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P43591 (YFH7_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent kinase YFH7

EC=2.7.1.-
Alternative name(s):
Altered inheritance of mitochondria protein 12
Gene names
Name:YFH7
Synonyms:AIM12
Ordered Locus Names:YFR007W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly. Ref.5

Disruption phenotype

Increases frequency of mitochondrial genome loss. Ref.6

Miscellaneous

Present with 161 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the YFH7 family.

Biophysicochemical properties

Kinetic parameters:

KM=1178 µM for ATP Ref.8

Binary interactions

With

Entry

#Exp.

IntAct

Notes

YBR056WP380811EBI-22928,EBI-21453

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 353353ATP-dependent kinase YFH7
PRO_0000202683

Regions

Nucleotide binding31 – 399ATP By similarity

Secondary structure

............................................................ 353
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P43591 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 521A76D6E9C9F11D

FASTA35339,885
        10         20         30         40         50         60 
MVDTHKLADD VLQLLDNRIE DNYRVCVILV GSPGSGKSTI AEELCQIINE KYHTFLSEHP 

        70         80         90        100        110        120 
NVIEVNDRLK PMVNLVDSLK TLQPNKVAEM IENQGLFKDH VEDVNFQPVK YSALTSNNEE 

       130        140        150        160        170        180 
CTAVVARGGT ANAIRIAAVD NPVNVNKLAQ DSINIAQIVP MDGFHLSRRC LDLFKDPQTA 

       190        200        210        220        230        240 
HKRRGSPSTF DSNNFLQLCK ILAKTSLCKV SSHHKFYSTS SVFEKLSKTF SQTIPDIFVP 

       250        260        270        280        290        300 
GFNHALKDPT PDQYCISKFT RIVILEGLYL LYDQENWKKI YKTLADTGAL LVYKIDIDYE 

       310        320        330        340        350 
ATEERVAKRH LQSGLVTTIA EGREKFRSND LLNGRDIDNH LIKVDNIVHI RND 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Parallel analysis of tagged deletion mutants efficiently identifies genes involved in endoplasmic reticulum biogenesis."
Wright R., Parrish M.L., Cadera E., Larson L., Matson C.K., Garrett-Engele P., Armour C., Lum P.Y., Shoemaker D.D.
Yeast 20:881-892(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis."
Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J., Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M., Troyanskaya O.G., Caudy A.A.
PLoS Genet. 5:E1000407-E1000407(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Crystal structure and functional analysis identify the P-loop containing protein YFH7 of Saccharomyces cerevisiae as an ATP-dependent kinase."
Gueguen-Chaignon V., Chaptal V., Lariviere L., Costa N., Lopes P., Morera S., Nessler S.
Proteins 71:804-812(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS), BIOPHYSICOCHEMICAL PROPERTIES.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09246.1.
AY558494 Genomic DNA. Translation: AAS56820.1.
BK006940 Genomic DNA. Translation: DAA12447.1.
PIRS56262.
RefSeqNP_116662.1. NM_001179972.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2GA8X-ray1.77A1-353[»]
2GAAX-ray1.95A1-353[»]
ProteinModelPortalP43591.
SMRP43591. Positions 2-353.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31156. 7 interactions.
DIPDIP-5443N.
IntActP43591. 2 interactions.
MINTMINT-518359.
STRING4932.YFR007W.

Proteomic databases

PaxDbP43591.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFR007W; YFR007W; YFR007W.
GeneID850558.
KEGGsce:YFR007W.

Organism-specific databases

CYGDYFR007w.
SGDS000001903. YFH7.

Phylogenomic databases

eggNOGCOG1072.
HOGENOMHOG000141840.
OMAILEGLYL.
OrthoDBEOG74J9JP.

Enzyme and pathway databases

BioCycYEAST:G3O-30460-MONOMER.

Gene expression databases

GenevestigatorP43591.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
ProtoNetSearch...

Other

EvolutionaryTraceP43591.
NextBio966350.

Entry information

Entry nameYFH7_YEAST
AccessionPrimary (citable) accession number: P43591
Secondary accession number(s): D6VTN7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references