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Protein

Hexose transporter HXT10

Gene

HXT10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable glucose transporter.

GO - Molecular functioni

  • fructose transmembrane transporter activity Source: SGD
  • galactose transmembrane transporter activity Source: SGD
  • glucose transmembrane transporter activity Source: SGD
  • mannose transmembrane transporter activity Source: SGD
  • sugar:proton symporter activity Source: GO_Central

GO - Biological processi

  • glucose import Source: GO_Central
  • hexose transport Source: SGD
  • transmembrane transport Source: SGD

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-30445-MONOMER.
ReactomeiR-SCE-189200. Cellular hexose transport.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Protein family/group databases

TCDBi2.A.1.1.5. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Hexose transporter HXT10
Gene namesi
Name:HXT10
Ordered Locus Names:YFL011W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL011W.
SGDiS000001883. HXT10.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44CytoplasmicSequence analysisAdd BLAST44
Transmembranei45 – 65Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini66 – 100ExtracellularSequence analysisAdd BLAST35
Transmembranei101 – 121Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini122 – 127CytoplasmicSequence analysis6
Transmembranei128 – 148Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini149 – 158ExtracellularSequence analysis10
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 185CytoplasmicSequence analysis6
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 220ExtracellularSequence analysisAdd BLAST14
Transmembranei221 – 241Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini242 – 324CytoplasmicSequence analysisAdd BLAST83
Transmembranei325 – 341Helical; Name=7Sequence analysisAdd BLAST17
Topological domaini342 – 347ExtracellularSequence analysis6
Transmembranei348 – 365Helical; Name=8Sequence analysisAdd BLAST18
Topological domaini366 – 372CytoplasmicSequence analysis7
Transmembranei373 – 393Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini394 – 415ExtracellularSequence analysisAdd BLAST22
Transmembranei416 – 436Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini437 – 453CytoplasmicSequence analysisAdd BLAST17
Transmembranei454 – 474Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini475ExtracellularSequence analysis1
Transmembranei476 – 496Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini497 – 546CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000504001 – 546Hexose transporter HXT10Add BLAST546

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP43581.

PTM databases

iPTMnetiP43581.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HSP82P028292EBI-8750,EBI-8659

Protein-protein interaction databases

BioGridi31135. 61 interactors.
DIPiDIP-5424N.
IntActiP43581. 1 interactor.
MINTiMINT-519639.
STRINGi4932.YFL011W.

Structurei

3D structure databases

ProteinModelPortaliP43581.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00890000139648.
HOGENOMiHOG000202870.
InParanoidiP43581.
KOiK08139.
OMAiHFLQQWT.
OrthoDBiEOG092C1Q5W.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiView protein in InterPro
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR036259. MFS_trans_sf.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
PfamiView protein in Pfam
PF00083. Sugar_tr. 1 hit.
PRINTSiPR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiView protein in PROSITE
PS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P43581-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSSSVSILG TSAKASTSLS RKDEIKLTPE TREASLDIPY KPIIAYWTVM
60 70 80 90 100
GLCLMIAFGG FIFGWDTGTI SGFINQTDFK RRFGELQRDG SFQLSDVRTG
110 120 130 140 150
LIVGIFNIGC ALGGLTLGRL GDIYGRKIGL MCVILVYVVG IVIQIASSDK
160 170 180 190 200
WYQYFIGRIV SGMGVGGVAV LSPTLISEIS PKHLRGTCVS FYQLMITLGI
210 220 230 240 250
FLGYCTNYGT KKYSNSIQWR VPLGLCFAWA IFMVIGMVMV PESPRYLVEK
260 270 280 290 300
GKYEEARRSL AKSNKVTVTD PGVVFEFDTI VANMELERAV GNASWHELFS
310 320 330 340 350
NKGAILPRVI MGIVIQSLQQ LTGCNYFFYY GTTIFNAVGM QDSFETSIVL
360 370 380 390 400
GAVNFASTFV ALYIVDKFGR RKCLLWGSAS MAICFVIFAT VGVTRLWPQG
410 420 430 440 450
KDQPSSQSAG NVMIVFTCFF IFSFAITWAP IAYVIVAETY PLRVKNRAMA
460 470 480 490 500
IAVGANWMWG FLIGFFTPFI TRSIGFSYGY VFMGCLIFSY FYVFFFVCET
510 520 530 540
KGLTLEEVNE MYEERIKPWK SGGWIPSSRR TPQPTSSTPL VIVDSK
Length:546
Mass (Da):60,662
Last modified:November 1, 1995 - v1
Checksum:iB2D80CDBBECC398F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA. Translation: BAA09227.1.
Z46255 Genomic DNA. Translation: CAA86344.1.
BK006940 Genomic DNA. Translation: DAA12428.1.
PIRiS48313.
RefSeqiNP_116644.1. NM_001179955.1.

Genome annotation databases

EnsemblFungiiBAA09227; BAA09227; BAA09227.
YFL011W; YFL011W; YFL011W.
GeneIDi850536.
KEGGisce:YFL011W.

Similar proteinsi

Entry informationi

Entry nameiHXT10_YEAST
AccessioniPrimary (citable) accession number: P43581
Secondary accession number(s): D6VTL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 25, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names