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P43579 (IES1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ino eighty subunit 1
Gene names
Name:IES1
Ordered Locus Names:YFL013C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length692 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

Subunit structure

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80. Ref.4

Subcellular location

Nucleus Ref.5.

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

NHP10Q034355EBI-22775,EBI-12010

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 692692Ino eighty subunit 1
PRO_0000084153

Regions

Coiled coil340 – 38546 Potential

Amino acid modifications

Modified residue271Phosphoserine Ref.9
Modified residue4871Phosphoserine Ref.9
Modified residue4931Phosphoserine Ref.9
Modified residue5041Phosphoserine Ref.9
Modified residue5071Phosphothreonine Ref.9

Experimental info

Sequence conflict2191D → G in AAU09719. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P43579 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 9C0084A36431B241

FASTA69278,753
        10         20         30         40         50         60 
MGKRVYDPIH DTFQLREDNS DETKADSPMQ SVKSGSQEEA SPSSIQSETE TVTTKSIPVI 

        70         80         90        100        110        120 
HEIEIDDKND DDSTQSEEEN TNILLNFEPS TVPEATGAST ATGPVTTNTV RRKPKESNAS 

       130        140        150        160        170        180 
KYNRHLKKPD GEPFNRKDIQ FSFMQELLMD KRQIFTNVLK PLYKNSIVPI NIDGDKLSIN 

       190        200        210        220        230        240 
VTDKEYDART FVFNDKLTFA QLYVLTIATS IKCSKILRDK LLLDQQVAFS TCVLALLVNI 

       250        260        270        280        290        300 
GRLNTTINFY LEMTSQLRTF HSVPVLQLHA NDPKLLQDTP RLKSILKNLP WGNEQLSLME 

       310        320        330        340        350        360 
TYKKVDQNDG EVDTVNKFNI INMLFSICDN SGLIDKRFLS KYVEVESKAQ EQDMVDEQNE 

       370        380        390        400        410        420 
VKETEAENEK QESKAAYATT LFDILDYSKY EPKDRSNILI WLLYIHLETN LSQEEVEESV 

       430        440        450        460        470        480 
RFFNGLEDGA PAGKFILRCT ERSYDTDPED ELEFGANQRI KRREFMSKME EGRKRERTNV 

       490        500        510        520        530        540 
TEVKKPSIGG DKSEEDGEGE DDKSEETVEE TRSLLTPTPI LESSSPMTLN RKKVTPQLPK 

       550        560        570        580        590        600 
VTPAAPTETE EEITSAAIID KNDLNLTPLK KYNSSATVNK VDKLISLDLN KHVSENGKTQ 

       610        620        630        640        650        660 
EEFLADLKKS QVPNRLKRRD IGLIKIFNEF EDIPVASVLG IRGKKRKKFK DNLLGFETDF 

       670        680        690 
MKNLGASKKV LLNKIERAEI DDEEATAMFK LE 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
Shen X., Ranallo R., Choi E., Wu C.
Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE INO80 COMPLEX.
[5]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[6]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[7]"Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: ADR376.
[8]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-487; SER-493; SER-504 AND THR-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50617 Genomic DNA. Translation: BAA09225.1.
Z46255 Genomic DNA. Translation: CAA86347.1.
AY723802 Genomic DNA. Translation: AAU09719.1.
BK006940 Genomic DNA. Translation: DAA12426.1.
PIRS48316.
RefSeqNP_116641.1. NM_001179953.1.

3D structure databases

ProteinModelPortalP43579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31133. 198 interactions.
DIPDIP-3869N.
IntActP43579. 19 interactions.
MINTMINT-534170.
STRING4932.YFL013C.

Proteomic databases

MaxQBP43579.
PaxDbP43579.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYFL013C; YFL013C; YFL013C.
GeneID850534.
KEGGsce:YFL013C.

Organism-specific databases

CYGDYFL013c.
SGDS000001881. IES1.

Phylogenomic databases

eggNOGNOG45146.
HOGENOMHOG000066131.
KOK11675.
OMAMTSQLRT.
OrthoDBEOG7K6Q3H.

Enzyme and pathway databases

BioCycYEAST:G3O-30443-MONOMER.

Gene expression databases

GenevestigatorP43579.

Family and domain databases

ProtoNetSearch...

Other

NextBio966283.

Entry information

Entry nameIES1_YEAST
AccessionPrimary (citable) accession number: P43579
Secondary accession number(s): D6VTL6, E9P952
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD