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Protein

Hexose transporter HXT10

Gene

HXT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • transmembrane transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30445-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Protein family/group databases

TCDBi2.A.1.1.5. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT10
Gene namesi
Name:HXT10
Ordered Locus Names:YFL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL011W.
SGDiS000001883. HXT10.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 4443CytoplasmicSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 10035ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12121Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini122 – 1276CytoplasmicSequence analysis
Transmembranei128 – 14821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini149 – 15810ExtracellularSequence analysis
Transmembranei159 – 17921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 1856CytoplasmicSequence analysis
Transmembranei186 – 20621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini207 – 22014ExtracellularSequence analysisAdd
BLAST
Transmembranei221 – 24121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini242 – 32483CytoplasmicSequence analysisAdd
BLAST
Transmembranei325 – 34117Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini342 – 3476ExtracellularSequence analysis
Transmembranei348 – 36518Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini366 – 3727CytoplasmicSequence analysis
Transmembranei373 – 39321Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini394 – 41522ExtracellularSequence analysisAdd
BLAST
Transmembranei416 – 43621Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini437 – 45317CytoplasmicSequence analysisAdd
BLAST
Transmembranei454 – 47421Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini475 – 4751ExtracellularSequence analysis
Transmembranei476 – 49621Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini497 – 54650CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 546545Hexose transporter HXT10PRO_0000050400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei20 – 201PhosphoserineBy similarity
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP43581.

PTM databases

iPTMnetiP43581.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028292EBI-8750,EBI-8659

Protein-protein interaction databases

BioGridi31135. 45 interactions.
DIPiDIP-5424N.
IntActiP43581. 1 interaction.
MINTiMINT-519639.

Structurei

3D structure databases

ProteinModelPortaliP43581.
SMRiP43581. Positions 59-513.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP43581.
KOiK08139.
OrthoDBiEOG73JM4H.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSSVSILG TSAKASTSLS RKDEIKLTPE TREASLDIPY KPIIAYWTVM
60 70 80 90 100
GLCLMIAFGG FIFGWDTGTI SGFINQTDFK RRFGELQRDG SFQLSDVRTG
110 120 130 140 150
LIVGIFNIGC ALGGLTLGRL GDIYGRKIGL MCVILVYVVG IVIQIASSDK
160 170 180 190 200
WYQYFIGRIV SGMGVGGVAV LSPTLISEIS PKHLRGTCVS FYQLMITLGI
210 220 230 240 250
FLGYCTNYGT KKYSNSIQWR VPLGLCFAWA IFMVIGMVMV PESPRYLVEK
260 270 280 290 300
GKYEEARRSL AKSNKVTVTD PGVVFEFDTI VANMELERAV GNASWHELFS
310 320 330 340 350
NKGAILPRVI MGIVIQSLQQ LTGCNYFFYY GTTIFNAVGM QDSFETSIVL
360 370 380 390 400
GAVNFASTFV ALYIVDKFGR RKCLLWGSAS MAICFVIFAT VGVTRLWPQG
410 420 430 440 450
KDQPSSQSAG NVMIVFTCFF IFSFAITWAP IAYVIVAETY PLRVKNRAMA
460 470 480 490 500
IAVGANWMWG FLIGFFTPFI TRSIGFSYGY VFMGCLIFSY FYVFFFVCET
510 520 530 540
KGLTLEEVNE MYEERIKPWK SGGWIPSSRR TPQPTSSTPL VIVDSK
Length:546
Mass (Da):60,662
Last modified:November 1, 1995 - v1
Checksum:iB2D80CDBBECC398F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09227.1.
Z46255 Genomic DNA. Translation: CAA86344.1.
BK006940 Genomic DNA. Translation: DAA12428.1.
PIRiS48313.
RefSeqiNP_116644.1. NM_001179955.1.

Genome annotation databases

EnsemblFungiiBAA09227; BAA09227; BAA09227.
YFL011W; YFL011W; YFL011W.
GeneIDi850536.
KEGGisce:YFL011W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09227.1.
Z46255 Genomic DNA. Translation: CAA86344.1.
BK006940 Genomic DNA. Translation: DAA12428.1.
PIRiS48313.
RefSeqiNP_116644.1. NM_001179955.1.

3D structure databases

ProteinModelPortaliP43581.
SMRiP43581. Positions 59-513.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31135. 45 interactions.
DIPiDIP-5424N.
IntActiP43581. 1 interaction.
MINTiMINT-519639.

Protein family/group databases

TCDBi2.A.1.1.5. the major facilitator superfamily (mfs).

PTM databases

iPTMnetiP43581.

Proteomic databases

PRIDEiP43581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiBAA09227; BAA09227; BAA09227.
YFL011W; YFL011W; YFL011W.
GeneIDi850536.
KEGGisce:YFL011W.

Organism-specific databases

EuPathDBiFungiDB:YFL011W.
SGDiS000001883. HXT10.

Phylogenomic databases

GeneTreeiENSGT00720000108754.
HOGENOMiHOG000202870.
InParanoidiP43581.
KOiK08139.
OrthoDBiEOG73JM4H.

Enzyme and pathway databases

BioCyciYEAST:G3O-30445-MONOMER.
ReactomeiR-SCE-428790. Facilitative Na+-independent glucose transporters.

Miscellaneous databases

PROiP43581.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Barrell B.G., Churcher C., Rajandream M.A.
    Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  4. "A global topology map of the Saccharomyces cerevisiae membrane proteome."
    Kim H., Melen K., Oesterberg M., von Heijne G.
    Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: ATCC 208353 / W303-1A.

Entry informationi

Entry nameiHXT10_YEAST
AccessioniPrimary (citable) accession number: P43581
Secondary accession number(s): D6VTL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 6, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.