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Reviewed, UniProtKB/Swiss-Prot P43569 (CAF16_YEAST)

Last modified November 3, 2009. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    CCR4-associated factor 16
Gene names
Name: CAF16
Ordered Locus Names: YFL028C
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Subunit structure

Interacts with CCR4 and SSN2. Ref.2

Subcellular location

Cytoplasm. Nucleus. Ref.3

Miscellaneous

Present with 1620 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the ABC transporter superfamily.

Contains 1 ABC transporter domain.

Ontologies

Keywords
   Biological processTransport
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processregulation of transcription, DNA-dependent

Inferred from mutant phenotype. Source: SGD

transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentCCR4-NOT complex Ref.2

Inferred from physical interaction. Source: SGD

cytoplasm

Inferred from direct assay. Source: SGD

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289CCR4-associated factor 16
PRO_0000093464

Regions

Domain7 – 249243ABC transporter
Nucleotide binding41 – 488ATP Potential

Sequences

Sequence LengthMass (Da)Tools
P43569-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 2250CC15F9CE1354

FASTA28933,090
        10         20         30         40         50         60 
MVSQFAIEVR NLTYKFKESS DPSVVDINLQ IPWNTRSLVV GANGAGKSTL LKLLSGKHLC 

        70         80         90        100        110        120 
LDGKILVNGL DPFSPLSMNQ VDDDESVEDS TNYQTTTYLG TEWCHMSIIN RDIGVLELLK 

       130        140        150        160        170        180 
SIGFDHFRER GERLVRILDI DVRWRMHRLS DGQKRRVQLA MGLLKPWRVL LLDEVTVDLD 

       190        200        210        220        230        240 
VIARARLLEF LKWETETRRC SVVYATHIFD GLAKWPNQVY HMKSGKIVDN LDYQKDVEFS 

       250        260        270        280 
EVVNAKVNGQ VAFENDNNKV VISKVNSLHP LALEWLKRDN QIPDKEIGI 

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae."
Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T.
Nat. Genet. 10:261-268(1995) [PubMed: 7670463] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme."
Liu H.-Y., Chiang Y.-C., Pan J., Chen J., Salvadore C., Audino D.C., Badarinarayana V., Palaniswamy V., Anderson B., Denis C.L.
J. Biol. Chem. 276:7541-7548(2001) [PubMed: 11113136] [Abstract]
Cited for: INTERACTION WITH CCR4 AND SSN2.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

D50617 Genomic DNA. Translation: BAA09210.1.
PIRS56226.
RefSeqNP_116625.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:5946N.
IntActP43569. 7 interactions.
STRINGP43569.

Proteomic databases

PeptideAtlasP43569.

Genome annotation databases

EnsemblYFL028C; YFL028C; YFL028C; Saccharomyces cerevisiae. [Genome view]
GeneID850516.
GenomeReviewsGene locus YFL028C in contig D50617_GR.
KEGGsce:YFL028C.
NMPDRfig|4932.3.peg.2252.

Organism-specific databases

CYGDYFL028c.
SGDS000001866. CAF16.

Phylogenomic databases

HOGENOMP43569.
OMARIETIGK.

Gene expression databases

ArrayExpressP43569.
GenevestigatorP43569.
GermOnlineYFL028C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00005. ABC_tran. 1 hit.
[Graphical view]
ProDomPD000006. ABC_transporter. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS00211. ABC_TRANSPORTER_1. False negative.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio966239.

Entry information

Entry nameCAF16_YEAST
AccessionPrimary (citable) accession number: P43569
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 3, 2009
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome VI

Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents