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Protein

Uncharacterized peptidase YFR006W

Gene

YFR006W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Mn2+CuratedNote: Binds 2 manganese ions per subunit.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi316Manganese 2Sequence analysis1
Metal bindingi327Manganese 1Sequence analysis1
Metal bindingi327Manganese 2Sequence analysis1
Metal bindingi412Manganese 1Sequence analysis1
Metal bindingi452Manganese 1Sequence analysis1
Metal bindingi493Manganese 1Sequence analysis1
Metal bindingi493Manganese 2Sequence analysis1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-30459-MONOMER.

Protein family/group databases

MEROPSiM24.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized peptidase YFR006W (EC:3.4.-.-)
Gene namesi
Ordered Locus Names:YFR006W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR006W.
SGDiS000001902. YFR006W.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 24HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001850991 – 535Uncharacterized peptidase YFR006WAdd BLAST535

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki50Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP43590.
PRIDEiP43590.

Interactioni

Protein-protein interaction databases

BioGridi31154. 12 interactors.
DIPiDIP-6829N.
IntActiP43590. 1 interactor.
MINTiMINT-631609.

Structurei

3D structure databases

ProteinModelPortaliP43590.
SMRiP43590.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M24B family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00550000074992.
HOGENOMiHOG000008763.
InParanoidiP43590.
KOiK14213.
OMAiGYDPICC.
OrthoDBiEOG092C3XFN.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR007865. Aminopep_P_N.
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000994. Pept_M24.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SMARTiSM01011. AMP_N. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCLEPISLVV FGSLVFFFGL VKYFKRGERQ RTRGILQPEY KDKYYYSKEK
60 70 80 90 100
GEEMGEVANV NEIPVKIRNH KYPAKEHNLR VKDLLLNRNP KLSKISTAFF
110 120 130 140 150
IAGEELEGNK YCDTNKDFRQ NRYFYHLSGV DIPASAILFN CSTDKLTLFL
160 170 180 190 200
PNIDEEDVIW SGMPLSLDEA MRVFDIDEAL YISDLGKKFK ELQDFAIFTT
210 220 230 240 250
DLDNVHDENI ARSLIPSDPN FFYAMDETRA IKDWYEIESI RKACQISDKS
260 270 280 290 300
HLAVMSALPI ELNELQIQAE FEYHATRQGG RSLGYDPICC SGPACGTLHY
310 320 330 340 350
VKNSEDIKGK HSILIDAGAE WRQYTSDITR CFPTSGKFTA EHREVYETVL
360 370 380 390 400
DMQNQAMERI KPGAKWDDLH ALTHKVLIKH FLSMGIFKKE FSEDEIFKRR
410 420 430 440 450
ASCAFYPHGL GHMLGLDVHD VGGNPNYDDP DPMFRYLRIR RPLKENMVIT
460 470 480 490 500
NEPGCYFNQF LIKEFLEKHP ERLEVVDMSV LKRYMYVGGV RIEDDILVTK
510 520 530
DGYENLTGIT SDPDEIEKIV QKGLKKPRSG FHVIV
Length:535
Mass (Da):61,754
Last modified:November 1, 1995 - v1
Checksum:i4D251041CE9627FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti326S → G in AAU09720 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09245.1.
AY723803 Genomic DNA. Translation: AAU09720.1.
BK006940 Genomic DNA. Translation: DAA12446.1.
PIRiS56261.
RefSeqiNP_116661.1. NM_001179971.1.

Genome annotation databases

EnsemblFungiiBAA09245; BAA09245; BAA09245.
YFR006W; YFR006W; YFR006W.
GeneIDi850556.
KEGGisce:YFR006W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09245.1.
AY723803 Genomic DNA. Translation: AAU09720.1.
BK006940 Genomic DNA. Translation: DAA12446.1.
PIRiS56261.
RefSeqiNP_116661.1. NM_001179971.1.

3D structure databases

ProteinModelPortaliP43590.
SMRiP43590.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31154. 12 interactors.
DIPiDIP-6829N.
IntActiP43590. 1 interactor.
MINTiMINT-631609.

Protein family/group databases

MEROPSiM24.A09.

Proteomic databases

MaxQBiP43590.
PRIDEiP43590.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09245; BAA09245; BAA09245.
YFR006W; YFR006W; YFR006W.
GeneIDi850556.
KEGGisce:YFR006W.

Organism-specific databases

EuPathDBiFungiDB:YFR006W.
SGDiS000001902. YFR006W.

Phylogenomic databases

GeneTreeiENSGT00550000074992.
HOGENOMiHOG000008763.
InParanoidiP43590.
KOiK14213.
OMAiGYDPICC.
OrthoDBiEOG092C3XFN.

Enzyme and pathway databases

BioCyciYEAST:G3O-30459-MONOMER.

Miscellaneous databases

PROiP43590.

Family and domain databases

Gene3Di3.40.350.10. 1 hit.
3.90.230.10. 1 hit.
InterProiIPR007865. Aminopep_P_N.
IPR029149. Creatin/AminoP/Spt16_NTD.
IPR028980. Creatinase/Aminopeptidase_P_N.
IPR000994. Pept_M24.
IPR001131. Peptidase_M24B_aminopep-P_CS.
[Graphical view]
PfamiPF05195. AMP_N. 1 hit.
PF00557. Peptidase_M24. 1 hit.
[Graphical view]
SMARTiSM01011. AMP_N. 1 hit.
[Graphical view]
SUPFAMiSSF53092. SSF53092. 1 hit.
SSF55920. SSF55920. 1 hit.
PROSITEiPS00491. PROLINE_PEPTIDASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYFH6_YEAST
AccessioniPrimary (citable) accession number: P43590
Secondary accession number(s): D6VTN6, Q66RB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.