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P43579

- IES1_YEAST

UniProt

P43579 - IES1_YEAST

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Protein
Ino eighty subunit 1
Gene
IES1, YFL013C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin-remodeling complex.

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. nucleosome mobilization Source: SGD
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-30443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ino eighty subunit 1
Gene namesi
Name:IES1
Ordered Locus Names:YFL013C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VI

Organism-specific databases

CYGDiYFL013c.
SGDiS000001881. IES1.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. Ino80 complex Source: SGD
  2. cytosol Source: SGD
  3. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 692692Ino eighty subunit 1
PRO_0000084153Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271Phosphoserine1 Publication
Modified residuei487 – 4871Phosphoserine1 Publication
Modified residuei493 – 4931Phosphoserine1 Publication
Modified residuei504 – 5041Phosphoserine1 Publication
Modified residuei507 – 5071Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43579.
PaxDbiP43579.

Expressioni

Gene expression databases

GenevestigatoriP43579.

Interactioni

Subunit structurei

Component of the chromatin-remodeling INO80 complex, at least composed of ARP4, ARP5, ARP8, RVB1, RVB2, TAF14, NHP10, IES1, IES3, IES4, IES6, ACT1, IES2, IES5 and INO80.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
NHP10Q034355EBI-22775,EBI-12010

Protein-protein interaction databases

BioGridi31133. 198 interactions.
DIPiDIP-3869N.
IntActiP43579. 19 interactions.
MINTiMINT-534170.
STRINGi4932.YFL013C.

Structurei

3D structure databases

ProteinModelPortaliP43579.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili340 – 38546 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG45146.
HOGENOMiHOG000066131.
KOiK11675.
OMAiMTSQLRT.
OrthoDBiEOG7K6Q3H.

Sequencei

Sequence statusi: Complete.

P43579-1 [UniParc]FASTAAdd to Basket

« Hide

MGKRVYDPIH DTFQLREDNS DETKADSPMQ SVKSGSQEEA SPSSIQSETE    50
TVTTKSIPVI HEIEIDDKND DDSTQSEEEN TNILLNFEPS TVPEATGAST 100
ATGPVTTNTV RRKPKESNAS KYNRHLKKPD GEPFNRKDIQ FSFMQELLMD 150
KRQIFTNVLK PLYKNSIVPI NIDGDKLSIN VTDKEYDART FVFNDKLTFA 200
QLYVLTIATS IKCSKILRDK LLLDQQVAFS TCVLALLVNI GRLNTTINFY 250
LEMTSQLRTF HSVPVLQLHA NDPKLLQDTP RLKSILKNLP WGNEQLSLME 300
TYKKVDQNDG EVDTVNKFNI INMLFSICDN SGLIDKRFLS KYVEVESKAQ 350
EQDMVDEQNE VKETEAENEK QESKAAYATT LFDILDYSKY EPKDRSNILI 400
WLLYIHLETN LSQEEVEESV RFFNGLEDGA PAGKFILRCT ERSYDTDPED 450
ELEFGANQRI KRREFMSKME EGRKRERTNV TEVKKPSIGG DKSEEDGEGE 500
DDKSEETVEE TRSLLTPTPI LESSSPMTLN RKKVTPQLPK VTPAAPTETE 550
EEITSAAIID KNDLNLTPLK KYNSSATVNK VDKLISLDLN KHVSENGKTQ 600
EEFLADLKKS QVPNRLKRRD IGLIKIFNEF EDIPVASVLG IRGKKRKKFK 650
DNLLGFETDF MKNLGASKKV LLNKIERAEI DDEEATAMFK LE 692
Length:692
Mass (Da):78,753
Last modified:November 1, 1995 - v1
Checksum:i9C0084A36431B241
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191D → G in AAU09719. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09225.1.
Z46255 Genomic DNA. Translation: CAA86347.1.
AY723802 Genomic DNA. Translation: AAU09719.1.
BK006940 Genomic DNA. Translation: DAA12426.1.
PIRiS48316.
RefSeqiNP_116641.1. NM_001179953.1.

Genome annotation databases

EnsemblFungiiYFL013C; YFL013C; YFL013C.
GeneIDi850534.
KEGGisce:YFL013C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D50617 Genomic DNA. Translation: BAA09225.1 .
Z46255 Genomic DNA. Translation: CAA86347.1 .
AY723802 Genomic DNA. Translation: AAU09719.1 .
BK006940 Genomic DNA. Translation: DAA12426.1 .
PIRi S48316.
RefSeqi NP_116641.1. NM_001179953.1.

3D structure databases

ProteinModelPortali P43579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31133. 198 interactions.
DIPi DIP-3869N.
IntActi P43579. 19 interactions.
MINTi MINT-534170.
STRINGi 4932.YFL013C.

Proteomic databases

MaxQBi P43579.
PaxDbi P43579.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YFL013C ; YFL013C ; YFL013C .
GeneIDi 850534.
KEGGi sce:YFL013C.

Organism-specific databases

CYGDi YFL013c.
SGDi S000001881. IES1.

Phylogenomic databases

eggNOGi NOG45146.
HOGENOMi HOG000066131.
KOi K11675.
OMAi MTSQLRT.
OrthoDBi EOG7K6Q3H.

Enzyme and pathway databases

BioCyci YEAST:G3O-30443-MONOMER.

Miscellaneous databases

NextBioi 966283.

Gene expression databases

Genevestigatori P43579.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Involvement of actin-related proteins in ATP-dependent chromatin remodeling."
    Shen X., Ranallo R., Choi E., Wu C.
    Mol. Cell 12:147-155(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE, IDENTIFICATION IN THE INO80 COMPLEX.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  7. "Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae."
    Li X., Gerber S.A., Rudner A.D., Beausoleil S.A., Haas W., Villen J., Elias J.E., Gygi S.P.
    J. Proteome Res. 6:1190-1197(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: ADR376.
  8. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution."
    Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.
    Science 325:1682-1686(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; SER-487; SER-493; SER-504 AND THR-507, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiIES1_YEAST
AccessioniPrimary (citable) accession number: P43579
Secondary accession number(s): D6VTL6, E9P952
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 11, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome VI
    Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

External Data

Dasty 3

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