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P43582 (WWM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
WW domain-containing protein WWM1
Alternative name(s):
WW domain-containing protein interacting with metacaspase
Gene names
Name:WWM1
Ordered Locus Names:YFL010C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed. Ref.5 Ref.6

Subunit structure

Interacts with metacaspase MCA1. Ref.4

Subcellular location

Cytoplasm. Nucleus. Mitochondrion Ref.6 Ref.7 Ref.9 Ref.11.

Miscellaneous

Present with 6020 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 WW domain.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentCytoplasm
Mitochondrion
Nucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentmitochondrion

Inferred from direct assay Ref.9Ref.11. Source: SGD

nucleus

Inferred from direct assay Ref.6Ref.7. Source: SGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 211211WW domain-containing protein WWM1
PRO_0000076096

Regions

Domain9 – 4335WW
Compositional bias40 – 12182Pro-rich
Compositional bias64 – 12360Gln-rich
Compositional bias135 – 20874Gly-rich
Compositional bias164 – 21047Asp-rich

Sequences

Sequence LengthMass (Da)Tools
P43582 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2731E7C69817B82F

FASTA21122,655
        10         20         30         40         50         60 
MAQSKSNPPQ VPSGWKAVFD DEYQTWYYVD LSTNSSQWEP PRGTTWPRPK GPPPGVNNEK 

        70         80         90        100        110        120 
SSRQQADQAP PPYSSQSTPQ VQAGAQAQQP RYYQPQQPQY PQYPQQQRYY PQQAPMPAAA 

       130        140        150        160        170        180 
PQQAYYGTAP STSKGSGHGG AMMGGLLGVG AGLLGGAMLE HAFDDHNYDG PDTVVVENNY 

       190        200        210 
YGDDAGGSDG GFDDAGGFDG GFDDGFDGSD F 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]Barrell B.G., Churcher C., Rajandream M.A.
Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[4]"A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae."
Uetz P., Giot L., Cagney G., Mansfield T.A., Judson R.S., Knight J.R., Lockshon D., Narayan V., Srinivasan M., Pochart P., Qureshi-Emili A., Li Y., Godwin B., Conover D., Kalbfleisch T., Vijayadamodar G., Yang M., Johnston M., Fields S., Rothberg J.M.
Nature 403:623-627(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MCA1.
[5]"A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes."
Stevenson L.F., Kennedy B.K., Harlow E.
Proc. Natl. Acad. Sci. U.S.A. 98:3946-3951(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae."
Szallies A., Kubata B.K., Duszenko M.
FEBS Lett. 517:144-150(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[7]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"The proteome of Saccharomyces cerevisiae mitochondria."
Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C.
Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
Strain: ATCC 76625 / YPH499.
[10]"Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins."
Hesselberth J.R., Miller J.P., Golob A., Stajich J.E., Michaud G.A., Fields S.
Genome Biol. 7:R30.1-R30.15(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: DOMAIN.
[11]"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics."
Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A.
J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09228.1.
Z46255 Genomic DNA. Translation: CAA86342.1.
BK006940 Genomic DNA. Translation: DAA12430.1.
PIRS48311.
RefSeqNP_570898.1. NM_001179956.1.

3D structure databases

ProteinModelPortalP43582.
SMRP43582. Positions 9-42.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-3899N.
IntActP43582. 63 interactions.
MINTMINT-537455.
STRING4932.YFL010C.

Proteomic databases

PaxDbP43582.
PeptideAtlasP43582.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL010C; YFL010C; YFL010C.
GeneID850538.
KEGGsce:YFL010C.

Organism-specific databases

CYGDYFL010c.
SGDS000001884. WWM1.

Phylogenomic databases

eggNOGNOG74144.
OMAMADFAPP.
OrthoDBEOG4S4SS3.

Gene expression databases

GenevestigatorP43582.
GermOnlineYFL010C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR001202. WW_dom.
[Graphical view]
PfamPF00397. WW. 1 hit.
[Graphical view]
SMARTSM00456. WW. 1 hit.
[Graphical view]
SUPFAMSSF51045. WW_Rsp5_WWP. 1 hit.
PROSITEPS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio966295.

Entry information

Entry nameWWM1_YEAST
AccessionPrimary (citable) accession number: P43582
Secondary accession number(s): D6VTM0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families