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Protein

Transcriptional regulatory protein GAT1

Gene

GAT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Positive regulator of multiple nitrogen catabolic genes.

Miscellaneous

Present with 1180 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri310 – 334GATA-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • RNA polymerase II transcription factor binding Source: GO_Central
  • sequence-specific DNA binding Source: SGD
  • transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: SGD
  • transcription factor activity, RNA polymerase II transcription factor binding Source: SGD
  • zinc ion binding Source: InterPro

GO - Biological processi

  • cell differentiation Source: GO_Central
  • nitrogen catabolite activation of transcription Source: SGD
  • nitrogen catabolite activation of transcription from RNA polymerase II promoter Source: SGD
  • positive regulation of autophagy Source: SGD
  • positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

BioCyciYEAST:G3O-30439-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional regulatory protein GAT1
Gene namesi
Name:GAT1
Ordered Locus Names:YFL021W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome VI

Organism-specific databases

EuPathDBiFungiDB:YFL021W
SGDiS000001873 GAT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000834841 – 510Transcriptional regulatory protein GAT1Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei167PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1
Modified residuei369PhosphothreonineCombined sources1
Modified residuei399PhosphoserineCombined sources1
Modified residuei418PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43574
PaxDbiP43574
PRIDEiP43574

PTM databases

iPTMnetiP43574

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31125, 74 interactors
DIPiDIP-4276N
IntActiP43574, 7 interactors
MINTiP43574
STRINGi4932.YFL021W

Structurei

3D structure databases

ProteinModelPortaliP43574
SMRiP43574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 158Poly-Asp8

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri310 – 334GATA-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000119221
InParanoidiP43574
KOiK09184
OrthoDBiEOG092C43RR

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR013860 DUF1752_fun
IPR000679 Znf_GATA
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF08550 DUF1752, 1 hit
PF00320 GATA, 1 hit
PRINTSiPR00619 GATAZNFINGER
SMARTiView protein in SMART
SM00401 ZnF_GATA, 1 hit
PROSITEiView protein in PROSITE
PS00344 GATA_ZN_FINGER_1, 1 hit
PS50114 GATA_ZN_FINGER_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVFFPLLFR PSPVLFIACA YIYIDIYIHC TRCTVVNITM STNRVPNLDP
60 70 80 90 100
DLNLNKEIWD LYSSAQKILP DSNRILNLSW RLHNRTSFHR INRIMQHSNS
110 120 130 140 150
IMDFSASPFA SGVNAAGPGN NDLDDTDTDN QQFFLSDMNL NGSSVFENVF
160 170 180 190 200
DDDDDDDDVE THSIVHSDLL NDMDSASQRA SHNASGFPNF LDTSCSSSFD
210 220 230 240 250
DHFIFTNNLP FLNNNSINNN HSHNSSHNNN SPSIANNTNA NTNTNTSAST
260 270 280 290 300
NTNSPLLRRN PSPSIVKPGS RRNSSVRKKK PALKKIKSST SVQSSATPPS
310 320 330 340 350
NTSSNPDIKC SNCTTSTTPL WRKDPKGLPL CNACGLFLKL HGVTRPLSLK
360 370 380 390 400
TDIIKKRQRS STKINNNITP PPSSSLNPGA AGKKKNYTAS VAASKRKNSL
410 420 430 440 450
NIVAPLKSQD IPIPKIASPS IPQYLRSNTR HHLSSSVPIE AETFSSFRPD
460 470 480 490 500
MNMTMNMNLH NASTSSFNNE AFWKPLDSAI DHHSGDTNPN SNMNTTPNGN
510
LSLDWLNLNL
Length:510
Mass (Da):56,328
Last modified:November 1, 1995 - v1
Checksum:i62D805E42695F35F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27344 Genomic DNA Translation: AAB03516.1
D50617 Genomic DNA Translation: BAA09217.1
BK006940 Genomic DNA Translation: DAA12419.1
PIRiS56233
RefSeqiNP_116632.1, NM_001179945.1

Genome annotation databases

EnsemblFungiiBAA09217; BAA09217; BAA09217
YFL021W; YFL021W; YFL021W
GeneIDi850523
KEGGisce:YFL021W

Similar proteinsi

Entry informationi

Entry nameiGAT1_YEAST
AccessioniPrimary (citable) accession number: P43574
Secondary accession number(s): D6VTK9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health