P43582 (WWM1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
WW domain-containing protein WWM1

Alternative name(s):
WW domain-containing protein interacting with metacaspase

Gene names

Name:	WWM1
Ordered Locus Names:	YFL010C

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in apoptosis. May play a role in nuclear function controlling cellular proliferation coupled to mitochondrial biogenesis. Causes impaired growth when overexpressed. Ref.5 Ref.6
Subunit structure	Interacts with metacaspase MCA1. Ref.4
Subcellular location	Cytoplasm. Nucleus. Mitochondrion Ref.6 Ref.7 Ref.9 Ref.11.
Miscellaneous	Present with 6020 molecules/cell in log phase SD medium.
Sequence similarities	Contains 1 WW domain.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Cytoplasm Mitochondrion Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from direct assay Ref.9Ref.11. Source: SGD nucleus Inferred from direct assay Ref.6Ref.7. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	WW domain-containing protein WWM1		PRO_0000076096
Regions
	Domain	9 – 43	35	WW
	Compositional bias	40 – 121	82	Pro-rich
	Compositional bias	64 – 123	60	Gln-rich
	Compositional bias	135 – 208	74	Gly-rich
	Compositional bias	164 – 210	47	Asp-rich

Sequences

	Sequence		Length	Mass (Da)
	P43582 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2731E7C69817B82F	FASTA	211	22,655
	10 20 30 40 50 60 MAQSKSNPPQ VPSGWKAVFD DEYQTWYYVD LSTNSSQWEP PRGTTWPRPK GPPPGVNNEK 70 80 90 100 110 120 SSRQQADQAP PPYSSQSTPQ VQAGAQAQQP RYYQPQQPQY PQYPQQQRYY PQQAPMPAAA 130 140 150 160 170 180 PQQAYYGTAP STSKGSGHGG AMMGGLLGVG AGLLGGAMLE HAFDDHNYDG PDTVVVENNY 190 200 210 YGDDAGGSDG GFDDAGGFDG GFDDGFDGSD F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	Barrell B.G., Churcher C., Rajandream M.A. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	"A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae." Uetz P., Giot L., Cagney G., Mansfield T.A., Judson R.S., Knight J.R., Lockshon D., Narayan V., Srinivasan M., Pochart P., Qureshi-Emili A., Li Y., Godwin B., Conover D., Kalbfleisch T., Vijayadamodar G., Yang M., Johnston M., Fields S., Rothberg J.M. Nature 403:623-627(2000) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MCA1.
[5]	"A large-scale overexpression screen in Saccharomyces cerevisiae identifies previously uncharacterized cell cycle genes." Stevenson L.F., Kennedy B.K., Harlow E. Proc. Natl. Acad. Sci. U.S.A. 98:3946-3951(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[6]	"A metacaspase of Trypanosoma brucei causes loss of respiration competence and clonal death in the yeast Saccharomyces cerevisiae." Szallies A., Kubata B.K., Duszenko M. FEBS Lett. 517:144-150(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, FUNCTION.
[7]	"Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]	"The proteome of Saccharomyces cerevisiae mitochondria." Sickmann A., Reinders J., Wagner Y., Joppich C., Zahedi R.P., Meyer H.E., Schoenfisch B., Perschil I., Chacinska A., Guiard B., Rehling P., Pfanner N., Meisinger C. Proc. Natl. Acad. Sci. U.S.A. 100:13207-13212(2003) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. Strain: ATCC 76625 / YPH499.
[10]	"Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins." Hesselberth J.R., Miller J.P., Golob A., Stajich J.E., Michaud G.A., Fields S. Genome Biol. 7:R30.1-R30.15(2006) [PubMed] [Europe PMC] [Abstract] Cited for: DOMAIN.
[11]	"Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics." Reinders J., Zahedi R.P., Pfanner N., Meisinger C., Sickmann A. J. Proteome Res. 5:1543-1554(2006) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09228.1. Z46255 Genomic DNA. Translation: CAA86342.1. BK006940 Genomic DNA. Translation: DAA12430.1.
PIR	S48311.
RefSeq	NP_570898.1. NM_001179956.1.
3D structure databases
ProteinModelPortal	P43582.
SMR	P43582. Positions 9-42.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-3899N.
IntAct	P43582. 63 interactions.
MINT	MINT-537455.
STRING	4932.YFL010C.
Proteomic databases
PaxDb	P43582.
PeptideAtlas	P43582.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFL010C; YFL010C; YFL010C.
GeneID	850538.
KEGG	sce:YFL010C.
Organism-specific databases
CYGD	YFL010c.
SGD	S000001884. WWM1.
Phylogenomic databases
eggNOG	NOG74144.
OMA	MADFAPP.
OrthoDB	EOG4S4SS3.
Gene expression databases
Genevestigator	P43582.
GermOnline	YFL010C. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR001202. WW_dom. [Graphical view]
Pfam	PF00397. WW. 1 hit. [Graphical view]
SMART	SM00456. WW. 1 hit. [Graphical view]
SUPFAM	SSF51045. WW_Rsp5_WWP. 1 hit.
PROSITE	PS01159. WW_DOMAIN_1. 1 hit. PS50020. WW_DOMAIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966295.

Entry information

Entry name

WWM1_YEAST

Accession

Primary (citable) accession number: P43582
Secondary accession number(s): D6VTM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program