Hexose transporter HXT10 - Saccharomyces cerevisiae (Baker's yeast)

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Reviewed, UniProtKB/Swiss-Prot P43581 (HXT10_YEAST)

Last modified November 24, 2009. Version 77. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
Hexose transporter HXT10

Gene names

Name:	HXT10
Ordered Locus Names:	YFL011W

Organism

Saccharomyces cerevisiae (Baker's yeast) [Complete proteome]

Taxonomic identifier

4932 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Probable glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

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Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Repeat Transmembrane
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	hexose transport Inferred from genetic interaction. Source: SGD transmembrane transport Inferred from genetic interaction. Source: SGD
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay. Source: SGD
Molecular function	fructose transmembrane transporter activity Inferred from genetic interaction. Source: SGD galactose transmembrane transporter activity Inferred from genetic interaction. Source: SGD glucose transmembrane transporter activity Inferred from genetic interaction. Source: SGD mannose transmembrane transporter activity Inferred from genetic interaction. Source: SGD
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 546

546

Hexose transporter HXT10

PRO_0000050400

Regions

Topological domain

1 – 44

Cytoplasmic Potential

Transmembrane

45 – 65

1 Potential

Topological domain

66 – 100

Extracellular Potential

Transmembrane

101 – 121

2 Potential

Topological domain

122 – 127

Cytoplasmic Potential

Transmembrane

128 – 148

3 Potential

Topological domain

149 – 158

Extracellular Potential

Transmembrane

159 – 179

4 Potential

Topological domain

180 – 185

Cytoplasmic Potential

Transmembrane

186 – 206

5 Potential

Topological domain

207 – 220

Extracellular Potential

Transmembrane

221 – 241

6 Potential

Topological domain

242 – 324

Cytoplasmic Potential

Transmembrane

325 – 341

7 Potential

Topological domain

342 – 347

Extracellular Potential

Transmembrane

348 – 365

8 Potential

Topological domain

366 – 372

Cytoplasmic Potential

Transmembrane

373 – 393

9 Potential

Topological domain

394 – 415

Extracellular Potential

Transmembrane

416 – 436

10 Potential

Topological domain

437 – 453

Cytoplasmic Potential

Transmembrane

454 – 474

11 Potential

Topological domain

475

Extracellular Potential

Transmembrane

476 – 496

12 Potential

Topological domain

497 – 546

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

P43581-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B2D80CDBBECC398F
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FASTA

546

60,662

        10         20         30         40         50         60 
MVSSSVSILG TSAKASTSLS RKDEIKLTPE TREASLDIPY KPIIAYWTVM GLCLMIAFGG 

        70         80         90        100        110        120 
FIFGWDTGTI SGFINQTDFK RRFGELQRDG SFQLSDVRTG LIVGIFNIGC ALGGLTLGRL 

       130        140        150        160        170        180 
GDIYGRKIGL MCVILVYVVG IVIQIASSDK WYQYFIGRIV SGMGVGGVAV LSPTLISEIS 

       190        200        210        220        230        240 
PKHLRGTCVS FYQLMITLGI FLGYCTNYGT KKYSNSIQWR VPLGLCFAWA IFMVIGMVMV 

       250        260        270        280        290        300 
PESPRYLVEK GKYEEARRSL AKSNKVTVTD PGVVFEFDTI VANMELERAV GNASWHELFS 

       310        320        330        340        350        360 
NKGAILPRVI MGIVIQSLQQ LTGCNYFFYY GTTIFNAVGM QDSFETSIVL GAVNFASTFV 

       370        380        390        400        410        420 
ALYIVDKFGR RKCLLWGSAS MAICFVIFAT VGVTRLWPQG KDQPSSQSAG NVMIVFTCFF 

       430        440        450        460        470        480 
IFSFAITWAP IAYVIVAETY PLRVKNRAMA IAVGANWMWG FLIGFFTPFI TRSIGFSYGY 

       490        500        510        520        530        540 
VFMGCLIFSY FYVFFFVCET KGLTLEEVNE MYEERIKPWK SGGWIPSSRR TPQPTSSTPL 


VIVDSK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Barrell B.G., Churcher C., Rajandream M.A. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	D50617 Genomic DNA. Translation: BAA09227.1. Z46255 Genomic DNA. Translation: CAA86344.1.
PIR	S48313.
RefSeq	NP_116644.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP:5424N.
IntAct	P43581. 2 interactions.
STRING	P43581.
Protein family/group databases
TCDB	2.A.1.1.5. major facilitator superfamily (MFS).
Genome annotation databases
Ensembl	YFL011W; YFL011W; YFL011W; Saccharomyces cerevisiae. [Genome view]
GeneID	850536.
KEGG	sce:YFL011W.
NMPDR	fig\|4932.3.peg.2274.
Organism-specific databases
CYGD	YFL011w.
SGD	S000001883. HXT10.
Phylogenomic databases
HOGENOM	P43581.
OMA	ANMELER
OrthoDB	EOG95HTDF
Gene expression databases
ArrayExpress	P43581.
Genevestigator	P43581.
GermOnline	YFL011W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR016196. MFS_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	966289.

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Entry information

Entry name

HXT10_YEAST

Accession

Primary (citable) accession number: P43581

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents