Hexose transporter HXT10 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P43581 (HXT10_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 96. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Hexose transporter HXT10

Gene names

Name:	HXT10
Ordered Locus Names:	YFL011W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probable glucose transporter.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]

Ontologies

Keywords
Biological process	Sugar transport Transport
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrion Inferred from direct assay. Source: SGD
Molecular function	fructose transmembrane transporter activity Inferred from genetic interaction. Source: SGD galactose transmembrane transporter activity Inferred from genetic interaction. Source: SGD glucose transmembrane transporter activity Inferred from genetic interaction. Source: SGD mannose transmembrane transporter activity Inferred from genetic interaction. Source: SGD protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HSP82	P02829	2	EBI-8750,EBI-8659

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 546

546

Hexose transporter HXT10

PRO_0000050400

Regions

Topological domain

1 – 44

Cytoplasmic Potential

Transmembrane

45 – 65

Helical; Name=1; Potential

Topological domain

66 – 100

Extracellular Potential

Transmembrane

101 – 121

Helical; Name=2; Potential

Topological domain

122 – 127

Cytoplasmic Potential

Transmembrane

128 – 148

Helical; Name=3; Potential

Topological domain

149 – 158

Extracellular Potential

Transmembrane

159 – 179

Helical; Name=4; Potential

Topological domain

180 – 185

Cytoplasmic Potential

Transmembrane

186 – 206

Helical; Name=5; Potential

Topological domain

207 – 220

Extracellular Potential

Transmembrane

221 – 241

Helical; Name=6; Potential

Topological domain

242 – 324

Cytoplasmic Potential

Transmembrane

325 – 341

Helical; Name=7; Potential

Topological domain

342 – 347

Extracellular Potential

Transmembrane

348 – 365

Helical; Name=8; Potential

Topological domain

366 – 372

Cytoplasmic Potential

Transmembrane

373 – 393

Helical; Name=9; Potential

Topological domain

394 – 415

Extracellular Potential

Transmembrane

416 – 436

Helical; Name=10; Potential

Topological domain

437 – 453

Cytoplasmic Potential

Transmembrane

454 – 474

Helical; Name=11; Potential

Topological domain

475

Extracellular Potential

Transmembrane

476 – 496

Helical; Name=12; Potential

Topological domain

497 – 546

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

P43581 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B2D80CDBBECC398F
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FASTA

546

60,662

        10         20         30         40         50         60 
MVSSSVSILG TSAKASTSLS RKDEIKLTPE TREASLDIPY KPIIAYWTVM GLCLMIAFGG 

        70         80         90        100        110        120 
FIFGWDTGTI SGFINQTDFK RRFGELQRDG SFQLSDVRTG LIVGIFNIGC ALGGLTLGRL 

       130        140        150        160        170        180 
GDIYGRKIGL MCVILVYVVG IVIQIASSDK WYQYFIGRIV SGMGVGGVAV LSPTLISEIS 

       190        200        210        220        230        240 
PKHLRGTCVS FYQLMITLGI FLGYCTNYGT KKYSNSIQWR VPLGLCFAWA IFMVIGMVMV 

       250        260        270        280        290        300 
PESPRYLVEK GKYEEARRSL AKSNKVTVTD PGVVFEFDTI VANMELERAV GNASWHELFS 

       310        320        330        340        350        360 
NKGAILPRVI MGIVIQSLQQ LTGCNYFFYY GTTIFNAVGM QDSFETSIVL GAVNFASTFV 

       370        380        390        400        410        420 
ALYIVDKFGR RKCLLWGSAS MAICFVIFAT VGVTRLWPQG KDQPSSQSAG NVMIVFTCFF 

       430        440        450        460        470        480 
IFSFAITWAP IAYVIVAETY PLRVKNRAMA IAVGANWMWG FLIGFFTPFI TRSIGFSYGY 

       490        500        510        520        530        540 
VFMGCLIFSY FYVFFFVCET KGLTLEEVNE MYEERIKPWK SGGWIPSSRR TPQPTSSTPL 


VIVDSK

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	Barrell B.G., Churcher C., Rajandream M.A. Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[4]	"A global topology map of the Saccharomyces cerevisiae membrane proteome." Kim H., Melen K., Oesterberg M., von Heijne G. Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract] Cited for: TOPOLOGY [LARGE SCALE ANALYSIS]. Strain: ATCC 208353 / W303-1A.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09227.1. Z46255 Genomic DNA. Translation: CAA86344.1. BK006940 Genomic DNA. Translation: DAA12428.1.
PIR	S48313.
RefSeq	NP_116644.1. NM_001179955.1.
3D structure databases
ProteinModelPortal	P43581.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-5424N.
IntAct	P43581. 1 interaction.
MINT	MINT-519639.
STRING	P43581.
Protein family/group databases
TCDB	2.A.1.1.5. major facilitator superfamily (MFS).
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFL011W; YFL011W; YFL011W.
GeneID	850536.
KEGG	sce:YFL011W.
NMPDR	fig\|4932.3.peg.2274.
Organism-specific databases
CYGD	YFL011w.
SGD	S000001883. HXT10.
Phylogenomic databases
eggNOG	fuNOG06406.
GeneTree	EFGT00070000008710.
HOGENOM	HBG744444.
OrthoDB	EOG43246F.
Gene expression databases
ArrayExpress	P43581.
Genevestigator	P43581.
GermOnline	YFL011W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR005828. Sub_transporter. IPR003663. Sugar/inositol_transpt. IPR005829. Sugar_transporter_CS. [Graphical view]
KO	K08139.
Pfam	PF00083. Sugar_tr. 1 hit. [Graphical view]
PRINTS	PR00171. SUGRTRNSPORT.
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00879. SP. 1 hit.
PROSITE	PS50850. MFS. 1 hit. PS00216. SUGAR_TRANSPORT_1. 1 hit. PS00217. SUGAR_TRANSPORT_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	966289.

Entry information

Entry name

HXT10_YEAST

Accession

Primary (citable) accession number: P43581
Secondary accession number(s): D6VTL8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	December 14, 2011
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents