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P43569

- CAF16_YEAST

UniProt

P43569 - CAF16_YEAST

Protein

CCR4-associated factor 16

Gene

CAF16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi41 – 488ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity Source: SGD
    2. ATP binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-30432-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CCR4-associated factor 16
    Gene namesi
    Name:CAF16
    Ordered Locus Names:YFL028C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VI

    Organism-specific databases

    CYGDiYFL028c.
    SGDiS000001866. CAF16.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. CCR4-NOT complex Source: SGD
    2. cytoplasm Source: UniProtKB-SubCell
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289CCR4-associated factor 16PRO_0000093464Add
    BLAST

    Proteomic databases

    MaxQBiP43569.
    PaxDbiP43569.
    PeptideAtlasiP43569.

    Expressioni

    Gene expression databases

    GenevestigatoriP43569.

    Interactioni

    Subunit structurei

    Interacts with CCR4 and SSN2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SAH1P399543EBI-22808,EBI-16451

    Protein-protein interaction databases

    BioGridi31118. 15 interactions.
    DIPiDIP-5946N.
    IntActiP43569. 3 interactions.
    MINTiMINT-4484852.
    STRINGi4932.YFL028C.

    Structurei

    3D structure databases

    ProteinModelPortaliP43569.
    SMRiP43569. Positions 7-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 249243ABC transporterPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ABC transporter superfamily.Curated
    Contains 1 ABC transporter domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG4586.
    HOGENOMiHOG000200636.
    KOiK12608.
    OMAiSTHLIAE.
    OrthoDBiEOG7WDNCD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF00005. ABC_tran. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43569-1 [UniParc]FASTAAdd to Basket

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    MVSQFAIEVR NLTYKFKESS DPSVVDINLQ IPWNTRSLVV GANGAGKSTL    50
    LKLLSGKHLC LDGKILVNGL DPFSPLSMNQ VDDDESVEDS TNYQTTTYLG 100
    TEWCHMSIIN RDIGVLELLK SIGFDHFRER GERLVRILDI DVRWRMHRLS 150
    DGQKRRVQLA MGLLKPWRVL LLDEVTVDLD VIARARLLEF LKWETETRRC 200
    SVVYATHIFD GLAKWPNQVY HMKSGKIVDN LDYQKDVEFS EVVNAKVNGQ 250
    VAFENDNNKV VISKVNSLHP LALEWLKRDN QIPDKEIGI 289
    Length:289
    Mass (Da):33,090
    Last modified:November 1, 1995 - v1
    Checksum:i2250CC15F9CE1354
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09210.1.
    BK006940 Genomic DNA. Translation: DAA12412.1.
    PIRiS56226.
    RefSeqiNP_116625.1. NM_001179938.1.

    Genome annotation databases

    EnsemblFungiiYFL028C; YFL028C; YFL028C.
    GeneIDi850516.
    KEGGisce:YFL028C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50617 Genomic DNA. Translation: BAA09210.1 .
    BK006940 Genomic DNA. Translation: DAA12412.1 .
    PIRi S56226.
    RefSeqi NP_116625.1. NM_001179938.1.

    3D structure databases

    ProteinModelPortali P43569.
    SMRi P43569. Positions 7-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31118. 15 interactions.
    DIPi DIP-5946N.
    IntActi P43569. 3 interactions.
    MINTi MINT-4484852.
    STRINGi 4932.YFL028C.

    Proteomic databases

    MaxQBi P43569.
    PaxDbi P43569.
    PeptideAtlasi P43569.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YFL028C ; YFL028C ; YFL028C .
    GeneIDi 850516.
    KEGGi sce:YFL028C.

    Organism-specific databases

    CYGDi YFL028c.
    SGDi S000001866. CAF16.

    Phylogenomic databases

    eggNOGi COG4586.
    HOGENOMi HOG000200636.
    KOi K12608.
    OMAi STHLIAE.
    OrthoDBi EOG7WDNCD.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-30432-MONOMER.

    Miscellaneous databases

    NextBioi 966239.

    Gene expression databases

    Genevestigatori P43569.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003593. AAA+_ATPase.
    IPR003439. ABC_transporter-like.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF00005. ABC_tran. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50893. ABC_TRANSPORTER_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme."
      Liu H.-Y., Chiang Y.-C., Pan J., Chen J., Salvadore C., Audino D.C., Badarinarayana V., Palaniswamy V., Anderson B., Denis C.L.
      J. Biol. Chem. 276:7541-7548(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CCR4 AND SSN2.
    4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    5. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCAF16_YEAST
    AccessioniPrimary (citable) accession number: P43569
    Secondary accession number(s): D6VTK2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1620 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome VI
      Yeast (Saccharomyces cerevisiae) chromosome VI: entries and gene names

    External Data

    Dasty 3