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Protein

60S ribosomal subunit assembly/export protein LOC1

Gene

LOC1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient assembly and nuclear export of the 60S ribosomal subunit. Involved in asymmetric localization of ASH1 mRNA.2 Publications

Miscellaneous

Present with 3650 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • mRNA binding Source: SGD

GO - Biological processi

  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • intracellular mRNA localization Source: SGD
  • mRNA transport Source: UniProtKB-KW
  • ribosomal large subunit biogenesis Source: SGD

Keywordsi

Biological processmRNA transport, Ribosome biogenesis, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30454-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal subunit assembly/export protein LOC1
Alternative name(s):
Localization of ASH1 mRNA protein 1
Gene namesi
Name:LOC1
Ordered Locus Names:YFR001W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFR001W.
SGDiS000001897. LOC1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002026801 – 20460S ribosomal subunit assembly/export protein LOC1Add BLAST204

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43586.
PRIDEiP43586.

PTM databases

iPTMnetiP43586.

Interactioni

Subunit structurei

Component of the 66S pre-ribosomal particle. Interacts with NOP7, RRP1, RRP15 and SHE2.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi31149. 119 interactors.
DIPiDIP-6615N.
IntActiP43586. 71 interactors.
MINTiMINT-620051.
STRINGi4932.YFR001W.

Structurei

3D structure databases

ProteinModelPortaliP43586.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 166Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 199Lys-richAdd BLAST161

Sequence similaritiesi

Belongs to the LOC1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000066132.
InParanoidiP43586.
KOiK14817.
OMAiMMTILAM.
OrthoDBiEOG092C5HSE.

Sequencei

Sequence statusi: Complete.

P43586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKKPSKRQ NLRREVAPEV FQDSQARNQL ANVPHLTEKS AQRKPSKTKV
60 70 80 90 100
KKEQSLARLY GAKKDKKGKY SEKDLNIPTL NRAIVPGVKI RRGKKGKKFI
110 120 130 140 150
ADNDTLTLNR LITTIGDKYD DIAESKLEKA RRLEEIRELK RKEIERKEAL
160 170 180 190 200
KQDKLEEKKD EIKKKSSVAR TIRRKNKRDM LKSEAKASES KTEGRKVKKV

SFAQ
Length:204
Mass (Da):23,590
Last modified:November 1, 1995 - v1
Checksum:i69970294E9C980F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09240.1.
AY557809 Genomic DNA. Translation: AAS56135.1.
BK006940 Genomic DNA. Translation: DAA12441.1.
PIRiS56256.
RefSeqiNP_116656.1. NM_001179966.1.

Genome annotation databases

EnsemblFungiiBAA09240; BAA09240; BAA09240.
YFR001W; YFR001W; YFR001W.
GeneIDi850551.
KEGGisce:YFR001W.

Similar proteinsi

Entry informationi

Entry nameiLOC1_YEAST
AccessioniPrimary (citable) accession number: P43586
Secondary accession number(s): D6VTN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names