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Protein

Uncharacterized peptidase YFR006W

Gene

YFR006W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi316Manganese 2Sequence analysis1
Metal bindingi327Manganese 1Sequence analysis1
Metal bindingi327Manganese 2Sequence analysis1
Metal bindingi412Manganese 1Sequence analysis1
Metal bindingi452Manganese 1Sequence analysis1
Metal bindingi493Manganese 1Sequence analysis1
Metal bindingi493Manganese 2Sequence analysis1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30459-MONOMER.

Protein family/group databases

MEROPSiM24.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized peptidase YFR006W (EC:3.4.-.-)
Gene namesi
Ordered Locus Names:YFR006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR006W.
SGDiS000001902. YFR006W.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850991 – 535Uncharacterized peptidase YFR006WAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP43590.
PRIDEiP43590.

Interactioni

Protein-protein interaction databases

BioGridi31154. 105 interactors.
DIPiDIP-6829N.
IntActiP43590. 1 interactor.
MINTiMINT-631609.
STRINGi4932.YFR006W.

Structurei

3D structure databases

ProteinModelPortaliP43590.
SMRiP43590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074992.
HOGENOMiHOG000008763.
InParanoidiP43590.
KOiK14213.
OMAiHALFFPH.
OrthoDBiEOG092C3XFN.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
InterProiView protein in InterPro
IPR007865. Aminopep_P_N.
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000994. Pept_M24.
IPR001131. Peptidase_M24B_aminopep-P_CS.
PfamiView protein in Pfam
PF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
SMARTiView protein in SMART
SM01011. AMP_N. 1 hit.
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiView protein in PROSITE
PS00491. PROLINE_PEPTIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

P43590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLEPISLVV FGSLVFFFGL VKYFKRGERQ RTRGILQPEY KDKYYYSKEK
60 70 80 90 100
GEEMGEVANV NEIPVKIRNH KYPAKEHNLR VKDLLLNRNP KLSKISTAFF
110 120 130 140 150
IAGEELEGNK YCDTNKDFRQ NRYFYHLSGV DIPASAILFN CSTDKLTLFL
160 170 180 190 200
PNIDEEDVIW SGMPLSLDEA MRVFDIDEAL YISDLGKKFK ELQDFAIFTT
210 220 230 240 250
DLDNVHDENI ARSLIPSDPN FFYAMDETRA IKDWYEIESI RKACQISDKS
260 270 280 290 300
HLAVMSALPI ELNELQIQAE FEYHATRQGG RSLGYDPICC SGPACGTLHY
310 320 330 340 350
VKNSEDIKGK HSILIDAGAE WRQYTSDITR CFPTSGKFTA EHREVYETVL
360 370 380 390 400
DMQNQAMERI KPGAKWDDLH ALTHKVLIKH FLSMGIFKKE FSEDEIFKRR
410 420 430 440 450
ASCAFYPHGL GHMLGLDVHD VGGNPNYDDP DPMFRYLRIR RPLKENMVIT
460 470 480 490 500
NEPGCYFNQF LIKEFLEKHP ERLEVVDMSV LKRYMYVGGV RIEDDILVTK
510 520 530
DGYENLTGIT SDPDEIEKIV QKGLKKPRSG FHVIV
Length:535
Mass (Da):61,754
Last modified:November 1, 1995 - v1
Checksum:i4D251041CE9627FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326S → G in AAU09720 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09245.1.
AY723803 Genomic DNA. Translation: AAU09720.1.
BK006940 Genomic DNA. Translation: DAA12446.1.
PIRiS56261.
RefSeqiNP_116661.1. NM_001179971.1.

Genome annotation databases

EnsemblFungiiBAA09245; BAA09245; BAA09245.
YFR006W; YFR006W; YFR006W.
GeneIDi850556.
KEGGisce:YFR006W.

Similar proteinsi

Entry informationi

Entry nameiYFH6_YEAST
AccessioniPrimary (citable) accession number: P43590
Secondary accession number(s): D6VTN6, Q66RB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names