Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P43579

- IES1_YEAST

UniProt

P43579 - IES1_YEAST

Protein

Ino eighty subunit 1

Gene

IES1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. nucleosome mobilization Source: SGD
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30443-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ino eighty subunit 1
    Gene namesi
    Name:IES1
    Ordered Locus Names:YFL013C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL013c.
    SGDiS000001881. IES1.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. cytosol Source: SGD
    2. Ino80 complex Source: SGD
    3. nucleus Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 692692Ino eighty subunit 1PRO_0000084153Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271Phosphoserine1 Publication
    Modified residuei487 – 4871Phosphoserine1 Publication
    Modified residuei493 – 4931Phosphoserine1 Publication
    Modified residuei504 – 5041Phosphoserine1 Publication
    Modified residuei507 – 5071Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP43579.
    PaxDbiP43579.

    Expressioni

    Gene expression databases

    GenevestigatoriP43579.

    Interactioni

    Subunit structurei

    Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    NHP10Q034355EBI-22775,EBI-12010

    Protein-protein interaction databases

    BioGridi31133. 198 interactions.
    DIPiDIP-3869N.
    IntActiP43579. 19 interactions.
    MINTiMINT-534170.
    STRINGi4932.YFL013C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43579.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili340 – 38546Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG45146.
    HOGENOMiHOG000066131.
    KOiK11675.
    OMAiMTSQLRT.
    OrthoDBiEOG7K6Q3H.

    Sequencei

    Sequence statusi: Complete.

    P43579-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKRVYDPIH DTFQLREDNS DETKADSPMQ SVKSGSQEEA SPSSIQSETE    50
    TVTTKSIPVI HEIEIDDKND DDSTQSEEEN TNILLNFEPS TVPEATGAST 100
    ATGPVTTNTV RRKPKESNAS KYNRHLKKPD GEPFNRKDIQ FSFMQELLMD 150
    KRQIFTNVLK PLYKNSIVPI NIDGDKLSIN VTDKEYDART FVFNDKLTFA 200
    QLYVLTIATS IKCSKILRDK LLLDQQVAFS TCVLALLVNI GRLNTTINFY 250
    LEMTSQLRTF HSVPVLQLHA NDPKLLQDTP RLKSILKNLP WGNEQLSLME 300
    TYKKVDQNDG EVDTVNKFNI INMLFSICDN SGLIDKRFLS KYVEVESKAQ 350
    EQDMVDEQNE VKETEAENEK QESKAAYATT LFDILDYSKY EPKDRSNILI 400
    WLLYIHLETN LSQEEVEESV RFFNGLEDGA PAGKFILRCT ERSYDTDPED 450
    ELEFGANQRI KRREFMSKME EGRKRERTNV TEVKKPSIGG DKSEEDGEGE 500
    DDKSEETVEE TRSLLTPTPI LESSSPMTLN RKKVTPQLPK VTPAAPTETE 550
    EEITSAAIID KNDLNLTPLK KYNSSATVNK VDKLISLDLN KHVSENGKTQ 600
    EEFLADLKKS QVPNRLKRRD IGLIKIFNEF EDIPVASVLG IRGKKRKKFK 650
    DNLLGFETDF MKNLGASKKV LLNKIERAEI DDEEATAMFK LE 692
    Length:692
    Mass (Da):78,753
    Last modified:November 1, 1995 - v1
    Checksum:i9C0084A36431B241
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti219 – 2191D → G in AAU09719. (PubMed:17322287)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09225.1.
    Z46255 Genomic DNA. Translation: CAA86347.1.
    AY723802 Genomic DNA. Translation: AAU09719.1.
    BK006940 Genomic DNA. Translation: DAA12426.1.
    PIRiS48316.
    RefSeqiNP_116641.1. NM_001179953.1.

    Genome annotation databases

    EnsemblFungiiYFL013C; YFL013C; YFL013C.
    GeneIDi850534.
    KEGGisce:YFL013C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09225.1 .
    Z46255 Genomic DNA. Translation: CAA86347.1 .
    AY723802 Genomic DNA. Translation: AAU09719.1 .
    BK006940 Genomic DNA. Translation: DAA12426.1 .
    PIRi S48316.
    RefSeqi NP_116641.1. NM_001179953.1.

    3D structure databases

    ProteinModelPortali P43579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31133. 198 interactions.
    DIPi DIP-3869N.
    IntActi P43579. 19 interactions.
    MINTi MINT-534170.
    STRINGi 4932.YFL013C.

    Proteomic databases

    MaxQBi P43579.
    PaxDbi P43579.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL013C ; YFL013C ; YFL013C .
    GeneIDi 850534.
    KEGGi sce:YFL013C.

    Organism-specific databases

    CYGDi YFL013c.
    SGDi S000001881. IES1.

    Phylogenomic databases

    eggNOGi NOG45146.
    HOGENOMi HOG000066131.
    KOi K11675.
    OMAi MTSQLRT.
    OrthoDBi EOG7K6Q3H.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30443-MONOMER.

    Miscellaneous databases

    NextBioi 966283.

    Gene expression databases

    Genevestigatori P43579.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
      Shen X., Ranallo R., Choi E., Wu C.
      Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE INO80 COMPLEX.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
      Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
      J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Strain: ADR376.
    8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
      Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
      Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-487; SER-493; SER-504 AND THR-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiIES1_YEAST
    AccessioniPrimary (citable) accession number: P43579
    Secondary accession number(s): D6VTL6, E9P952
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1400 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3