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Protein

Ino eighty subunit 1

Gene

IES1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30443-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ino eighty subunit 1
Gene namesi
Name:IES1
Ordered Locus Names:YFL013C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL013C
SGDiS000001881 IES1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000841531 – 692Ino eighty subunit 1Add BLAST692

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1
Modified residuei493PhosphoserineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei507PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43579
PaxDbiP43579
PRIDEiP43579

PTM databases

iPTMnetiP43579

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NHP10Q034354EBI-22775,EBI-12010

Protein-protein interaction databases

BioGridi31133, 489 interactors
ComplexPortaliCPX-863 INO80 chromatin remodeling complex
DIPiDIP-3869N
IntActiP43579, 19 interactors
MINTiP43579
STRINGi4932.YFL013C

Structurei

3D structure databases

ProteinModelPortaliP43579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili340 – 385Sequence analysisAdd BLAST46

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOGENOMiHOG000066131
InParanoidiP43579
KOiK11675
OMAiMTSQLRT
OrthoDBiEOG092C17TH

Family and domain databases

InterProiView protein in InterPro
IPR038014 Ies1
PANTHERiPTHR37287 PTHR37287, 2 hits

Sequencei

Sequence statusi: Complete.

P43579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKRVYDPIH DTFQLREDNS DETKADSPMQ SVKSGSQEEA SPSSIQSETE
60 70 80 90 100
TVTTKSIPVI HEIEIDDKND DDSTQSEEEN TNILLNFEPS TVPEATGAST
110 120 130 140 150
ATGPVTTNTV RRKPKESNAS KYNRHLKKPD GEPFNRKDIQ FSFMQELLMD
160 170 180 190 200
KRQIFTNVLK PLYKNSIVPI NIDGDKLSIN VTDKEYDART FVFNDKLTFA
210 220 230 240 250
QLYVLTIATS IKCSKILRDK LLLDQQVAFS TCVLALLVNI GRLNTTINFY
260 270 280 290 300
LEMTSQLRTF HSVPVLQLHA NDPKLLQDTP RLKSILKNLP WGNEQLSLME
310 320 330 340 350
TYKKVDQNDG EVDTVNKFNI INMLFSICDN SGLIDKRFLS KYVEVESKAQ
360 370 380 390 400
EQDMVDEQNE VKETEAENEK QESKAAYATT LFDILDYSKY EPKDRSNILI
410 420 430 440 450
WLLYIHLETN LSQEEVEESV RFFNGLEDGA PAGKFILRCT ERSYDTDPED
460 470 480 490 500
ELEFGANQRI KRREFMSKME EGRKRERTNV TEVKKPSIGG DKSEEDGEGE
510 520 530 540 550
DDKSEETVEE TRSLLTPTPI LESSSPMTLN RKKVTPQLPK VTPAAPTETE
560 570 580 590 600
EEITSAAIID KNDLNLTPLK KYNSSATVNK VDKLISLDLN KHVSENGKTQ
610 620 630 640 650
EEFLADLKKS QVPNRLKRRD IGLIKIFNEF EDIPVASVLG IRGKKRKKFK
660 670 680 690
DNLLGFETDF MKNLGASKKV LLNKIERAEI DDEEATAMFK LE
Length:692
Mass (Da):78,753
Last modified:November 1, 1995 - v1
Checksum:i9C0084A36431B241
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti219D → G in AAU09719 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50617 Genomic DNA Translation: BAA09225.1
Z46255 Genomic DNA Translation: CAA86347.1
AY723802 Genomic DNA Translation: AAU09719.1
BK006940 Genomic DNA Translation: DAA12426.1
PIRiS48316
RefSeqiNP_116641.1, NM_001179953.1

Genome annotation databases

EnsemblFungiiBAA09225; BAA09225; BAA09225
YFL013C; YFL013C; YFL013C
GeneIDi850534
KEGGisce:YFL013C

Similar proteinsi

Entry informationi

Entry nameiIES1_YEAST
AccessioniPrimary (citable) accession number: P43579
Secondary accession number(s): D6VTL6, E9P952
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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