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Protein

ATP-dependent kinase YFH7

Gene

YFH7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.1 Publication

Miscellaneous

Present with 161 molecules/cell in log phase SD medium.1 Publication

Kineticsi

  1. KM=1178 µM for ATP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi31 – 39ATPBy similarity9

    GO - Molecular functioni

    • ATPase activity Source: SGD
    • ATP binding Source: UniProtKB-KW
    • kinase activity Source: SGD
    • uridine kinase activity Source: GO_Central

    GO - Biological processi

    • phosphorylation Source: SGD
    • pyrimidine nucleobase metabolic process Source: GO_Central
    • pyrimidine nucleoside salvage Source: GO_Central

    Keywordsi

    Molecular functionKinase, Transferase
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30460-MONOMER

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent kinase YFH7 (EC:2.7.1.-)
    Alternative name(s):
    Altered inheritance of mitochondria protein 12
    Gene namesi
    Name:YFH7
    Synonyms:AIM12
    Ordered Locus Names:YFR007W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    Proteomesi
    • UP000002311 Componenti: Chromosome VI

    Organism-specific databases

    EuPathDBiFungiDB:YFR007W
    SGDiS000001903 YFH7

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Pathology & Biotechi

    Disruption phenotypei

    Increases frequency of mitochondrial genome loss.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00002026831 – 353ATP-dependent kinase YFH7Add BLAST353

    Proteomic databases

    MaxQBiP43591
    PaxDbiP43591
    PRIDEiP43591

    Interactioni

    Protein-protein interaction databases

    BioGridi31156, 60 interactors
    DIPiDIP-5443N
    IntActiP43591, 1 interactor
    STRINGi4932.YFR007W

    Structurei

    Secondary structure

    1353
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Helixi4 – 17Combined sources14
    Turni18 – 21Combined sources4
    Beta strandi25 – 30Combined sources6
    Helixi37 – 58Combined sources22
    Beta strandi79 – 81Combined sources3
    Helixi84 – 92Combined sources9
    Turni93 – 95Combined sources3
    Helixi98 – 100Combined sources3
    Beta strandi109 – 113Combined sources5
    Beta strandi121 – 125Combined sources5
    Helixi129 – 132Combined sources4
    Beta strandi134 – 136Combined sources3
    Beta strandi155 – 160Combined sources6
    Helixi161 – 164Combined sources4
    Helixi168 – 171Combined sources4
    Beta strandi174 – 176Combined sources3
    Helixi178 – 181Combined sources4
    Turni182 – 185Combined sources4
    Helixi187 – 189Combined sources3
    Helixi192 – 206Combined sources15
    Helixi222 – 227Combined sources6
    Beta strandi237 – 243Combined sources7
    Turni244 – 247Combined sources4
    Beta strandi248 – 256Combined sources9
    Beta strandi262 – 269Combined sources8
    Helixi275 – 285Combined sources11
    Turni286 – 288Combined sources3
    Beta strandi290 – 296Combined sources7
    Helixi299 – 312Combined sources14
    Helixi319 – 328Combined sources10
    Turni330 – 332Combined sources3
    Helixi335 – 339Combined sources5
    Beta strandi347 – 351Combined sources5

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2GA8X-ray1.77A1-353[»]
    2GAAX-ray1.95A1-353[»]
    ProteinModelPortaliP43591
    SMRiP43591
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43591

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the YFH7 family.Curated

    Phylogenomic databases

    HOGENOMiHOG000141840
    InParanoidiP43591
    OMAiILEGLYL
    OrthoDBiEOG092C3MYG

    Family and domain databases

    InterProiView protein in InterPro
    IPR011704 ATPase_dyneun-rel_AAA
    IPR027417 P-loop_NTPase
    PfamiView protein in Pfam
    PF07728 AAA_5, 1 hit
    SUPFAMiSSF52540 SSF52540, 3 hits

    Sequencei

    Sequence statusi: Complete.

    P43591-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MVDTHKLADD VLQLLDNRIE DNYRVCVILV GSPGSGKSTI AEELCQIINE
    60 70 80 90 100
    KYHTFLSEHP NVIEVNDRLK PMVNLVDSLK TLQPNKVAEM IENQGLFKDH
    110 120 130 140 150
    VEDVNFQPVK YSALTSNNEE CTAVVARGGT ANAIRIAAVD NPVNVNKLAQ
    160 170 180 190 200
    DSINIAQIVP MDGFHLSRRC LDLFKDPQTA HKRRGSPSTF DSNNFLQLCK
    210 220 230 240 250
    ILAKTSLCKV SSHHKFYSTS SVFEKLSKTF SQTIPDIFVP GFNHALKDPT
    260 270 280 290 300
    PDQYCISKFT RIVILEGLYL LYDQENWKKI YKTLADTGAL LVYKIDIDYE
    310 320 330 340 350
    ATEERVAKRH LQSGLVTTIA EGREKFRSND LLNGRDIDNH LIKVDNIVHI

    RND
    Length:353
    Mass (Da):39,885
    Last modified:November 1, 1995 - v1
    Checksum:i521A76D6E9C9F11D
    GO

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    D50617 Genomic DNA Translation: BAA09246.1
    AY558494 Genomic DNA Translation: AAS56820.1
    BK006940 Genomic DNA Translation: DAA12447.1
    PIRiS56262
    RefSeqiNP_116662.1, NM_001179972.1

    Genome annotation databases

    EnsemblFungiiBAA09246; BAA09246; BAA09246
    YFR007W; YFR007W; YFR007W
    GeneIDi850558
    KEGGisce:YFR007W

    Similar proteinsi

    Entry informationi

    Entry nameiYFH7_YEAST
    AccessioniPrimary (citable) accession number: P43591
    Secondary accession number(s): D6VTN7
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: May 23, 2018
    This is version 121 of the entry and version 1 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

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