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Protein

MICOS complex subunit MIC19

Gene

MIC19

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.2 Publications

Miscellaneous

Present with 3550 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • cristae formation Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-30464-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
MICOS complex subunit MIC19
Alternative name(s):
Altered inheritance of mitochondria protein 13, mitochondrial
Mitochondrial contact site complex 19 kDa subunit
Gene namesi
Name:MIC19
Synonyms:AIM13, MCS19
Ordered Locus Names:YFR011C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR011C
SGDiS000001907 MIC19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Increases frequency of mitochondrial genome loss. Partially altered shape of the mitochondrial network with condensed, fragmented mitochondria accumulating at the periphery of cells. 20-40% of mitochondria exhibit an increased inner membrane surface and stacks of lamellar cristae disconnected from the inner boundary membrane.3 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026841 – 170MICOS complex subunit MIC19Add BLAST170

Proteomic databases

MaxQBiP43594
PaxDbiP43594
PRIDEiP43594

Interactioni

Subunit structurei

Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MIC10, MIC12, MIC19, MIC26, MIC27 and MIC60. This complex was also known under the names MINOS or MitOS complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MIC60P361125EBI-22936,EBI-27078

Protein-protein interaction databases

BioGridi31161, 182 interactors
DIPiDIP-1570N
IntActiP43594, 14 interactors
MINTiP43594
STRINGi4932.YFR011C

Structurei

3D structure databases

ProteinModelPortaliP43594
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MICOS complex subunit Mic19 family.Curated

Phylogenomic databases

InParanoidiP43594
KOiK17788
OMAiGKSLNCW
OrthoDBiEOG092C4SIH

Family and domain databases

InterProiView protein in InterPro
IPR012471 DUF1690
PfamiView protein in Pfam
PF07956 DUF1690, 1 hit

Sequencei

Sequence statusi: Complete.

P43594-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSNTSKVGA GAEKQQVYTP LTQIDFSQSL VSQLDSSKES DYVTKQNAEK
60 70 80 90 100
FIEKKVSQRL SNLEVETLKK FEDTLNNSLL SDDDKDAVDG ISSSSLNNQI
110 120 130 140 150
ESLNKKLTLF DQLELQKLEK YGGAKGKSDK KTDNGSISIK AKLTECLLAN
160 170
KGKPLNCYEE MEEFKKLVMG
Length:170
Mass (Da):18,855
Last modified:November 1, 1995 - v1
Checksum:i0E6670669D3AD0AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09250.1
AY692683 Genomic DNA Translation: AAT92702.1
BK006940 Genomic DNA Translation: DAA12451.1
PIRiS56266
RefSeqiNP_116666.1, NM_001179976.1

Genome annotation databases

EnsemblFungiiBAA09250; BAA09250; BAA09250
YFR011C; YFR011C; YFR011C
GeneIDi850563
KEGGisce:YFR011C

Similar proteinsi

Entry informationi

Entry nameiMIC19_YEAST
AccessioniPrimary (citable) accession number: P43594
Secondary accession number(s): D6VTP1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health