications
    Note: Enriched at crista junctions.

    GO - Cellular componenti

    1. MICOS complex Source: SGD
    2. mitochondrial crista junction Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Disruption phenotypei

    Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.3 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170MICOS complex subunit MIC19PRO_0000202684Add
    BLAST

    Proteomic databases

    MaxQBiP43594.
    PaxDbiP43594.
    PeptideAtlasiP43594.

    Expressioni

    Gene expression databases

    GenevestigatoriP43594.

    Interactioni

    Subunit structurei

    Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

    Protein-protein interaction databases

    BioGridi31161. 55 interactions.
    DIPiDIP-1570N.
    IntActiP43594. 10 interactions.
    MINTiMINT-391945.
    STRINGi4932.YFR011C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43594.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MICOS complex subunit Mic19 family.Curated

    Phylogenomic databases

    eggNOGiNOG86925.
    KOiK17788.
    OMAiCYEEMEE.
    OrthoDBiEOG7N37RD.

    Family and domain databases

    InterProiIPR012471. DUF1690.
    [Graphical view]
    PfamiPF07956. DUF1690. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43594-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGSNTSKVGA GAEKQQVYTP LTQIDFSQSL VSQLDSSKES DYVTKQNAEK    50
    FIEKKVSQRL SNLEVETLKK FEDTLNNSLL SDDDKDAVDG ISSSSLNNQI 100
    ESLNKKLTLF DQLELQKLEK YGGAKGKSDK KTDNGSISIK AKLTECLLAN 150
    KGKPLNCYEE MEEFKKLVMG 170
    Length:170
    Mass (Da):18,855
    Last modified:November 1, 1995 - v1
    Checksum:i0E6670669D3AD0AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09250.1.
    AY692683 Genomic DNA. Translation: AAT92702.1.
    BK006940 Genomic DNA. Translation: DAA12451.1.
    PIRiS56266.
    RefSeqiNP_116666.1. NM_001179976.1.

    Genome annotation databases

    EnsemblFungiiYFR011C; YFR011C; YFR011C.
    GeneIDi850563.
    KEGGisce:YFR011C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09250.1 .
    AY692683 Genomic DNA. Translation: AAT92702.1 .
    BK006940 Genomic DNA. Translation: DAA12451.1 .
    PIRi S56266.
    RefSeqi NP_116666.1. NM_001179976.1.

    3D structure databases

    ProteinModelPortali P43594.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31161. 55 interactions.
    DIPi DIP-1570N.
    IntActi P43594. 10 interactions.
    MINTi MINT-391945.
    STRINGi 4932.YFR011C.

    Proteomic databases

    MaxQBi P43594.
    PaxDbi P43594.
    PeptideAtlasi P43594.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFR011C ; YFR011C ; YFR011C .
    GeneIDi 850563.
    KEGGi sce:YFR011C.

    Organism-specific databases

    CYGDi YFR011c.
    SGDi S000001907. MIC19.

    Phylogenomic databases

    eggNOGi NOG86925.
    KOi K17788.
    OMAi CYEEMEE.
    OrthoDBi EOG7N37RD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30464-MONOMER.

    Miscellaneous databases

    NextBioi 966364.

    Gene expression databases

    Genevestigatori P43594.

    Family and domain databases

    InterProi IPR012471. DUF1690.
    [Graphical view ]
    Pfami PF07956. DUF1690. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. "Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
      Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
      J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    7. "Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
      Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
      PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE.
    8. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    10. "The mitochondrial contact site complex, a determinant of mitochondrial architecture."
      Harner M., Korner C., Walther D., Mokranjac D., Kaesmacher J., Welsch U., Griffith J., Mann M., Reggiori F., Neupert W.
      EMBO J. 30:4356-4370(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE MICOS COMPLEX, MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    11. "A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria."
      Hoppins S., Collins S.R., Cassidy-Stone A., Hummel E., Devay R.M., Lackner L.L., Westermann B., Schuldiner M., Weissman J.S., Nunnari J.
      J. Cell Biol. 195:323-340(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, COMPOSITION OF THE MICOS COMPLEX, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    12. Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiMIC19_YEAST
    AccessioniPrimary (citable) accession number: P43594
    Secondary accession number(s): D6VTP1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3550 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3