P43592 (FAR7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Factor arrest protein 7

Gene names

Name:	FAR7
Ordered Locus Names:	YFR008W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Participates in the control of the reentry into the cell cycle following pheromone treatment. Ref.3
Subunit structure	Component of a complex at least composed of FAR3, FAR7, FAR8, FAR10, FAR11 and VPS64.
Miscellaneous	Present with 1540 molecules/cell in log phase SD medium.

Ontologies

Keywords
Biological process	Cell cycle
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	re-entry into mitotic cell cycle after pheromone arrest Inferred from genetic interaction Ref.3. Source: SGD
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
FAR3	P46671	4	EBI-22932,EBI-6789

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 221	221	Factor arrest protein 7		PRO_0000087192
Regions
	Compositional bias	11 – 22	12	Poly-Gln

Sequences

	Sequence		Length	Mass (Da)
	P43592 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 81156978FF7AAD54	FASTA	221	25,915
	10 20 30 40 50 60 MSDQINVLSM QQQQQQQQQQ QQVYMSPQAE NLNHMYLLVN KLVKQLRENQ AEKAKILRNI 70 80 90 100 110 120 DILSGSLNKY ETSEEPHDTT ENIALFNRFL EQRGKAPITE KEQLSNNLDE NAKDDVMLGV 130 140 150 160 170 180 LKRQNSMLRK SLQESKQVTL ESMDLLSYSE DSLNYIVAQL RGNILMHHKE TIKLIRQKFQ 190 200 210 220 TETIPLEDEE FKMYLENVNG LQKLTDISHT YRLLLRLHAQ D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae." Kemp H.A., Sprague G.F. Jr. Mol. Cell. Biol. 23:1750-1763(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH FAR3; FAR8; FAR10; FAR11 AND VPS64.
[4]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09247.1. BK006940 Genomic DNA. Translation: DAA12448.1.
PIR	S56263.
RefSeq	NP_116663.1. NM_001179973.1.
3D structure databases
ProteinModelPortal	P43592.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1315N.
IntAct	P43592. 9 interactions.
MINT	MINT-393204.
STRING	4932.YFR008W.
Proteomic databases
PaxDb	P43592.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFR008W; YFR008W; YFR008W.
GeneID	850559.
KEGG	sce:YFR008W.
Organism-specific databases
CYGD	YFR008w.
SGD	S000001904. FAR7.
Phylogenomic databases
eggNOG	NOG47872.
HOGENOM	HOG000112502.
OMA	SITRESY.
OrthoDB	EOG4B0202.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30461-MONOMER.
Gene expression databases
Genevestigator	P43592.
GermOnline	YFR008W. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	966353.

Entry information

Entry name

FAR7_YEAST

Accession

Primary (citable) accession number: P43592
Secondary accession number(s): D6VTN8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 29, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program